KEGG   DRUG: OmeprazoleHelp
Entry
D00455                      Drug                                   

Name
Omeprazole (JP17/USP/INN);
Prilosec (TN)
Product
  Generic
OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (Actavis Pharma), OMEPRAZOLE (Aidarex Pharmaceuticals LLC), OMEPRAZOLE (Aidarex Pharmaceuticals LLC), OMEPRAZOLE (Altura Pharmaceuticals), OMEPRAZOLE (American Health Packaging), OMEPRAZOLE (American Health Packaging), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Apotex Corp), OMEPRAZOLE (Aurobindo Pharma Limited), OMEPRAZOLE (AvKARE), OMEPRAZOLE (AvPAK), OMEPRAZOLE (Avera McKennan Hospital), OMEPRAZOLE (Blenheim Pharmacal), OMEPRAZOLE (Blenheim Pharmacal), OMEPRAZOLE (Blenheim Pharmacal), OMEPRAZOLE (Blenheim Pharmacal), OMEPRAZOLE (Breckenridge Pharmaceutical), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Cadila Healthcare Limited), OMEPRAZOLE (Cardinal Health), OMEPRAZOLE (Cardinal Health), OMEPRAZOLE (Cardinal Health), OMEPRAZOLE (Carilion Materials Management), OMEPRAZOLE (Clinical Solutions Wholesale), OMEPRAZOLE (Contract Pharmacy Services-PA), OMEPRAZOLE (Contract Pharmacy Services-PA), OMEPRAZOLE DELAYED-RELEASE (DOH CENTRAL PHARMACY), OMEPRAZOLE (Denton Pharma), OMEPRAZOLE (Dispensing Solutions), OMEPRAZOLE (Dr. Reddy's Laboratories Limited), OMEPRAZOLE (Dr. Reddy's Laboratories Limited), OMEPRAZOLE (Glenmark Pharmaceuticals), OMEPRAZOLE (Glenmark Pharmaceuticals), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (H.J. Harkins Company), OMEPRAZOLE (KAISER FOUNDATION HOSPITALS), OMEPRAZOLE (KAISER FOUNDATION HOSPITALS), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lannett Company), OMEPRAZOLE (Life Line Home Care Services), OMEPRAZOLE (Major Pharmaceuticals), OMEPRAZOLE (Major Pharmaceuticals), OMEPRAZOLE (Mas Management Group), OMEPRAZOLE (McKesson Corporation), OMEPRAZOLE (Medsource Pharmaceuticals), OMEPRAZOLE (Midwest Drug Distribution), OMEPRAZOLE (Mylan Institutional), OMEPRAZOLE (Mylan Pharmaceuticals), OMEPRAZOLE (NCS HealthCare of KY), OMEPRAZOLE (NCS HealthCare of KY), OMEPRAZOLE (NCS HealthCare of KY), OMEPRAZOLE (NCS HealthCare of KY), OMEPRAZOLE (New Horizon Rx Group), OMEPRAZOLE (NorthStar Rx LLC), OMEPRAZOLE (Northwind Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCarePharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (Physicians Total Care), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (RPK Pharmaceuticals), OMEPRAZOLE (ReadyMeds), OMEPRAZOLE (Rebel Distributors Corp), OMEPRAZOLE (Rebel Distributors Corp), OMEPRAZOLE (Rebel Distributors Corp.), OMEPRAZOLE (RedPharm Drug), OMEPRAZOLE (RedPharm Drug), OMEPRAZOLE (RedPharm Drug), OMEPRAZOLE (Rising Health), OMEPRAZOLE (RxChange), OMEPRAZOLE (Safecor Health), OMEPRAZOLE (Sandoz), OMEPRAZOLE (Sandoz), OMEPRAZOLE (St. Mary's Medical Park Pharmacy), OMEPRAZOLE (St. Mary's Medical Park Pharmacy), OMEPRAZOLE (State of Florida DOH Central Pharmacy), OMEPRAZOLE (State of Florida DOH Central Pharmacy), OMEPRAZOLE (TYA Pharmaceuticals), OMEPRAZOLE (Teva Pharmaceuticals USA), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Zydus Pharmaceuticals (USA)), OMEPRAZOLE AND SODIUM BICARBONATE (Aurolife Pharma), OMEPRAZOLE AND SODIUM BICARBONATE (Medarbor Llc), OMEPRAZOLE AND SODIUM BICARBONATE (Medarbor Llc), OMEPRAZOLE/SODIUM BICARBONATE (Par Pharmaceutical), OMEPRAZOLE AND SODIUM BICARBONATE (ScieGen Pharmaceuticals), OMEPRAZOLE DR (Direct Rx), OMEPRAZOLE (Northwind Pharmaceuticals)
Formula
C17H19N3O3S
Exact mass
345.1147
Mol weight
345.4161
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Gastrointestinal agent
 DG01646  Proton pump inhibitor (PPI)
 DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Cyp substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01933  CYP2C19 inhibitor
Cyp inducer
 DG01637  CYP1A2 inducer
Remark
Same as: C07324
Therapeutic category: 2329
ATC code: A02BC01
Chemical structure group: DG00020
Product (DG00020): D00455<JP/US> D05261<JP> D05259<US>
Product (mixture): D10246<US>
Efficacy
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor
  Disease
Duodenal ulcer [DS:H01634]
Gastric ulcer [DS:H01634]
Gastroesophageal reflux disease [DS:H01602]
Zollinger-Ellison syndrome [DS:H01522]
Multiple endocrine adenomas [DS:H01102]
Comment
Benzimidazole derivative
Target
ATP4 [HSA:495 496] [KO:K01542 K01543]
  Pathway
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557]; CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07038  Antiulcer drugs
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC01 Omeprazole
      D00455  Omeprazole (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Omeprazole
    D00455  Omeprazole (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00455  Omeprazole (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D00455  Omeprazole (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00455  Omeprazole
  D00455  Omeprazole enteric-coated tablets
Drug classes of therapeutic agents [br08360.html]
 Gastrointestinal agents
  D00455
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00455
Rx-to-OTC switch list in the USA [br08315.html]
 D00455
BRITE hierarchy
Other DBs
CAS: 73590-58-6
PubChem: 7847521
ChEBI: 77260 7772
ChEMBL: CHEMBL1503
DrugBank: DB00338
LigandBox: D00455
NIKKAJI: J33.884B
LinkDB All DBs
KCF data Show

