KEGG   DRUG: Vancomycin hydrochlorideHelp
Entry
D00926                      Drug                                   

Name
Vancomycin hydrochloride (JP17/USP);
Vancoled (TN)
Product
  Generic
VANCOMYCIN HYDROCHLORIDE (Breckenridge Pharmaceutical), VANCOMYCIN HYDROCHLORIDE (AGILA SPECIALTIES PRIVATE LIMITED), VANCOMYCIN HYDROCHLORIDE (ANI Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (APP Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (APP Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Akorn), VANCOMYCIN HYDROCHLORIDE (Alvogen), VANCOMYCIN HYDROCHLORIDE (Athenex Pharmaceutical Division), VANCOMYCIN HYDROCHLORIDE (AuroMedics Pharma LLC), VANCOMYCIN HYDROCHLORIDE (AuroMedics Pharma LLC), VANCOMYCIN HYDROCHLORIDE (Cardinal Health), VANCOMYCIN HYDROCHLORIDE (Cardinal Health), VANCOMYCIN HYDROCHLORIDE (Cardinal Health), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), STERILE VANCOMYCIN HYDROCHLORIDE (General Injectables & Vaccines), VANCOMYCIN HYDROCHLORIDE (Gland Pharma Limited), VANCOMYCIN HYDROCHLORIDE (Heritage Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Heritage Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Lupin Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Pfizer Laboratories Div Pfizer), STERILE VANCOMYCIN HYDROCHLORIDE (Pfizer Laboratories Div Pfizer), VANCOMYCIN HYDROCHLORIDE (Pfizer Laboratories Div Pfizer), VANCOMYCIN HYDROCHLORIDE (Pfizer Laboratories Div Pfizer), VANCOMYCIN HYDROCHLORIDE (Prasco Laboratories), STERILE VANCOMYCIN HYDROCHLORIDE (Rebel Distributors Corp), VANCOMYCIN HYDROCHLORIDE (SAMSON MEDICAL TECHNOLOGIES LLC), VANCOMYCIN (Sagent Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Sandoz), VANCOMYCIN HYDROCHLORIDE (Xellia Pharmaceuticals ApS), VANCOMYCIN HYDROCHLORIDE (Xellia Pharmaceuticals), VANCOMYCIN HYDROCLORIDE (Heritage Pharmaceuticals)
  Other
Formula
C66H75Cl2N9O24. HCl
Exact mass
1483.4069
Mol weight
1485.7145
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antibacterial
 DG01580  Glycopeptide antibiotic
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antibacterial, Cell wall biosynthesis inhibitor
Comment
Vancomycin makes complex formation with D-alanyl-D-alanine of Peptidoglycan, and inhibites cross-link between protein and peptideglycan.
Glycopeptide
Target
Peptidoglycan (D-Ala-D-Ala)
  Pathway
Peptidoglycan biosynthesis
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA09 Vancomycin
      D00926  Vancomycin hydrochloride (JP17/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XA Glycopeptide antibacterials
     J01XA01 Vancomycin
      D00926  Vancomycin hydrochloride (JP17/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Vancomycin
    D00926  Vancomycin hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   611  Acting mainly on gram-positive bacteria
    6113  Vancomycins
     D00926  Vancomycin hydrochloride (JP17/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Others
    Glycopeptides
     Vancomycin
      D00926  Vancomycin hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00926  Vancomycin hydrochloride
  D00926  Vancomycin hydrochloride for injection
Antibacterials [br08350.html]
 D00926
BRITE hierarchy
Other DBs
CAS: 
1404-93-9
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        102
            1   X   Cl   50.3279  -23.5014
            2   C1y C    39.5722  -29.5878
            3   C1x C    39.5115  -28.2456
            4   O2x O    40.7243  -30.2558
            5   C1z C    40.7427  -27.5938
            6   C1y C    41.8857  -29.6039
            7   C1y C    41.8949  -28.2617
            8   C1a C    39.8150  -26.5077
            9   N1a N    41.7058  -26.5208
            10  C1a C    43.0453  -30.2719
            11  O1a O    43.0637  -27.6100
            12  C8y C    37.3497  -25.3159
            13  C8y C    38.5062  -24.6485
            14  C8y C    36.1926  -24.6558
            15  O2a O    37.3580  -26.6508
            16  C8x C    38.4989  -23.3064
            17  O2x O    39.6557  -25.3086
            18  C8x C    36.1853  -23.3212
            19  O2x O    35.0286  -25.3086
            20  C1y C    36.1979  -28.4156
            21  C8y C    37.3348  -22.6391
            22  C8y C    40.8199  -24.6411
            23  C8y C    33.8643  -24.6485
            24  C1y C    36.1979  -29.7576
            25  O2x O    35.0339  -27.7483
            26  C1y C    37.2975  -20.5243
            27  C8y C    40.8199  -23.3064
            28  C8x C    41.9767  -25.3011
            29  C8y C    32.7076  -25.3086
            30  C8x C    33.8569  -23.3064
            31  C1y C    35.0486  -30.4401
            32  C1y C    33.8696  -28.4304
            33  C5x C    38.4469  -19.8494
            34  N1x N    36.1483  -19.8567
            35  C8x C    41.9767  -22.6315
            36  X   Cl   39.6557  -22.6242
            37  C8x C    43.1261  -24.6411
            38  C8x C    31.5506  -24.6558
            39  X   Cl   32.7000  -26.6435
            40  C8x C    32.6927  -22.6391
            41  C1y C    33.8768  -29.7800
            42  O1a O    35.0412  -31.7673
            43  N1x N    39.6112  -20.5243
            44  O5x O    38.4396  -18.5147
            45  C5x C    34.9913  -20.5316
            46  C8y C    43.1261  -23.3064
            47  C8y C    31.5434  -23.3212
            48  O1a O    32.7126  -30.4326
