KEGG ORTHOLOGY: K00227

ORTHOLOGY: K00227

Entry

K00227 KO

Name

SC5DL, ERG3

Definition

Delta7-sterol 5-desaturase [EC:1.14.19.20]

Pathway

ko00100

Steroid biosynthesis

Module

M00101	Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
M00102	Ergocalciferol biosynthesis

Disease

H01281

Lathosterolosis

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Lipid metabolism
   00100 Steroid biosynthesis
    K00227  SC5DL, ERG3; Delta7-sterol 5-desaturase
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
     K00227  SC5DL, ERG3; Delta7-sterol 5-desaturase
    M00102  Ergocalciferol biosynthesis
     K00227  SC5DL, ERG3; Delta7-sterol 5-desaturase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.20  Delta7-sterol 5(6)-desaturase
     K00227  SC5DL, ERG3; Delta7-sterol 5-desaturase

Other DBs

RN:

R07215 R07486 R07491 R07505

GO:

0050046

Genes

HSA:	6309(SC5D)
PTR:	451624(SC5D)
PPS:	100979606(SC5D)
GGO:	101151866(SC5D) 101152464
PON:	100459805(SC5D)
NLE:	100604476(SC5D)
MCC:	706827(SC5D)
MCF:	101867112(SC5D)
CSAB:	103248668(SC5D)
RRO:	104657234(SC5D)
CJC:	100387284(SC5D)
SBQ:	101038292(SC5D)
MMU:	235293(Sc5d)
RNO:	114100(Sc5d)
CGE:	100752960(Sc5d)
NGI:	103727913(Sc5d)
HGL:	101713479(Sc5d)
CCAN:	109698547(Sc5d)
OCU:	100358493(SC5D)
TUP:	102481940(SC5D)
CFA:	610411(SC5D)
AML:	100467645(SC5D)
UMR:	103662293(SC5D)
FCA:	101099997(SC5D)
PTG:	102956406(SC5D)
AJU:	106976671(SC5D)
BTA:	525154(SC5D)
BOM:	102283021(SC5D)
BIU:	109569702(SC5D)
PHD:	102340338(SC5D)
CHX:	102180515(SC5D)
OAS:	101109313 101117697(SC5D)
SSC:	100520925(SC5D)
CFR:	102520592(SC5D)
BACU:	103004682(SC5D)
LVE:	103083016(SC5D)
ECB:	100063543(SC5D)
MYB:	102246367(SC5D)
MYD:	102754805(SC5D)
HAI:	109395291(SC5D)
RSS:	109439575(SC5D)
PALE:	102891666(SC5D)
LAV:	100661853(SC5D)
MDO:	100030841(SC5D)
SHR:	100932949(SC5D)
OAA:	100073392(SC5D)
GGA:	100857756(SC5D)
MGP:	100538497(SC5D)
CJO:	107324219(SC5D)
APLA:	101803446(SC5D)
ACYG:	106039809(SC5D)
TGU:	100226384(SC5D)
GFR:	102043549(SC5D)
FAB:	101811093(SC5D)
PHI:	102109366(SC5D)
CCW:	104692196(SC5D)
FPG:	101920444(SC5D)
FCH:	102057522(SC5D)
CLV:	102095349(SC5D)
AAM:	106490218(SC5D) 106491711
ASN:	102385911(SC5D)
AMJ:	102571716(SC5D)
PSS:	102463426(SC5D)
CMY:	102931181(SC5D)
CPIC:	101952975(SC5D)
ACS:	100566753(sc5d)
PBI:	103051481(SC5D)
GJA:	107125348(SC5D)
XLA:	108697607(sc5d.S) 447026(sc5d.L)
XTR:	100490845(sc5d)
NPR:	108797036(SC5D)
DRE:	447891(sc5d)
SRX:	107715322 107756074
SANH:	107703513
SGH:	107548136 107561054
IPU:	100528129(sc5d)
TRU:	101067117(sc5d)
TNG:	GSTEN00004803G001
LCO:	104921101(sc5d) 104938430
NCC:	104945906 104953696
MZE:	101470905(sc5d) 101479398
OLA:	101173647(sc5d)
XMA:	102219081(sc5d)
CSEM:	103395378(sc5d)
LCF:	108891924(sc5d) 108901922
SASA:	100195087(sc5d) 106576971
ELS:	105023255 105024195(sc5d)
SFM:	108936096(sc5d)
LCM:	102365779(SC5D)
