Entry |
|
Name |
Fluphenazine maleate (JAN); Flumezin (TN) |
Formula |
C22H26F3N3OS. C4H4O4
|
Exact mass |
553.1858
|
Mol weight |
553.5937
|
Structure |
|
Simcomp |
|
Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
Remark |
Therapeutic category: | 1172 |
Product (DG00874): | D00791<US> D00793<JP/US> D02163<JP> |
|
Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist |
Comment |
Phenothiazine derivative
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
Interaction |
|
Structure map |
map07029 | Antipsychotics - phenothiazines |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB02 Fluphenazine
D02163 Fluphenazine maleate (JAN) <JP>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Fluphenazine
D02163 Fluphenazine maleate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1172 Phenothiazines
D02163 Fluphenazine maleate (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00874 Fluphenazine
D02163 Fluphenazine maleate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00874 Fluphenazine
D02163 Fluphenazine maleate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00874 Fluphenazine
D02163 Fluphenazine maleate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D02163 Fluphenazine maleate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02163
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00874 Fluphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00874 Fluphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00874 Fluphenazine
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 38
1 C8y C 16.7464 -19.7213
2 N1y N 17.9613 -19.0204
3 C8y C 16.7464 -21.1232
4 C8x C 15.5315 -19.0204
5 C8y C 19.2230 -19.7213
6 C1b C 17.9613 -17.6186
7 S2x S 17.9613 -21.7773
8 C8x C 15.5315 -21.7773
9 C8x C 14.3633 -19.7213
10 C8y C 19.2230 -21.0764
11 C8x C 20.4380 -19.0204
12 C1b C 19.2230 -16.9177
13 C8x C 14.3633 -21.0764
14 C8x C 20.4380 -21.7773
15 C8y C 21.6529 -19.7681
16 C1b C 19.2230 -15.4690
17 C8x C 21.6529 -21.0764
18 N1y N 20.4380 -14.7681
19 C1x C 20.4380 -13.4130
20 C1x C 21.6062 -15.4690
21 C1x C 21.6529 -12.7121
22 C1x C 22.8678 -14.7681
23 N1y N 22.8678 -13.4130
24 C1b C 24.1295 -12.7588
25 C1b C 25.3321 -13.4901
26 O1a O 26.5577 -12.8192
27 C1d C 22.8691 -19.0883
28 X F 24.0800 -18.4100
29 X F 23.5900 -20.3000
30 X F 22.1900 -17.9200
31 C2b C 32.7051 -16.3098
32 C2b C 31.0687 -16.3098
33 C6a C 33.3596 -17.4786
34 C6a C 30.4143 -17.4786
35 O6a O 32.7051 -18.6475
36 O6a O 34.7622 -17.4786
37 O6a O 29.0117 -17.4786
38 O6a O 31.0687 -18.6475
BOND 40
1 18 19 1
2 18 20 1
3 19 21 1
4 20 22 1
5 21 23 1
6 23 24 1
7 7 10 1
8 9 13 1
9 15 17 1
10 22 23 1
11 1 2 1
12 1 3 2
13 1 4 1
14 2 5 1
15 2 6 1
16 3 7 1
17 3 8 1
18 4 9 2
19 5 10 2
20 5 11 1
21 6 12 1
22 8 13 2
23 10 14 1
24 11 15 2
25 12 16 1
26 14 17 2
27 16 18 1
28 24 25 1
29 25 26 1
30 15 27 1
31 27 28 1
32 27 29 1
33 27 30 1
34 31 32 2
35 31 33 1
36 32 34 1
37 33 35 1
38 33 36 2
39 34 37 1
40 34 38 2
|