KEGG   DRUG: NabumetoneHelp
Entry
D00425                      Drug                                   

Name
Nabumetone (JP17/USP/INN);
Relafen (TN)
Product
  Generic
NABUMETONE (American Health Packaging), NABUMETONE (Avera McKennan Hospital), NABUMETONE (Eon Labs), NABUMETONE (Lake Erie Medical DBA Quality Care Products LLC), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (REMEDYREPACK), NABUMETONE (Actavis Pharma), NABUMETONE (Aidarex Pharmaceuticals LLC), NABUMETONE (Aidarex Pharmaceuticals LLC), NABUMETONE (Aidarex Pharmaceuticals LLC), NABUMETONE (Altura Pharmaceuticals), NABUMETONE (AvKARE), NABUMETONE (AvPAK), NABUMETONE (Blenheim Pharmacal), NABUMETONE (Blenheim Pharmacal), NABUMETONE (Blenheim Pharmacal), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Cardinal Health), NABUMETONE (Carilion Materials Management), NABUMETONE (Clinical Solutions Wholesale), NABUMETONE (DIRECT RX), NABUMETONE (Direct Rx), NABUMETONE (Direct Rx), NABUMETONE (Dispensing Solutions), NABUMETONE (Dr. Reddy's Laboratories Limited), NABUMETONE (Exelan Pharmaceuticals), NABUMETONE (Glenmark Pharmaceuticals), NABUMETONE (H.J. Harkins Company), NABUMETONE (Impax Generics), NABUMETONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), NABUMETONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), NABUMETONE (Lake Erie Medical DBA Quality Care Products LLC), NABUMETONE (Lake Erie Medical DBA Quality Care Products LLC), NABUMETONE (Liberty Pharmaceuticals), NABUMETONE (Lupin Pharmaceuticals), NABUMETONE (Major Pharmaceuticals), NABUMETONE (Medsource Pharmaceuticals), NABUMETONE (Medsource Pharmaceuticals), NABUMETONE (Mylan Pharmaceuticals), NABUMETONE (NCS HealthCare of KY), NABUMETONE (NCS HealthCare of KY), NABUMETONE (NCS HealthCare of KY), NABUMETONE (Northwind Pharmaceuticals), NABUMETONE (NuCare Pharmaceuticals), NABUMETONE (NuCare Pharmaceuticals), NABUMETONE (Par Pharmaceutical), NABUMETONE (Physicians Total Care), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Rebel Distributors Corp.), NABUMETONE (RxChange), NABUMETONE (STAT RX USA LLC), NABUMETONE (STAT Rx USA LLC), NABUMETONE (STAT Rx USA LLC), NABUMETONE (St.Mary's Medical Park Pharmacy), NABUMETONE (Teva Pharmaceuticals USA), NABUMETONE (Unit Dose Services), NABUMETONE (Unit Dose Services)
Formula
C15H16O2
Exact mass
228.115
Mol weight
228.2863
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Anti-inflammatory
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
 DG01922  Selective COX2 inhibitor
Cyp substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Analgesic, Anti-inflammatory, COX-2 inhibitor
Target
PTGS2 (COX2) [HSA:5743] [KO:K11987];
PTGS1 (COX1) [HSA:5742] [KO:K00509]
  Pathway
Arachidonic acid metabolism
VEGF signaling pathway
Metabolism
Enzyme: CYP2J2 [HSA:1573], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Naphthalene family
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AX Other antiinflammatory and antirheumatic agents, non-steroids
     M01AX01 Nabumetone
      D00425  Nabumetone (JP17/USP/INN)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Nabumetone
    D00425  Nabumetone (JP17/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Nabumetone
    D00425  Nabumetone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00425  Nabumetone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Nabumetone
     D00425  Nabumetone (JP17/USP/INN)
   cyclooxygenase-2 (COX-2)
    Nabumetone
     D00425  Nabumetone (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2A6
   Nabumetone
    D00425  Nabumetone (JP17/USP/INN)
  CYP2J2
   Nabumetone
    D00425  Nabumetone (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00425  Nabumetone
  D00425  Nabumetone tablets
Antirheumatic and antigout drugs [br08366.html]
 Antirheumatic drugs
  D00425
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Anti-inflammatory drugs
  D00425
BRITE hierarchy
Other DBs
CAS: 
42924-53-8
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        17
            1   C8y C    27.8600  -24.7800
            2   C8y C    27.8600  -26.1800
            3   C8x C    29.0500  -24.0800
            4   C8x C    26.6000  -24.0800
            5   C8x C    26.6000  -26.8800
            6   C8x C    29.0500  -26.8800
            7   C8y C    30.2400  -24.7800
            8   C8x C    25.4100  -24.7800
            9   C8y C    25.4100  -26.1800
            10  C8x C    30.2400  -26.1800
            11  C1b C    31.4300  -24.0800
            12  O2a O    24.2200  -26.8800
            13  C1b C    32.6200  -24.7800
            14  C1a C    22.9600  -26.1800
            15  C5a C    33.8100  -24.0800
            16  C1a C    35.0700  -24.7800
            17  O5a O    33.8100  -22.6800
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   15  17 2
            17    7  10 1
            18    8   9 2

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