CMK:	103190397(sc5d)
BFO:	BRAFLDRAFT_117097 BRAFLDRAFT_288915
SPU:	588561
SKO:	100375039
TCA:	103315179
NVL:	108559476
BMOR:	101737328
DPX:	DAPPUDRAFT_300451
HRO:	HELRODRAFT_92484
LGI:	LOTGIDRAFT_206094
CRG:	105323182 105348227
NVE:	NEMVE_v1g243571
TAD:	TRIADDRAFT_18639
AQU:	100635449
ATH:	AT3G02580(STE1) AT3G02590
ALY:	ARALYDRAFT_330295 ARALYDRAFT_477495 ARALYDRAFT_477496 ARALYDRAFT_896235 ARALYDRAFT_915873
CRB:	CARUB_v10014344mg
EUS:	EUTSA_v10011706mg EUTSA_v10021274mg EUTSA_v10021293mg
BRP:	103843392 103843402 103858971 103858974 103870908
BNA:	106362772 106366810 106366811 106366813 106382858 106385223 106387284 106438943 106438944 106443864
THJ:	104820939 104822096 104827161 104827162
CIT:	102630557
CIC:	CICLE_v10012450mg
TCC:	18602021
GRA:	105788590
GHI:	107934227 107953438
EGR:	104422113
GMX:	100782638 100790906
PVU:	PHAVU_004G067300g
VRA:	106765343
VAR:	108345518
CCAJ:	109791074
MTR:	MTR_6g018820 MTR_6g018860 MTR_6g018900
CAM:	101511716
ADU:	107471510 107486912
AIP:	107623531 107637475
LJA:	Lj0g3v0103419.1(Lj0g3v0103419.1)
LANG:	109347424 109347425
FVE:	101292472
PPER:	18783760
PMUM:	103342673
MDM:	103401753 103416166 103431669 103444140
PXB:	103936617 103937470 103948488
CSV:	101204738
CMO:	103487532
RCU:	8261209
JCU:	105638767
POP:	POPTR_0004s09680g(POPTRDRAFT_831136) POPTR_0005s15430g
VVI:	100257622 100262743 100265283
SLY:	101256156 101264777
SPEN:	107008645 107011506
SOT:	102587419 102594482 102602151
INI:	109168439 109174285
SIND:	105177929
BVG:	104888098 104888101 104906256
NNU:	104602594 104602901
OSA:	4325687
DOSA:	Os01t0134500-01(Os01g0134500)
OBR:	102707173
BDI:	100823877
ATS:	F775_26597
SBI:	8061354
ZMA:	100282407 100282855
SITA:	101780951
PDA:	103718827 103723275
EGU:	105041251 105048406
MUS:	103968710 103977203 103987407 103987803
ATR:	18432187
SMO:	SELMODRAFT_146325 SELMODRAFT_182646
PPP:	PHYPADRAFT_135889
CRE:	CHLREDRAFT_59933
VCN:	VOLCADRAFT_81225
OLU:	OSTLU_6297
OTA:	Ot05g00940
BPG:	Bathy03g00990
MIS:	MICPUN_112695
MPP:	MICPUCDRAFT_55427
CSL:	COCSUDRAFT_15746
CVR:	CHLNCDRAFT_37407
APRO:	F751_6009
CME:	CYME_CMC055C
GSL:	Gasu_09900
CCP:	CHC_T00006481001
SCE:	YLR056W(ERG3)
AGO:	AGOS_AFR151C
ERC:	Ecym_1501
KLA:	KLLA0F08855g
LTH:	KLTH0G18304g
VPO:	Kpol_1035p33
ZRO:	ZYRO0F03212g
CGR:	CAGL0F01793g
NDI:	NDAI_0C06430(NDAI0C06430)
TPF:	TPHA_0D00440(TPHA0D00440) TPHA_0P00250(TPHA0P00250)
TBL:	TBLA_0D02520(TBLA0D02520)
TDL:	TDEL_0C00670(TDEL0C00670)
KAF:	KAFR_0D01010(KAFR0D01010)
PPA:	PAS_chr1-4_0367
DHA:	DEHA2F08866g
PIC:	PICST_28450(ERG3)
SPAA:	SPAPADRAFT_48108(ERG3)
LEL:	LELG_01797
CAL:	CAALFM_C104770CA(ERG3)
CTP:	CTRG_04480
COT:	CORT_0B06770
CDU:	CD36_04520(ERG3)
CTEN:	CANTEDRAFT_99337
YLI:	YALI0D20878g
CLU:	CLUG_05120
CAUR:	QG37_00933
NCR:	NCU04983 NCU06207
NTE:	NEUTE1DRAFT116882(NEUTE1DRAFT_116882) NEUTE1DRAFT78153(NEUTE1DRAFT_78153)
SMP:	SMAC_07109 SMAC_08592
PAN:	PODANSg5469
