| Entry |
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| Name |
melilotate 3-monooxygenase;
2-hydroxyphenylpropionate hydroxylase;
melilotate hydroxylase;
2-hydroxyphenylpropionic hydroxylase;
melilotic hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)
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| Reaction(IUBMB) |
3-(2-hydroxyphenyl)propanoate + NADH + H+ + O2 = 3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O [RN: R03369]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD).
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| History |
EC 1.14.13.4 created 1972
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| Pathway |
| Phenylalanine metabolism | | Microbial metabolism in diverse environments |
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| Reference |
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| Authors |
Levy CC. |
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| Title |
Melilotate hydroxylase. Purification of the enzyme and the nature of the prosthetic group. |
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| Journal |
J. Biol. Chem. 242 (1967) 747-53. |
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| Reference |
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| Authors |
Levy CC, Frost P. |
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| Title |
The metabolism of coumarin by a microorganism. V. Melilotate hydroxylase. |
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| Journal |
J. Biol. Chem. 241 (1966) 997-1003. |
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| Reference |
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| Authors |
Strickland S, Massey V. |
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| Title |
The purification and properties of the flavoprotein melilotate hydroxylase. |
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| Journal |
J. Biol. Chem. 248 (1973) 2944-52. |
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| Reference |
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| Authors |
Strickland S, Massey V. |
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| Title |
The mechanism of action of the flavoprotein melilotate hydroxylase. |
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| Journal |
J. Biol. Chem. 248 (1973) 2953-62. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37256-72-7 |
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| LinkDB |
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