KEGG   DRUG: Desvenlafaxine succinateHelp
Entry
D02570                      Drug                                   

Name
Desvenlafaxine succinate (USAN);
Desvenlafaxine succinate hydrate (JAN);
Pristiq (TN)
Product
  Generic
Formula
C16H25NO2. C4H6O4. H2O
Exact mass
399.2257
Mol weight
399.4785
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: 
Chemical structure group: 
Product in DG00963: 
D07793<US> D02570<US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
Comment
Treatment of major depressive disorder
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
Serotonergic synapse
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX23 Desvenlafaxine
      D02570  Desvenlafaxine succinate (USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Desvenlafaxine
    D02570  Desvenlafaxine succinate (USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Desvenlafaxine
      D02570  Desvenlafaxine succinate (USAN)
    SLC6A4 (serotonin transporter)
     Desvenlafaxine
      D02570  Desvenlafaxine succinate (USAN)
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D02570
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02570
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02570
BRITE hierarchy
Other DBs
CAS: 
386750-22-7
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        28
            1   O6a O    27.9300  -21.8400
            2   C6a C    29.1900  -21.1400
            3   C1b C    30.3800  -21.8400
            4   C1b C    31.5700  -21.1400
            5   C6a C    32.7600  -21.8400
            6   O6a O    34.0200  -21.1400
            7   O6a O    29.1900  -19.7400
            8   O6a O    32.7600  -23.1700
            9   O0  O    37.3800  -21.1400
            10  C8x C    18.9700  -22.3300
            11  C8y C    18.9700  -23.7300
            12  C8x C    20.1600  -24.4300
            13  C8x C    21.3500  -23.7300
            14  C8y C    21.3500  -22.3300
            15  C8x C    20.1600  -21.6300
            16  C1x C    23.8000  -23.7300
            17  C1z C    23.8000  -22.3300
            18  C1c C    22.5400  -21.6300
            19  C1x C    24.9900  -24.4300
            20  C1x C    26.1800  -23.7300
            21  C1x C    26.1800  -22.3300
            22  C1x C    24.9900  -21.6300
            23  O1a O    17.7800  -24.4300
            24  O1a O    23.8000  -20.9300
            25  C1b C    22.5228  -20.2301
            26  N1c N    21.3149  -19.5524
            27  C1a C    20.0958  -20.2768
            28  C1a C    21.2978  -18.1301
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     2   7 2
            7     5   8 2
            8    10  11 2
            9    11  12 1
            10   12  13 2
            11   13  14 1
            12   14  15 2
            13   10  15 1
            14   16  17 1
            15   17  18 1
            16   14  18 1
            17   16  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   17  22 1
            22   11  23 1
            23   17  24 1
            24   18  25 1
            25   25  26 1
            26   26  27 1
            27   26  28 1

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