TTT:	THITE_64954
MTM:	MYCTH_112329
CTHR:	CTHT_0019590
MGR:	MGG_08832
TMN:	UCRPA7_1625 UCRPA7_347
FGR:	FGSG_02502 FGSG_04994
FPU:	FPSE_08622 FPSE_12291
FVR:	FVEG_06768 FVEG_09178
FOX:	FOXG_09168 FOXG_10530
NHE:	NECHADRAFT_43685 NECHADRAFT_45966
TRE:	TRIREDRAFT_78130
MAW:	MAC_00353 MAC_03659
MAJ:	MAA_00604 MAA_02529
CMT:	CCM_01839 CCM_08632
VAL:	VDBG_00635 VDBG_08651
VDA:	VDAG_00248 VDAG_06314
CFJ:	CFIO01_04916 CFIO01_13103
ELA:	UCREL1_10295
PFY:	PFICI_03760 PFICI_10769
SSL:	SS1G_08964
BFU:	BC1G_12308
MBE:	MBM_05730
PSCO:	LY89DRAFT_470878
GLZ:	GLAREA_10324
ANI:	AN3638.2 AN6506.2
AFM:	AFUA_6G05140 AFUA_8G01070
AOR:	AOR_1_42114(AO090701000022) AOR_1_860034(AO090103000138)
ANG:	ANI_1_28134(An15g00150) ANI_1_406144(An16g02930)
AFV:	AFLA_010890 AFLA_054820
ACT:	ACLA_020750 ACLA_095400
NFI:	NFIA_051710 NFIA_094510
PCS:	Pc12g04600
PDP:	PDIP_18830 PDIP_52770
CIM:	CIMG_02610 CIMG_10100
CPW:	CPC735_037410
PBL:	PAAG_03651
PBN:	PADG_06181
URE:	UREG_03145
ABE:	ARB_04289 ARB_05812
TVE:	TRV_05362 TRV_06270
AJE:	HCAG_06888
PNO:	SNOG_09349
PTE:	PTT_15444
BZE:	COCCADRAFT_23737 COCCADRAFT_8476
BSC:	COCSADRAFT_111459 COCSADRAFT_182796
BOR:	COCMIDRAFT_2100 COCMIDRAFT_93800
ZTR:	MYCGRDRAFT_74506(ERG3)
PFJ:	MYCFIDRAFT_32401
BCOM:	BAUCODRAFT_68200
NPA:	UCRNP2_7814 UCRNP2_8453
TML:	GSTUM_00007875001
SPO:	SPAC1687.16c(erg31) SPBC27B12.03c(erg32)
CNE:	CNA05010
CNB:	CNBA4830
CGI:	CGB_A5290W
TMS:	TREMEDRAFT_45020
TVS:	TRAVEDRAFT_149751
DSQ:	DICSQDRAFT_166781
PCO:	PHACADRAFT_252075
SHS:	STEHIDRAFT_90966
HIR:	HETIRDRAFT_314892
PSQ:	PUNSTDRAFT_125877
ADL:	AURDEDRAFT_112131
FME:	FOMMEDRAFT_103044
GTR:	GLOTRDRAFT_101052
LBC:	LACBIDRAFT_190564(ERG3)
MRR:	Moror_3018 Moror_3020
CCI:	CC1G_12572
SCM:	SCHCODRAFT_67790 SCHCODRAFT_85519
ABP:	AGABI1DRAFT59529(AGABI1DRAFT_59529)
ABV:	AGABI2DRAFT218236(AGABI2DRAFT_218236)
CPUT:	CONPUDRAFT_135618 CONPUDRAFT_159631 CONPUDRAFT_84469
SLA:	SERLADRAFT_348962
WSE:	WALSEDRAFT_61115
WIC:	J056_003563
UMA:	UMAG_03593
PFP:	PFL1_02493
MGL:	MGL_0204
MLR:	MELLADRAFT_50057
MBR:	MONBRDRAFT_32318
SRE:	PTSG_01052 PTSG_08398 PTSG_10510 PTSG_11590
DFA:	DFA_02096
ACAN:	ACA1_035520
TET:	TTHERM_00438800 TTHERM_00446080 TTHERM_00758950 TTHERM_01194720
PTM:	GSPATT00009441001 GSPATT00010502001 GSPATT00010676001 GSPATT00017257001 GSPATT00019457001 GSPATT00019548001 GSPATT00024717001 GSPATT00029323001
SMIN:	v1.2.034753.t1(symbB.v1.2.034753.t1) v1.2.037901.t1(symbB.v1.2.037901.t1)
PTI:	PHATRDRAFT_14208
FCY:	FRACYDRAFT_141664
PIF:	PITG_21426
PSOJ:	PHYSODRAFT_474456
SPAR:	SPRG_11773 SPRG_18544
EHX:	EMIHUDRAFT_220113 EMIHUDRAFT_435021 EMIHUDRAFT_441353 EMIHUDRAFT_442614
TBR:	Tb927.8.3240(Tb08.28L1.250)
TCR:	473111.10 507853.10
LMA:	LMJF_23_1300
LIF:	LINJ_23_1560
LDO:	LDBPK_231560
LMI:	LMXM_23_1300
LBZ:	LBRM_23_1420
NGR:	NAEGRDRAFT_77816
HCH:	HCH_01597
SAMY:	DB32_000704 DB32_004537
MRM:	A7982_05543 A7982_06884

