KEGG   DRUG: MeloxicamHelp
Entry
D00969                      Drug                                   

Name
Meloxicam (JAN/USAN/INN);
Mobic (TN)
Product
  Generic
MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (Aidarex Pharmaceuticals LLC), MELOXICAM (American Health Packaging), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Apotex Corp), MELOXICAM (Aurobindo Pharma Limited), MELOXICAM (AvPAK), MELOXICAM (Belcher Pharmaceuticals), MELOXICAM (Blenheim Pharmacal), MELOXICAM (Blenheim Pharmacal), MELOXICAM (Blenheim Pharmacal), MELOXICAM (Blenheim Pharmacal), MELOXICAM (Blenheim Pharmacal), MELOXICAM (Blenheim Pharmacal), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Cadila Healthcare Limited), MELOXICAM (Cardinal Health), MELOXICAM (Cardinal Health), MELOXICAM (Carilion Materials Management), MELOXICAM (Carlsbad Technology), MELOXICAM (Cipla USA), MELOXICAM (Clinical Solutions Wholesale), MELOXICAM (Clinical Solutions Wholesale), MELOXICAM (Denton Pharma), MELOXICAM (Direct Rx), MELOXICAM (Dispensing Solutions), MELOXICAM (Dispensing Solutions), MELOXICAM (Exelan Pharmaceuticals), MELOXICAM (Glenmark Pharmaceuticals), MELOXICAM (International Laboratories), MELOXICAM (International Labs), MELOXICAM (KAISER FOUNDATION HOSPITALS), MELOXICAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), MELOXICAM (Lake Erie Medical DBA Quality Care Products LLC), MELOXICAM (Lake Erie Medical DBA Quality Care Products LLC), MELOXICAM (Lake Erie Medical DBA Quality Care Products LLC), MELOXICAM (Lake Erie Medical DBA Quality Care Products LLC), MELOXICAM (Liberty Pharmaceuticals), MELOXICAM (Life Line Home Care Services), MELOXICAM (Lupin Pharmaceuticals), MELOXICAM (McKesson Contract Packaging), MELOXICAM (McKesson Packaging Services a business unit of McKesson Corporation), MELOXICAM (MedVantx), MELOXICAM (MedVantx), MELOXICAM (MedVantx), MELOXICAM (MedVantx), MELOXICAM (MedVantx), MELOXICAM (MedVantx), MELOXICAM (Medsource Pharmaceuticals), MELOXICAM (Mylan Pharmaceuticals), MELOXICAM (NCS HealthCare of KY), MELOXICAM (NCS HealthCare of KY), MELOXICAM (NCS HealthCare of KY), MELOXICAM (New Horizon Rx Group), MELOXICAM (Northwind Pharmaceuticals), MELOXICAM (Northwind Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), COMFORT PAC WITH MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), COMFORT PAC WITH MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (Physicians Total Care), MELOXICAM (Preferred Pharmaceuticals), MELOXICAM (Preferred Pharmaceuticals), MELOXICAM (Proficient Rx LP), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (ReadyMeds), MELOXICAM (ReadyMeds), MELOXICAM (Rebel Distributors Corp.), MELOXICAM (RedPharm Drug), MELOXICAM (RedPharm Drug), MELOXICAM (Roxane Laboratories), MELOXICAM (STAT RX USA LLC), MELOXICAM (STAT Rx USA LLC), MELOXICAM (STERLING KNIGHT PHARMACEUTICALS), MELOXICAM (Strides Shasun Limited), MELOXICAM (Unichem Pharmaceuticals (USA)), MELOXICAM (Unit Dose Services), MELOXICAM (Unit Dose Services), MELOXICAM (Unit Dose Services), MELOXICAM (Unit Dose Services), MELOXICAM (Zydus Pharmaceuticals (USA))
Formula
C14H13N3O4S2
Exact mass
351.0347
Mol weight
351.4007
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01910  Antiinflammatory drug, oxicams
 DG01922  Selective COX2 inhibitor
 DG01910  Antiinflammatory drug, oxicams
Cyp substrate
 DG01633  CYP3A substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Analgesic, Anti-inflammatory, COX-2 inhibitor
Comment
Oxicams
Target
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AC Oxicams
     M01AC06 Meloxicam
      D00969  Meloxicam (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Meloxicam
    D00969  Meloxicam (JAN/USAN/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Meloxicam
    D00969  Meloxicam (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00969  Meloxicam (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-2 (COX-2)
    Meloxicam
     D00969  Meloxicam (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Meloxicam
    D00969  Meloxicam (JAN/USAN/INN)
  CYP3A4
   Meloxicam
    D00969  Meloxicam (JAN/USAN/INN)
Antirheumatic and antigout drugs [br08366.html]
 Antirheumatic drugs
  D00969
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Anti-inflammatory drugs
  D00969
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00969
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00969
BRITE hierarchy
Other DBs
CAS: 
71125-38-7
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        23
            1   C8y C    29.1386  -17.3775
            2   C8y C    29.1152  -18.7625
            3   C8y C    30.3483  -16.6996
            4   C8x C    27.9406  -16.6586
            5   S2x S    30.3015  -19.4695
            6   C8x C    27.9055  -19.4403
            7   C8y C    31.5345  -17.4125
            8   O1a O    30.3717  -15.3088
            9   C8x C    26.7310  -17.3481
            10  N4y N    31.5112  -18.7975
            11  O3c O    31.3591  -20.4571
            12  O3c O    29.1211  -20.5273
            13  C8x C    26.7135  -18.7391
            14  C5a C    32.7500  -16.7347
            15  C1a C    32.7149  -19.5105
            16  N1b N    33.9480  -17.4534
            17  O5a O    32.7734  -15.3438
            18  C8y C    35.1635  -16.7755
            19  N5x N    36.4943  -17.1641
            20  S2x S    35.1230  -15.3776
            21  C8x C    37.2806  -16.0189
            22  C8y C    36.4368  -14.9158
            23  C1a C    36.8219  -13.5763
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    5  12 2
            12    6  13 2
            13    7  14 1
            14   10  15 1
            15   14  16 1
            16   14  17 2
            17   16  18 1
            18   18  19 2
            19   18  20 1
            20   19  21 1
            21   20  22 1
            22   22  23 1
            23    7  10 1
            24    9  13 1
            25   21  22 2

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