ORTHOLOGY: K00032
Entry
K00032 KO
Name
E1.1.1.43
Definition
phosphogluconate 2-dehydrogenase [EC:
1.1.1.43
]
Pathway
ko00030
Pentose phosphate pathway
ko00480
Glutathione metabolism
Brite
KEGG Orthology (KO) [BR:
ko00001
]
Metabolism
Carbohydrate metabolism
00030 Pentose phosphate pathway
K00032 E1.1.1.43; phosphogluconate 2-dehydrogenase
Metabolism of other amino acids
00480 Glutathione metabolism
K00032 E1.1.1.43; phosphogluconate 2-dehydrogenase
Enzymes [BR:
ko01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.43 phosphogluconate 2-dehydrogenase
K00032 E1.1.1.43; phosphogluconate 2-dehydrogenase
Other DBs
RN:
R02032
R02034
GO:
0008114
Genes
PAE:
PA2263
PAEV:
N297_2336
PAEI:
N296_2336
PAU:
PA14_35320
(kguD)
PAP:
PSPA7_2977
PAG:
PLES_30411
PAF:
PAM18_2777
PNC:
NCGM2_3273
(kguD)
PAEB:
NCGM1900_4267
(kguD)
PDK:
PADK2_13960
PSG:
G655_13725
PRP:
M062_11835
PAEP:
PA1S_14305
PAER:
PA1R_gp0064
PAEM:
U769_13890
PAEL:
T223_15535
PAES:
SCV20265_3062
PAEU:
BN889_02470
PAEG:
AI22_19550
PAEC:
M802_2333
PAEO:
M801_2335
PCQ:
PcP3B5_34720
(ghrB_4)
PPU:
PP_3376
(ptxD)
PPF:
Pput_2382
PPG:
PputGB1_2568
PPW:
PputW619_2000
PputW619_2571
PPT:
PPS_2854
PPB:
PPUBIRD1_2404
PPI:
YSA_11138
PPX:
T1E_5148
(tkrA)
PPUH:
B479_14190
PPUT:
L483_13870
PPUN:
PP4_27660
(kguD)
PPUD:
DW66_3112
PMON:
X969_13660
PMOT:
X970_13305
PMOS:
O165_011465
PPJ:
RK21_01808
POR:
APT59_06300
PFL:
PFL_2717
(ghrB1)
PPRC:
PFLCHA0_c27780
(ghrB2)
PPRO:
PPC_2764
(ghrB1)
PFO:
Pfl01_2904
(yiaE)
PFS:
PFLU_2712
PFE:
PSF113_3674
(kguD)
PFC:
PflA506_2981
(ghrB1)
PFN:
HZ99_04035
PFW:
PF1751_v1c23760
(ghrB)
PFB:
VO64_0047
PFF:
PFLUOLIPICF724840
PFX:
A7318_10960
PPZ:
H045_10165
PMAN:
OU5_0566
PTV:
AA957_01705
PVR:
PverR02_13675
PAZO:
AYR47_20865
PSTT:
CH92_21465
PBA:
PSEBR_a3251
PBC:
CD58_12930
PPUU:
PputUW4_02430
PSK:
U771_18235
PCH:
EY04_16640
PCZ:
PCL1606_20570
PCL1606_27210
PCP:
JM49_14100
PFZ:
AV641_12810
PPV:
NJ69_11480
PSEM:
TO66_17295
TO66_21615
PSEC:
CCOS191_2350
(ghrB2)
PPSY:
AOC04_09425
PSOS:
POS17_3330
(ghrB1)
PKR:
AYO71_17590
PFK:
PFAS1_25365
PANR:
A7J50_2583
AVN:
Avin_26910
(kguD)
AVL:
AvCA_26910
(kguD)
AVD:
AvCA6_26910
(kguD)
ACX:
Achr_21860
(kguD)
CSA:
Csal_0273
HCS:
FF32_18040
HAK:
KO116_02812
HAM:
HALO3070
HHU:
AR456_01360
AR456_06690
HCO:
LOKO_02347
(ghrB)
HALO:
BWR19_17920
HAA:
A5892_14845
CMAI:
BFX80_06870
REH:
H16_B1813
(kguD)
JAL:
BZG29_17715
HHT:
F506_17185
» show all
Reference
PMID:
17483213
Authors
del Castillo T, Ramos JL, Rodriguez-Herva JJ, Fuhrer T, Sauer U, Duque E
Title
Convergent peripheral pathways catalyze initial glucose catabolism in Pseudomonas putida: genomic and flux analysis.
