KEGG   DRUG: Trazodone hydrochlorideHelp
Entry
D00820                      Drug                                   

Name
Trazodone hydrochloride (JAN/USP);
Desyrel (TN)
Product
  Generic
TRAZODONE (Northwind Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Rebel Distributors Corp.), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions LLC), TRAZODONE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), TRAZODONE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), TRAZODONE HYDROCHLORIDE (American Health Packaging), TRAZODONE HYDROCHLORIDE (American Health Packaging), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Apotex Corp), TRAZODONE HYDROCHLORIDE (Apotheca), TRAZODONE HYDROCHLORIDE (AvKARE), TRAZODONE HYDROCHLORIDE (AvPAK), TRAZODONE HYDROCHLORIDE (Avera McKennan Hospital), TRAZODONE HYDROCHLORIDE (Avera McKennan Hospital), TRAZODONE HYDROCHLORIDE (Avera McKennan Hospital), TRAZODONE HYDROCHLORIDE (Blenheim Pharmacal), TRAZODONE HYDROCHLORIDE (Blenheim Pharmacal), TRAZODONE HYDROCHLORIDE (Blenheim Pharmacal), TRAZODONE HYDROCHLORIDE (Blenheim Pharmacal), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Cardinal Health), TRAZODONE HYDROCHLORIDE (Cardinal Health), TRAZODONE HYDROCHLORIDE (Cardinal Health), TRAZODONE HYDROCHLORIDE (Cardinal Health), TRAZODONE HYDROCHLORIDE (Cardinal Health), TRAZODONE HYDROCHLORIDE (Carilion Materials Management), TRAZODONE HYDROCHLORIDE (Clinical Solutions Wholesale), TRAZODONE HYDROCHLORIDE (Clinical Solutions Wholesale), TRAZODONE HYDROCHLORIDE (Contract Pharmacy Services-PA), TRAZODONE HYDROCHLORIDE (DIRECT RX), TRAZODONE HYDROCHLORIDE (DIRECT RX), TRAZODONE HYDROCHLORIDE (Direct Rx), TRAZODONE HYDROCHLORIDE (Dispensing Solutions), TRAZODONE HYDROCHLORIDE (Dispensing Solutions), TRAZODONE HYDROCHLORIDE (Golden State Medical Supply), TRAZODONE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), TRAZODONE HYDROCHLORIDE (Keltman Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAZODONE HYDROCHLORIDE (Major Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Major Pharmaceuticals), TRAZODONE HYDROCHLORIDE (McKesson Contract Packaging), TRAZODONE HYDROCHLORIDE (MedVantx), TRAZODONE HYDROCHLORIDE (MedVantx), TRAZODONE HYDROCHLORIDE (NCS HealthCare of KY), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Physicians Total Care), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Qualitest Pharmaceuticals), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (STAT RX LLC USA), TRAZODONE HYDROCHLORIDE (STAT Rx USA LLC), TRAZODONE HYDROCHLORIDE (Sun Pharmaceutical Industries), TRAZODONE HYDROCHLORIDE (TYA Pharmaceuticals), TRAZODONE HYDROCHLORIDE (TYA Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Teva Pharmaceuticals USA), TRAZODONE HYDROCHLORIDE (Teva Pharmaceuticals USA), TRAZODONE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), TRAZODONE HYDROCHLORIDE (Unit Dose Services), TRAZODONE HYDROCHLORIDE (Unit Dose Services), TRAZODONE HYDROCHLORIDE (Contract Pharmacy Services-PA)
Formula
C19H22ClN5O. HCl
Exact mass
407.128
Mol weight
408.3248
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antidepressant, Serotonin antagonist and reuptake inhibitor (SARI)
Comment
triazolopyridine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037];
HTR2A [HSA:3356] [KO:K04157]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX05 Trazodone
      D00820  Trazodone hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Trazodone
    D00820  Trazodone hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00820  Trazodone hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT2A-receptor
     Trazodone
      D00820  Trazodone hydrochloride (JAN/USP)
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Trazodone
      D00820  Trazodone hydrochloride (JAN/USP)
     Trazodone
      D00820  Trazodone hydrochloride (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Trazodone
    D00820  Trazodone hydrochloride (JAN/USP)
  CYP3A4
   Trazodone
    D00820  Trazodone hydrochloride (JAN/USP)
  CYP3A5
   Trazodone
    D00820  Trazodone hydrochloride (JAN/USP)
  CYP3A7
   Trazodone
    D00820  Trazodone hydrochloride (JAN/USP)
Psychiatric agents [br08363.html]
 Antidepressants
  D00820
BRITE hierarchy
Other DBs
CAS: 
25332-39-2
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        27
            1   X   Cl   22.1900  -26.5300
            2   N4y N    11.9000  -24.0100
            3   C1b C    13.0900  -24.7100
            4   C1b C    14.2800  -24.0800
            5   C1b C    15.4700  -24.7800
            6   N1y N    16.7300  -24.0800
            7   C1x C    16.7300  -22.6800
            8   C1x C    17.9200  -24.7800
            9   C1x C    17.9200  -21.9100
            10  C1x C    19.1800  -24.0800
            11  N1y N    19.1800  -22.6800
            12  C8y C    20.3700  -21.9100
            13  C8x C    20.3700  -20.5100
            14  C8x C    21.5600  -22.6800
            15  C8y C    21.5600  -19.8100
            16  C8x C    22.8200  -21.9100
            17  C8x C    22.8200  -20.5100
            18  X   Cl   21.5600  -18.4100
            19  N5x N    11.4904  -22.6712
            20  C8y C    10.0906  -22.6471
            21  N4y N     9.6351  -23.9709
            22  C8y C    10.7533  -24.8132
            23  O5x O    10.8003  -26.1791
            24  C8x C     9.1720  -21.5906
            25  C8x C     7.7977  -21.8580
            26  C8x C     7.3422  -23.1818
            27  C8x C     8.2608  -24.2383
BOND        29
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     6   8 1
            7     7   9 1
            8     8  10 1
            9     9  11 1
            10   11  12 1
            11   12  13 1
            12   12  14 2
            13   13  15 2
            14   14  16 1
            15   15  17 1
            16   15  18 1
            17   10  11 1
            18   16  17 2
            19    2  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 1
            23    2  22 1
            24   22  23 2
            25   20  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   21  27 1

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