KEGG   ORTHOLOGY: K00440Help
Entry
K00440                      KO                                     

Name
frhA
Definition
coenzyme F420 hydrogenase subunit alpha [EC:1.12.98.1]
Pathway
Methane metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00680 Methane metabolism
    K00440  frhA; coenzyme F420 hydrogenase subunit alpha
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.12  Acting on hydrogen as donor
   1.12.98  With other, known, physiological acceptors
    1.12.98.1  coenzyme F420 hydrogenase
     K00440  frhA; coenzyme F420 hydrogenase subunit alpha
BRITE hierarchy
Other DBs
RN: 
COG: 
GO: 
Genes
TAM: 
DTE: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0820(frcA) MMP1382(fruA)
MMQ: 
MmarC5_0196 MmarC5_0649
MMX: 
MmarC6_1291
MMZ: 
MmarC7_0627
MMD: 
GYY_04760 GYY_07740
MMAK: 
MMKA1_09050(frhA) MMKA1_16060(fruA)
MMAO: 
MMOS7_08830(frhA) MMOS7_14870(fruA)
MAE: 
Maeo_1045
MVN: 
Mevan_0073 Mevan_0692
MVO: 
Mvol_0587 Mvol_0991
MOK: 
Metok_0180 Metok_0896
MAC: 
MA_0975(frhA)
MBA: 
Mbar_A0452 Mbar_A2287
MBY: 
MSBRM_1453 MSBRM_3020
MBW: 
MSBRW_0550 MSBRW_2457
MBAR: 
MSBR2_0950 MSBR2_2978
MBAK: 
MSBR3_2973
MMA: 
MM_3045
MMAZ: 
MmTuc01_3124
MMJ: 
MSMAS_1645
MMAC: 
MSMAC_2996
MVC: 
MSVAZ_1820 MSVAZ_3110
MEK: 
MSKOL_1798 MSKOL_3073
MSJ: 
MSSAC_0976
MSZ: 
MSSIH_0878
MSW: 
MSSIT_0912
MTHE: 
MSTHC_1871
MTHR: 
MSTHT_1418
MHOR: 
MSHOH_2436
MHU: 
Mhun_2332
MLA: 
Mlab_0015
MEM: 
Memar_2174
MBG: 
BN140_1378(frhA)
MEMA: 
MMAB1_1762 MMAB1_1763
MPI: 
Mpet_0590
MBN: 
Mboo_0479
MFO: 
Metfor_2713
MPL: 
Mpal_0084
MPD: 
MCP_2409(frhA-1) MCP_2452(frhA-2)
MEZ: 
Mtc_1001(frhA-1) Mtc_2127(frhA-2)
RCI: 
RCIX2138(frhA-2) RCIX2388(frhA-1)
MTH: 
MTH_1300
MMG: 
MTBMA_c16860(frhA)
METC: 
MTCT_1180
MWO: 
MWSIV6_1689(frhA)
MST: 
Msp_1302(frhA)
MSI: 
Msm_1124
MRU: 
mru_2064(frhA)
MEB: 
Abm4_1634(frhA)
MMIL: 
sm9_0191(frhA)
MEYE: 
TL18_09880
MOL: 
YLM1_1805
MEL: 
Metbo_0218
MEW: 
MSWAN_2265
METH: 
MBMB1_1911(frhA)
MFC: 
BRM9_2252(frhA)
MFI: 
DSM1535_1184(frhA)
MCUB: 
MCBB_2187(frhA3)
MFV: 
Mfer_1032
MKA: 
MK0931
PYA: 
PYCH_10960
PYC: 
TQ32_09745
TON: 
TON_1559
TGA: 
TGAM_0068(frhA)
THE: 
GQS_02355
THM: 
CL1_1151
THS: 
TES1_1498 TES1_1501
TNU: 
BD01_1902
TEU: 
TEU_01935
TGY: 
X802_04315
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2207102
  Authors
Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT
  Title
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
  Journal
Biochemistry 29:7237-44 (1990)
DOI:10.1021/bi00483a011
  Sequence
[mth:MTH_1300]
LinkDB All DBs

KEGG   ORTHOLOGY: K00441Help
Entry
K00441                      KO                                     

Name
frhB
Definition
coenzyme F420 hydrogenase subunit beta [EC:1.12.98.1]
Pathway
Methane metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00680 Methane metabolism
    K00441  frhB; coenzyme F420 hydrogenase subunit beta
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.12  Acting on hydrogen as donor
   1.12.98  With other, known, physiological acceptors
    1.12.98.1  coenzyme F420 hydrogenase
