KEGG   DRUG: Duloxetine hydrochlorideHelp
Entry
D01179                      Drug                                   

Name
Duloxetine hydrochloride (JAN/USAN);
Cymbalta (TN);
Yentreve (TN)
Product
  Generic
DULOXETINE HYDROCHLORIDE (Cardinal Health), DULOXETINE HYDROCHLORIDE (Major Pharmaceuticals), DULOXETINE HYDROCHLORIDE (NCS HealthCare of KY), DULOXETINE HYDROCHLORIDE (Proficient Rx LP), DULOXETINE HYDROCHLORIDE (REMEDYREPACK), DULOXETINE HYDROCHLORIDE (TORRENT PHARMACEUTICALS LIMITED), DULOXETINE HYDROCHLORIDE (TYA Pharmaceuticals), DULOXETINE HYDROCHLORIDE (Unit Dose Services), DULOXETINE HYDROCHLORIDE (Unit Dose Services), DULOXETINE (Actavis Pharma), DULOXETINE (Ajanta Pharma Limited), DULOXETINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), DULOXETINE (American Health Packaging), DULOXETINE (Ascend Laboratories), DULOXETINE (BluePoint Laboratories), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Cadila Healthcare Limited), DULOXETINE (Cadila Healthcare Limited), DULOXETINE (Camber Pharmaceuticals), DULOXETINE (Cardinal Health), DULOXETINE (Cipla USA), DULOXETINE (DIRECT RX), DULOXETINE (DIRECT RX), DULOXETINE (DIRECT RX), DULOXETINE (Dr. Reddy's Laboratories Limited), IRENKA (LUPIN PHARMA), DULOXETINE (Lupin Pharmaceuticals), DULOXETINE (Medsource Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (Solco Healthcare US), DULOXETINE (Sun Pharma Global FZE), DULOXETINE (TYA Pharmaceuticals), DULOXETINE (Teva Pharmaceuticals USA), DULOXETINE (Trigen Laboratories), DULOXETINE (Unit Dose Services), DULOXETINE (Zydus Pharmaceuticals (USA)), DULOXETINE DELAYED-RELEASE (Aidarex Pharmaceuticals LLC), DULOXETINE (Aphena Pharma Solutions - Tennessee), DULOXETINE HYDROCHLORIDE (Apotex Corp.), DULOXETINE (Aurobindo Pharma Limited), DULOXETINE (AvPAK), DULOXETINE (Avera McKennan Hospital), DULOXETINE (Avera McKennan Hospital), DULOXETINE (Blenheim Pharmacal), DULOXETINE (Breckenridge Pharmaceutical), DULOXETINE HYDROCHLORIDE (Cardinal Health), DULOXETINE (Carilion Materials Management), DULOXETINE (Citron Pharma LLC), DULOXETINE HYDROCHLORIDE (DIRECT RX), DULOXETINE HYDROCHLORIDE (DIRECT RX), DULOXETINE (Golden State Medical Supply), DULOXETINE (KAISER FOUNDATION HOSPITALS), DULOXETINE (Lake Erie Medical DBA Quality Care Products LLC), DULOXETINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), DULOXETINE (Lake Erie Medical DBA Quality Care Products LLC), DULOXETINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DULOXETINE HYDROCHLORIDE (Major Pharmaceuticals), DULOXETINE (Mylan Institutional), DULOXETINE HYDROCHLORIDE (NCS HealthCare of KY), DULOXETINE (Prasco Laboratories), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE HYDROCHLORIDE (Preferred Pharmaceuticals), DULOXETINE HYDROCHLORIDE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE HYDROCHLORIDE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (REMEDYREPACK), DULOXETINE HYDROCHLORIDE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE HYDROCHLORIDE (REMEDYREPACK), DULOXETINE (TYA Pharmaceuticals), DULOXETINE HYDROCHLORIDE (Unit Dose Services), DULOXETINE HYDROCHLORIDE (Unit Dose Services)
Formula
C18H19NOS. HCl
Exact mass
333.0954
Mol weight
333.8755
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Major depressive disorder [DS:H01646]
Generalized anxiety disorder [DS:H01662]
Diabetic peripheral neuropathic pain [DS:H01459]
Fibromyalgia [DS:H01636]
Comment
Fluoxetine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037];
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX21 Duloxetine
      D01179  Duloxetine hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USAN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USAN)
 Central Nervous System Agents
  Fibromyalgia Agents
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01179  Duloxetine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Duloxetine
      D01179  Duloxetine hydrochloride (JAN/USAN)
    SLC6A4 (serotonin transporter)
     Duloxetine
      D01179  Duloxetine hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USAN)
 CYP substrates
  CYP1A2
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USAN)
  CYP2D6
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USAN)
Psychiatric agents [br08363.html]
 Antidepressants
  D01179
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01179
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01179
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01179
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01179
BRITE hierarchy
Other DBs
CAS: 
136434-34-9
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        22
            1   S2x S    17.1214  -19.0627
            2   C8x C    15.9783  -19.8891
            3   C8x C    16.4140  -21.2272
            4   C8x C    17.8216  -21.2272
            5   C8y C    18.2576  -19.8891
            6   C1c C    19.4627  -19.1831
            7   C1b C    20.6722  -19.8833
            8   C1b C    21.8817  -19.1831
            9   N1b N    23.0912  -19.8833
            10  C1a C    24.3007  -19.1831
            11  O2a O    19.4589  -17.7826
            12  C8y C    20.6699  -17.0791
            13  C8x C    21.8781  -17.7788
            14  C8x C    23.0891  -17.0756
            15  C8x C    23.0856  -15.6751
            16  C8y C    20.6599  -15.6814
            17  C8y C    21.8696  -14.9832
            18  C8x C    21.8698  -13.5864
            19  C8x C    20.6603  -12.8879
            20  C8x C    19.4506  -13.5861
            21  C8x C    19.4504  -14.9828
            22  X   Cl   27.5966  -17.5067
BOND        23
            1     4   5 2
            2     6  11 1 #Up
            3     5   1 1
            4    11  12 1
            5     2   3 2
            6     5   6 1
            7    12  13 2
            8    13  14 1
            9    14  15 2
            10   15  17 1
            11   16  12 1
            12    6   7 1
            13    7   8 1
            14    1   2 1
            15    8   9 1
            16    3   4 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  16 1
            23    9  10 1

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