KEGG   DRUG: Alendronate sodiumHelp
Entry
D00939                      Drug                                   

Name
Alendronate sodium (USAN);
Alendronate sodium hydrate (JP17);
Binosto (TN);
Fosamax (TN)
Product
  Generic
ALENDRONATE SODIUM (Actavis Pharma), ALENDRONATE SODIUM (Aidarex Pharmaceuticals LLC), ALENDRONATE SODIUM (Aidarex Pharmaceuticals LLC), ALENDRONATE SODIUM (Aidarex Pharmaceuticals LLC), ALENDRONATE SODIUM (Aidarex Pharmaceuticals LLC), ALENDRONATE SODIUM (Aurobindo Pharma Limited), ALENDRONATE SODIUM (Avera McKennan Hospital), ALENDRONATE SODIUM (Cipla USA), ALENDRONATE SODIUM (Department of State Health Services), ALENDRONATE SODIUM (Dispensing Solutions), ALENDRONATE SODIUM (Golden State Medical Supply), ALENDRONATE SODIUM (Impax Generics), ALENDRONATE SODIUM (Jubilant Cadista Pharmaceuticals), ALENDRONATE SODIUM (MedVantx), ALENDRONATE SODIUM (Mylan Institutional), ALENDRONATE SODIUM (Mylan Pharmaceuticals), ALENDRONATE SODIUM (NorthStar Rx LLC), ALENDRONATE SODIUM (NuCare Pharmaceuticals), ALENDRONATE SODIUM (NuCare Pharmaceuticals), ALENDRONATE (NuCare Pharmaceuticals), ALENDRONATE (NuCare Pharmaceuticals), ALENDRONATE SODIUM (NuCare Pharmaceuticals), ALENDRONATE SODIUM (Physicians Total Care), ALENDRONATE SODIUM (Preferred Pharmaceuticals), ALENDRONATE SODIUM (Preferred Pharmaceuticals), ALENDRONATE SODIUM (Proficient Rx LP), ALENDRONATE SODIUM (Proficient Rx LP), ALENDRONATE SODIUM (REMEDYREPACK), ALENDRONATE SODIUM (REMEDYREPACK), ALENDRONATE SODIUM (Rebel Distributors Corp), ALENDRONATE SODIUM (Rising Pharmaceuticals), ALENDRONATE SODIUM (TAGI Pharma), ALENDRONATE SODIUM (Teva Pharmaceuticals USA), ALENDRONATE SODIUM (Unit Dose Services), ALENDRONATE SODIUM (Unit Dose Services), ALENDRONATE SODIUM (Unit Dose Services), ALENDRONATE SODIUM (Unit Dose Services), ALENDRONATE (Virtus Pharmaceuticals), ALENDRONATE SODIUM (Watson Laboratories)
Formula
C4H12NO7P2. 3H2O. Na
Exact mass
325.0304
Mol weight
325.1237
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Other
 DG01600  Bisphosphonate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiresorptive, Osteoporosis agent, Farnesylpyrophosphate synthetase inhibitor
  Disease
Osteoporosis [DS:H01593]
Glucocorticoid-induced osteoporosis [DS:H01709]
Paget's disease of bone [DS:H00437]
Comment
Bisphosphonate
Target
FDPS [HSA:2224] [KO:K00787]
  Pathway
Terpenoid backbone biosynthesis
Interaction
Drug interaction
Structure map
Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M05 DRUGS FOR TREATMENT OF BONE DISEASES
   M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
    M05BA Bisphosphonates
     M05BA04 Alendronic acid
      D00939  Alendronate sodium (USAN)
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Alendronate
   D00939  Alendronate sodium (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D00939  Alendronate sodium (USAN); Alendronate sodium hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases
   farnesyl-diphosphate farnesyltransferase
    Alendronic acid
     D00939  Alendronate sodium (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00939  Alendronate sodium hydrate
  D00939  Alendronate sodium tablets
  D00939  Alendronate sodium injection
Osteoporosis drugs [br08368.html]
 D00939
BRITE hierarchy
Other DBs
CAS: 
121268-17-5
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        18
            1   O0  O    29.9425  -25.6767
            2   Z   Na   26.3872  -22.7066 #+
            3   P1b P    22.2600  -24.5000
            4   C1d C    23.5900  -24.5000
            5   C1b C    23.5900  -22.6100
            6   O1a O    23.5900  -25.8300
            7   P1b P    24.9900  -24.5000
            8   O1c O    26.3200  -24.5000 #-
            9   O1c O    20.8600  -24.5000
            10  O1c O    22.2600  -23.1000
            11  O1c O    24.9900  -23.1000
            12  C1b C    24.7800  -21.9800
            13  C1b C    24.7800  -20.5800
            14  N1a N    25.9700  -19.8800
            15  O1c O    22.2600  -25.8300
            16  O1c O    24.9900  -25.8300
            17  O0  O    29.9425  -25.6767
            18  O0  O    29.9425  -25.6767
BOND        13
            1     3   4 1
            2     4   5 1
            3     4   6 1
            4     4   7 1
            5     7   8 1
            6     3   9 1
            7     3  10 2
            8     7  11 2
            9     5  12 1
            10   12  13 1
            11   13  14 1
            12    3  15 1
            13    7  16 1
BRACKET     1    28.2800  -26.7400   28.2800  -24.7800
            1    30.3100  -24.7800   30.3100  -26.7400
            1  3
 ORIGINAL  1    1
 REPEAT    1   17  18

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