     K00441  frhB; coenzyme F420 hydrogenase subunit beta
BRITE hierarchy
Other DBs
RN: 
COG: 
GO: 
Genes
TPS: 
PBM: 
MICC: 
MAGA: 
TMB: 
HHA: 
HHC: 
EBS: 
PDQ: 
RAC: 
LIH: 
L63ED372_00671
RGE: 
RGE_14160
RBN: 
RBXJA2T_16747
METR: 
BSY238_1534 BSY238_421
MEU: 
ACJ67_08100
BEB: 
AEM42_08485
DAF: 
Desaf_1867
DRT: 
Dret_0422
DSF: 
UWK_00468
DOL: 
Dole_1150
DML: 
Dmul_28810
DAL: 
Dalk_2982 Dalk_4964
DAT: 
HRM2_13650 HRM2_33500
DTI: 
Desti_1358
DBR: 
Deba_0887
MLN: 
A9174_30235
MAMO: 
A6B35_10450
AAK: 
AA2016_4908
RPA: 
RPA1501
RPB: 
RPB_4023
RPC: 
RPC_1245
RPD: 
RPD_3777
RPE: 
RPE_1300
RPT: 
Rpal_1688
RPX: 
Rpdx1_4020
RVA: 
Rvan_2125
BSB: 
Bresu_1932
BRL: 
BZG35_10160
JAN: 
Jann_0300
RDE: 
RD1_3988
RLI: 
RLO149_c004490
DSH: 
Dshi_3268
THW: 
BMG03_14215
LVS: 
LOKVESSMR4R_00309
HBC: 
AEM38_14705
SSAN: 
NX02_24175
CIJ: 
WG74_05475
BLAS: 
BSY18_1802
ADO: 
A6F68_00892
PNS: 
A9D12_02835
RRU: 
Rru_A0937
RRF: 
F11_04830
RCE: 
RC1_0144(frhB)
RPM: 
RSPPHO_01934(frhB)
PGM: 
PGRAT_08430
PAEF: 
R50345_19830
PAEQ: 
R50912_24675
PRI: 
PRIO_1788
BPB: 
bpr_I2415
DKU: 
Desku_1352
DGI: 
Desgi_0750
PTH: 
PTH_1492(FrhB)
AWO: 
Awo_c13400(frhB)
CHY: 
CHY_1362
PFT: 
JBW_00662 JBW_00687
FRO: 
AALO17_22500
MCHE: 
BB28_08225
ROP: 
ROP_54820
ROA: 
Pd630_LPD01993
SALU: 
DC74_399
SALL: 
SAZ_02480
STRE: 
GZL_08882
SNR: 
SNOUR_40375
ACH: 
Achl_2944
MPH: 
MLP_48650
NML: 
Namu_4481
ARD: 
AXF14_02990
RXY: 
Rxyl_0964
RRD: 
RradSPS_0875
AYM: 
YM304_10050
ABAI: 
IMCC26256_11151
MPRO: 
BJP34_09040
DET: 
DET0214
DEB: 
DehaBAV1_0139
DMD: 
dcmb_217
DMY: 
X793_00995
DUC: 
UCH007_02440
TTR: 
Tter_1334
CTM: 
Cabther_B0079
TAM: 
Theam_1119
DTE: 
Dester_0451
TID: 
Thein_1778
MJA: 
MJ_0032 MJ_0725 MJ_1349
MFE: 
Mefer_0177 Mefer_1239
MVU: 
Metvu_0631 Metvu_0895 Metvu_1285
MFS: 
MFS40622_0230 MFS40622_0947 MFS40622_1447
MIF: 
Metin_0512 Metin_0869
MJH: 
JH146_0253 JH146_1152 JH146_1537
MIG: 
Metig_0360 Metig_1038 Metig_1792
MMP: 
MMP0083 MMP0817(frcB) MMP1385(fruB)
MMQ: 
MmarC5_0193 MmarC5_0646 MmarC5_1595
MMX: 
MmarC6_0585 MmarC6_0866 MmarC6_1288
MMZ: 
MmarC7_0630 MmarC7_1081
MMD: 
GYY_00425 GYY_04745 GYY_07755
MMAK: 
MMKA1_00860 MMKA1_09020(frhB) MMKA1_16090(frhB)
MMAO: 
MMOS7_01110 MMOS7_08800(frhB) MMOS7_14900(frhB)
MAE: 
Maeo_1042 Maeo_1303
MVN: 
Mevan_0076 Mevan_0695 Mevan_1095
MVO: 
Mvol_0590 Mvol_0988 Mvol_1429
MOK: 
Metok_0177 Metok_0606 Metok_0899
MAC: 
MA_0978(frhB) MA_4220 MA_4520
MBA: 
Mbar_A0449 Mbar_A0662 Mbar_A0881 Mbar_A2290
MBY: 
MSBRM_0112 MSBRM_1455 MSBRM_3017 MSBRM_3227
MBW: 
MSBRW_0117 MSBRW_0341 MSBRW_0553 MSBRW_2454
MBAR: 
MSBR2_0948 MSBR2_2268 MSBR2_2975 MSBR2_3187
MBAK: 
MSBR3_2970 MSBR3_3176
MMA: 
MM_0969 MM_1225 MM_3042
MMAZ: 
MmTuc01_1000 MmTuc01_1266 MmTuc01_3121
MMJ: 
MSMAS_0087 MSMAS_0334 MSMAS_1648
MMAC: 
MSMAC_0093 MSMAC_0352 MSMAC_2999
MVC: 
MSVAZ_3107 MSVAZ_3226 MSVAZ_3399
MEK: 
MSKOL_1795 MSKOL_3070 MSKOL_3194 MSKOL_3359
MLS: 
MSLAZ_0135 MSLAZ_2767
METM: 
MSMTP_0120 MSMTP_0381 MSMTP_0383 MSMTP_0389 MSMTP_0393
MEF: 
MSWH1_0115 MSWH1_2850
MEQ: 
MSWHS_0117 MSWHS_2152
MSJ: 
MSSAC_0973 MSSAC_3863 MSSAC_4279
MSZ: 
