KEGG ORTHOLOGY: K00483

ORTHOLOGY: K00483

Entry

K00483 KO

Name

hpaB

Definition

4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]

Pathway

ko00350	Tyrosine metabolism
ko01220	Degradation of aromatic compounds

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K00483  hpaB; 4-hydroxyphenylacetate 3-monooxygenase
  Amino acid metabolism
   00350 Tyrosine metabolism
    K00483  hpaB; 4-hydroxyphenylacetate 3-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.9  4-hydroxyphenylacetate 3-monooxygenase
     K00483  hpaB; 4-hydroxyphenylacetate 3-monooxygenase

Other DBs

RN:

R02698 R03299

COG:

COG2368

GO:

0052881

Genes

PPP:	PHYPADRAFT_103859
EOJ:	ECO26_5549(hpaB)
EOI:	ECO111_5206(hpaB)
EOH:	ECO103_5128(hpaB)
ECX:	EcHS_A4576(hpaB)
ECY:	ECSE_4621
ECR:	ECIAI1_4567(hpaB)
EUM:	ECUMN_4966(hpaB)
ECL:	EcolC_3710
EBR:	ECB_04222(hpaB)
EBD:	ECBD_3674
EKO:	EKO11_3968
EKF:	KO11_23365(hpaB)
ELW:	ECW_m4705(hpaB)
ELL:	WFL_22920(hpaB)
EBL:	ECD_04222(hpaB)
EBE:	B21_04188(hpaB)
ECOA:	APECO78_02880
ECOL:	LY180_22800
ECOO:	ECRM13514_5600
ECOH:	ECRM13516_5313
EFE:	EFER_3070(hpaB)
STY:	STY1131(hpaB)
STT:	t1820(hpaB)
SEX:	STBHUCCB_19360
SENT:	TY21A_09265
STM:	STM1099(hpaB)
SEO:	STM14_1247(hpaB)
SEV:	STMMW_11091
SEY:	SL1344_1038(hpaB)
SEM:	STMDT12_C11180
SEJ:	STMUK_1068(hpaB)
SEB:	STM474_1091(hpaB)
SEF:	UMN798_1140(hpaB)
SETU:	STU288_01825
SETC:	CFSAN001921_11680
SENR:	STMDT2_10351(hpaB)
SEND:	DT104_10811(hpaB)
SENI:	CY43_05615
SEEN:	SE451236_11345
SPT:	SPA1751(hpaB)
SEK:	SSPA1627
SPQ:	SPAB_02454
SEI:	SPC_2651(hpaB)
SEC:	SCH_1049(hpaB)
SEH:	SeHA_C1209(hpaB)
SHB:	SU5_01730
SENH:	CFSAN002069_03525
SEEH:	SEEH1578_14720
SEE:	SNSL254_A1194(hpaB)
SENN:	SN31241_21660
SEW:	SeSA_A1163(hpaB)
SEA:	SeAg_B1058(hpaB)
SENS:	Q786_04910
SED:	SeD_A1174(hpaB)
SEG:	SG0988(hpaB)
SEL:	SPUL_1958(hpaB)
SEGA:	SPUCDC_1944(hpaB)
SET:	SEN0963(hpaB)
SENA:	AU38_04970
SENO:	AU37_04960
SENV:	AU39_04960
SENQ:	AU40_05575
SENL:	IY59_05060
SENJ:	CFSAN001992_06150
SEEC:	CFSAN002050_11890
SEEB:	SEEB0189_014075
SEEP:	I137_08900
SENB:	BN855_10540
SENE:	IA1_05410
SENC:	SEET0819_12155
SES:	SARI_01904
SBG:	SBG_0945(hpaB)
SBZ:	A464_1038
SBV:	N643_04505
SFN:	SFy_6275 SFy_6277
SFS:	SFyv_6346 SFyv_6348
SFT:	NCTC1_04750(hpaB_1) NCTC1_04751(hpaB_2)
SSN:	SSON_4489(hpaB)
SBO:	SBO_4404(hpaB)
SBC:	SbBS512_E4882(hpaB)
SHQ:	A0259_03505
ENC:	ECL_00750(hpaB)
ENO:	ECENHK_03095
ECLO:	ENC_44640
EEC:	EcWSU1_00548(hpaB)
ENL:	A3UG_03000
ECLG:	EC036_05870
ECLE:	ECNIH2_03900
ECLN:	ECNIH4_19900
ECLI:	ECNIH5_03025
ECLX:	LI66_03020
ECLY:	LI62_03490
ECLZ:	LI64_02995
ECLA:	ECNIH3_03025
ECLC:	ECR091_03005
ESC:	Entcl_3805
KLE:	AO703_02890
EAS:	Entas_0528
EAU:	DI57_15620
EHM:	AB284_21985
EKB:	BFV64_02640
ELG:	BH714_17625
EXF:	BFV63_02975
ECLS:	LI67_003955
ENX:	NI40_002865
KPN:	KPN_04780(hpaB)
KPU:	KP1_0734(hpaB)
KPM:	KPHS_06260
KPP:	A79E_4372
KPK:	A593_13955
KPH:	KPNIH24_03225
KPZ:	KPNIH27_03100
KPV:	KPNIH29_03415
KPW:	KPNIH30_03375
KPY:	KPNIH31_04690
KPG:	KPNIH32_03380
KPC:	KPNIH10_03205
KPQ:	KPR0928_03215
KPT:	VK055_2659(hpaB)
KPO:	KPN2242_02035
KPR:	KPR_0857 KPR_0858
KPJ:	N559_4516
KPI:	D364_24355
KPA:	KPNJ1_04832
KPS:	KPNJ2_04780
KPX:	PMK1_02239(hpaB)
