KEGG   DRUG: AcyclovirHelp
Entry
D00222                      Drug                                   

Name
Acyclovir (USP);
Aciclovir (JP17/INN);
Aciclovir granules (JP17);
Aciclovir ophthalmic oinment (JP17);
Aciclovir tablets (JP17);
Sitavig (TN);
Zovirax (TN)
Product
  Generic
ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (Actavis Pharma), ACYCLOVIR (Actavis Pharma), ACYCLOVIR (Aidarex Pharmaceuticals LLC), ACYCLOVIR (Aidarex Pharmaceuticals LLC), ACYCLOVIR (Alembic Pharmaceuticals), ACYCLOVIR (Alembic Pharmaceuticals Limited), ACYCLOVIR (American Health Packaging), ACYCLOVIR (American Health Packaging), ACYCLOVIR (Amneal Pharmaceuticals of New York), ACYCLOVIR (Aphena Pharma Solutions - Tennessee), ACYCLOVIR (Apotex Corp.), ACYCLOVIR (Apotex Corp.), ACYCLOVIR (Apotheca), ACYCLOVIR (Apotheca), ACYCLOVIR (Atlantic Biologicals Corps), ACYCLOVIR (AvPAK), ACYCLOVIR (AvPAK), ACYCLOVIR (Avera McKennan Hospital), ACYCLOVIR (Avera McKennan Hospital), ACYCLOVIR (Avera McKennan Hospital), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Cadila Healthcare Limited), ACYCLOVIR (Cadila Healthcare Limited), ACYCLOVIR (Cadila Pharmaceuticals Limited), ACYCLOVIR (Cadila Pharmaceuticals Limited), ACYCLOVIR (Camber Pharmaceuticals), ACYCLOVIR (Cardinal Health), ACYCLOVIR (Cardinal Health), ACYCLOVIR (Cardinal Health), ACYCLOVIR (Cardinal Health), ACYCLOVIR (Carlsbad Technology), ACYCLOVIR (Carlsbad Technology), ACYCLOVIR (Carlsbad Technology), ACYCLOVIR (Clinical Solutions Wholesale), ACYCLOVIR (DIRECT RX), ACYCLOVIR (Direct RX), ACYCLOVIR (Direct Rx), ACYCLOVIR (DirectRX), ACYCLOVIR (E. Fougera & Co. a division of Fougera Pharmaceuticals), ACYCLOVIR (G&W Laboratories), ACYCLOVIR (Glenmark Pharmaceuticals), ACYCLOVIR (Golden State Medical Supply), ACYCLOVIR (Golden State Medical Supply), ACYCLOVIR (H.J. Harkins Company), ACYCLOVIR (H.J. Harkins Company), ACYCLOVIR (Heritage Pharmaceuticals), ACYCLOVIR (Heritage Pharmaceuticals), ACYCLOVIR (Heritage Pharmaceuticals), ACYCLOVIR (Hi-Tech Pharmacal), ACYCLOVIR (Lake Erie Medical DBA Quality Care Products LLC), ACYCLOVIR (Lake Erie Medical DBA Quality Care Products LLC), ACYCLOVIR (Lake Erie Medical DBA Quality Care Products LLC), ACYCLOVIR (Liberty Pharmaceuticals), ACYCLOVIR (MAS MANAGEMENT GROUP), ACYCLOVIR (Major Pharmaceuticals), ACYCLOVIR (Major Pharmaceuticals), ACYCLOVIR (McKesson Corporation), ACYCLOVIR (MedVantx), ACYCLOVIR (Mylan Institutional), ACYCLOVIR (Mylan Pharmaceuticals), ACYCLOVIR (Nivagen Pharmaceuticals), ACYCLOVIR (Nivagen Pharmaceuticals), ACYCLOVIR (NorthStar Rx LLC), ACYCLOVIR (Northwind Pharmaceuticals), ACYCLOVIR (Northwind Pharmaceuticals), ACYCLOVIR (Northwind Pharmaceuticals), ACYCLOVIR (NuCare Pharmaceuticals), ACYCLOVIR (NuCare Pharmaceuticals), ACYCLOVIR (NuCare Pharmaceuticals), ACYCLOVIR (NuCare Pharmaceuticals), ACYCLOVIR (NuCare Pharmaceuticals), ACYCLOVIR (NuCarePharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (Physicians Total Care), ACYCLOVIR (Physicians Total Care), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Quinn Pharmaceuticals), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (RPK Pharmaceuticals), ACYCLOVIR (RPK Pharmaceuticals), ACYCLOVIR (Ranbaxy Laboratories), ACYCLOVIR (Rebel Distributors Corp), ACYCLOVIR (Rebel Distributors Corp), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (Renaissance Pharma), ACYCLOVIR (St. Mary's Medical Park Pharmacy), ACYCLOVIR (State of Florida DOH Central Pharmacy), ACYCLOVIR (State of Florida DOH Central Pharmacy), ACYCLOVIR (State of Florida DOH Central Pharmacy), ACYCLOVIR (TOLMAR), ACYCLOVIR (Taro Pharmaceuticals U.S.A.), ACYCLOVIR (Teva Pharmaceuticals USA), ACYCLOVIR (Unit Dose Services), ACYCLOVIR (Unit Dose Services), ACYCLOVIR (Unit Dose Services), ACYCLOVIR (Unit Dose Services), ACYCLOVIR (YILING PHARMACEUTICAL), ACYCLOVIR (YILING PHARMACEUTICAL), ACYCLOVIR (Zydus Pharmaceuticals (USA)), ACYCLOVIR (Zydus Pharmaceuticals (USA))
