ENZYME: 1.2.1.61
Entry
EC 1.2.1.61 Enzyme
Name
4-hydroxymuconic-semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase
Reaction(IUBMB)
4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + 2 H+ [RN:
R05236
]
Reaction(KEGG)
R05236
Substrate
4-hydroxymuconic semialdehyde [CPD:
C06603
];
NAD+ [CPD:
C00003
];
H2O [CPD:
C00001
]
Product
maleylacetate [CPD:
C02222
];
NADH [CPD:
C00004
];
H+ [CPD:
C00080
]
Comment
Involved in the 4-nitrophenol degradation pathway.
History
EC 1.2.1.61 created 2000
Pathway
ec00361
Chlorocyclohexane and chlorobenzene degradation
ec01120
Microbial metabolism in diverse environments
Reference
1 [PMID:
16348446
]
Authors
Spain JC, Gibson DT.
Title
Pathway for Biodegradation of p-Nitrophenol in a Moraxella sp.
Journal
Appl. Environ. Microbiol. 57 (1991) 812-819.
Other DBs
ExplorEnz - The Enzyme Database:
1.2.1.61
IUBMB Enzyme Nomenclature:
1.2.1.61
ExPASy - ENZYME nomenclature database:
1.2.1.61
UM-BBD (Biocatalysis/Biodegradation Database):
1.2.1.61
BRENDA, the Enzyme Database:
1.2.1.61
LinkDB
REACTION: R05236
Entry
R05236 Reaction
Name
4-Hydroxymuconic-semialdehyde:NAD+ oxidoreductase
Definition
cis,cis-4-Hydroxymuconic semialdehyde + NAD+ + H2O <=> 2-Maleylacetate + NADH + H+
Equation
C06603
+
C00003
+
C00001
<=>
C02222
+
C00004
+
C00080
Reaction class
RC00001
C00003_C00004
RC02451
C02222_C06603
Enzyme
1.2.1.61
Pathway
rn00361
Chlorocyclohexane and chlorobenzene degradation
rn01120
Microbial metabolism in diverse environments
Other DBs
RHEA:
22423
LinkDB
DBGET
integrated database retrieval system