» show all

Reference

PMID:8976377

Authors

Matsushima M, Inazawa J, Takahashi E, Suzumori K, Nakamura Y

Title

Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase.

Journal

Cytogenet Cell Genet 74:252-4 (1996)

Sequence

[hsa:6309]

Reference

PMID:1864507

Authors

Arthington BA, Bennett LG, Skatrud PL, Guynn CJ, Barbuch RJ, Ulbright CE, Bard M

Title

Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase.

Journal

Gene 102:39-44 (1991)
DOI:10.1016/0378-1119(91)90535-J

Sequence

[sce:YLR056W]

LinkDB

ENZYME: 1.14.19.20

Entry

EC 1.14.19.20 Enzyme

Name

Delta7-sterol 5(6)-desaturase;
lathosterol oxidase;
Delta7-sterol Delta5-dehydrogenase;
Delta7-sterol 5-desaturase;
Delta7-sterol-C5(6)-desaturase;
5-DES;
SC5DL (gene name);
ERG3 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Sysname

Delta7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating

Reaction(IUBMB)

a Delta7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a Delta5,7-sterol + 2 ferricytochrome b5 + 2 H2O

Reaction(KEGG)

(other) R07215 R07486 R07491 R07505

Substrate

Delta7-sterol;
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]

Product

Delta5,7-sterol;
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]

Comment

This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Delta7-sterols, to yield the corresponding Delta5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound.

