KEGG   DRUG: Amlodipine besylateHelp
Entry
D00615                      Drug                                   

Name
Amlodipine besylate (USAN);
Amlodipine besilate (JP17);
Norvasc (TN)
Product
  Generic
AMLODIPINE (Macleods Pharmaceuticals Limited), AMLODIPINE BESYLATE (Aidarex Pharmaceuticals LLC), AMLODIPINE BESYLATE (American Health Packaging), AMLODIPINE BESYLATE (American Health Packaging), AMLODIPINE BESYLATE (Amneal Pharmaceuticals LLC), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Apotex Corp.), AMLODIPINE BESYLATE (Apotheca), AMLODIPINE BESYLATE (Apotheca), AMLODIPINE BESYLATE (Apotheca), AMLODIPINE BESYLATE (Ascend Laboratories), AMLODIPINE BESYLATE (Aurobindo Pharma Limited), AMLODIPINE BESYLATE (AvPAK), AMLODIPINE BESYLATE (Avera McKennan Hospital), AMLODIPINE BESYLATE (Avera McKennan Hospital), AMLODIPINE BESYLATE (Bi-Coastal Pharma International LLC), AMLODIPINE BESYLATE (Blenheim Pharmacal), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Cadila Healthcare Limited), AMLODIPINE BESYLATE (Camber Pharmaceuticals), AMLODIPINE BESYLATE (Caraco Pharmaceutical Laboratories), AMLODIPINE BESYLATE (Cardinal Health), AMLODIPINE BESYLATE (Cardinal Health), AMLODIPINE BESYLATE (Cardinal Health), AMLODIPINE BESYLATE (Cardinal Health), AMLODIPINE BESYLATE (Cardinal Health), AMLODIPINE BESYLATE (Cardinal Health), AMLODIPINE BESYLATE (Cardinal Health), AMLODIPINE BESYLATE (Carilion Materials Management), AMLODIPINE BESYLATE (Central Texas Community Health Centers), AMLODIPINE BESYLATE (China Resources Saike Pharmaceutical), AMLODIPINE BESYLATE (Cipla USA), AMLODIPINE BESYLATE (Cipla USA), AMLODIPINE BESYLATE (Clinical Solutions Wholesale), AMLODIPINE BESYLATE (Clinical Solutions Wholesale), AMLODIPINE BESYLATE (Contract Pharmacy Services-PA), AMLODIPINE BESYLATE (Contract Pharmacy Services-PA), AMLODIPINE BESYLATE (Contract Pharmacy Services-PA), AMLODIPINE BESYLATE (Contract Pharmacy Services-PA), AMLODIPINE BESYLATE (DIRECT RX), AMLODIPINE BESYLATE (DIRECT RX), AMLODIPINE BESYLATE (DIRECT RX), AMLODIPINE BESYLATE (Direct Rx), AMLODIPINE BESYLATE (DirectRX), AMLODIPINE BESYLATE (Dr Reddy's Laboratories), AMLODIPINE BESYLATE (Epic Pharma), AMLODIPINE BESYLATE (Exelan Pharmaceuticals), AMLODIPINE BESYLATE (Golden State Medical Supply), AMLODIPINE BESYLATE (Greenstone LLC), AMLODIPINE BESYLATE (Hikma Pharmaceutical), AMLODIPINE BESYLATE (KAISER FOUNDATION HOSPITALS), AMLODIPINE BESYLATE (KAISER FOUNDATION HOSPITALS), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Legacy Pharmaceutical Packaging), AMLODIPINE BESYLATE (Legacy Pharmaceutical Packaging), AMLODIPINE BESYLATE (Lupin Pharmaceuticals), AMLODIPINE BESYLATE (Major Pharmaceuticals), AMLODIPINE BESYLATE (Major Pharmaceuticals), AMLODIPINE BESYLATE (Marlex Pharmaceuticals), AMLODIPINE BESYLATE (McKesson Contract Packaging), AMLODIPINE BESYLATE (McKesson Packaging Services a business unit of McKesson Corporation), AMLODIPINE BESYLATE (MedVantx), AMLODIPINE BESYLATE (Medsource Pharmaceuticals), AMLODIPINE BESYLATE (Mylan Institutional), AMLODIPINE BESYLATE (Mylan Pharmaceuticals), AMLODIPINE BESYLATE (NCS HealthCare of KY), AMLODIPINE BESYLATE (NCS HealthCare of KY), AMLODIPINE BESYLATE (New Horizon Rx Group), AMLODIPINE BESYLATE (Northwind Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (POLYGEN PHARMACEUTICALS), AMLODIPINE BESYLATE (Par Pharmaceutical), AMLODIPINE BESYLATE (Physicians Total Care), AMLODIPINE BESYLATE (Preferred Pharmaceutical), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (Ranbaxy Pharmaceuticals), AMLODIPINE BESYLATE (RedPharm Drug), AMLODIPINE BESYLATE (RedPharm Drug), AMLODIPINE BESYLATE (RedPharm Drug), AMLODIPINE BESYLATE (RedPharm Drug), AMLODIPINE BESYLATE (STAT RX USA LLC), AMLODIPINE BESYLATE (Safecor Health), AMLODIPINE BESYLATE (St Marys Medical Park Pharmacy), AMLODIPINE BESYLATE (St Marys Medical Park Pharmacy), AMLODIPINE BESYLATE (St Marys Medical Park Pharmacy), AMLODIPINE BESYLATE (State of Florida DOH Central Pharmacy), AMLODIPINE BESYLATE (State of Florida DOH Central Pharmacy), AMLODIPINE BESYLATE (State of Florida DOH Central Pharmacy), AMLODIPINE (State of Florida DOH Central Pharmacy), AMLODIPINE BESYLATE (TYA Pharmaceuticals), AMLODIPINE BESYLATE (Teva Pharmaceuticals USA), AMLODIPINE BESYLATE (Teva Pharmaceuticals USA), AMLODIPINE BESYLATE (Torrent Pharmaceuticals Limited), AMLODIPINE BESYLATE (Unichem Pharmaceuticals (USA)), AMLODIPINE BESYLATE (Unit Dose Services), AMLODIPINE BESYLATE (Unit Dose Services), AMLODIPINE BESYLATE (Unit Dose Services), AMLODIPINE BESYLATE (Unit Dose Services), AMLODIPINE BESYLATE (Unit Dose Services), AMLODIPINE BESYLATE (Upsher-Smith Laboratories), AMLODIPINE BESYLATE (WOCKHARDT LIMITED), AMLODIPINE BESYLATE (WOCKHARDT USA LLC.), AMLODIPINE BESYLATE (West-Ward Pharmaceuticals Corp), AMLODIPINE BESYLATE (West-Ward Pharmaceuticals Corp.), AMLODIPINE BESYLATE (Zydus Pharmaceuticals (USA)), AMLODIPINE BESYLATE (Northwind Pharmaceuticals)
