KEGG   DRUG: ParicalcitolHelp
Entry
D00930                      Drug                                   

Name
Paricalcitol (JAN/USAN/INN);
Zemplar (TN)
Product
  Generic
Formula
C27H44O3
Exact mass
416.329
Mol weight
416.6365
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Other
 DG01607  Vitamin D derivatives
Remark
Same as: 
ATC code: 
Efficacy
Antihyperparathyroidism, Vitamin D receptor agonist
  Disease
Secondary hyperparathyroidism [DS:H01699]
Comment
Vitamin D analog
Treatment of osteodystrophy (for the reduction of parathyroid hormone levels)
Target
NR1I1 (VDR) [HSA:7421] [KO:K08539]
  Pathway
Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H05 CALCIUM HOMEOSTASIS
   H05B ANTI-PARATHYROID AGENTS
    H05BX Other anti-parathyroid agents
     H05BX02 Paricalcitol
      D00930  Paricalcitol (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Paricalcitol
   D00930  Paricalcitol (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Vitamin D3 like receptor
    vitamin D receptor
     Paricalcitol
      D00930  Paricalcitol (JAN/USAN/INN)
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D00930
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00930
BRITE hierarchy
Other DBs
CAS: 
131918-61-1
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        30
            1   C1x C    14.1400  -22.7500
            2   C1x C    14.1400  -24.1500
            3   C2y C    15.3524  -24.8500
            4   C1y C    16.5649  -24.1500
            5   C1z C    16.5649  -22.7500
            6   C1x C    15.3524  -22.0500
            7   C1x C    17.8964  -24.5826
            8   C1x C    18.7193  -23.4500
            9   C1y C    17.8964  -22.3174
            10  C1a C    16.5649  -21.3500
            11  C2b C    15.3524  -26.2498
            12  C2b C    14.1232  -26.9597
            13  C2y C    14.1234  -28.3499
            14  C1x C    12.9235  -29.0430
            15  C1y C    12.9238  -30.4430
            16  C1x C    14.1364  -31.1427
            17  C1y C    15.3363  -30.4496
            18  C1x C    15.3360  -29.0496
            19  O1a O    16.5443  -31.1468
            20  O1a O    11.7284  -31.1338
            21  C1c C    18.3275  -20.9906
            22  C2b C    19.7275  -20.9906
            23  C1a C    17.5135  -19.8700
            24  C2b C    20.4266  -19.7799
            25  C1c C    21.8397  -19.7797
            26  C1a C    22.5533  -21.0147
            27  C1d C    22.5265  -18.5899
            28  O1a O    23.9397  -18.5895
            29  C1a C    21.8427  -17.4060
            30  C1a C    23.2432  -19.8306
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    5  10 1 #Up
            12    3  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   13  18 1
            21   17  19 1 #Up
            22   15  20 1 #Down
            23    9  21 1
            24   21  22 1
            25   21  23 1 #Down
            26   22  24 2
            27   24  25 1
            28   25  26 1 #Up
            29   25  27 1
            30   27  28 1
            31   27  29 1
            32   27  30 1

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