| Entry |
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| Name |
3-hydroxybenzoate 4-monooxygenase;
3-hydroxybenzoate 4-hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)
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| Reaction(IUBMB) |
3-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O [RN: R01628]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.
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| History |
EC 1.14.13.23 created 1972 as EC 1.14.99.13, transferred 1984 to EC 1.14.13.23
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| Pathway |
| Benzoate degradation | | Polycyclic aromatic hydrocarbon degradation | | Microbial metabolism in diverse environments |
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| Orthology |
| 3-hydroxybenzoate 4-monooxygenase |
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| Genes |
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| Reference |
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| Authors |
Michalover JL, Ribbons DW, Hughes H. |
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| Title |
3-Hydroxybenzoate 4-hydroxylase from Pseudomonas testosteroni. |
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| Journal |
Biochem. Biophys. Res. Commun. 55 (1973) 888-96. |
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| Reference |
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| Authors |
Premkumar R, Rao PV, Sreeleela NS, Vaidyanathan CS. |
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| Title |
m-Hydroxybenzoic acid 4-hydroxylase from Aspergillus niger. |
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| Journal |
Can. J. Biochem. 47 (1969) 825-7. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 37256-76-1 |
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| LinkDB |
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