KEGG   DRUG: OndansetronHelp
Entry
D00456                      Drug                                   

Name
Ondansetron (JAN/USP/INN);
Zofran ODT (TN)
Product
  Generic
ONDANSETRON (Accord Healthcare), ONDANSETRON (Accord Healthcare), ONDANSETRON (Aidarex Pharmaceuticals LLC), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON (Avera McKennan Hospital), ONDANSETRON (BluePoint Laboratories), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Citron Pharma LLC), ONDANSETRON (Clinical Solutions Wholesale), ONDANSETRON (DIRECT RX), ONDANSETRON (DIRECT RX), ONDANSETRON (Direct Rx), ONDANSETRON (Dispensing Solutions), ONDANSETRON (Dispensing Solutions), ONDANSETRON (HHS/Program Support Center/Supply Service Center), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Medsource Pharmaceuticals), ONDANSETRON (Medsource Pharmaceuticals), ONDANSETRON (Mylan Pharmaceuticals), ONDANSETRON (NuCare Pharmaceutical), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (Physicians Total Care), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (Rebel Distributors Corp), ONDANSETRON (Rebel Distributors Corp), ONDANSETRON (Rebel Distributors Corp), ONDANSETRON (Rebel Distributors Corp.), ONDANSETRON (Rnabaxy Pharmaceuticals), ONDANSETRON (RxChange), ONDANSETRON (RxChange), ONDANSETRON (Sandoz), ONDANSETRON (St Marys Medical Park Pharmacy), ONDANSETRON (St Marys Medical Park Pharmacy), ONDANSETRON (Stat Rx USA), ONDANSETRON (Sun Pharmaceutical Industries Limited), ONDANSETRON (Unit Dose Services), ONDANSETRON (Unit Dose Services)
Formula
C18H19N3O
Exact mass
293.1528
Mol weight
293.363
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Gastrointestinal agent
 DG01762  Antiemetic
Other
 DG01489  5-HT3-receptor antagonist
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antianxiety, Anti-emetic, Antipsychotic, Serotonin 5-HT3 receptor antagonist
Target
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Serotonin receptor agonists/antagonists
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA01 Ondansetron
      D00456  Ondansetron (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Ondansetron
    D00456  Ondansetron (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00456  Ondansetron (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT3-receptor
     Ondansetron
      D00456  Ondansetron (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Ondansetron
    D00456  Ondansetron (JAN/USP/INN)
  CYP2D6
   Ondansetron
    D00456  Ondansetron (JAN/USP/INN)
  CYP3A4
   Ondansetron
    D00456  Ondansetron (JAN/USP/INN)
Gastrointestinal agents [br08371.html]
 Antiemetic
  D00456
BRITE hierarchy
Other DBs
CAS: 
99614-02-5
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C    33.5159  -17.7325
            2   C8y C    34.8490  -18.1807
            3   C8y C    33.5217  -16.3295
            4   C5x C    32.3109  -18.4368
            5   C8y C    35.6698  -17.0396
            6   C8x C    35.4254  -19.4557
            7   N4y N    34.8607  -15.9044
            8   C1x C    32.3109  -15.6367
            9   C1y C    31.0941  -17.7325
            10  O5x O    32.3166  -19.8341
            11  C8x C    37.0613  -17.1794
            12  C8x C    36.8167  -19.5896
            13  C1a C    35.2972  -14.5771
            14  C1x C    31.0941  -16.3295
            15  C1b C    29.8831  -18.4368
            16  C8x C    37.6318  -18.4544
            17  N4y N    28.6780  -17.7325
            18  C8y C    28.7203  -16.3253
            19  C8x C    27.3348  -18.1219
            20  N5x N    27.3985  -15.8508
            21  C1a C    29.8791  -15.5437
            22  C8x C    26.5473  -16.9625
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 1
            16   15  17 1
            17   17  18 1
            18   17  19 1
            19   18  20 2
            20   18  21 1
            21   19  22 2
            22    5   7 1
            23    9  14 1
            24   12  16 2
            25   20  22 1

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