KEGG   DRUG: AcyclovirHelp
Entry
D00222                      Drug                                   

Name
Acyclovir (USP);
Aciclovir (JP17/INN);
Aciclovir granules (JP17);
Aciclovir ophthalmic oinment (JP17);
Aciclovir tablets (JP17);
Sitavig (TN);
Zovirax (TN)
Product
  Generic
ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (A-S Medication Solutions), ACYCLOVIR (Actavis Mid Atlantic LLC), ACYCLOVIR (Actavis Pharma), ACYCLOVIR (Aidarex Pharmaceuticals LLC), ACYCLOVIR (Aidarex Pharmaceuticals LLC), ACYCLOVIR (American Health Packaging), ACYCLOVIR (American Health Packaging), ACYCLOVIR (Amneal Pharmaceuticals of New York), ACYCLOVIR (Aphena Pharma Solutions - Tennessee), ACYCLOVIR (Apotex Corp.), ACYCLOVIR (Apotex Corp.), ACYCLOVIR (Apotheca), ACYCLOVIR (Apotheca), ACYCLOVIR (Atlantic Biologicals Corps), ACYCLOVIR (AvKARE), ACYCLOVIR (AvKARE), ACYCLOVIR (AvKARE), ACYCLOVIR (AvPAK), ACYCLOVIR (AvPAK), ACYCLOVIR (Avera McKennan Hospital), ACYCLOVIR (Avera McKennan Hospital), ACYCLOVIR (Avera McKennan Hospital), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Blenheim Pharmacal), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Bryant Ranch Prepack), ACYCLOVIR (Cadila Healthcare Limited), ACYCLOVIR (Cadila Healthcare Limited), ACYCLOVIR (Cadila Pharmaceuticals Limited), ACYCLOVIR (Cadila Pharmaceuticals Limited), ACYCLOVIR (Camber Pharmaceuticals), ACYCLOVIR (Cardinal Health), ACYCLOVIR (Cardinal Health), ACYCLOVIR (Cardinal Health), ACYCLOVIR (Cardinal Health), ACYCLOVIR (Carlsbad Technology), ACYCLOVIR (Carlsbad Technology), ACYCLOVIR (Clinical Solutions Wholesale), ACYCLOVIR (DIRECT RX), ACYCLOVIR (Direct RX), ACYCLOVIR (Direct Rx), ACYCLOVIR (DirectRX), ACYCLOVIR (E. Fougera & Co. a division of Fougera Pharmaceuticals), ACYCLOVIR (Golden State Medical Supply), ACYCLOVIR (Golden State Medical Supply), ACYCLOVIR (Golden State Medical Supply), ACYCLOVIR (Golden State Medical Supply), ACYCLOVIR (Golden State Medical Supply), ACYCLOVIR (H.J. Harkins Company), ACYCLOVIR (Heritage Pharmaceuticals), ACYCLOVIR (Heritage Pharmaceuticals), ACYCLOVIR (Heritage Pharmaceuticals), ACYCLOVIR (Hi-Tech Pharmacal), ACYCLOVIR (Lake Erie Medical DBA Quality Care Products LLC), ACYCLOVIR (Lake Erie Medical DBA Quality Care Products LLC), ACYCLOVIR (Liberty Pharmaceuticals), ACYCLOVIR (Major Pharmaceuticals), ACYCLOVIR (Major Pharmaceuticals), ACYCLOVIR (Major Pharmaceuticals), ACYCLOVIR (McKesson Packaging Services a business unit of McKesson Corporation), ACYCLOVIR (MedVantx), ACYCLOVIR (Medsource Pharmaceuticals), ACYCLOVIR (Mylan Institutional), ACYCLOVIR (Mylan Pharmaceuticals), ACYCLOVIR (Mylan Pharmaceuticals), ACYCLOVIR (Nivagen Pharmaceuticals), ACYCLOVIR (Nivagen Pharmaceuticals), ACYCLOVIR (Northwind Pharmaceuticals), ACYCLOVIR (Northwind Pharmaceuticals), ACYCLOVIR (Northwind Pharmaceuticals), ACYCLOVIR (NuCare Pharmaceuticals), ACYCLOVIR (NuCarePharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (PD-Rx Pharmaceuticals), ACYCLOVIR (Physicians Total Care), ACYCLOVIR (Physicians Total Care), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Preferred Pharmaceuticals), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Proficient Rx LP), ACYCLOVIR (Quinn Pharmaceuticals), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (REMEDYREPACK), ACYCLOVIR (Ranbaxy Laboratories), ACYCLOVIR (Rebel Distributors Corp), ACYCLOVIR (Rebel Distributors Corp), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (RedPharm Drug), ACYCLOVIR (Renaissance Pharma), ACYCLOVIR (Stat Rx USA), ACYCLOVIR (State of Florida DOH Central Pharmacy), ACYCLOVIR (State of Florida DOH Central Pharmacy), ACYCLOVIR (State of Florida DOH Central Pharmacy), ACYCLOVIR (Taro Pharmaceuticals U.S.A.), ACYCLOVIR (Teva Pharmaceuticals USA), ACYCLOVIR (Unit Dose Services), ACYCLOVIR (Unit Dose Services), ACYCLOVIR (Unit Dose Services), ACYCLOVIR (Unit Dose Services), ACYCLOVIR (Zydus Pharmaceuticals (USA)), ACYCLOVIR (Zydus Pharmaceuticals (USA))
Formula
C8H11N5O3
Exact mass
225.0862
Mol weight
225.2046
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiviral, DNA polymerase inhibitor
  Disease
Varicella [DS:H00366]
Comment
Acyclovir type
Target
DNA polymerase
Metabolism
Transporter: SLC22A1 [HSA:6580], SLC22A6 [HSA:9356], SLC22A8 [HSA:9376]
Interaction
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06B CHEMOTHERAPEUTICS FOR TOPICAL USE
    D06BB Antivirals
     D06BB03 Aciclovir
      D00222  Acyclovir (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB01 Aciclovir
      D00222  Acyclovir (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AD Antivirals
     S01AD03 Aciclovir
      D00222  Acyclovir (USP)
USP drug classification [BR:br08302]
 Antivirals
  Antiherpetic Agents
   Acyclovir
    D00222  Acyclovir (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00222  Acyclovir (USP); Aciclovir (JP17/INN); Aciclovir granules (JP17); Aciclovir ophthalmic oinment (JP17); Aciclovir tablets (JP17)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00222  Acyclovir (USP); Aciclovir (JP17/INN); Aciclovir granules (JP17); Aciclovir ophthalmic oinment (JP17); Aciclovir tablets (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  91 Antivirals
   D00222  Acyclovir (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Aciclovir
    D00222  Acyclovir (USP)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HSV agents
   DNA polymerase inhibitor
    Purine analogue
     Aciclovir
      D00222  Acyclovir (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Aciclovir
    D00222  Acyclovir (USP)
 Transporter substrates
  OAT1
   Aciclovir
    D00222  Acyclovir (USP)
  OAT3
   Aciclovir
    D00222  Acyclovir (USP)
  SLC22A1
   Aciclovir
    D00222  Acyclovir (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00222  Aciclovir
  D00222  Aciclovir tablets
  D00222  Aciclovir granules
  D00222  Aciclovir syrup
  D00222  Aciclovir for syrup
  D00222  Aciclovir injection
  D00222  Aciclovir for injection
  D00222  Aciclovir ophthalmic oinment
  D00222  Aciclovir ointment
Antivirals [br08351.html]
 D00222
Rx-to-OTC switch list in Japan [br08314.html]
 D00222
BRITE hierarchy
Other DBs
CAS: 
59277-89-3
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        16
            1   N4y N    23.9021  -15.7728
            2   C8y C    25.2251  -15.3140
            3   C8y C    25.1976  -13.9138
            4   N5x N    23.8575  -13.5074
            5   C8x C    23.0568  -14.6564
            6   N5x N    26.4513  -15.9900
            7   C8y C    27.6500  -15.2662
            8   N4x N    27.6224  -13.8662
            9   C8y C    26.3961  -13.1901
            10  O5x O    26.3689  -11.8062
            11  N1a N    28.8860  -15.9474
            12  C1b C    23.9021  -17.1728
            13  O2a O    22.6761  -17.8812
            14  C1b C    21.4530  -17.1758
            15  C1b C    20.2280  -17.8843
            16  O1a O    19.0018  -17.1780
BOND        17
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     1   5 1
            6     2   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 1
            10    3   9 1
            11    9  10 2
            12    7  11 1
            13    1  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1

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