KEGG   DRUG: Methylphenidate hydrochlorideHelp
Entry
D01296                      Drug                                   

Name
Methylphenidate hydrochloride (JAN/USP);
Concerta (TN);
Metadate (TN);
Quillivant xr (TN);
Ritalin (TN)
Product
  Generic
METHYLPHENIDATE (Sandoz), METHYLPHENIDATE HYDROCHLORIDE (Actavis Pharma), METHYLPHENIDATE HYDROCHLORIDE (Actavis Pharma), METHYLPHENIDATE HYDROCHLORIDE (Alvogen), METHYLPHENIDATE HYDROCHLORIDE (Alvogen), METHYLPHENIDATE HYDROCHLORIDE (American Health Packaging), METHYLPHENIDATE HYDROCHLORIDE (American Health Packaging), METHYLPHENIDATE HYDROCHLORIDE (American Health Packaging), METHYLPHENIDATE HYDROCHLORIDE (Avera McKennan Hospital), METHYLPHENIDATE HYDROCHLORIDE (Avera McKennan Hospital), METHYLPHENIDATE HYDROCHLORIDE (Avera McKennan Hospital), METHYLPHENIDATE HYDROCHLORIDE (Breckenridge Pharmaceutical), METHYLPHENIDATE HYDROCHLORIDE (Breckenridge Pharmaceutical), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Camber Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), METHYLPHENIDATE HYDROCHLORIDE (CorePharma), METHYLPHENIDATE HYDROCHLORIDE (CorePharma), METHYLPHENIDATE HYDROCHLORIDE (County Line Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Golden State Medical Supply), METHYLPHENIDATE HYDROCHLORIDE (KVK-TECH), METHYLPHENIDATE (KVK-Tech), METHYLPHENIDATE HYDROCHLORIDE (Kremers Urban Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE CD (Kremers Urban Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METHYLPHENIDATE HYDROCHLORIDE (Lupin Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Lupin Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Lupin Pharmaceuticals), METHYLPHENIDATE HCL ORAL SOLUTION (Mallinckrodt), METHYLPHENIDATE HYDROCHLORIDE (Mallinckrodt), METHYLPHENIDATE HYDROCHLORIDE (Mallinckrodt), METHYLPHENIDATE HYDROCHLORIDE (Mallinckrodt), METHYLPHENIDATE HYDROCHLORIDE (LA) (Mayne Pharma), METHYLPHENIDATE HYDROCHLORIDE (Mylan Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Nostrum Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Nostrum Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Novel Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Novel Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Novel laboratories), METHYLPHENIDATE HYDROCHLORIDE (Par Pharmaceutical), METHYLPHENIDATE HYDROCHLORIDE (Physicians Total Care), METHYLPHENIDATE (Physicians Total Care), METHYLPHENIDATE HYDROCHLORIDE (Physicians Total Care), METHYLPHENIDATE (STAT RX USA LLC), METHYLPHENIDATE HYDROCHLORIDE (Sandoz), METHYLPHENIDATE HYDROCHLORIDE (Sun Pharmaceutical Industries), METHYLPHENIDATE HYDROCHLORIDE (Teva Pharmaceuticals USA), METHYLPHENIDATE HYDROCHLORIDE (Teva Pharmaceuticals USA), METHYLPHENIDATE HYDROCHLORIDE (Trigen Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Tris Pharma), METADATE ER (Unither Manufacturing), METHYLPHENIDATE HYDROCHLORIDE (Unither Manufacturing), METADATE ER (Upstate Pharma), METHYLPHENIDATE HYDROCHLORIDE (Upstate Pharma), METHYLPHENIDATE HYDROCHLORIDE (bryant ranch prepack), METHYLPHENIDATE HYDROCHLORIDE EXTENDED RELEASE (KVK-Tech)
Formula
C14H19NO2. HCl
Exact mass
269.1183
Mol weight
269.7671
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01970  Agents for ADHD
 DG01971  Agents for narcolepsy
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Efficacy
Stimulant (central)
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Narcolepsy [DS:H01293]
Comment
piperidine derivative
Target
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA04 Methylphenidate
      D01296  Methylphenidate hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non- amphetamines
   Methylphenidate
    D01296  Methylphenidate hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01296  Methylphenidate hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Methylphenidate
      D01296  Methylphenidate hydrochloride (JAN/USP)
    SLC6A3 (dopamine transporter)
     Methylphenidate
      D01296  Methylphenidate hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
298-59-9
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        18
            1   C1c C    24.3131  -18.3693
            2   C8y C    24.3014  -19.7673
            3   C1y C    23.1133  -17.6530
            4   C7a C    25.5364  -17.6763
            5   C8x C    23.0840  -20.4546
            6   C8x C    25.5072  -20.4779
            7   C1x C    21.8959  -18.3403
            8   N1x N    23.1307  -16.2550
            9   O7a O    25.5538  -16.2783
            10  O6a O    26.7421  -18.3926
            11  C8x C    23.0724  -21.8583
            12  C8x C    25.4898  -21.8759
            13  C1x C    20.6902  -17.6296
            14  C1x C    21.9249  -15.5385
            15  C1a C    26.7712  -15.5910
            16  C8x C    24.2665  -22.5689
            17  C1x C    20.7018  -16.2258
            18  X   Cl   30.7573  -18.5477
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 2
            16   13  17 1
            17   12  16 1
            18   14  17 1

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