History

EC 1.14.19.20 created 1972 as EC 1.3.3.2, transferred 2005 to EC 1.14.21.6, transferred 2015 to EC 1.14.19.20

Pathway

ec00100	Steroid biosynthesis
ec01100	Metabolic pathways
ec01110	Biosynthesis of secondary metabolites
ec01130	Biosynthesis of antibiotics

Orthology

K00227

Delta7-sterol 5-desaturase

Genes

HSA:	6309(SC5D)
PTR:	451624(SC5D)
PPS:	100979606(SC5D)
GGO:	101151866(SC5D) 101152464
PON:	100459805(SC5D)
NLE:	100604476(SC5D)
MCC:	706827(SC5D)
MCF:	101867112(SC5D)
CSAB:	103248668(SC5D)
RRO:	104657234(SC5D)
CJC:	100387284(SC5D)
SBQ:	101038292(SC5D)
MMU:	235293(Sc5d)
RNO:	114100(Sc5d)
CGE:	100752960(Sc5d)
NGI:	103727913(Sc5d)
HGL:	101713479(Sc5d)
CCAN:	109698547(Sc5d)
OCU:	100358493(SC5D)
TUP:	102481940(SC5D)
CFA:	610411(SC5D)
AML:	100467645(SC5D)
UMR:	103662293(SC5D)
FCA:	101099997(SC5D)
PTG:	102956406(SC5D)
AJU:	106976671(SC5D)
BTA:	525154(SC5D)
BOM:	102283021(SC5D)
BIU:	109569702(SC5D)
PHD:	102340338(SC5D)
CHX:	102180515(SC5D)
OAS:	101109313 101117697(SC5D)
SSC:	100520925(SC5D)
CFR:	102520592(SC5D)
BACU:	103004682(SC5D)
LVE:	103083016(SC5D)
ECB:	100063543(SC5D)
MYB:	102246367(SC5D)
MYD:	102754805(SC5D)
HAI:	109395291(SC5D)
RSS:	109439575(SC5D)
PALE:	102891666(SC5D)
LAV:	100661853(SC5D)
MDO:	100030841(SC5D)
SHR:	100932949(SC5D)
OAA:	100073392(SC5D)
GGA:	100857756(SC5D)
MGP:	100538497(SC5D)
CJO:	107324219(SC5D)
APLA:	101803446(SC5D)
ACYG:	106039809(SC5D)
TGU:	100226384(SC5D)
GFR:	102043549(SC5D)
FAB:	101811093(SC5D)
PHI:	102109366(SC5D)
CCW:	104692196(SC5D)
FPG:	101920444(SC5D)
FCH:	102057522(SC5D)
CLV:	102095349(SC5D)
AAM:	106490218(SC5D) 106491711
ASN:	102385911(SC5D)
AMJ:	102571716(SC5D)
PSS:	102463426(SC5D)
CMY:	102931181(SC5D)
CPIC:	101952975(SC5D)
ACS:	100566753(sc5d)
PBI:	103051481(SC5D)
GJA:	107125348(SC5D)
XLA:	108697607(sc5d.S) 447026(sc5d.L)
XTR:	100490845(sc5d)
NPR:	108797036(SC5D)
DRE:	447891(sc5d)
SRX:	107715322 107756074
SANH:	107703513
SGH:	107548136 107561054
IPU:	100528129(sc5d)
TRU:	101067117(sc5d)
TNG:	GSTEN00004803G001
LCO:	104921101(sc5d) 104938430
NCC:	104945906 104953696
MZE:	101470905(sc5d) 101479398
OLA:	101173647(sc5d)
XMA:	102219081(sc5d)
CSEM:	103395378(sc5d)
LCF:	108891924(sc5d) 108901922
SASA:	100195087(sc5d) 106576971
ELS:	105023255 105024195(sc5d)
SFM:	108936096(sc5d)
LCM:	102365779(SC5D)
CMK:	103190397(sc5d)
BFO:	BRAFLDRAFT_117097 BRAFLDRAFT_288915
SPU:	588561
SKO:	100375039
TCA:	103315179
NVL:	108559476
BMOR:	101737328
DPX:	DAPPUDRAFT_300451
HRO:	HELRODRAFT_92484
LGI:	LOTGIDRAFT_206094
CRG:	105323182 105348227
NVE:	NEMVE_v1g243571
TAD:	TRIADDRAFT_18639
AQU:	100635449
ATH:	AT3G02580(STE1) AT3G02590
ALY:	ARALYDRAFT_330295 ARALYDRAFT_477495 ARALYDRAFT_477496 ARALYDRAFT_896235 ARALYDRAFT_915873
