KEGG   DRUG: D01966Help
Entry
D01966                      Drug                                   

Name
Ezetimibe (JAN/USAN/INN);
Zetia (TN)
Product
Formula
C24H21F2NO3
Exact mass
409.149
Mol weight
409.4252
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihyperlipidemic [intestinal cholesterol absorption inhibitor]
Remark
Therapeutic category: 
ATC code: 
Target
NPC1L1 (Niemann-Pick C1 like 1) inhibitor [HSA:29881] [KO:K14461]
  Pathway
hsa04975  Fat digestion and absorption  
 
Metabolism
Enzyme: UGT [KO:K00699]
Transporter: SLCO1B1 [HSA:10599], MRP2 [HSA:1244]
Interaction
Drug interaction
Structure map
Antidyslipidemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AX Other lipid modifying agents
     C10AX09 Ezetimibe
      D01966  Ezetimibe (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Other
   Ezetimibe
    D01966  Ezetimibe (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D01966  Ezetimibe (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Others
   NPC1L1 (Niemann-Pick C1 like protein 1)
    Ezetimibe
     D01966  Ezetimibe (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
163222-33-1
PubChem: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        30
            1   C1y C    13.5100  -21.2800
            2   C5x C    13.5100  -22.6800
            3   N1y N    14.9100  -22.6800
            4   C1y C    14.9100  -21.2800
            5   O5x O    12.3200  -23.3800
            6   C8y C    16.1000  -23.3800
            7   C8x C    16.1000  -24.7800
            8   C8x C    17.3600  -25.4800
            9   C8y C    18.5500  -24.7800
            10  C8x C    18.5500  -23.3800
            11  C8x C    17.3600  -22.6800
            12  X   F    19.7400  -25.4800
            13  C8y C    16.1000  -20.5800
            14  C8x C    17.2900  -21.2800
            15  C8x C    18.5500  -20.5800
            16  C8y C    18.5500  -19.1800
            17  C8x C    17.3600  -18.4800
            18  C8x C    16.1000  -19.1800
            19  O1a O    19.7400  -18.4800
            20  C1b C    12.3200  -20.5800
            21  C1b C    11.1300  -21.2800
            22  C1c C     9.9400  -20.5800
            23  C8y C     8.7500  -21.2800
            24  O1a O     9.9400  -19.1800
            25  C8x C     7.5600  -20.5800
            26  C8x C     6.3000  -21.2800
            27  C8y C     6.3000  -22.6800
            28  C8x C     7.4900  -23.3800
            29  C8x C     8.7500  -22.6800
            30  X   F     5.1100  -23.3800
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     1   4 1
            5     5   2 2
            6     3   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12    6  11 1
            13    9  12 1
            14    4  13 1 #Up
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   16  19 1
            22    1  20 1 #Down
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 1 #Up
            27   23  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   23  29 1
            33   27  30 1

» Japanese version   » Back

DBGET integrated database retrieval system