| Entry |
|
|---|
| Name |
Cyclophosphamide (USP);
Cyclophosphamide hydrate (JP17);
Cyclophosphamide tablets (JP17);
Cytoxan (TN);
Neosar (TN)
|
|---|
| Product |
|
|---|
| Generic |
|
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| Formula |
C7H15Cl2N2O2P. H2O
|
|---|
| Exact mass |
278.0354
|
|---|
| Mol weight |
279.1012
|
|---|
| Structure |
     |
|---|
| Simcomp |
 |
|---|
| Class |
Antineoplastic
DG01677 Alkylating agent
DG01678 Nitrogen mustard analogue
DG01720 Isophosphoramide mustard analogue
Cyp substrate
DG01638 CYP2A6 substrate
DG01633 CYP3A substrate
|
|---|
| Remark |
Same as: Therapeutic category: ATC code: Chemical group: |
|---|
| Activity |
Antineoplastic, Alkylating agent, Immunosuppressant |
|---|
| Comment |
Active form of prodrug: 4-Hydroxycyclophosphamide [CPD: C07643]
|
|---|
| Target |
DNA |
|---|
| Metabolism |
Enzyme: CYP2A6 [HSA: 1548], CYP2B6 [HSA: 1555], CYP2C8 [HSA: 1558], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
|---|
| Structure map |
| Antineoplastics - alkylating agents | | Immunosuppressive agents | | Antirheumatics - DMARDs and biological agents |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01A ALKYLATING AGENTS
L01AA Nitrogen mustard analogues
L01AA01 Cyclophosphamide
D00287 Cyclophosphamide (USP)
USP drug classification [BR:br08302]
Antineoplastics
Alkylating Agents
Cyclophosphamide
D00287 Cyclophosphamide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
421 Alkylating agents
4211 Chlorethylamines
D00287 Cyclophosphamide (USP); Cyclophosphamide hydrate (JP17); Cyclophosphamide tablets (JP17)
Target-based classification of drugs [BR:br08310]
Others
Nucleic acid
DNA
Cyclophosphamide
D00287 Cyclophosphamide (USP)
Cytochrome P450 interactions [BR:br08309]
CYP substrates
CYP2B6
Cyclophosphamide
D00287 Cyclophosphamide (USP)
CYP2C8
Cyclophosphamide
D00287 Cyclophosphamide (USP)
CYP2C9
Cyclophosphamide
D00287 Cyclophosphamide (USP)
CYP3A4
Cyclophosphamide
D00287 Cyclophosphamide (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00287 Cyclophosphamide hydrate
D00287 Cyclophosphamide tablets
Antineoplastics [br08340.html]
D00287
Antirheumatic and antigout drugs [br08366.html]
Antirheumatic drugs
D00287
 |
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| Other DBs |
CAS: 6055-19-2 PubChem: ChEBI: ChEMBL: DrugBank: LigandBox: NIKKAJI: |
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| LinkDB |
 |
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| KCF data |
ATOM 15
1 P1a P 22.9658 -14.9801
2 N1c N 22.9715 -13.5156
3 N1x N 24.0976 -15.6395
4 O2x O 21.8279 -15.6395
5 O3b O 21.6997 -14.2450
6 C1b C 21.6646 -12.8388
7 C1b C 24.2027 -12.7220
8 C1x C 24.0976 -16.9523
9 C1x C 21.8279 -16.9523
10 C1b C 20.4335 -13.6264
11 C1b C 25.5096 -13.3990
12 C1x C 22.9658 -17.5999
13 X Cl 19.1265 -12.9613
14 X Cl 26.7467 -12.6054
15 O0 O 27.7975 -15.3471
BOND 14
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 2
5 2 6 1
6 2 7 1
7 3 8 1
8 4 9 1
9 6 10 1
10 7 11 1
11 8 12 1
12 10 13 1
13 11 14 1
14 9 12 1
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