ATOM        24
            1   C8x C    14.6300  -20.7200
            2   C8y C    14.6300  -22.1200
            3   C8x C    15.8424  -22.8200
            4   C8y C    17.0549  -22.1200
            5   C8y C    17.0549  -20.7200
            6   C8x C    15.8424  -20.0200
            7   N5x N    18.3864  -22.5526
            8   C8y C    19.2093  -21.4200
            9   N4x N    18.3864  -20.2874
            10  S4a S    20.5800  -21.4200
            11  O2a O    13.4176  -22.8200
            12  C1a C    12.2221  -22.1296
            13  C1b C    21.2800  -22.6324
            14  O3c O    21.2800  -20.2076
            15  C8y C    22.6798  -22.6324
            16  C8y C    23.3703  -23.8280
            17  C8y C    24.7703  -23.8278
            18  C8y C    25.4701  -22.6153
            19  C8x C    24.7797  -21.4198
            20  N5x N    23.3797  -21.4199
            21  C1a C    26.8800  -22.6152
            22  O2a O    25.4610  -25.0232
            23  C1a C    26.8796  -25.0232
            24  C1a C    22.6849  -25.0152
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12    2  11 1
            13   11  12 1
            14   10  13 1
            15   10  14 2
            16   13  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   18  21 1
            24   17  22 1
            25   22  23 1
            26   16  24 1

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