MSSIH_0875 MSSIH_3394 MSSIH_3784
MSW: 
MSSIT_0909 MSSIT_3464 MSSIT_3861
MTHE: 
MSTHC_1634 MSTHC_1723 MSTHC_1874
MTHR: 
MSTHT_1415 MSTHT_1566
MHOR: 
MSHOH_0103 MSHOH_0435 MSHOH_2439
MBU: 
Mbur_2261
MMET: 
MCMEM_0409 MCMEM_1996
MMH: 
Mmah_1792 Mmah_1967
MHAZ: 
BHR79_03800 BHR79_04710
MEV: 
Metev_1040
MZH: 
Mzhil_0169 Mzhil_0337
MPY: 
Mpsy_1310 Mpsy_1371 Mpsy_2036
MHZ: 
Metho_0305 Metho_1361
MTP: 
Mthe_0174
MCJ: 
MCON_2320(frhB)
MHI: 
Mhar_2358
MHU: 
Mhun_0783 Mhun_2329
MLA: 
Mlab_0012
MEM: 
Memar_0331 Memar_2177
MBG: 
BN140_1381(frhB) BN140_1566
MEMA: 
MMAB1_1766(frhB) MMAB1_2005
MPI: 
Mpet_0593 Mpet_1260
MBN: 
Mboo_0476 Mboo_1693
MFO: 
Metfor_1221 Metfor_2716
MPL: 
Mpal_0087 Mpal_2707
MPD: 
MCP_2174(frhB-1) MCP_2412(frhB-2) MCP_2454(frhB-3)
MEZ: 
Mtc_0999(frhB-1) Mtc_1195(frhB-3) Mtc_2130(frhB-2)
RCI: 
RCIX1471(frhB-3) RCIX2136(frhB-2) RCIX2391(frhB-1) RCIX2759(frhB-4)
MTH: 
MTH_1297 MTH_193 MTH_341
MMG: 
MTBMA_c06440 MTBMA_c16830(frhB)
METC: 
MTCT_0158 MTCT_1177
MWO: 
MWSIV6_0607(frhB1) MWSIV6_0735(frhB3) MWSIV6_1686(frhB5)
MST: 
Msp_1305(frhB)
MSI: 
Msm_0135 Msm_1121
MRU: 
mru_2061(frhB1) mru_2081(frhB2)
MEB: 
Abm4_0826(frhB2) Abm4_1630(frhB1)
MMIL: 
sm9_0194(frhB1) sm9_1453(frhB2)
MEYE: 
TL18_02075 TL18_09865
MOL: 
YLM1_1808
MEL: 
Metbo_0221 Metbo_0574 Metbo_0863
MEW: 
MSWAN_1791 MSWAN_2262
METH: 
MBMB1_1414 MBMB1_1908(frhB)
MFC: 
BRM9_0650(frhB2) BRM9_2249(frhB)
MFI: 
DSM1535_0622 DSM1535_1181(frhB)
MCUB: 
MCBB_1652(frhB1) MCBB_2184(frhB3)
MFV: 
Mfer_1035 Mfer_1105
MKA: 
MK0539 MK0929
AFU: 
AF_1833
AFG: 
AFULGI_00020870
APO: 
Arcpr_1575 Arcpr_1589
AVE: 
Arcve_0530 Arcve_1117
AST: 
Asulf_00863 Asulf_01741
FPL: 
Ferp_1713
GAC: 
GACE_0015
GAH: 
GAH_00337
HJE: 
HacjB3_10145
NPH: 
NP_4006A
HUT: 
Huta_0177 Huta_1326
HME: 
HFX_6483
HBO: 
Hbor_39930
HTU: 
Htur_0242 Htur_3038
HDA: 
BB347_12790
HXA: 
Halxa_1303 Halxa_1972
NAT: 
NJ7G_0302
NPE: 
Natpe_0727 Natpe_3732
NOU: 
Natoc_0114 Natoc_4170
SALI: 
L593_06175
HLR: 
HALLA_05305
PYA: 
PYCH_10980
PYC: 
TQ32_09755
TON: 
TON_1561
TGA: 
TGAM_0066(frhB)
THE: 
GQS_02345
THM: 
CL1_1149
THS: 
TES1_1499
TNU: 
BD01_1900
TEU: 
TEU_01945
TGY: 
X802_04305
FFO: 
FFONT_0644
CSU: 
CSUB_C1525
BARC: 
AOA65_2033(frhB)
LOKI: 
Lokiarch_07380(frhB_1) Lokiarch_09920(frhB_2) Lokiarch_09930(frhB_3) Lokiarch_10850(frhB_4) Lokiarch_12690(fpoF_1) Lokiarch_17890(fpoF_2) Lokiarch_19690(frhB_5) Lokiarch_21140(frhB_6) Lokiarch_51590(frhB_9)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2207102
  Authors
Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT
  Title
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
  Journal
Biochemistry 29:7237-44 (1990)
DOI:10.1021/bi00483a011
  Sequence
[mth:MTH_1297]
LinkDB All DBs

KEGG   ORTHOLOGY: K00442Help
Entry
K00442                      KO                                     

Name
frhD
Definition
coenzyme F420 hydrogenase subunit delta
Pathway
Methane metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00680 Methane metabolism
    K00442  frhD; coenzyme F420 hydrogenase subunit delta
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
