| Entry |
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| Name |
cocaine esterase;
CocE;
hCE2;
hCE-2;
human carboxylesterase 2
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| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
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| Sysname |
cocaine benzoylhydrolase
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| Reaction(IUBMB) |
cocaine + H2O = ecgonine methyl ester + benzoate [RN: R06728]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy [2,3].
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| History |
EC 3.1.1.84 created 2010
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| Pathway |
| Tropane, piperidine and pyridine alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
| carboxylesterase 2 | | cocaine esterase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | CFR: | | BACU: | | LVE: | | ECB: | | HAI: | | RSS: | | PALE: | | LAV: | | MDO: | | SHR: | | GGA: | | CJO: | | APLA: | | ACYG: | | TGU: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | NPR: | | DRE: | | SRX: | | SANH: | | SGH: | | IPU: | | TRU: | | TNG: | | LCO: | | NCC: | | MZE: | | OLA: | | XMA: | | CSEM: | | LCF: | | SASA: | | ELS: | | SFM: | | LCM: | | CMK: | | BFO: | | CIN: | | SKO: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | MDE: | | TCA: | | DPA: | | NVL: | | API: | | DPX: | | TUT: | | CEL: | | CBR: | | NAI: | | LGI: | | CRG: | | OBI: | | ADF: | | TMN: | | FGR: | | FPU: | | FVR: | | NHE: | | CFJ: | | PFY: | | SSL: | | BFU: | | PSCO: | | GLZ: | | ANI: | | AFM: | | AOR: | | ANG: | | AFV: | | NFI: | | PCS: | | ABE: | | TVE: | | BZE: | | NPA: | | SHS: | | ACAN: | | PSOJ: | |
» show all
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| Reference |
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| Authors |
Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG |
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| Title |
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. |
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| Journal |
Mol. Pharmacol. 75 (2009) 318-23. |
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| Reference |
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| Authors |
Bresler MM, Rosser SJ, Basran A, Bruce NC |
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| Title |
Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1. |
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| Journal |
Appl. Environ. Microbiol. 66 (2000) 904-8. |
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| Sequence |
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| Reference |
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| Authors |
Britt AJ, Bruce NC, Lowe CR |
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| Title |
Identification of a cocaine esterase in a strain of Pseudomonas maltophilia. |
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| Journal |
J. Bacteriol. 174 (1992) 2087-94. |
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| Reference |
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| Authors |
Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA |
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| Title |
Crystal structure of a bacterial cocaine esterase. |
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| Journal |
Nat. Struct. Biol. 9 (2002) 17-21. |
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| Sequence |
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| Reference |
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| Authors |
Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF |
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| Title |
Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. |
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| Journal |
J. Biol. Chem. 272 (1997) 14769-75. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: |
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| LinkDB |
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