| Entry |
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| Name |
dichloromuconate cycloisomerase;
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
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| Class |
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
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| Sysname |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
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| Reaction(IUBMB) |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate [RN: R04345]
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| Reaction(KEGG) |
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| Substrate |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate [CPD: C04625]
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| Product |
2,4-dichloro-cis,cis-muconate [CPD: C03918]
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| Comment |
Requires Mn2+. The product of cycloisomerization of dichloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylene-3-chlorobut-2-en-4-olide. Also acts, in the reverse direction, on cis,cis-muconate and its monochloro-derivatives, but with lower affinity. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.7 (chloromuconate cycloisomerase).
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| History |
EC 5.5.1.11 created 1992
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| Pathway |
| Chlorocyclohexane and chlorobenzene degradation | | Microbial metabolism in diverse environments |
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| Reference |
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| Authors |
Kuhm AE, Schlomann M, Knackmuss HJ, Pieper DH. |
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| Title |
Purification and characterization of dichloromuconate cycloisomerase from Alcaligenes eutrophus JMP 134. |
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| Journal |
Biochem. J. 266 (1990) 877-83. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 126904-95-8 |
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| LinkDB |
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