| Entry |
|
| Name |
L-galactose 1-dehydrogenase;
L-GalDH;
L-galactose dehydrogenase
|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
| Sysname |
L-galactose:NAD+ 1-oxidoreductase
|
| Reaction(IUBMB) |
L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+ [RN: R07675]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
The enzyme catalyses a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway). The activity with NADP+ is less than 10% of the activity with NAD+.
|
| History |
EC 1.1.1.316 created 2011
|
| Pathway |
| Ascorbate and aldarate metabolism | | Metabolic pathways | | Biosynthesis of secondary metabolites |
|
| Orthology |
| L-galactose dehydrogenase |
|
| Genes |
ATH: | | ALY: | | CRB: | | EUS: | | BRP: | | BNA: | | THJ: | | CIT: | | CIC: | | TCC: | | GRA: | | GHI: | | EGR: | | GMX: | | PVU: | | VRA: | | VAR: | | CCAJ: | | MTR: | | CAM: | | ADU: | | AIP: | | LJA: | | LANG: | | FVE: | | PPER: | | PMUM: | | MDM: | | PXB: | | ZJU: | | CSV: | | CMO: | | RCU: | | JCU: | | POP: | | VVI: | | SLY: | | SPEN: | | SOT: | | INI: | | SIND: | | BVG: | | NNU: | | OSA: | | DOSA: | | OBR: | | BDI: | | ATS: | | SBI: | | ZMA: | | SITA: | | PDA: | | EGU: | | MUS: | | ATR: | | SMO: | | PPP: | | CRE: | | VCN: | | CSL: | | CVR: | | APRO: | | CME: | | GSL: | | CCP: | | PGR: | | DFA: | | SPAR: | | PBV: | | CCZ: | | VBA: | | PHM: | | » show all
 |
| Reference |
|
| Authors |
Mieda T, Yabuta Y, Rapolu M, Motoki T, Takeda T, Yoshimura K, Ishikawa T, Shigeoka S |
| Title |
Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate. |
| Journal |
Plant. Cell. Physiol. 45 (2004) 1271-9. |
| Sequence |
|
| Reference |
|
| Authors |
Gatzek S, Wheeler GL, Smirnoff N |
| Title |
Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis. |
| Journal |
Plant. J. 30 (2002) 541-53. |
| Sequence |
|
| Reference |
|
| Authors |
Wheeler GL, Jones MA, Smirnoff N |
| Title |
The biosynthetic pathway of vitamin C in higher plants. |
| Journal |
Nature. 393 (1998) 365-9. |
| Reference |
|
| Authors |
Oh MM, Carey EE, Rajashekar CB |
| Title |
Environmental stresses induce health-promoting phytochemicals in lettuce. |
| Journal |
Plant. Physiol. Biochem. 47 (2009) 578-83. |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
| LinkDB |
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