CRB:	CARUB_v10014344mg
EUS:	EUTSA_v10011706mg EUTSA_v10021274mg EUTSA_v10021293mg
BRP:	103843392 103843402 103858971 103858974 103870908
BNA:	106362772 106366810 106366811 106366813 106382858 106385223 106387284 106438943 106438944 106443864
THJ:	104820939 104822096 104827161 104827162
CIT:	102630557
CIC:	CICLE_v10012450mg
TCC:	18602021
GRA:	105788590
GHI:	107934227 107953438
EGR:	104422113
GMX:	100782638 100790906
PVU:	PHAVU_004G067300g
VRA:	106765343
VAR:	108345518
CCAJ:	109791074
MTR:	MTR_6g018820 MTR_6g018860 MTR_6g018900
CAM:	101511716
ADU:	107471510 107486912
AIP:	107623531 107637475
LJA:	Lj0g3v0103419.1(Lj0g3v0103419.1)
LANG:	109347424 109347425
FVE:	101292472
PPER:	18783760
PMUM:	103342673
MDM:	103401753 103416166 103431669 103444140
PXB:	103936617 103937470 103948488
CSV:	101204738
CMO:	103487532
RCU:	8261209
JCU:	105638767
POP:	POPTR_0004s09680g(POPTRDRAFT_831136) POPTR_0005s15430g
VVI:	100257622 100262743 100265283
SLY:	101256156 101264777
SPEN:	107008645 107011506
SOT:	102587419 102594482 102602151
INI:	109168439 109174285
SIND:	105177929
BVG:	104888098 104888101 104906256
NNU:	104602594 104602901
OSA:	4325687
DOSA:	Os01t0134500-01(Os01g0134500)
OBR:	102707173
BDI:	100823877
ATS:	F775_26597
SBI:	8061354
ZMA:	100282407 100282855
SITA:	101780951
PDA:	103718827 103723275
EGU:	105041251 105048406
MUS:	103968710 103977203 103987407 103987803
ATR:	18432187
SMO:	SELMODRAFT_146325 SELMODRAFT_182646
PPP:	PHYPADRAFT_135889
CRE:	CHLREDRAFT_59933
VCN:	VOLCADRAFT_81225
OLU:	OSTLU_6297
OTA:	Ot05g00940
BPG:	Bathy03g00990
MIS:	MICPUN_112695
MPP:	MICPUCDRAFT_55427
CSL:	COCSUDRAFT_15746
CVR:	CHLNCDRAFT_37407
APRO:	F751_6009
CME:	CYME_CMC055C
GSL:	Gasu_09900
CCP:	CHC_T00006481001
SCE:	YLR056W(ERG3)
AGO:	AGOS_AFR151C
ERC:	Ecym_1501
KLA:	KLLA0F08855g
LTH:	KLTH0G18304g
VPO:	Kpol_1035p33
ZRO:	ZYRO0F03212g
CGR:	CAGL0F01793g
NDI:	NDAI_0C06430(NDAI0C06430)
TPF:	TPHA_0D00440(TPHA0D00440) TPHA_0P00250(TPHA0P00250)
TBL:	TBLA_0D02520(TBLA0D02520)
TDL:	TDEL_0C00670(TDEL0C00670)
KAF:	KAFR_0D01010(KAFR0D01010)
PPA:	PAS_chr1-4_0367
DHA:	DEHA2F08866g
PIC:	PICST_28450(ERG3)
SPAA:	SPAPADRAFT_48108(ERG3)
LEL:	LELG_01797
CAL:	CAALFM_C104770CA(ERG3)
CTP:	CTRG_04480
COT:	CORT_0B06770
CDU:	CD36_04520(ERG3)
CTEN:	CANTEDRAFT_99337
YLI:	YALI0D20878g
CLU:	CLUG_05120
CAUR:	QG37_00933
NCR:	NCU04983 NCU06207
NTE:	NEUTE1DRAFT116882(NEUTE1DRAFT_116882) NEUTE1DRAFT78153(NEUTE1DRAFT_78153)
SMP:	SMAC_07109 SMAC_08592
PAN:	PODANSg5469
TTT:	THITE_64954
MTM:	MYCTH_112329
CTHR:	CTHT_0019590
MGR:	MGG_08832
TMN:	UCRPA7_1625 UCRPA7_347
FGR:	FGSG_02502 FGSG_04994
FPU:	FPSE_08622 FPSE_12291
FVR:	FVEG_06768 FVEG_09178