KPB:	FH42_20420
KPNE:	KU54_023370
KPNU:	LI86_23210
KVA:	Kvar_4472
KVD:	KR75_11405
KVQ:	SP68_18040
KOX:	KOX_10015
KOE:	A225_0705
KOY:	J415_27720
KOK:	KONIH1_03740
KOC:	AB185_20685 AB185_32450
KOM:	HR38_08740
KQU:	AVR78_07750
EAE:	EAE_10315
EAR:	CCG31932
CBRA:	A6J81_18505
EBT:	EBL_c34040(hpaB)
ROR:	RORB6_15565
RON:	TE10_05455
CED:	LH89_16320
PGE:	LG71_25560
LAX:	APT61_19365
EBF:	D782_3927
YPE:	YPO1769(hpaB)
YPK:	y2539(hpaB)
YPA:	YPA_1141
YPN:	YPN_2354
YPM:	YP_1624(hpaB)
YPP:	YPDSF_1354
YPG:	YpAngola_A1640(hpaB)
YPZ:	YPZ3_1949(hpaB)
YPT:	A1122_17020
YPD:	YPD4_1567(hpaB)
YPX:	YPD8_1987(hpaB)
YPH:	YPC_2512(hpaB)
YPW:	CH59_3398(hpaB)
YPJ:	CH55_908(hpaB)
YPV:	BZ15_1780(hpaB)
YPL:	CH46_3354(hpaB)
YPS:	YPTB1645(hpaB)
YPO:	BZ17_857(hpaB)
YPI:	YpsIP31758_2357(hpaB)
YPY:	YPK_2453
YPB:	YPTS_1769
YPQ:	DJ40_578(hpaB)
YPU:	BZ21_995(hpaB)
YPR:	BZ20_330(hpaB)
YPC:	BZ23_1273(hpaB)
YPF:	BZ19_1072(hpaB)
SPE:	Spro_0634
SRR:	SerAS9_0570
SRL:	SOD_c05020(hpaB)
SRY:	M621_02650
SPLY:	Q5A_002640(hpaB)
SRS:	SerAS12_0570
SRA:	SerAS13_0570
SMAF:	D781_0578
SMW:	SMWW4_v1c05900
SMAR:	SM39_4967(hpaB)
SMAC:	SMDB11_4710(hpaB)
SLQ:	M495_02515
SERF:	L085_01150
SERS:	SERRSCBI_02790
SRZ:	AXX16_4529
SFO:	Z042_16840
PCV:	BCS7_01655
DZE:	Dd1591_0652
PLU:	plu0246 plu0975(hpaB) plu4027 plu4258
PAY:	PAU_00189(hpaB) PAU_00478 PAU_00910(hpaB)
PTT:	VY86_09160 VY86_13810
XBO:	XBJ1_3600
XBV:	XBW1_1452(hpaB) XBW1_4467
XNE:	XNC1_0446 XNC1_0449 XNC1_0811
XNM:	XNC2_0437 XNC2_0439 XNC2_0797
XDO:	XDD1_0415 XDD1_1013(hpaB)
XHO:	A9255_13900 A9255_13930 A9255_20565
PSI:	S70_06520
PSX:	DR96_1964(hpaB)
PSTA:	BGK56_09560
PRG:	RB151_008030(hpaB)
HAV:	AT03_16960
PMU:	PM1523
PMV:	PMCN06_1790(hpaB)
PUL:	NT08PM_1850
PMP:	Pmu_17900(hpaB)
PMUL:	DR93_372(hpaB)
PAE:	PA4091(hpaA)
PAEV:	N297_4221(hpaB)
PAEI:	N296_4221(hpaB)
PAU:	PA14_11000(hpaA)
PAP:	PSPA7_1007(hpaB)
PAG:	PLES_08851(hpaA)
PAF:	PAM18_0849(hpaA)
PNC:	NCGM2_5292(hpaA)
PAEB:	NCGM1900_0869(hpaA)
PDK:	PADK2_03870
PSG:	G655_04225
PRP:	M062_21575
PAEP:	PA1S_04375
PAER:	PA1R_gp1980
PAEM:	U769_04385
PAEL:	T223_04325
PAES:	SCV20265_0881
PAEU:	BN889_04541(hpaB)
PAEG:	AI22_29240
PAEC:	M802_4219(hpaB)
PAEO:	M801_4087(hpaB)
PFL:	PFL_3356(hpaB)
PPRC:	PFLCHA0_c33860(hpaB)
PPRO:	PPC_3380(hpaB)
PCH:	EY04_16655 EY04_26305
PCZ:	PCL1606_27180
PCP:	JM49_05440 JM49_14085
PSEM:	TO66_17310
PSOS:	POS17_3333(hpaB)
SWD:	Swoo_2019
CPS:	CPS_2047
CZA:	CYCME_2117(hpaB)
HAA:	A5892_03490
GBI:	PG2T_01205 PG2T_12225
RPJ:	N234_22415 N234_22475 N234_29420
REU:	Reut_A1585 Reut_C6314
REH:	H16_B0496(h16_B0496)
CNC:	CNE_2c04450(hpaH) CNE_BB1p03440(tcpA)
BUR:	Bcep18194_B2410
BCN:	Bcen_4663
BCH:	Bcen2424_3700
BCM:	Bcenmc03_3821
BCJ:	BCAM0734
BCEN:	DM39_4430
BCEO:	I35_4633
BCT:	GEM_5625
BCED:	DM42_4353
BCEP:	APZ15_20730
BCON:	NL30_22200
BLAT:	WK25_13940
BSEM:	WJ12_23670
BPSL:	WS57_10300
BMEC:	WJ16_22580
BYI:	BYI23_C002090 BYI23_C002900
BUE:	BRPE67_CCDS09320 BRPE67_CCDS10130
PPK:	U875_16245
PPNO:	DA70_08135
PPNM:	LV28_22445
PRB:	X636_18135
PPUL:	RO07_16865
PAPI:	SG18_15675
DAC:	Daci_3024
DEL:	DelCs14_3704
DTS:	BI380_08205
DHK:	BO996_13935
RBU:	PG1C_06920
MSD:	MYSTI_04802
SCU:	SCE1572_13565
DBR:	Deba_1051
MCI:	Mesci_0674
MOP:	Mesop_0688