DAF: 
DPS: 
DPR: 
DAL: 
DAT: 
HRM2_11700(hyaD2)
DAO: 
SFU: 
DET: 
DEH: 
DEB: 
DEV: 
DhcVS_554
DEG: 
DehalGT_0551
DMC: 
btf_576
DMD: 
dcmb_622
DMG: 
GY50_0542(hycl)
DMX: 
X792_02995
DMY: 
X793_02740
DMZ: 
X794_02480
DUC: 
UCH007_05380
DLY: 
Dehly_0725
DEW: 
DGWBC_1413
DFO: 
Dform_00936
MJA: 
MJ_0030 MJ_0253
MFE: 
Mefer_0104 Mefer_1241
MVU: 
Metvu_0700 Metvu_1283
MFS: 
MFS40622_0493 MFS40622_0949
MIF: 
Metin_0514 Metin_1362
MJH: 
JH146_0172 JH146_1535
MIG: 
Metig_0334 Metig_1201 Metig_1794
MMP: 
MMP0819(frcD) MMP1337 MMP1383(fruD)
MMQ: 
MmarC5_0195 MmarC5_0256 MmarC5_0648
MMX: 
MmarC6_1290 MmarC6_1336
MMZ: 
MmarC7_0582 MmarC7_0628
MMD: 
GYY_04755 GYY_07510 GYY_07745
MMAK: 
MMKA1_09040(frhD) MMKA1_15600 MMKA1_16070(frhD)
MMAO: 
MMOS7_08820(frhD) MMOS7_14410 MMOS7_14880(frhD)
MAE: 
Maeo_0777 Maeo_1044
MVN: 
Mevan_0074 Mevan_0648 Mevan_0693
MVO: 
Mvol_0588 Mvol_0932 Mvol_0990
MOK: 
Metok_0179 Metok_0445 Metok_0897
MAC: 
MA_0976(frhD)
MBA: 
Mbar_A0451
MBY: 
MSBRM_3019
MBW: 
MSBRW_0551
MBAR: 
MSBR2_2977
MBAK: 
MSBR3_2972
MMA: 
MM_3044
MMAZ: 
MmTuc01_3123
MMJ: 
MSMAS_1646
MMAC: 
MSMAC_2997
MVC: 
MSVAZ_3109
MEK: 
MSKOL_3072
MSJ: 
MSSAC_0975
MSZ: 
MSSIH_0877
MSW: 
MSSIT_0911
MTHE: 
MSTHC_1872
MTHR: 
MSTHT_1417
MHOR: 
MSHOH_2437
MHU: 
Mhun_2331
MLA: 
Mlab_0014
MEM: 
Memar_2175
MBG: 
BN140_1379(frhD1) BN140_2359(frhD3)
MEMA: 
MMAB1_1764(frhD)
MPI: 
Mpet_0591 Mpet_1994
MBN: 
Mboo_0478
MFO: 
Metfor_0856 Metfor_2714
MPL: 
Mpal_0085
MPD: 
MCP_2410(frhD)
MEZ: 
Mtc_2128(frhD)
RCI: 
RCIA172(frhD-1)
MTH: 
MTH_1299
MMG: 
MTBMA_c16850(frhD)
METC: 
MTCT_1179
MWO: 
MWSIV6_1688(frhD)
MST: 
Msp_1303(frhD) Msp_1514
MSI: 
Msm_1123
MRU: 
mru_2063(frhD)
MEB: 
Abm4_1633(frhD)
MMIL: 
sm9_0190(frhD1) sm9_0192(frhD2)
MEYE: 
TL18_09875
MOL: 
YLM1_1806
MEL: 
Metbo_0219
MEW: 
MSWAN_2264
METH: 
MBMB1_1910(frhD)
MFC: 
BRM9_2251(frhD)
MFI: 
DSM1535_1183(frhD)
MCUB: 
MCBB_2186(frhD)
MFV: 
Mfer_1033
MKA: 
MK1624(hyaD_2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2207102
  Authors
Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT
  Title
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
  Journal
Biochemistry 29:7237-44 (1990)
DOI:10.1021/bi00483a011
  Sequence
[mth:MTH_1299]
LinkDB All DBs

KEGG   ORTHOLOGY: K00443Help
Entry
K00443                      KO                                     

Name
frhG
Definition
coenzyme F420 hydrogenase subunit gamma [EC:1.12.98.1]
Pathway
Methane metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00680 Methane metabolism
    K00443  frhG; coenzyme F420 hydrogenase subunit gamma
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.12  Acting on hydrogen as donor
   1.12.98  With other, known, physiological acceptors
    1.12.98.1  coenzyme F420 hydrogenase
     K00443  frhG; coenzyme F420 hydrogenase subunit gamma
BRITE hierarchy
Other DBs
RN: 
COG: 
GO: 
Genes
TAM: 
DTE: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0818(frcG) MMP1384(fruG)
MMQ: 
MmarC5_0194 MmarC5_0647
MMX: 
MmarC6_1289
MMZ: 
MmarC7_0629
MMD: 
GYY_04750 GYY_07750
MMAK: 
