KEGG   DRUG: FlunisolideHelp
Entry
D00324                      Drug                                   

Name
Flunisolide (JAN/USP);
Aerospan (TN);
Nasalide (TN)
Product
  Generic
Formula
(C24H31FO6)2. H2O
Exact mass
886.4315
Mol weight
887.0108
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: 
Chemical group: 
Activity
Anti-inflammatory, Glucocorticoid receptor agonist
Comment
Glucocorticoid, Corticosteroid
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD04 Flunisolide
      D00324  Flunisolide (JAN/USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA03 Flunisolide
      D00324  Flunisolide (JAN/USP)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Flunisolide
    D00324  Flunisolide (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    glucocorticoid receptor
     Flunisolide
      D00324  Flunisolide (JAN/USP)
Respiratory agents [br08372.html]
 Bronchodilator
  D00324
BRITE hierarchy
Other DBs
CAS: 
77326-96-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        63
            1   O0  O    35.9800  -28.5600
            2   C2x C    19.6000  -29.2600
            3   C5x C    19.6000  -30.5900
            4   C2x C    20.7900  -31.2900
            5   C2y C    21.9800  -30.5900
            6   C1z C    21.9800  -29.2600
            7   C2x C    20.7900  -28.5600
            8   C1y C    23.1700  -31.2900
            9   C1x C    24.3600  -30.5900
            10  C1y C    24.3600  -29.2600
            11  C1y C    23.1700  -28.5600
            12  C1y C    25.4800  -28.5600
            13  C1z C    25.4800  -27.2300
            14  C1x C    24.3600  -26.5300
            15  C1y C    23.1700  -27.2300
            16  C1x C    27.8600  -28.5600
            17  C1y C    27.8600  -27.2300
            18  C1z C    26.6700  -26.5300
            19  O5x O    18.4800  -31.2900
            20  C1a C    21.9800  -27.8600
            21  O1a O    21.9800  -26.5300
            22  C1a C    25.4800  -25.8300
            23  C5a C    26.6700  -24.9200
            24  O2x O    28.0700  -25.6200
            25  O5a O    27.8600  -24.2200
            26  C1b C    25.4800  -24.2200
            27  O1a O    24.3600  -24.9200
            28  O2x O    29.2600  -27.2300
            29  C1z C    29.4700  -25.6200
            30  C1a C    30.8700  -25.6200
            31  C1a C    29.4700  -24.2200
            32  X   F    23.1700  -32.6900
            33  C2x C    19.6000  -29.2600
            34  C5x C    19.6000  -30.5900
            35  C2x C    20.7900  -31.2900
            36  C2y C    21.9800  -30.5900
            37  C1z C    21.9800  -29.2600
            38  C2x C    20.7900  -28.5600
            39  C1y C    23.1700  -28.5600
            40  C1y C    24.3600  -29.2600
            41  C1x C    24.3600  -30.5900
            42  C1y C    23.1700  -31.2900
            43  X   F    23.1700  -32.6900
            44  C1y C    25.4800  -28.5600
            45  C1z C    25.4800  -27.2300
            46  C1x C    24.3600  -26.5300
            47  C1y C    23.1700  -27.2300
            48  O1a O    21.9800  -26.5300
            49  C1z C    26.6700  -26.5300
            50  C1y C    27.8600  -27.2300
            51  C1x C    27.8600  -28.5600
            52  O2x O    29.2600  -27.2300
            53  C1z C    29.4700  -25.6200
            54  O2x O    28.0700  -25.6200
            55  C1a C    30.8700  -25.6200
            56  C1a C    29.4700  -24.2200
            57  C5a C    26.6700  -24.9200
            58  O5a O    27.8600  -24.2200
            59  C1b C    25.4800  -24.2200
            60  O1a O    24.3600  -24.9200
            61  C1a C    25.4800  -25.8300
            62  C1a C    21.9800  -27.8600
            63  O5x O    18.4800  -31.2900
BOND        70
            1     2   3 1
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 1
            6     2   7 2
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12   10  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   11  15 1
            17   12  16 1
            18   16  17 1
            19   17  18 1
            20   13  18 1
            21    3  19 2
            22    6  20 1 #Up
            23   15  21 1 #Up
            24   13  22 1 #Up
            25   18  23 1 #Up
            26   18  24 1 #Down
            27   23  25 2
            28   23  26 1
            29   26  27 1
            30   17  28 1 #Down
            31   24  29 1
            32   29  28 1
            33   29  30 1
            34   29  31 1
            35    8  32 1 #Down
            36   33  34 1
            37   34  35 1
            38   35  36 2
            39   36  37 1
            40   37  38 1
            41   33  38 2
            42   36  42 1
            43   42  41 1
            44   41  40 1
            45   40  39 1
            46   37  39 1
            47   40  44 1
            48   44  45 1
            49   45  46 1
            50   46  47 1
            51   39  47 1
            52   44  51 1
            53   51  50 1
            54   50  49 1
            55   45  49 1
            56   34  63 2
            57   37  62 1 #Up
            58   47  48 1 #Up
            59   45  61 1 #Up
            60   49  57 1 #Up
            61   49  54 1 #Down
            62   57  58 2
            63   57  59 1
            64   59  60 1
            65   50  52 1 #Down
            66   54  53 1
            67   53  52 1
            68   53  55 1
            69   53  56 1
            70   42  43 1 #Down
BRACKET     1    17.2200  -33.6700   17.2200  -23.0300
            1    32.8300  -23.0300   32.8300  -33.6700
            1  2
 ORIGINAL  1    2   3   4   5   6   7  11  10   9   8  35  12  13  14  15  23
            1   18  17  16  31  32  27  33  34  26  28  29  30  25  24  22  21
            1   20  19
 REPEAT    1   36  37  38  39  40  41  42  43  44  45  46  47  48  49  50  51
            1   52  53  54  55  56  57  58  59  60  61  62  63  64  65  66  67
            1   68  69

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