| Entry |
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| Name |
dihydrosanguinarine 10-monooxygenase;
dihydrosanguinarine 10-hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)
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| Reaction(IUBMB) |
dihydrosanguinarine + NADPH + H+ + O2 = 10-hydroxydihydrosanguinarine + NADP+ + H2O [RN: R04702]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
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| History |
EC 1.14.13.56 created 1999
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| Pathway |
| Isoquinoline alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Reference |
1 |
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| Authors |
De-Eknamkul, W., Tanahashi, T. and Zenk, M.H. |
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| Title |
Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia. |
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| Journal |
Phytochemistry 31 (1992) 2713-2717. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 144388-41-0 |
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| LinkDB |
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