MMKA1_09030(frhG) MMKA1_16080(frhG)
MMAO: 
MMOS7_08810(frhG) MMOS7_14890(frhG)
MAE: 
Maeo_1043
MVN: 
Mevan_0075 Mevan_0694
MVO: 
Mvol_0589 Mvol_0989
MOK: 
Metok_0178 Metok_0898
MAC: 
MA_0977(frhG)
MBA: 
Mbar_A0450 Mbar_A2289
MBY: 
MSBRM_1454 MSBRM_3018
MBW: 
MSBRW_0552 MSBRW_2455
MBAR: 
MSBR2_0949 MSBR2_2976
MBAK: 
MSBR3_2971
MMA: 
MM_3043
MMAZ: 
MmTuc01_3122
MMJ: 
MSMAS_1647
MMAC: 
MSMAC_2998
MVC: 
MSVAZ_1818 MSVAZ_3108
MEK: 
MSKOL_1796 MSKOL_3071
MSJ: 
MSSAC_0974
MSZ: 
MSSIH_0876
MSW: 
MSSIT_0910
MTHE: 
MSTHC_1873
MTHR: 
MSTHT_1416
MHOR: 
MSHOH_2438
MHU: 
Mhun_2330
MLA: 
Mlab_0013
MEM: 
Memar_2176
MBG: 
BN140_1380(frhG)
MEMA: 
MMAB1_1765(frhG)
MPI: 
Mpet_0592
MBN: 
Mboo_0477
MFO: 
Metfor_2715
MPL: 
Mpal_0086
MPD: 
MCP_2411(frhG-1) MCP_2453(frhG-2)
MEZ: 
Mtc_1000(frhG-1) Mtc_2129(frhG-2)
RCI: 
RCIX2137(frhG-2) RCIX2390(frhG-1)
MTH: 
MTH_1298
MMG: 
MTBMA_c16840(frhG)
METC: 
MTCT_1178
MWO: 
MWSIV6_1687(frhG)
MST: 
Msp_1304(frhG)
MSI: 
Msm_1122
MRU: 
mru_2062(frhG)
MEB: 
Abm4_1632(frhG)
MMIL: 
sm9_0193(frhG)
MEYE: 
TL18_09870
MOL: 
YLM1_1807
MEL: 
Metbo_0220
MEW: 
MSWAN_2263
METH: 
MBMB1_1909(frhG)
MFC: 
BRM9_2250(frhG)
MFI: 
DSM1535_1182(frhG)
MCUB: 
MCBB_2185(frhG)
MFV: 
Mfer_1034
MKA: 
MK0538 MK0930
PYA: 
PYCH_10970
PYC: 
TQ32_09750
TON: 
TON_1560
TGA: 
TGAM_0067(frhG)
THE: 
GQS_02350
THM: 
CL1_1150
THS: 
TES1_1500
TNU: 
BD01_1901
TEU: 
TEU_01940
TGY: 
X802_04310
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2207102
  Authors
Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT
  Title
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
  Journal
Biochemistry 29:7237-44 (1990)
DOI:10.1021/bi00483a011
  Sequence
[mth:MTH_1298]
LinkDB All DBs

KEGG   ENZYME: 1.12.98.1Help
Entry
EC 1.12.98.1                Enzyme                                 

Name
coenzyme F420 hydrogenase;
8-hydroxy-5-deazaflavin-reducing hydrogenase;
F420-reducing hydrogenase;
coenzyme F420-dependent hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:coenzyme F420 oxidoreductase
Reaction(IUBMB)
H2 + oxidized coenzyme F420 = reduced coenzyme F420 [RN:R03025]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
oxidized coenzyme F420 [CPD:C00876]
Product
reduced coenzyme F420 [CPD:C01080]
Comment
An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F420, flavins and methylviologen, but to a lesser extent. The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.
History
EC 1.12.98.1 created 1989 as EC 1.12.99.1, transferred 2002 to EC 1.12.98.1
Pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00440  
coenzyme F420 hydrogenase subunit alpha
K00441  
coenzyme F420 hydrogenase subunit beta
K00443  
coenzyme F420 hydrogenase subunit gamma
Genes
TPS: 
PBM: 
MICC: 
MAGA: 
TMB: 
HHA: 
HHC: 
EBS: 
PDQ: 
RAC: 
LIH: 
L63ED372_00671
RGE: 
RGE_14160
RBN: 
RBXJA2T_16747
METR: 
BSY238_1534 BSY238_421
MEU: 
ACJ67_08100
BEB: 
AEM42_08485
DAF: 
Desaf_1867
DRT: 
Dret_0422
DSF: 
UWK_00468
DOL: 
Dole_1150
DML: 
Dmul_28810
DAL: 
Dalk_2982 Dalk_4964
DAT: 
HRM2_13650 HRM2_33500
DTI: 
Desti_1358
DBR: 
Deba_0887
MLN: 
A9174_30235
MAMO: 