MAMO:	A6B35_09760
MESW:	A9K65_003390
MES:	Meso_2465
AAK:	AA2016_5887
PLA:	Plav_1785
RHI:	NGR_b20090(hpaB)
SFH:	SFHH103_05222(hpaB)
SIX:	BSY16_2360 BSY16_3678 BSY16_4601
EAD:	OV14_a0070(hpaB)
EAH:	FA04_27315
RLT:	Rleg2_4429
RTR:	RTCIAT899_PC03915
SHZ:	shn_16275
XAU:	Xaut_0377 Xaut_2574
AZC:	AZC_4189
SNO:	Snov_2630
CHEL:	AL346_04825
HMC:	HYPMC_0261
DEQ:	XM25_03690(pvcC)
RHZ:	RHPLAN_16150 RHPLAN_17100 RHPLAN_22700 RHPLAN_32460 RHPLAN_51690 RHPLAN_54270 RHPLAN_62260
PSIN:	CAK95_10695 CAK95_16885 CAK95_27280
RHP:	LPB142_07400
PAMI:	JCM7686_pAMI6p015
PYE:	A6J80_01470
PTP:	RCA23_c29330(hpaH)
CON:	TQ29_11625 TQ29_16040
LAP:	ACP90_16480
LAGG:	B0E33_28320
DAA:	AKL17_0233 AKL17_3242 AKL17_3250
SSY:	SLG_11330
GXL:	H845_1141
KEU:	S101446_00275(hpaB)
ASZ:	ASN_1362(hpaB)
AACE:	A0U92_02580
APB:	SAR116_0256
BSU:	BSU18620(yoaI)
BSR:	I33_2090(hpaB)
BSL:	A7A1_2448
BSH:	BSU6051_18620(yoaI)
BSY:	I653_09690
BSUT:	BSUB_02002(yoaI)
BSUL:	BSUA_02002(yoaI)
BSUS:	Q433_11010
BSS:	BSUW23_09940(yoaI)
BST:	GYO_2242(hpaB)
BSN:	BSn5_00675
BSQ:	B657_18620(yoaI)
BSX:	C663_1926
BSP:	U712_09805
BAY:	RBAM_002630(yoaI)
BAQ:	BACAU_0205(yoaI)
BYA:	BANAU_0209(yoaI)
BAMP:	B938_01060
BAML:	BAM5036_0217(yoaI)
BAMA:	RBAU_0233(yoaI)
BAMN:	BASU_0220(yoaI)
BAMB:	BAPNAU_0209(yoaI)
BAMT:	AJ82_01435
BAMY:	V529_02230
BMP:	NG74_00247
BAO:	BAMF_0207(yoaI)
BAZ:	BAMTA208_01065(yoaI)
BQL:	LL3_00211(yoaI)
BXH:	BAXH7_00218
BQY:	MUS_0220(yoaI)
BAMI:	KSO_018345
BAMC:	U471_02150
BAMF:	U722_01355
BHA:	BH3836
BCA:	BCE_2601
BCB:	BCB4264_A2558
BCEF:	BcrFT9_02035
BCY:	Bcer98_0966
BTB:	BMB171_C2288
BTT:	HD73_3423 HD73_3424
BTHR:	YBT1520_16870
BTHI:	BTK_16895
BTC:	CT43_CH2513
BTF:	YBT020_12875 YBT020_29196
BTG:	BTB_c26350
BTHT:	H175_ch2554
BTHU:	YBT1518_14235 YBT1518_14245
BTHY:	AQ980_14115
BCL:	ABC0890
BMQ:	BMQ_2417(hpaB)
BMD:	BMD_2382(hpaB)
BMH:	BMWSH_2819(pvcC)
BMEG:	BG04_4791(hpaB)
BCO:	Bcell_2010
BJS:	MY9_2034
BACI:	B1NLA3E_10730 B1NLA3E_17945 B1NLA3E_17950
BIF:	N288_24560
BLE:	BleG1_3140
BACP:	SB24_08490
BACB:	OY17_04010
BBY:	CY96_11695
BACO:	OXB_2499 OXB_2686 OXB_3446 OXB_3454
BACY:	QF06_08435
BACL:	BS34A_20630(yoaI)
BALM:	BsLM_1985
BEO:	BEH_04630 BEH_12545
BSM:	BSM4216_0733 BSM4216_2177
BSJ:	UP17_15195 UP17_22410
BGY:	BGLY_3123
BGI:	BGM20_03880
BWH:	A9C19_03240
BHK:	B4U37_04110
OIH:	OB2872
GKA:	GK2138 GK3034
GTE:	GTCCBUS3UF5_24190 GTCCBUS3UF5_33960
GTK:	GT3570_10150 GT3570_14800
GTN:	GTNG_2992(hpaB)
GYC:	GYMC61_3113
GYA:	GYMC52_3140
GCT:	GC56T3_0470
GMC:	GY4MC1_0462 GY4MC1_1588
GGH:	GHH_c22230(yoaI) GHH_c31080(hpaB)
GJF:	M493_12230 M493_15810 M493_17955
GSE:	GT50_06875
GSR:	GS3922_06215
GTH:	Geoth_0530 Geoth_1671
PTL:	AOT13_00545 AOT13_14480
ANM:	GFC28_1574(hpaB) GFC28_3725(hpaB)
AAMY:	GFC30_1755(hpaB)
ANL:	GFC29_1708(hpaB) GFC29_54(hpaB)
LSP:	Bsph_3875(pvcC)
LGY:	T479_15720 T479_19670
LFU:	HR49_07505
HHD:	HBHAL_2383(hpaB) HBHAL_3970(yoaI)
HMN:	HM131_07195 HM131_18375
TAP:	GZ22_02140
VIR:	X953_15535
VHL:	BME96_15020
VIG:	BKP57_18425
FPN:	ABE65_007020 ABE65_019825
FAR:	ABE41_002760 ABE41_008075
GYM:	GYMC10_2686
PMS:	KNP414_04955
PMQ:	PM3016_4358
PMW:	B2K_22570
PLV:	ERIC2_c16720(hpaB)
PBD:	PBOR_19255
PAEF:	R50345_13370
PAEJ:	H70737_12745