Formula
C20H25ClN2O5. C6H6O3S
Exact mass
566.149
Mol weight
567.0509
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, Vasodilator, Calcium channel blocker
  Disease
Hypertension [DS:H01633]
Chronic stable angina [DS:H01632]
Vasospastic angina [DS:H01632]
Comment
Dihydropyridine derivative
Target
CACNA1C [HSA:775] [KO:K04850];
CACNA1D [HSA:776] [KO:K04851];
CACNA1F [HSA:778] [KO:K04853];
CACNA1S [HSA:779] [KO:K04857]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA01 Amlodipine
      D00615  Amlodipine besylate (USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Amlodipine
    D00615  Amlodipine besylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00615  Amlodipine besylate (USAN); Amlodipine besilate (JP17)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Amlodipine
      D00615  Amlodipine besylate (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP3A
   Amlodipine
    D00615  Amlodipine besylate (USAN)
 CYP substrates
  CYP3A4
   Amlodipine
    D00615  Amlodipine besylate (USAN)
  CYP3A5
   Amlodipine
    D00615  Amlodipine besylate (USAN)
  CYP3A7
   Amlodipine
    D00615  Amlodipine besylate (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00615  Amlodipine besylate
  D00615  Amlodipine besylate tablets
  D00615  Amlodipine besilate orally disintegrating tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00615
BRITE hierarchy
Other DBs
CAS: 
111470-99-6
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        38
            1   C8y C    29.5695  -18.6304
            2   C8x C    28.3142  -19.3278
            3   C8x C    30.7550  -19.3278
            4   S4a S    29.5698  -17.2357
            5   C8x C    28.3142  -20.6528
            6   C8x C    30.7550  -20.6528
            7   O1d O    29.5698  -15.8409
            8   O1d O    28.1750  -17.2357
            9   O1d O    30.9645  -17.2357
            10  C8x C    29.5695  -21.3502
            11  C1y C    19.3368  -16.0762
            12  C2y C    20.5198  -15.3803
            13  C2y C    18.1539  -15.3803
            14  C8y C    19.3368  -18.4421
            15  C2y C    20.5198  -13.9886
            16  C7a C    21.7028  -16.0762
            17  C2y C    18.1539  -13.9886
            18  C7a C    16.9709  -16.0066
            19  C8y C    20.5198  -19.1380
            20  C8x C    18.1539  -19.1380
            21  N1x N    19.3368  -13.2927
            22  C1b C    21.7028  -13.2927
            23  O7a O    22.8858  -15.3803
            24  O6a O    21.7028  -17.3983
            25  C1a C    16.9709  -13.2927
            26  O7a O    15.7879  -15.3803
            27  O6a O    16.9709  -17.3983
            28  C8x C    20.5198  -20.4601
            29  X   Cl   21.7028  -18.4421
            30  C8x C    18.1539  -20.4601
            31  O2a O    22.8858  -13.9886
            32  C1b C    24.0687  -16.0762
            33  C1a C    14.6049  -16.0066
            34  C8x C    19.3368  -21.1560
            35  C1b C    24.0687  -13.2927
            36  C1a C    25.2517  -15.3803
            37  C1b C    25.2517  -13.9886
            38  N1a N    26.4347  -13.2927
BOND        39
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     4   9 2
            9     5  10 1
            10    6  10 2
            11   11  12 1
            12   11  13 1
            13   11  14 1
            14   12  15 2
            15   12  16 1
            16   13  17 2
            17   13  18 1
            18   14  19 1
            19   14  20 2
            20   15  21 1
            21   15  22 1
            22   16  23 1
            23   16  24 2
            24   17  25 1
            25   18  26 1
            26   18  27 2
            27   19  28 2
            28   19  29 1
            29   20  30 1
            30   22  31 1
            31   23  32 1
            32   26  33 1
            33   28  34 1
            34   31  35 1
            35   32  36 1
            36   35  37 1
            37   37  38 1
            38   17  21 1
            39   30  34 2

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