A6B35_10450
AAK: 
AA2016_4908
RPA: 
RPA1501
RPB: 
RPB_4023
RPC: 
RPC_1245
RPD: 
RPD_3777
RPE: 
RPE_1300
RPT: 
Rpal_1688
RPX: 
Rpdx1_4020
RVA: 
Rvan_2125
BSB: 
Bresu_1932
BRL: 
BZG35_10160
JAN: 
Jann_0300
RDE: 
RD1_3988
RLI: 
RLO149_c004490
DSH: 
Dshi_3268
THW: 
BMG03_14215
LVS: 
LOKVESSMR4R_00309
HBC: 
AEM38_14705
SSAN: 
NX02_24175
CIJ: 
WG74_05475
BLAS: 
BSY18_1802
ADO: 
A6F68_00892
PNS: 
A9D12_02835
RRU: 
Rru_A0937
RRF: 
F11_04830
RCE: 
RC1_0144(frhB)
RPM: 
RSPPHO_01934(frhB)
PGM: 
PGRAT_08430
PAEF: 
R50345_19830
PAEQ: 
R50912_24675
PRI: 
PRIO_1788
BPB: 
bpr_I2415
DKU: 
Desku_1352
DGI: 
Desgi_0750
PTH: 
PTH_1492(FrhB)
AWO: 
Awo_c13400(frhB)
CHY: 
CHY_1362
PFT: 
JBW_00662 JBW_00687
FRO: 
AALO17_22500
MCHE: 
BB28_08225
ROP: 
ROP_54820
ROA: 
Pd630_LPD01993
SALU: 
DC74_399
SALL: 
SAZ_02480
STRE: 
GZL_08882
SNR: 
SNOUR_40375
ACH: 
Achl_2944
MPH: 
MLP_48650
NML: 
Namu_4481
ARD: 
AXF14_02990
RXY: 
Rxyl_0964
RRD: 
RradSPS_0875
AYM: 
YM304_10050
ABAI: 
IMCC26256_11151
MPRO: 
BJP34_09040
DET: 
DET0214
DEB: 
DehaBAV1_0139
DMD: 
dcmb_217
DMY: 
X793_00995
DUC: 
UCH007_02440
TTR: 
Tter_1334
CTM: 
Cabther_B0079
TAM: 
Theam_1117 Theam_1118 Theam_1119
DTE: 
Dester_0449 Dester_0450 Dester_0451
TID: 
Thein_1778
MJA: 
MJ_0031 MJ_0032 MJ_0725 MJ_0726 MJ_0727 MJ_1349
MFE: 
Mefer_0177 Mefer_1239 Mefer_1240 Mefer_1242
MVU: 
Metvu_0629 Metvu_0630 Metvu_0631 Metvu_0895 Metvu_1282 Metvu_1284 Metvu_1285
MFS: 
MFS40622_0230 MFS40622_0947 MFS40622_0948 MFS40622_0950 MFS40622_1445 MFS40622_1446 MFS40622_1447
MIF: 
Metin_0065 Metin_0512 Metin_0513 Metin_0515 Metin_0869
MJH: 
JH146_0253 JH146_1152 JH146_1153 JH146_1154 JH146_1534 JH146_1536 JH146_1537
MIG: 
Metig_0358 Metig_0359 Metig_0360 Metig_1038 Metig_1200 Metig_1202 Metig_1792 Metig_1793 Metig_1795
MMP: 
MMP0083 MMP0817(frcB) MMP0818(frcG) MMP0820(frcA) MMP1382(fruA) MMP1384(fruG) MMP1385(fruB)
MMQ: 
MmarC5_0193 MmarC5_0194 MmarC5_0196 MmarC5_0646 MmarC5_0647 MmarC5_0649 MmarC5_1595
MMX: 
MmarC6_0585 MmarC6_0866 MmarC6_1288 MmarC6_1289 MmarC6_1291
MMZ: 
MmarC7_0627 MmarC7_0629 MmarC7_0630 MmarC7_1081
MMD: 
GYY_00425 GYY_04745 GYY_04750 GYY_04760 GYY_07740 GYY_07750 GYY_07755
MMAK: 
MMKA1_00860 MMKA1_09020(frhB) MMKA1_09030(frhG) MMKA1_09050(frhA) MMKA1_16060(fruA) MMKA1_16080(frhG) MMKA1_16090(frhB)
MMAO: 
MMOS7_01110 MMOS7_08800(frhB) MMOS7_08810(frhG) MMOS7_08830(frhA) MMOS7_14870(fruA) MMOS7_14890(frhG) MMOS7_14900(frhB)
MAE: 
Maeo_1042 Maeo_1043 Maeo_1045 Maeo_1303
MVN: 
Mevan_0073 Mevan_0075 Mevan_0076 Mevan_0692 Mevan_0694 Mevan_0695 Mevan_1095
MVO: 
Mvol_0587 Mvol_0589 Mvol_0590 Mvol_0988 Mvol_0989 Mvol_0991 Mvol_1429
MOK: 
Metok_0177 Metok_0178 Metok_0180 Metok_0606 Metok_0896 Metok_0898 Metok_0899
MAC: 
MA_0975(frhA) MA_0977(frhG) MA_0978(frhB) MA_4220 MA_4520
MBA: 
Mbar_A0449 Mbar_A0450 Mbar_A0452 Mbar_A0662 Mbar_A0881 Mbar_A2287 Mbar_A2289 Mbar_A2290
MBY: 
MSBRM_0112 MSBRM_1453 MSBRM_1454 MSBRM_1455 MSBRM_3017 MSBRM_3018 MSBRM_3020 MSBRM_3227
MBW: 
MSBRW_0117 MSBRW_0341 MSBRW_0550 MSBRW_0552 MSBRW_0553 MSBRW_2454 MSBRW_2455 MSBRW_2457
MBAR: 