PBJ:	VN24_08080 VN24_09465 VN24_09470 VN24_23030 VN24_23040
PIH:	UB51_09320
PRI:	PRIO_3489
PNP:	IJ22_02430 IJ22_35230 IJ22_35330 IJ22_36190 IJ22_40300 IJ22_40320 IJ22_47340 IJ22_47350
POW:	IJ21_24840 IJ21_24850
PXL:	BS614_17050 BS614_22065
ANX:	ACH33_14090
AAC:	Aaci_0339
AAD:	TC41_0460(hpaB)
BTS:	Btus_1571 Btus_2072
SIV:	SSIL_0564(yoaI)
SSIL:	SOLI23_15940
SPSY:	AZE41_13970 AZE41_14175
SPOR:	SporoP33_07570
SPOP:	SporoP37_08005
SURE:	SporoP32a_08025
RST:	ATY39_04190
LGR:	LCGT_0012
LGV:	LCGL_0012
LPK:	LACPI_0013
LPL:	lp_0070
LPJ:	JDM1_0079
LPT:	zj316_0284
LPS:	LPST_C0059
LPR:	LBP_cg0058
LPB:	SH83_00305
LPX:	ASU28_03125
LBT:	AYR52_01005
DSY:	DSY4732
TMR:	Tmar_1818
SAY:	TPY_2462(hpaB)
SAP:	Sulac_3216
MVA:	Mvan_3156
MIZ:	BAB75_18985
MMC:	Mmcs_2617
MKM:	Mkms_2661
MJL:	Mjls_2646
MFT:	XA26_16640
MVQ:	MYVA_2937
CII:	CIMIT_11890
CHM:	B842_09825
CTED:	CTEST_09800(nphA1)
NFA:	NFA_20870 NFA_30560 NFA_43650
NFR:	ERS450000_01009(hpaB_1) ERS450000_02023(hpaB_2) ERS450000_05550(hpaB_3)
NBR:	O3I_018985
RHA:	RHA1_ro01782 RHA1_ro02380 RHA1_ro02514(pheA1) RHA1_ro03853 RHA1_ro03872 RHA1_ro08077
RER:	RER_54270
REY:	O5Y_25790 O5Y_28105
REB:	XU06_26125
ROP:	ROP_14550 ROP_20940 ROP_pROB02-01900(hpaB)
ROA:	Pd630_LPD00219 Pd630_LPD05941 Pd630_LPD06576 Pd630_LPD06741
RPY:	Y013_12530 Y013_13560
RAV:	AAT18_08140 AAT18_20190 AAT18_24410
GBR:	Gbro_0220 Gbro_1818
GPO:	GPOL_c17090
SBH:	SBI_01405
SVE:	SVEN_5100
SRC:	M271_03085
SVT:	SVTN_26250
SXI:	SXIM_24760
SPAV:	Spa2297_23925
STSI:	A4E84_01180
SNW:	BBN63_09610
CPHY:	B5808_01110
ART:	Arth_1935 Arth_2569
ARR:	ARUE_c05860(hpaB)
ARI:	UM93_06905
ARH:	AHiyo8_57300 AHiyo8_57310
AAU:	AAur_0618
RSA:	RSal33209_1499
KFV:	AS188_10310
SATK:	SA2016_3710
BCV:	Bcav_0870
LMOI:	VV02_01280 VV02_15335
PSIM:	KR76_24440
FRA:	Francci3_2770
BSD:	BLASA_1435
AOI:	AORI_4289(hpaB)
AJA:	AJAP_17445(hpaH)
AMQ:	AMETH_1856 AMETH_5243
ALU:	BB31_31855
PDX:	Psed_2227 Psed_2279 Psed_3087 Psed_6066
PSEA:	WY02_09470
PSEE:	FRP1_25220
PSEH:	XF36_28690
PSEQ:	AD006_04400
PECQ:	AD017_12220
PHH:	AFB00_29310
SESP:	BN6_55630 BN6_58660(sam5)
KPHY:	AOZ06_39990
LED:	BBK82_43835
ACTI:	UA75_20985
ACAD:	UA74_20490
RXY:	Rxyl_1857
CWO:	Cwoe_4365
CYJ:	Cyan7822_6021
RRS:	RoseRS_2569
RCA:	Rcas_2414
CAU:	Caur_1347
CAG:	Cagg_2030
CHL:	Chy400_1469
TRO:	trd_1395 trd_A0929 trd_A0931
STI:	Sthe_2805
CAP:	CLDAP_41000
DRA:	DR_A0223
DGE:	Dgeo_2418
DDR:	Deide_2p00060
DMR:	Deima_0220 Deima_1883
DPT:	Deipr_2619
DGO:	DGo_CA0562
DPD:	Deipe_0884
TRA:	Trad_1888
TTH:	TT_C0594
TTJ:	TTHA0960 TTHB249
TTS:	Ththe16_0956
TTL:	TtJL18_1092
TSC:	TSC_c10450(hpaB)
THC:	TCCBUS3UF1_12430
TOS:	Theos_0972
TAQ:	TO73_1002
TPAR:	AV541_05910
TBC:	A0O31_00119
MRB:	Mrub_1332
MRE:	K649_06315
MSV:	Mesil_2312
MHD:	Marky_1264
AFU:	AF_0885 AF_1027
AFG:	AFULGI_00009740
FPL:	Ferp_0911
GAC:	GACE_0594
HDL:	HALDL1_15845
SSO:	SSO2053(hpaA)
STO:	STK_07260(pheA1)
SAI:	Saci_2294(hpaA)
SACN:	SacN8_11190
SACR:	SacRon12I_11430
SACS:	SUSAZ_10780
SIS:	LS215_0936
SIA:	M1425_0686
SIM:	M1627_0691
SID:	M164_0713
SIY:	YG5714_1009
SIN:	YN1551_1864
SII:	LD85_0739
SIH:	SiH_0629
SIR:	SiRe_0706
SIC:	SiL_0742
SULA:	BFU36_08220
MSE:	Msed_0996 Msed_1776
MCN:	Mcup_0455 Mcup_1186
AMAN:	B6F84_05385
POG:	Pogu_1357