FOX:	FOXG_09168 FOXG_10530
NHE:	NECHADRAFT_43685 NECHADRAFT_45966
TRE:	TRIREDRAFT_78130
MAW:	MAC_00353 MAC_03659
MAJ:	MAA_00604 MAA_02529
CMT:	CCM_01839 CCM_08632
VAL:	VDBG_00635 VDBG_08651
VDA:	VDAG_00248 VDAG_06314
CFJ:	CFIO01_04916 CFIO01_13103
ELA:	UCREL1_10295
PFY:	PFICI_03760 PFICI_10769
SSL:	SS1G_08964
BFU:	BC1G_12308
MBE:	MBM_05730
PSCO:	LY89DRAFT_470878
GLZ:	GLAREA_10324
ANI:	AN3638.2 AN6506.2
AFM:	AFUA_6G05140 AFUA_8G01070
AOR:	AOR_1_42114(AO090701000022) AOR_1_860034(AO090103000138)
ANG:	ANI_1_28134(An15g00150) ANI_1_406144(An16g02930)
AFV:	AFLA_010890 AFLA_054820
ACT:	ACLA_020750 ACLA_095400
NFI:	NFIA_051710 NFIA_094510
PCS:	Pc12g04600
PDP:	PDIP_18830 PDIP_52770
CIM:	CIMG_02610 CIMG_10100
CPW:	CPC735_037410
PBL:	PAAG_03651
PBN:	PADG_06181
URE:	UREG_03145
ABE:	ARB_04289 ARB_05812
TVE:	TRV_05362 TRV_06270
AJE:	HCAG_06888
PNO:	SNOG_09349
PTE:	PTT_15444
BZE:	COCCADRAFT_23737 COCCADRAFT_8476
BSC:	COCSADRAFT_111459 COCSADRAFT_182796
BOR:	COCMIDRAFT_2100 COCMIDRAFT_93800
ZTR:	MYCGRDRAFT_74506(ERG3)
PFJ:	MYCFIDRAFT_32401
BCOM:	BAUCODRAFT_68200
NPA:	UCRNP2_7814 UCRNP2_8453
TML:	GSTUM_00007875001
SPO:	SPAC1687.16c(erg31) SPBC27B12.03c(erg32)
CNE:	CNA05010
CNB:	CNBA4830
CGI:	CGB_A5290W
TMS:	TREMEDRAFT_45020
TVS:	TRAVEDRAFT_149751
DSQ:	DICSQDRAFT_166781
PCO:	PHACADRAFT_252075
SHS:	STEHIDRAFT_90966
HIR:	HETIRDRAFT_314892
PSQ:	PUNSTDRAFT_125877
ADL:	AURDEDRAFT_112131
FME:	FOMMEDRAFT_103044
GTR:	GLOTRDRAFT_101052
LBC:	LACBIDRAFT_190564(ERG3)
MRR:	Moror_3018 Moror_3020
CCI:	CC1G_12572
SCM:	SCHCODRAFT_67790 SCHCODRAFT_85519
ABP:	AGABI1DRAFT59529(AGABI1DRAFT_59529)
ABV:	AGABI2DRAFT218236(AGABI2DRAFT_218236)
CPUT:	CONPUDRAFT_135618 CONPUDRAFT_159631 CONPUDRAFT_84469
SLA:	SERLADRAFT_348962
WSE:	WALSEDRAFT_61115
WIC:	J056_003563
UMA:	UMAG_03593
PFP:	PFL1_02493
MGL:	MGL_0204
MLR:	MELLADRAFT_50057
MBR:	MONBRDRAFT_32318
SRE:	PTSG_01052 PTSG_08398 PTSG_10510 PTSG_11590
DFA:	DFA_02096
ACAN:	ACA1_035520
TET:	TTHERM_00438800 TTHERM_00446080 TTHERM_00758950 TTHERM_01194720
PTM:	GSPATT00009441001 GSPATT00010502001 GSPATT00010676001 GSPATT00017257001 GSPATT00019457001 GSPATT00019548001 GSPATT00024717001 GSPATT00029323001
SMIN:	v1.2.034753.t1(symbB.v1.2.034753.t1) v1.2.037901.t1(symbB.v1.2.037901.t1)
PTI:	PHATRDRAFT_14208
FCY:	FRACYDRAFT_141664
PIF:	PITG_21426
PSOJ:	PHYSODRAFT_474456
SPAR:	SPRG_11773 SPRG_18544
EHX:	EMIHUDRAFT_220113 EMIHUDRAFT_435021 EMIHUDRAFT_441353 EMIHUDRAFT_442614
TBR:	Tb927.8.3240(Tb08.28L1.250)
TCR:	473111.10 507853.10
LMA:	LMJF_23_1300
LIF:	LINJ_23_1560
LDO:	LDBPK_231560
LMI:	LMXM_23_1300
LBZ:	LBRM_23_1420
NGR:	NAEGRDRAFT_77816
HCH:	HCH_01597
SAMY:	DB32_000704 DB32_004537
MRM:	A7982_05543 A7982_06884