MSBR2_0948 MSBR2_0949 MSBR2_0950 MSBR2_2268 MSBR2_2975 MSBR2_2976 MSBR2_2978 MSBR2_3187
MBAK: 
MSBR3_2970 MSBR3_2971 MSBR3_2973 MSBR3_3176
MMA: 
MM_0969 MM_1225 MM_3042 MM_3043 MM_3045
MMAZ: 
MmTuc01_1000 MmTuc01_1266 MmTuc01_3121 MmTuc01_3122 MmTuc01_3124
MMJ: 
MSMAS_0087 MSMAS_0334 MSMAS_1645 MSMAS_1647 MSMAS_1648
MMAC: 
MSMAC_0093 MSMAC_0352 MSMAC_2996 MSMAC_2998 MSMAC_2999
MVC: 
MSVAZ_1818 MSVAZ_1820 MSVAZ_3107 MSVAZ_3108 MSVAZ_3110 MSVAZ_3226 MSVAZ_3399
MEK: 
MSKOL_1795 MSKOL_1796 MSKOL_1798 MSKOL_3070 MSKOL_3071 MSKOL_3073 MSKOL_3194 MSKOL_3359
MLS: 
MSLAZ_0135 MSLAZ_2767
METM: 
MSMTP_0120 MSMTP_0381 MSMTP_0383 MSMTP_0389 MSMTP_0393
MEF: 
MSWH1_0115 MSWH1_2850
MEQ: 
MSWHS_0117 MSWHS_2152
MSJ: 
MSSAC_0973 MSSAC_0974 MSSAC_0976 MSSAC_3863 MSSAC_4279
MSZ: 
MSSIH_0875 MSSIH_0876 MSSIH_0878 MSSIH_3394 MSSIH_3784
MSW: 
MSSIT_0909 MSSIT_0910 MSSIT_0912 MSSIT_3464 MSSIT_3861
MTHE: 
MSTHC_1634 MSTHC_1723 MSTHC_1871 MSTHC_1873 MSTHC_1874
MTHR: 
MSTHT_1415 MSTHT_1416 MSTHT_1418 MSTHT_1566
MHOR: 
MSHOH_0103 MSHOH_0435 MSHOH_2436 MSHOH_2438 MSHOH_2439
MBU: 
Mbur_2261
MMET: 
MCMEM_0409 MCMEM_1996
MMH: 
Mmah_1792 Mmah_1967
MHAZ: 
BHR79_03800 BHR79_04710
MEV: 
Metev_1040
MZH: 
Mzhil_0169 Mzhil_0337
MPY: 
Mpsy_1310 Mpsy_1371 Mpsy_2036
MHZ: 
Metho_0305 Metho_1361
MTP: 
Mthe_0174
MCJ: 
MCON_2320(frhB)
MHI: 
Mhar_2358
MHU: 
Mhun_0783 Mhun_2329 Mhun_2330 Mhun_2332
MLA: 
Mlab_0012 Mlab_0013 Mlab_0015
MEM: 
Memar_0331 Memar_2174 Memar_2176 Memar_2177
MBG: 
BN140_1378(frhA) BN140_1380(frhG) BN140_1381(frhB) BN140_1566
MEMA: 
MMAB1_1762 MMAB1_1763 MMAB1_1765(frhG) MMAB1_1766(frhB) MMAB1_2005
MPI: 
Mpet_0590 Mpet_0592 Mpet_0593 Mpet_1260
MBN: 
Mboo_0476 Mboo_0477 Mboo_0479 Mboo_1693
MFO: 
Metfor_1221 Metfor_2713 Metfor_2715 Metfor_2716
MPL: 
Mpal_0084 Mpal_0086 Mpal_0087 Mpal_2707
MPD: 
MCP_2174(frhB-1) MCP_2409(frhA-1) MCP_2411(frhG-1) MCP_2412(frhB-2) MCP_2452(frhA-2) MCP_2453(frhG-2) MCP_2454(frhB-3)
MEZ: 
Mtc_0999(frhB-1) Mtc_1000(frhG-1) Mtc_1001(frhA-1) Mtc_1195(frhB-3) Mtc_2127(frhA-2) Mtc_2129(frhG-2) Mtc_2130(frhB-2)
RCI: 
RCIX1471(frhB-3) RCIX2136(frhB-2) RCIX2137(frhG-2) RCIX2138(frhA-2) RCIX2388(frhA-1) RCIX2390(frhG-1) RCIX2391(frhB-1) RCIX2759(frhB-4)
MTH: 
MTH_1297 MTH_1298 MTH_1300 MTH_193 MTH_341
MMG: 
MTBMA_c06440 MTBMA_c16830(frhB) MTBMA_c16840(frhG) MTBMA_c16860(frhA)
METC: 
MTCT_0158 MTCT_1177 MTCT_1178 MTCT_1180
MWO: 
MWSIV6_0607(frhB1) MWSIV6_0735(frhB3) MWSIV6_1686(frhB5) MWSIV6_1687(frhG) MWSIV6_1689(frhA)
MST: 
Msp_1302(frhA) Msp_1304(frhG) Msp_1305(frhB)
MSI: 
Msm_0135 Msm_1121 Msm_1122 Msm_1124
MRU: 
mru_2061(frhB1) mru_2062(frhG) mru_2064(frhA) mru_2081(frhB2)
MEB: 
Abm4_0826(frhB2) Abm4_1630(frhB1) Abm4_1632(frhG) Abm4_1634(frhA)
MMIL: 
sm9_0191(frhA) sm9_0193(frhG) sm9_0194(frhB1) sm9_1453(frhB2)
MEYE: 
TL18_02075 TL18_09865 TL18_09870 TL18_09880
MOL: 
YLM1_1805 YLM1_1807 YLM1_1808
MEL: 
Metbo_0218 Metbo_0220 Metbo_0221 Metbo_0574 Metbo_0863
MEW: 
MSWAN_1791 MSWAN_2262 MSWAN_2263 MSWAN_2265
METH: 
MBMB1_1414 MBMB1_1908(frhB) MBMB1_1909(frhG) MBMB1_1911(frhA)
MFC: 