» show all

Reference

PMID:10653707

Authors

Xun L, Sandvik ER

Title

Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase.

Journal

Appl Environ Microbiol 66:481-6 (2000)
DOI:10.1128/AEM.66.2.481-486.2000

Sequence

[elw:ECW_m4705]

LinkDB

ORTHOLOGY: K00484

Entry

K00484 KO

Name

hpaC

Definition

flavin reductase (NADH) [EC:1.5.1.36]

Pathway

ko00350	Tyrosine metabolism
ko00740	Riboflavin metabolism
ko01220	Degradation of aromatic compounds

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K00484  hpaC; flavin reductase (NADH)
  Amino acid metabolism
   00350 Tyrosine metabolism
    K00484  hpaC; flavin reductase (NADH)
  Metabolism of cofactors and vitamins
   00740 Riboflavin metabolism
    K00484  hpaC; flavin reductase (NADH)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.36  flavin reductase (NADH)
     K00484  hpaC; flavin reductase (NADH)

Other DBs

RN:

R02698 R03299 R05705 R09748 R09750

COG:

COG1853

GO:

0036382

Genes

EOJ:	ECO26_5548(hpaC)
EOI:	ECO111_5205(hpaC)
EOH:	ECO103_5127(hpaC)
ECX:	EcHS_A4575(hpaC)
ECY:	ECSE_4620
ECR:	ECIAI1_4566(hpaC)
EUM:	ECUMN_4965(hpaC)
ECL:	EcolC_3711
EBR:	ECB_04221(hpaC)
EBD:	ECBD_3675
EKO:	EKO11_3969
EKF:	KO11_23360(hpaC)
ELW:	ECW_m4704(hpaC)
ELL:	WFL_22915(hpaC)
EBL:	ECD_04221(hpaC)
EBE:	B21_04187(ybl221)
ECOA:	APECO78_02875
ECOL:	LY180_22795
ECOO:	ECRM13514_5599
ECOH:	ECRM13516_5312
EFE:	EFER_3071(hpaC)
STY:	STY1130(hpaC)
STT:	t1821(hpaC)
SEX:	STBHUCCB_19370
SENT:	TY21A_09270
STM:	STM1098(hpaC)
SEO:	STM14_1246(hpaC)
SEV:	STMMW_11081
SEY:	SL1344_1037(hpaC)
SEM:	STMDT12_C11170
SEJ:	STMUK_1067(hpaC)
SEB:	STM474_1090(hpaC)
SEF:	UMN798_1139(hpaC)
SETU:	STU288_01820(hpaC)
SETC:	CFSAN001921_11685(hpaC)
SENR:	STMDT2_10341(hpaC)
SEND:	DT104_10801(hpaC)
SENI:	CY43_05610(hpaC)
SEEN:	SE451236_11340(hpaC)
SPT:	SPA1752(hpaC)
SEK:	SSPA1628
SPQ:	SPAB_02455
SEI:	SPC_2652(hpaC)
SEC:	SCH_1048(hpaC)
SEH:	SeHA_C1208(hpaC)
SHB:	SU5_01729
SENH:	CFSAN002069_03530(hpaC)
SEEH:	SEEH1578_14715(hpaC)
SEE:	SNSL254_A1193(hpaC)
SENN:	SN31241_21650
SEW:	SeSA_A1162(hpaC)
SEA:	SeAg_B1057(hpaC)
SENS:	Q786_04905(hpaC)
SED:	SeD_A1173(hpaC)
SEG:	SG0987(hpaC)
SEL:	SPUL_1959(hpaC)
SEGA:	SPUCDC_1945(hpaC)
SET:	SEN0962(hpaC)
SENA:	AU38_04965(hpaC)
SENO:	AU37_04955(hpaC)
SENV:	AU39_04955(hpaC)
SENQ:	AU40_05570
SENL:	IY59_05055(hpaC)
SENJ:	CFSAN001992_06155(hpaC)
SEEC:	CFSAN002050_11885(hpaC)
SEEB:	SEEB0189_014080(hpaC)
SEEP:	I137_08905(hpaC)
SENB:	BN855_10530(hpaC)
SENE:	IA1_05405(hpaC)
SENC:	SEET0819_12150(hpaC)
SES:	SARI_01905
SBG:	SBG_0944(hpaC)
SBZ:	A464_1037
SFL:	SF4373(hpaC)
SFX:	S4643(hpaC)
SFV:	SFV_4374(hpaC)
SFE:	SFxv_4767
SFN:	SFy_6274
SFS:	SFyv_6345
SFT:	NCTC1_04749(hpaC)
SSN:	SSON_4488(hpaC)
SBO:	SBO_4403(hpaC)
SBC:	SbBS512_E4881(hpaC)
SHQ:	A0259_03500(hpaC)
ENC:	ECL_00749(hpaC)
ENO:	ECENHK_03090
ECLO:	ENC_44630
EEC:	EcWSU1_00546(hpaC)
ENL:	A3UG_02995
ECLG:	EC036_05860
ECLE:	ECNIH2_03895(hpaC)
ECLN:	ECNIH4_19905(hpaC)
ECLI:	ECNIH5_03020(hpaC)
ECLX:	LI66_03015(hpaC)
ECLY:	LI62_03485(hpaC)
ECLZ:	LI64_02990(hpaC)
ECLA:	ECNIH3_03020(hpaC)
ECLC:	ECR091_03000(hpaC)
ESC:	Entcl_3806
KLE:	AO703_02885(hpaC)
EAS:	Entas_0527
EAU:	DI57_15625(hpaC)
EHM:	AB284_21990(hpaC)
EKB:	BFV64_02635
ELG:	BH714_17620
EXF:	BFV63_02970
ECLS:	LI67_003950(hpaC)
ENX:	NI40_002860(hpaC)
KPN:	KPN_04779(hpaC)
KPU:	KP1_0733(hpaC)
KPM:	KPHS_06250
KPP:	A79E_4373
KPK:	A593_13950(hpaC)
KPH:	KPNIH24_03220(hpaC)
KPZ:	KPNIH27_03095(hpaC)
KPV:	KPNIH29_03410(hpaC)
KPW:	KPNIH30_03370(hpaC)
KPY:	KPNIH31_04695(hpaC)
KPG:	KPNIH32_03375(hpaC)
KPC:	KPNIH10_03200(hpaC)
KPQ:	KPR0928_03210(hpaC)
KPT:	VK055_2660(hpaC)
KPE:	KPK_4841(hpaC)
KPO:	KPN2242_02030(hpaC)
KPR:	KPR_0856(hpaC)
KPJ:	N559_4517
KPI:	D364_24350(hpaC)
KPA:	KPNJ1_04833
KPS:	KPNJ2_04781
KPX:	PMK1_02238(hpaC)
KPB:	FH42_20415(hpaC)
KPNE:	KU54_023375(hpaC)
KPNU:	LI86_23215(hpaC)
KVA:	Kvar_4473
KVD:	KR75_11400
KVQ:	SP68_18035
KOX:	KOX_10010(hpaC)
KOE:	A225_0704
KOY:	J415_27725(hpaC)
KOK:	KONIH1_03735(hpaC)
KOC:	AB185_32455(hpaC)
KOM:	HR38_08735(hpaC)
KQU:	AVR78_07745
EAE:	EAE_10310(hpaC)
EAR:	CCG31933
CBRA:	A6J81_18500
EBT:	EBL_c34050(hpaC)
ROR:	RORB6_15570(hpaC)
RON:	TE10_05450(hpaC)
PGE:	LG71_25565(hpaC)
KGO:	CEW81_19470(hpaC)
LAX:	APT61_19370(hpaC)
EBF:	D782_3928
YPE:	YPO1770(hpaC)
YPK:	y2538
YPA:	YPA_1142
YPN:	YPN_2353
YPM:	YP_1623(hpaC)
YPP:	YPDSF_1353
YPG:	YpAngola_A1639(hpaC)
YPZ:	YPZ3_1948(hpaC)
YPT:	A1122_17015
YPD:	YPD4_1568(hpaC)
YPX:	YPD8_1986(hpaC)
YPH:	YPC_2511(hpaC)
YPW:	CH59_3397(hpaC)
YPJ:	CH55_907(hpaC)
YPV:	BZ15_1779(hpaC)
YPL:	CH46_3353(hpaC)
YPS:	YPTB1646(hpaC)
YPO:	BZ17_856(hpaC)
YPI:	YpsIP31758_2356(hpaC)
YPY:	YPK_2452
YPB:	YPTS_1770
YPQ:	DJ40_577(hpaC)
YPU:	BZ21_996(hpaC)
YPR:	BZ20_329(hpaC)
YPC:	BZ23_1274(hpaC)
YPF:	BZ19_1073(hpaC)
SPE:	Spro_0635
SRR:	SerAS9_0571
SRL:	SOD_c05030(hpaC)
SRY:	M621_02655(hpaC)
SPLY:	Q5A_002645(hpaC)
SRS:	SerAS12_0571
SRA:	SerAS13_0571
SMAF:	D781_0579
SMW:	SMWW4_v1c05910(rutF)
SMAR:	SM39_4968(hpaC)
SMAC:	SMDB11_4711(hpaC)
SLQ:	M495_02520(hpaC)
SERF:	L085_01145
SERS:	SERRSCBI_02795
SRZ:	AXX16_4528
SFO:	Z042_16845(hpaC)
PLU:	plu0974(hpaC)
PAY:	PAU_00909(hpaC)
PTT:	VY86_13815(hpaC)
PMR:	PMI0246(hpaC)
PMIB:	BB2000_0397(hpaC)
PVL:	AOB99_03995(hpaC)
XBO:	XBJ1_3599(ycdH)
XBV:	XBW1_1453(hpaC)
XNE:	XNC1_0810(ycdH)
XNM:	XNC2_0796(ycdH)
XDO:	XDD1_1012(hpaC)
XHO:	A9255_20560
PSI:	S70_06525
PSX:	DR96_1963(hpaC)
PSTA:	BGK56_09565
PRG:	RB151_008020(hpaC)
MMK:	MU9_1190
HAV:	AT03_16965(hpaC)
OPO:	DSM2777_08260(hpaC)
HDU:	HD_0987(hpaC)
PMU:	PM1522
PMV:	PMCN06_1789(hpaC)
PUL:	NT08PM_1849
PMP:	Pmu_17890(hpaC)
PMUL:	DR93_371(hpaC)
MHT:	D648_19650
MHQ:	D650_6580
MHAT:	B824_19600
MHX:	MHH_c28120(hpaC)
MHAE:	F382_04765(hpaC)
MHAM:	J450_03765(hpaC)
MHAO:	J451_05010(hpaC)
MHAL:	N220_10895(hpaC)
MHAQ:	WC39_03320(hpaC)
MHAY:	VK67_03320(hpaC)
MVR:	X781_6410
MVI:	X808_16120
MVG:	X874_15050
MVE:	X875_4960
APL:	APL_1349(hpaC)
APJ:	APJL_1367(hpaC)
APA:	APP7_1401(hpaC)
ASI:	ASU2_11060
ASS:	ASU1_11085
AEU:	ACEE_11280(hpaC)
GAN:	UMN179_01465
BTO:	WQG_18690
BTRE:	F542_3890
BTRH:	F543_4540
BTRA:	F544_18490
VVY:	VV1574
VNI:	VIBNI_B1951(hpaC)
VMI:	AL543_16395
PAE:	PA4092(hpaC)
PAEV:	N297_4222(hpaC)
PAEI:	N296_4222(hpaC)
PAU:	PA14_10990(hpaC)
PAP:	PSPA7_1006(hpaC)
PAG:	PLES_08841(hpaC)
PAF:	PAM18_0848(hpaC)
PNC:	NCGM2_5293(hpaC)
PAEB:	NCGM1900_0868(hpaC)
PDK:	PADK2_03865
PSG:	G655_04220
PRP:	M062_21580
PAEP:	PA1S_04370
PAER:	PA1R_gp1981
PAEM:	U769_04380
PAEL:	T223_04320
PAES:	SCV20265_0880
PAEU:	BN889_04542(hpaC)
PAEG:	AI22_29245(hpaC)
PAEC:	M802_4220(hpaC)
PAEO:	M801_4088(hpaC)
PCQ:	PcP3B5_30280(hpaC)
PFL:	PFL_3357(hpaC)
PPRC:	PFLCHA0_c33870(hpaC)
PPRO:	PPC_3381(hpaC)
PPZ:	H045_09015
PCH:	EY04_16660
PCZ:	PCL1606_27170
PCP:	JM49_14080
PSEM:	TO66_17315
PSOS:	POS17_3334(hpaC)
CJA:	CJA_1958
NMA:	NMA0614
NME:	NMB1842
NMP:	NMBB_2105
NMH:	NMBH4476_1786(hpaC)
NMC:	NMC0375
NMN:	NMCC_0380
NMT:	NMV_2032
NMI:	NMO_0320
NMD:	NMBG2136_0375(hpaC)
NMM:	NMBM01240149_0343(hpaC)
NMS:	NMBM01240355_1776(hpaC)
NMQ:	NMBM04240196_1783(hpaC)
NMW:	NMAA_0302
NMZ:	NMBNZ0533_0480(hpaC)
NMX:	NMA510612_0679
NGO:	NGO_0059
NGK:	NGK_0083
NLA:	NLA_17890
NEL:	NELON_00345
NWE:	SAMEA3174300_1574(hpaC)
SALV:	SALWKB2_1950
KKI:	KKKWG1_0413(hpaC)
REU:	Reut_A1584 Reut_B5770
BTE:	BTH_II0316(hpaC)
BTQ:	BTQ_3610(hpaC)
BTJ:	BTJ_4646(hpaC)
BTZ:	BTL_5434(hpaC)
BTV:	BTHA_4769(hpaC)
BTHE:	BTN_5104(hpaC)
BTHM:	BTRA_5373(hpaC)
BTHA:	DR62_5234
BTHL:	BG87_5440(hpaC)
BOK:	DM82_6338(hpaC)
BOC:	BG90_4336(hpaC)
BUR:	Bcep18194_B2506
BCH:	Bcen2424_3609
BCM:	Bcenmc03_3911
BCJ:	BCAM0638
BCEN:	DM39_4519(hpaC) DM39_4923
BCEW:	DM40_5612
BCEO:	I35_4534 I35_5997(hpaC)
BAM:	Bamb_5345
BAC:	BamMC406_3515
BMU:	Bmul_5076 Bmul_5089
BMK:	DM80_4251 DM80_4266(hpaC)
BMUL:	NP80_3634(hpaC) NP80_3647
BCED:	DM42_4452(hpaC)
BCEP:	APZ15_21270
BPYR:	ABD05_18680
BCON:	NL30_22660
BLAT:	WK25_18270
BTEI:	WS51_01665 WS51_01730
BSEM:	WJ12_23160
BPSL:	WS57_10735 WS57_12535
BMEC:	WJ16_22180
BGL:	bglu_2g00870 bglu_2g17480
BGP:	BGL_2c23400(hpaC)
BGU:	KS03_3551(hpaC) KS03_4181
BGE:	BC1002_5130
BGF:	BC1003_3889
BGD:	bgla_1g15200 bgla_2g22850
BGO:	BM43_5956
BYI:	BYI23_A013770 BYI23_B005870
BUO:	BRPE64_BCDS07610
BUE:	BRPE67_ACDS14190 BRPE67_BCDS08150
BUQ:	AC233_26780
BPLA:	bpln_2g23680
BXE:	Bxe_B2309
BXB:	DR64_4641(hpaC)
BPY:	Bphyt_2167
BFN:	OI25_3713(hpaC)
BCAI:	K788_0003934 K788_0005053
PSPU:	NA29_23280
HSE:	Hsero_1338
HSZ:	ACP92_06700 ACP92_07435
HRB:	Hrubri_1149
DAR:	Daro_0903
AZO:	azo1943(hpaC)
MXA:	MXAN_4827
MFU:	LILAB_32095
MYM:	A176_002062
CCX:	COCOR_03296(ycdH)
BJA:	blr7290(hpaC)
RSP:	RSP_3957
HAT:	RC74_11675
NFA:	NFA_28410
NFR:	ERS450000_01248(hpaC)
RHA:	RHA1_ro02847(hpaC)
ROP:	ROP_25720(hpaC)
ROA:	Pd630_LPD07010
SBH:	SBI_09695
SRC:	M271_01535 M271_04295
AOI:	AORI_4210(hpaC)
AJA:	AJAP_17860
ALU:	BB31_31540
TTH:	TT_C0595
TTJ:	TTHA0961
TTS:	Ththe16_0957
TTL:	TtJL18_1091
TSC:	TSC_c10460
THC:	TCCBUS3UF1_12420
TOS:	Theos_0973
TAQ:	TO73_1001
TPAR:	AV541_05905
TBC:	A0O31_00118
MRB:	Mrub_1331
MRE:	K649_06310
MSV:	Mesil_2313
MHD:	Marky_1265

