KEGG   DRUG: Doxorubicin hydrochlorideHelp
Entry
D01275                      Drug                                   

Name
Doxorubicin hydrochloride (JP17/USP);
Adriacin (TN);
Adriamycin (TN);
Doxil (TN);
Rubex (TN)
Product
  Generic
DOXORUBICIN HYDROCHLORIDE (Amneal Biosciences), DOXORUBICIN HYDROCHLORIDE (Actavis Pharma), DOXORUBICIN HYDROCHLORIDE (Alvogen), DOXORUBICIN HYDROCHLORIDE (Athenex Pharmaceutical Division), DOXORUBICIN HYDROCHLORIDE (BluePoint Laboratories), DOXORUBICIN HYDROCHLORIDE (Dr. Reddy's Laboratories), DOXORUBICIN HYDROCHLORIDE (Dr. Reddy's Laboratories), DOXORUBICIN HYDROCHLORIDE (Fresenius Kabi USA), DOXORUBICIN HYDROCHLORIDE (Gland Pharma Limited), DOXORUBICIN HYDROCHLORIDE (Mylan Institutional LLC), DOXORUBICIN HYDROCHLORIDE (NorthStar RxLLC), DOXORUBICIN HYDROCHLORIDE (Sagent Pharmaceuticals), DOXORUBICIN HYDROCHLORIDE (Sun Pharma Global FZE), DOXORUBICIN HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), DOXORUBICIN HYDROCHLORIDE (Teva Parenteral Medicines), ADRIAMYCIN (West-Ward Pharmaceuticals Corp), ADRIAMYCIN (West-Ward Pharmaceuticals Corp)
  Other
Formula
C27H29NO11. HCl
Exact mass
579.1507
Mol weight
579.9802
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Source
Streptomyces peucetius [TAX:1950]
Class
Antineoplastic
 DG01682  Anthracycline antineoplastic
Other
 DG01529  Topoisomerase inhibitor
  DG01527  Topoisomerase II inhibitor
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Transporter substrate
 DG01665  P-glycoprotein substrate
Remark
Therapeutic category: 4235
ATC code: L01DB01
Chemical structure group: DG00696
Product (DG00696): D01275<JP/US>
Efficacy
Antineoplastic, Topoisomerase II inhibitor
  Disease
Ovarian cancer [DS:H00027]
AIDS-related Kaposi's sarcoma [DS:H00041]
Multiple myeloma [DS:H00010]
Acute lymphoblastic leukemia [DS:H00001 H00002]
Acute myeloblastic leukemia [DS:H00003]
Hodgkin lymphoma [DS:H00007]
Non-Hodgkin lymphoma [DS:H00011 H01613 H01463 H00005 H01464 H01613 H01892 H00008 H00001 H00002]
Breast cancer [DS:H00031]
Neuroblastoma [DS:H00043]
Ovarian carcinoma [DS:H00027]
Thyroid carcinoma [DS:H00032]
Gastric carcinoma [DS:H00018]
Target
TOP2 [HSA:7153 7155] [KO:K03164]
Interaction
Drug interaction
Structure map
map07042  Antineoplastics - agents from natural products
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DB Anthracyclines and related substances
     L01DB01 Doxorubicin
      D01275  Doxorubicin hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4235  Anthracycline antibiotics
     D01275  Doxorubicin hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases
   RNA polymerase
    Doxorubicin
     D01275  Doxorubicin hydrochloride (JP17/USP)
   DNA polymerase
    Doxorubicin
     D01275  Doxorubicin hydrochloride (JP17/USP)
  Isomerases
   topoisomerase II
    Doxorubicin
     D01275  Doxorubicin hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01275  Doxorubicin hydrochloride
  D01275  Doxorubicin hydrochloride for injection
Antineoplastics [br08340.html]
 D01275
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01275
BRITE hierarchy
Other DBs
CAS: 25316-40-9
PubChem: 7848338
ChEBI: 31522
ChEMBL: CHEMBL359744 CHEMBL543353
LigandBox: D01275
NIKKAJI: J262.563F
LinkDB All DBs
KCF data Show

ATOM        40
            1   C8x C    23.4525  -12.6014
            2   C8x C    23.4525  -14.0018
            3   C8y C    24.6429  -14.7020
            4   C8y C    25.9033  -14.0018
            5   C8y C    25.9033  -12.6014
            6   C8x C    24.6429  -11.9012
            7   C5x C    27.0936  -14.7020
            8   C8y C    28.2840  -14.0018
            9   C8y C    28.2840  -12.6014
            10  C5x C    27.0936  -11.9012
            11  C8y C    29.5443  -14.7020
            12  C8y C    30.7347  -14.0018
            13  C8y C    30.7347  -12.6014
            14  C8y C    29.5443  -11.9012
            15  C1y C    31.9250  -14.7020
            16  C1x C    33.1854  -14.0018
            17  C1z C    33.1854  -12.6014
            18  C1x C    31.9250  -11.9012
            19  O2a O    24.6429  -16.1024
            20  C1a C    23.4525  -16.8026
            21  O5x O    27.0936  -16.1024
            22  O5x O    27.0936  -10.5008
            23  O1a O    29.5443  -10.5008
            24  O1a O    29.5443  -16.1024
            25  O2a O    31.9250  -16.1024
            26  C1y C    33.1154  -16.8026
            27  C5a C    34.3758  -11.9012
            28  C1b C    35.5661  -12.6014
            29  O1a O    36.7565  -11.9012
            30  O5a O    34.3758  -10.5008
            31  O1a O    34.3758  -13.3016
            32  C1x C    33.1154  -18.2030
            33  C1y C    34.3758  -18.9032
            34  C1y C    35.5661  -18.2030
            35  C1y C    35.5661  -16.8026
            36  O2x O    34.3758  -16.1024
            37  N1a N    34.3930  -20.3035
            38  C1a C    36.7818  -16.1073
            39  O1a O    36.7818  -18.8983
            40  X   Cl   28.4940  -18.6932
BOND        43
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   12  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   13  18 1
            22    3  19 1
            23   19  20 1
            24    7  21 2
            25   10  22 2
            26   14  23 1
            27   11  24 1
            28   26  25 1 #Down
            29   15  25 1 #Down
            30   17  27 1 #Up
            31   27  28 1
            32   28  29 1
            33   27  30 2
            34   17  31 1 #Down
            35   26  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   35  36 1
            40   26  36 1
            41   33  37 1 #Up
            42   35  38 1 #Up
            43   34  39 1 #Up

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