BRM9_0650(frhB2) BRM9_2249(frhB) BRM9_2250(frhG) BRM9_2252(frhA)
MFI: 
DSM1535_0622 DSM1535_1181(frhB) DSM1535_1182(frhG) DSM1535_1184(frhA)
MCUB: 
MCBB_1652(frhB1) MCBB_2184(frhB3) MCBB_2185(frhG) MCBB_2187(frhA3)
MFV: 
Mfer_1032 Mfer_1034 Mfer_1035 Mfer_1105
MKA: 
MK0538 MK0539 MK0929 MK0930 MK0931
AFU: 
AF_1833
AFG: 
AFULGI_00020870
APO: 
Arcpr_1575 Arcpr_1589
AVE: 
Arcve_0530 Arcve_1117
AST: 
Asulf_00863 Asulf_01741
FPL: 
Ferp_1713
GAC: 
GACE_0015
GAH: 
GAH_00337
HJE: 
HacjB3_10145
NPH: 
NP_4006A
HUT: 
Huta_0177 Huta_1326
HME: 
HFX_6483
HBO: 
Hbor_39930
HTU: 
Htur_0242 Htur_3038
HDA: 
BB347_12790
HXA: 
Halxa_1303 Halxa_1972
NAT: 
NJ7G_0302
NPE: 
Natpe_0727 Natpe_3732
NOU: 
Natoc_0114 Natoc_4170
SALI: 
L593_06175
HLR: 
HALLA_05305
PYA: 
PYCH_10960 PYCH_10970 PYCH_10980
PYC: 
TQ32_09745 TQ32_09750 TQ32_09755
TON: 
TON_1559 TON_1560 TON_1561
TGA: 
TGAM_0066(frhB) TGAM_0067(frhG) TGAM_0068(frhA)
THE: 
GQS_02345 GQS_02350 GQS_02355
THM: 
CL1_1149 CL1_1150 CL1_1151
THS: 
TES1_1498 TES1_1499 TES1_1500 TES1_1501
TNU: 
BD01_1900 BD01_1901 BD01_1902
TEU: 
TEU_01935 TEU_01940 TEU_01945
TGY: 
X802_04305 X802_04310 X802_04315
FFO: 
FFONT_0644
CSU: 
CSUB_C1525
BARC: 
AOA65_2033(frhB)
LOKI: 
Lokiarch_07380(frhB_1) Lokiarch_09920(frhB_2) Lokiarch_09930(frhB_3) Lokiarch_10850(frhB_4) Lokiarch_12690(fpoF_1) Lokiarch_17890(fpoF_2) Lokiarch_19690(frhB_5) Lokiarch_21140(frhB_6) Lokiarch_51590(frhB_9)
 » show all
Taxonomy
Reference
1  [PMID:6786341]
  Authors
Adams MW, Mortenson LE, Chen JS.
  Title
Hydrogenase.
  Journal
Biochim. Biophys. Acta. 594 (1980) 105-76.
Reference
2  [PMID:6211447]
  Authors
Yamazaki S.
  Title
A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue.
  Journal
J. Biol. Chem. 257 (1982) 7926-9.
Reference
3  [PMID:3663585]
  Authors
Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT.
  Title
8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization.
  Journal
Biochemistry. 26 (1987) 4219-27.
  Sequence
Reference
4  [PMID:3121317]
  Authors
Muth E, Morschel E, Klein A.
  Title
Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae.
  Journal
Eur. J. Biochem. 169 (1987) 571-7.
Reference
5  [PMID:2738024]
  Authors
Baron SF, Ferry JG.
  Title
Purification and properties of the membrane-associated coenzyme F420-reducing hydrogenase from Methanobacterium formicicum.
  Journal
J. Bacteriol. 171 (1989) 3846-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-05-8
LinkDB All DBs

KEGG   REACTION: R03025Help
Entry
R03025                      Reaction                               

Name
Hydrogen:Coenzyme F420 oxidoreductase
Definition
Coenzyme F420 + Hydrogen <=> Reduced coenzyme F420
Equation
Reaction class
C00876_C01080
Enzyme
Pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00440  
coenzyme F420 hydrogenase subunit alpha [EC:1.12.98.1]
K00441  
coenzyme F420 hydrogenase subunit beta [EC:1.12.98.1]
K00442  
coenzyme F420 hydrogenase subunit delta
K00443  
coenzyme F420 hydrogenase subunit gamma [EC:1.12.98.1]
Other DBs
RHEA: 
LinkDB All DBs

DBGET integrated database retrieval system