» show all

Reference

1 [PMID:14189869]

Authors

DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW.

Title

THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS.

Journal

J. Biol. Chem. 239 (1964) 1381-7.

Reference

2 [PMID:4019441]

Authors

Honjo K, Ishibashi T, Imai Y

Title

Partial purification and characterization of lathosterol 5-desaturase from rat liver microsomes.

Journal

J. Biochem. 97 (1985) 955-9.

Reference

3 [PMID:1864507]

Authors

Arthington BA, Bennett LG, Skatrud PL, Guynn CJ, Barbuch RJ, Ulbright CE, Bard M

Title

Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase.

Journal

Gene. 102 (1991) 39-44.

Sequence

[sce:YLR056W]

Reference

4 [PMID:8561508]

Authors

Taton M, Rahier A.

Title

Plant sterol biosynthesis: identification and characterization of higher plant delta 7-sterol C5(6)-desaturase.

Journal

Arch. Biochem. Biophys. 325 (1996) 279-88.

Reference

5 [PMID:9056262]

Authors

Nishino H, Nakaya J, Nishi S, Kurosawa T, Ishibashi T.

Title

Temperature-induced differential kinetic properties between an initial burst and the following steady state in membrane-bound enzymes: studies on lathosterol 5-desaturase.

Journal

Arch. Biochem. Biophys. 339 (1997) 298-304.

Reference

6 [PMID:10651635]

Authors

Taton M, Husselstein T, Benveniste P, Rahier A.

Title

Role of highly conserved residues in the reaction catalyzed by recombinant Delta7-sterol-C5(6)-desaturase studied by site-directed mutagenesis.

Journal

Biochemistry. 39 (2000) 701-11.

Sequence

[ath:AT3G02580]

Reference

7 [PMID:22982564]

Authors

Poklepovich TJ, Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD

Title

The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae.

Journal

Steroids. 77 (2012) 1313-20.

Other DBs

ExplorEnz - The Enzyme Database:

1.14.19.20

IUBMB Enzyme Nomenclature:

1.14.19.20

ExPASy - ENZYME nomenclature database:

1.14.19.20

BRENDA, the Enzyme Database:

1.14.19.20

CAS: