KEGG   DRUG: AlprazolamHelp
Entry
D00225                      Drug                                   

Name
Alprazolam (JP17/USP/INN);
Xanax (TN)
Product
  Generic
ALPRAZOLAM (APOTHECA), ALPRAZOLAM (Actavis Pharma), ALPRAZOLAM (Actavis Pharma), ALPRAZOLAM (Actavis Pharma), ALPRAZOLAM (Aidarex Pharmaceuticals LLC), ALPRAZOLAM (Aidarex Pharmaceuticals LLC), ALPRAZOLAM (American Health Packaging), ALPRAZOLAM (Amneal Pharmaceuticals), ALPRAZOLAM (Aphena Pharma Solutions - Tennessee), ALPRAZOLAM (Aphena Pharma Solutions - Tennessee), ALPRAZOLAM (Aphena Pharma Solutions - Tennessee), ALPRAZOLAM (Apotex Corp), ALPRAZOLAM (Apotex Corp.), ALPRAZOLAM (Apotheca), ALPRAZOLAM (Aurobindo Pharma Limited), ALPRAZOLAM (Aurobindo Pharma Limited), ALPRAZOLAM (Bionpharma), ALPRAZOLAM (Blenheim Pharmacal), ALPRAZOLAM (Blenheim Pharmacal), ALPRAZOLAM (Blenheim Pharmacal), ALPRAZOLAM (Blenheim Pharmacal), ALPRAZOLAM (Blenheim Pharmacal), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Contract Pharmacy Services-PA), ALPRAZOLAM (Contract Pharmacy Services-PA), ALPRAZOLAM (Contract Pharmacy Services-PA), XANAX (DIRECT RX), ALPRAZOLAM (DIRECT RX), ALPRAZOLAM (DIRECT RX), ALPRAZOLAM (DIRECT RX), ALPRAZOLAM (Direct Rx), ALPRAZOLAM (DirectRX), ALPRAZOLAM (Dispensing Solutions), ALPRAZOLAM (Golden State Medical Supply), ALPRAZOLAM (Greenstone LLC), ALPRAZOLAM (Greenstone LLC), ALPRAZOLAM (H.J. Harkins Company), ALPRAZOLAM (KAISER FOUNDATION HOSPITALS), ALPRAZOLAM (KAISER FOUNDATION HOSPITALS), ALPRAZOLAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Life Line Home Care Services), ALPRAZOLAM (Major Pharmaceuticals), ALPRAZOLAM (McKesson Corporation), ALPRAZOLAM (Medsource Pharmaceuticals), ALPRAZOLAM (Medsource Pharmaceuticals), ALPRAZOLAM (Medsource Pharmaceuticals), ALPRAZOLAM (Medsource Pharmaceuticals), ALPRAZOLAM (Mylan Institutional), ALPRAZOLAM (Mylan Pharmaceuticals), ALPRAZOLAM (NCS HealthCare of KY), ALPRAZOLAM (NCS HealthCare of KY), ALPRAZOLAM (NCS HealthCare of KY), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (NuCare Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (Par Pharmaceutical), ALPRAZOLAM (Par Pharmaceutical), ALPRAZOLAM (Physicians Total Care), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Proficient Rx LP), ALPRAZOLAM (Proficient Rx LP), ALPRAZOLAM (Proficient Rx LP), ALPRAZOLAM (Proficient Rx LP), ALPRAZOLAM (Proficient Rx LP), ALPRAZOLAM (Proficient Rx LP), ALPRAZOLAM (Proficient Rx LP), ALPRAZOLAM (Proficient Rx LP), ALPRAZOLAM (REMEDYREPACK), ALPRAZOLAM (REMEDYREPACK), ALPRAZOLAM (REMEDYREPACK), ALPRAZOLAM (REMEDYREPACK), ALPRAZOLAM (RPK Pharmaceuticals), ALPRAZOLAM (RPK Pharmaceuticals), ALPRAZOLAM (Rebel Distributors Corp), ALPRAZOLAM (Rebel Distributors Corp), ALPRAZOLAM (Rebel Distributors Corp.), ALPRAZOLAM (Rebel Distributors Corp.), ALPRAZOLAM (RedPharm), ALPRAZOLAM (RedPharm Drug), ALPRAZOLAM (RedPharm Drug), ALPRAZOLAM (RedPharm Drug), ALPRAZOLAM (RedPharm Drug), ALPRAZOLAM (RedPharm Drug), ALPRAZOLAM (RedPharm Drug), ALPRAZOLAM (Rising Pharmaceuticals), ALPRAZOLAM (Sandoz), ALPRAZOLAM (St. Marys Medical Park Pharmacy), ALPRAZOLAM (TYA Pharmaceuticals), ALPRAZOLAM (Unit Dose Services), ALPRAZOLAM (Unit Dose Services), ALPRAZOLAM (Unit Dose Services), ALPRAZOLAM (Unit Dose Services), ALPRAZOLAM (Unit Dose Services), ALPRAZOLAM (West-Ward Pharmaceuticals Corp.)
Formula
C17H13ClN4
Exact mass
308.0829
Mol weight
308.7649
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
Cyp substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Same as: C06817
Therapeutic category: 1124
ATC code: N05BA12
Product: D00225<JP/US>
Efficacy
Antianxiety, Minor tranquilizer, Sedative-hypnotic
  Disease
Generalized anxiety disorder [DS:H01662]
Panic disorder [DS:H01664]
Comment
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
map07030  Anxiolytics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA12 Alprazolam
      D00225  Alprazolam (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anxiolytics
  Benzodiazepines
   Alprazolam
    D00225  Alprazolam (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00225  Alprazolam (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00225  Alprazolam (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00225  Alprazolam
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00225
BRITE hierarchy
Other DBs
CAS: 28981-97-7
PubChem: 7847292
ChEBI: 2611
ChEMBL: CHEMBL661
DrugBank: DB00404
PDB-CCD: 08H[PDBj]
LigandBox: D00225
NIKKAJI: J9.279G
LinkDB All DBs
KCF data Show

ATOM        22
            1   C2y C    11.2028  -17.3488
            2   C8y C    10.3478  -16.2505
            3   C8y C    10.6659  -14.8908
            4   N4y N    11.9188  -14.2978
            5   N2x N    12.6076  -17.3566
            6   C8y C    13.1789  -14.9040
            7   C1x C    13.4820  -16.2680
            8   C8x C     9.6478  -13.9358
            9   C8x C     8.3118  -14.3400
            10  C8y C     7.9936  -15.6997
            11  C8x C     9.0117  -16.6546
            12  C8y C    10.5740  -18.6251
            13  C8x C     9.1513  -18.6484
            14  C8x C     8.5338  -19.9703
            15  C8x C     9.3094  -21.1309
            16  C8x C    10.7341  -21.1074
            17  C8x C    11.3495  -19.7858
            18  N5x N    14.1449  -13.8929
            19  N5x N    13.4818  -12.6617
            20  C8y C    12.1059  -12.9119
            21  C1a C    11.0956  -11.9466
            22  X   Cl    6.6468  -16.1072
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    1  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    6  18 2
            21   18  19 1
            22   19  20 2
            23    4  20 1
            24   20  21 1
            25   10  22 1

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