Formula
C8H11N5O3
Exact mass
225.0862
Mol weight
225.2046
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antiviral
 DG02840  Herpesvirus DNA polymerase inhibitor
Remark
Same as: C06810
Therapeutic category: 1319 6250
ATC code: D06BB03 J05AB01 S01AD03
Chemical structure group: DG00406
Product (DG00406): D00222<JP/US> D02764<US>
Efficacy
Antiviral, DNA polymerase inhibitor
  Disease
Varicella [DS:H00366]
Herpes zoster [DS:H00366]
Genital herpes [DS:H00365]
Target
Herpesvirus DNA polymerase [KO:K18964]
Metabolism
Transporter: SLC22A1 [HSA:6580], SLC22A6 [HSA:9356], SLC22A8 [HSA:9376]
Interaction
Drug interaction
Structure map
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06B CHEMOTHERAPEUTICS FOR TOPICAL USE
    D06BB Antivirals
     D06BB03 Aciclovir
      D00222  Acyclovir (USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB01 Aciclovir
      D00222  Acyclovir (USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AD Antivirals
     S01AD03 Aciclovir
      D00222  Acyclovir (USP) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Antiherpetic Agents
   Acyclovir
    D00222  Acyclovir (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00222  Acyclovir (USP); Aciclovir (JP17/INN); Aciclovir granules (JP17); Aciclovir ophthalmic oinment (JP17); Aciclovir tablets (JP17)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00222  Acyclovir (USP); Aciclovir (JP17/INN); Aciclovir granules (JP17); Aciclovir ophthalmic oinment (JP17); Aciclovir tablets (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  91 Antivirals
   D00222  Acyclovir (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Aciclovir
    D00222  Acyclovir (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00222  Aciclovir
  D00222  Aciclovir tablets
  D00222  Aciclovir granules
  D00222  Aciclovir syrup
  D00222  Aciclovir for syrup
  D00222  Aciclovir injection
  D00222  Aciclovir for injection
  D00222  Aciclovir ophthalmic oinment
  D00222  Aciclovir ointment
Antiinfectives [br08350.html]
 Antivirals
  D00222
Rx-to-OTC switch list in Japan [br08314.html]
 D00222
Prodrugs [br08324.html]
 D00222
BRITE hierarchy
Other DBs
CAS: 59277-89-3
PubChem: 7847289
ChEBI: 2453
ChEMBL: CHEMBL184
DrugBank: DB00787
PDB-CCD: AC2[PDBj]
LigandBox: D00222
NIKKAJI: J11.247J
LinkDB All DBs
KCF data Show

ATOM        16
            1   N4y N    23.9021  -15.7728
            2   C8y C    25.2251  -15.3140
            3   C8y C    25.1976  -13.9138
            4   N5x N    23.8575  -13.5074
            5   C8x C    23.0568  -14.6564
            6   N5x N    26.4513  -15.9900
            7   C8y C    27.6500  -15.2662
            8   N4x N    27.6224  -13.8662
            9   C8y C    26.3961  -13.1901
            10  O5x O    26.3689  -11.8062
            11  N1a N    28.8860  -15.9474
            12  C1b C    23.9021  -17.1728
            13  O2a O    22.6761  -17.8812
            14  C1b C    21.4530  -17.1758
            15  C1b C    20.2280  -17.8843
            16  O1a O    19.0018  -17.1780
BOND        17
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     1   5 1
            6     2   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 1
            10    3   9 1
            11    9  10 2
            12    7  11 1
            13    1  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1

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