Journal
J Bacteriol 189:5142-52 (2007)
DOI:
10.1128/JB.00203-07
LinkDB
ENZYME: 1.1.1.43
Entry
EC 1.1.1.43 Enzyme
Name
phosphogluconate 2-dehydrogenase;
6-phosphogluconic dehydrogenase;
phosphogluconate dehydrogenase;
gluconate 6-phosphate dehydrogenase;
6-phosphogluconate dehydrogenase (NAD+);
2-keto-6-phosphogluconate reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+ [RN:
R02032
R02034
]
Reaction(KEGG)
R02032
R02034
Substrate
6-phospho-D-gluconate [CPD:
C00345
];
NAD+ [CPD:
C00003
];
NADP+ [CPD:
C00006
]
Product
6-phospho-2-dehydro-D-gluconate [CPD:
C01218
];
NADH [CPD:
C00004
];
NADPH [CPD:
C00005
];
H+ [CPD:
C00080
]
History
EC 1.1.1.43 created 1961
Pathway
ec00030
Pentose phosphate pathway
ec00480
Glutathione metabolism
ec01100
Metabolic pathways
ec01120
Microbial metabolism in diverse environments
Orthology
K00032
phosphogluconate 2-dehydrogenase
Genes
PAE:
PA2263
PAEV:
N297_2336
PAEI:
N296_2336
PAU:
PA14_35320
(kguD)
PAP:
PSPA7_2977
PAG:
PLES_30411
PAF:
PAM18_2777
PNC:
NCGM2_3273
(kguD)
PAEB:
NCGM1900_4267
(kguD)
PDK:
PADK2_13960
PSG:
G655_13725
PRP:
M062_11835
PAEP:
PA1S_14305
PAER:
PA1R_gp0064
PAEM:
U769_13890
PAEL:
T223_15535
PAES:
SCV20265_3062
PAEU:
BN889_02470
PAEG:
AI22_19550
PAEC:
M802_2333
PAEO:
M801_2335
PCQ:
PcP3B5_34720
(ghrB_4)
PPU:
PP_3376
(ptxD)
PPF:
Pput_2382
PPG:
PputGB1_2568
PPW:
PputW619_2000
PputW619_2571
PPT:
PPS_2854
PPB:
PPUBIRD1_2404
PPI:
YSA_11138
PPX:
T1E_5148
(tkrA)
PPUH:
B479_14190
PPUT:
L483_13870
PPUN:
PP4_27660
(kguD)
PPUD:
DW66_3112
PMON:
X969_13660
PMOT:
X970_13305
PMOS:
O165_011465
PPJ:
RK21_01808
POR:
APT59_06300
PFL:
PFL_2717
(ghrB1)
PPRC:
PFLCHA0_c27780
(ghrB2)
PPRO:
PPC_2764
(ghrB1)
PFO:
Pfl01_2904
(yiaE)
PFS:
PFLU_2712
PFE:
PSF113_3674
(kguD)
PFC:
PflA506_2981
(ghrB1)
PFN:
HZ99_04035
PFW:
PF1751_v1c23760
(ghrB)
PFB:
VO64_0047
PFF:
PFLUOLIPICF724840
PFX:
A7318_10960
PPZ:
H045_10165
PMAN:
OU5_0566
PTV:
AA957_01705
PVR:
PverR02_13675
PAZO:
AYR47_20865
PSTT:
CH92_21465
PBA:
PSEBR_a3251
PBC:
CD58_12930
PPUU:
PputUW4_02430
PSK:
U771_18235
PCH:
EY04_16640
PCZ:
PCL1606_20570
PCL1606_27210
PCP:
JM49_14100
PFZ:
AV641_12810
PPV:
NJ69_11480
PSEM:
TO66_17295
TO66_21615
PSEC:
CCOS191_2350
(ghrB2)
PPSY:
AOC04_09425
PSOS:
POS17_3330
(ghrB1)
PKR:
AYO71_17590
PFK:
PFAS1_25365
PANR:
A7J50_2583
AVN:
Avin_26910
(kguD)
AVL:
AvCA_26910
(kguD)
AVD:
AvCA6_26910
(kguD)
ACX:
Achr_21860
(kguD)
CSA:
Csal_0273
HCS:
FF32_18040
HAK:
KO116_02812
HAM:
HALO3070
HHU:
AR456_01360
AR456_06690
HCO:
LOKO_02347
(ghrB)
HALO:
BWR19_17920
HAA:
A5892_14845
CMAI:
BFX80_06870
REH:
H16_B1813
(kguD)
JAL:
BZG29_17715
HHT:
F506_17185
» show all
Reference
1 [PMID:
13894458
]
Authors
FRAMPTON EW, WOOD WA.
Title
Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate.
Journal
J. Biol. Chem. 236 (1961) 2571-7.
Other DBs
ExplorEnz - The Enzyme Database:
1.1.1.43
IUBMB Enzyme Nomenclature:
1.1.1.43
ExPASy - ENZYME nomenclature database:
1.1.1.43
BRENDA, the Enzyme Database:
1.1.1.43
CAS:
9001-82-5
LinkDB
REACTION: R02032
Entry
R02032 Reaction
Name
6-Phospho-2-dehydro-D-gluconate:NAD+ 2-oxidoreductase
Definition
6-Phospho-D-gluconate + NAD+ <=> 6-Phospho-2-dehydro-D-gluconate + NADH + H+
Equation
C00345
+
C00003
<=>
C01218
+
C00004
+
C00080
Comment
NADP+ (see
R02034
)
Reaction class
RC00001
C00003_C00004
RC00084
C00345_C01218
Enzyme
1.1.1.43
Pathway
rn00030
Pentose phosphate pathway
rn01100
Metabolic pathways
rn01120
Microbial metabolism in diverse environments
Orthology
K00032
phosphogluconate 2-dehydrogenase [EC:
1.1.1.43
]
Other DBs
RHEA:
16824
LinkDB
REACTION: R02034
Entry
R02034 Reaction
Name
6-phospho-D-gluconate:NADP+ 2-oxidoreductase
Definition
6-Phospho-D-gluconate + NADP+ <=> 6-Phospho-2-dehydro-D-gluconate + NADPH + H+
Equation
C00345
+
C00006
<=>
C01218
+
C00005
+
C00080
Comment
NAD+ (see
R02032
)
Reaction class
RC00001
C00005_C00006
RC00084
C00345_C01218
Enzyme
1.1.1.43
Pathway
rn00030
Pentose phosphate pathway
rn00480
Glutathione metabolism
rn01100
Metabolic pathways
rn01120
Microbial metabolism in diverse environments
Orthology
K00032
phosphogluconate 2-dehydrogenase [EC:
1.1.1.43
]
Other DBs
RHEA:
16820
LinkDB
DBGET
integrated database retrieval system
