KEGG   DRUG: AcetaminophenHelp
Entry
D00217                      Drug                                   

Name
Acetaminophen (JP17/USP);
Paracetamol (INN);
Tylenol (TN)
Product
  Generic
  Other
Formula
C8H9NO2
Exact mass
151.0633
Mol weight
151.1626
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01981  Antiinflammatory drug, anilide derivatives
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01638  CYP2A6 substrate
 DG01633  CYP3A substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Analgesic, Antipyretic
Comment
Aniline derivative, Anilide derivative
Metabolism
Enzyme: CYP2E1 [HSA:1571], CYP2A6 [HSA:1548], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antimigraines
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02B OTHER ANALGESICS AND ANTIPYRETICS
    N02BE Anilides
     N02BE01 Paracetamol
      D00217  Acetaminophen (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1141  Anilines
     D00217  Acetaminophen (JP17/USP); Paracetamol (INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00217  Acetaminophen (JP17/USP)
  03 Antipyretic analgesic agents
   D00217  Acetaminophen (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Acetaminophen
    D00217  Acetaminophen (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Paracetamol
    D00217  Acetaminophen (JP17/USP)
  CYP3A4
   Paracetamol
    D00217  Acetaminophen (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00217  Acetaminophen
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Anti-inflammatory drugs
  D00217
Rx-to-OTC switch list in the USA [br08315.html]
 D00217
BRITE hierarchy
Other DBs
CAS: 
103-90-2
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        11
            1   C8y C    21.1806  -16.6437
            2   C8x C    21.1806  -18.0466
            3   C8x C    19.9699  -15.9511
            4   N1b N    22.3914  -15.9511
            5   C8x C    19.9699  -18.7509
            6   C8x C    18.7534  -16.6437
            7   C5a C    23.6080  -16.6496
            8   C8y C    18.7534  -18.0466
            9   C1a C    24.8186  -15.9511
            10  O5a O    23.6020  -18.0466
            11  O1a O    17.5425  -18.7509
BOND        11
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     7  10 2
            10    8  11 1
            11    6   8 2

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