            49  C1y C    40.8305  -19.8494
            50  C1y C    33.8347  -19.8643
            51  O5x O    34.9841  -21.8664
            52  C1y C    44.2755  -22.6242
            53  C1y C    30.3790  -22.6391
            54  C8y C    40.7679  -18.5147
            55  C5x C    41.9174  -20.5167
            56  N1x N    32.6778  -20.5392
            57  C1y C    44.2680  -20.5243
            58  O1a O    45.4323  -23.2991
            59  C1y C    30.3716  -20.5465
            60  O1a O    29.2149  -23.3064
            61  C8x C    41.9249  -17.8472
            62  C8x C    39.6039  -17.8472
            63  N1x N    43.0740  -19.8419
            64  C5x C    31.5285  -19.8716
            65  C5x C    45.4250  -19.8494
            66  N1b N    29.2075  -19.8791
            67  C8y C    41.9249  -16.5051
            68  C8x C    39.6039  -16.5124
            69  O5x O    31.5909  -18.5369
            70  N1x N    45.4175  -18.5147
            71  O5x O    46.5816  -20.5243
            72  C5a C    28.0507  -20.5392
            73  C8y C    43.0889  -15.8524
            74  C8y C    40.7605  -15.8375
            75  C1y C    44.2531  -17.8472
            76  C1c C    26.8938  -19.8716
            77  O5a O    28.0433  -21.8737
            78  C8y C    44.2458  -16.5124
            79  C8y C    43.0816  -14.5104
            80  C6a C    46.4927  -16.5644
            81  C1b C    26.8865  -18.5369
            82  N1b N    25.7296  -20.5316
            83  C8x C    45.4026  -15.8375
            84  C8x C    44.2310  -13.8355
            85  O1a O    41.9174  -13.8355
            86  C8y C    45.3953  -14.4955
            87  O1a O    46.5445  -13.8134
            88  O5x O    41.9208  -21.8830
            89  O1a O    40.7552  -14.4429
            90  O6a O    47.6827  -17.2570
            91  O6a O    46.4972  -15.2008
            92  C1a C    25.7267  -21.8829
            93  C1c C    25.7012  -17.8621
            94  C1a C    24.4841  -18.5745
            95  C1a C    25.6926  -16.5097
            96  C1b C    33.8310  -17.6810
            97  C5a C    35.0048  -16.9989
            98  N1a N    36.1772  -17.6715
            99  O5a O    35.0011  -15.6143
            100 C1b C    32.6764  -27.7509
            101 O1a O    31.5141  -28.4312
            102 O2a O    37.8151  -30.4432
BOND        110
            1     2   3 1
            2     2   4 1
            3     3   5 1
            4     4   6 1
            5     5   7 1
            6     5   8 1 #Up
            7     5   9 1 #Down
            8     6  10 1 #Down
            9     7  11 1 #Down
            10    6   7 1
            11   12  13 1
            12   12  14 2
            13   12  15 1
            14   13  16 2
            15   13  17 1
            16   14  18 1
            17   14  19 1
            18   20  15 1 #Up
            19   16  21 1
            20   17  22 1
            21   19  23 1
            22   20  24 1
            23   20  25 1
            24   21  26 1
            25   22  27 1
            26   22  28 2
            27   23  29 1
            28   23  30 2
            29   24  31 1
            30   25  32 1
            31   26  33 1
            32   26  34 1 #Up
            33   27  35 2
            34   27  36 1
            35   28  37 1
            36   29  38 2
            37   29  39 1
            38   30  40 1
            39   31  41 1
            40   31  42 1 #Up
            41   33  43 1
            42   33  44 2
            43   34  45 1
            44   35  46 1
            45   38  47 1
            46   41  48 1 #Down
            47   43  49 1
            48   45  50 1
            49   45  51 2
            50   46  52 1
            51   47  53 1
            52   49  54 1
            53   49  55 1 #Down
            54   50  56 1
            55   52  57 1
            56   52  58 1 #Down
            57   53  59 1
            58   53  60 1 #Up
            59   54  61 1
            60   54  62 2
            61   55  63 1
            62   56  64 1
            63   57  65 1
            64   59  66 1 #Up
            65   61  67 2
            66   62  68 1
            67   64  69 2
            68   65  70 1
            69   65  71 2
            70   66  72 1
            71   67  73 1
            72   67  74 1
            73   70  75 1
            74   72  76 1
            75   72  77 2
            76   73  78 2
            77   73  79 1
            78   75  80 1 #Down
            79   76  81 1
            80   76  82 1 #Down
            81   78  83 1
            82   79  84 2
            83   79  85 1
            84   83  86 2
            85   86  87 1
            86   18  21 2
            87   32  41 1
            88   37  46 2
            89   40  47 2
            90   57  63 1 #Down
            91   59  64 1 #Down
            92   68  74 2
            93   75  78 1
            94   84  86 1
            95   55  88 2
            96   74  89 1
            97   80  90 1
            98   80  91 2
            99   82  92 1
            100  81  93 1
            101  93  94 1
            102  93  95 1
            103  50  96 1 #Up
            104  96  97 1
            105  97  98 1
            106  97  99 2
            107  32 100 1 #Up
            108 100 101 1
            109  24 102 1 #Down
            110   2 102 1 #Up

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