» show all

Reference

PMID:10633095

Authors

Galan B, Diaz E, Prieto MA, Garcia JL

Title

Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily.

Journal

J Bacteriol 182:627-36 (2000)
DOI:10.1128/JB.182.3.627-636.2000

Sequence

[elw:ECW_m4704]

LinkDB

ORTHOLOGY: K16901

Entry

K16901 KO

Name

K16901

Definition

anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]

Pathway

ko00350	Tyrosine metabolism
ko00380	Tryptophan metabolism
ko01220	Degradation of aromatic compounds

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
  Amino acid metabolism
   00350 Tyrosine metabolism
    K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
   00380 Tryptophan metabolism
    K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.8  anthranilate 3-monooxygenase (FAD)
     K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
    1.14.14.9  4-hydroxyphenylacetate 3-monooxygenase
     K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase

Other DBs

RN:

R02698 R03299 R09517

GO:

0052881

Genes

BCA:	BCE_2148
BCX:	BCA_2146
BCF:	bcf_10170
BCER:	BCK_24265
BCEF:	BcrFT9_01682
BTL:	BALH_1835
BMYC:	DJ92_4629
BMQ:	BMQ_3596(hpaB)
BMD:	BMD_3581(hpaB)
GST:	HW35_13010
GTN:	GTNG_3160
BBE:	BBR47_29710
PDX:	Psed_0216

» show all

Reference

PMID:19942660

Authors

Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L

Title

Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.

Journal

Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0

Sequence

[gtn:GTNG_3160]

LinkDB

ENZYME: 1.14.14.9

Entry

EC 1.14.14.9 Enzyme

Name

4-hydroxyphenylacetate 3-monooxygenase;
p-hydroxyphenylacetate 3-hydroxylase;
4-hydroxyphenylacetic acid-3-hydroxylase;
p-hydroxyphenylacetate hydroxylase (FAD);
4 HPA 3-hydroxylase;
p-hydroxyphenylacetate 3-hydroxylase (FAD);
HpaB

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

4-hydroxyphenylacetate,FADH2:oxygen oxidoreductase (3-hydroxylating)

Reaction(IUBMB)

4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O

Reaction(KEGG)

(other) R02698 R03299

Substrate

4-hydroxyphenylacetate [CPD:C00642];
FADH2 [CPD:C01352];
O2 [CPD:C00007]

Product

3,4-dihydroxyphenylacetate [CPD:C01161];
FAD [CPD:C00016];
H2O [CPD:C00001]

Comment

The enzyme from Escherichia coli attacks a broad spectrum of phenolic compounds. The enzyme uses FADH2 as a substrate rather than a cofactor [4]. FADH2 is provided by EC 1.5.1.36, flavin reductase (NADH) [5,6].

History

EC 1.14.14.9 created 1972 as EC 1.14.13.3, transferred 2011 to EC 1.14.14.9

Pathway

ec00350	Tyrosine metabolism
ec01120	Microbial metabolism in diverse environments

Orthology

K00483	4-hydroxyphenylacetate 3-monooxygenase
K16901	anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase

Genes

PPP:	PHYPADRAFT_103859
EOJ:	ECO26_5549(hpaB)
EOI:	ECO111_5206(hpaB)
EOH:	ECO103_5128(hpaB)
ECX:	EcHS_A4576(hpaB)
ECY:	ECSE_4621
ECR:	ECIAI1_4567(hpaB)
EUM:	ECUMN_4966(hpaB)
ECL:	EcolC_3710
EBR:	ECB_04222(hpaB)
EBD:	ECBD_3674
EKO:	EKO11_3968
EKF:	KO11_23365(hpaB)
ELW:	ECW_m4705(hpaB)
ELL:	WFL_22920(hpaB)
EBL:	ECD_04222(hpaB)
EBE:	B21_04188(hpaB)
ECOA:	APECO78_02880
ECOL:	LY180_22800
ECOO:	ECRM13514_5600
ECOH:	ECRM13516_5313
EFE:	EFER_3070(hpaB)
STY:	STY1131(hpaB)
STT:	t1820(hpaB)
SEX:	STBHUCCB_19360
SENT:	TY21A_09265
STM:	STM1099(hpaB)
SEO:	STM14_1247(hpaB)
SEV:	STMMW_11091
SEY:	SL1344_1038(hpaB)
SEM:	STMDT12_C11180
SEJ:	STMUK_1068(hpaB)
SEB:	STM474_1091(hpaB)
SEF:	UMN798_1140(hpaB)
SETU:	STU288_01825
SETC:	CFSAN001921_11680
SENR:	STMDT2_10351(hpaB)
SEND:	DT104_10811(hpaB)
SENI:	CY43_05615
SEEN:	SE451236_11345
SPT:	SPA1751(hpaB)
SEK:	SSPA1627
SPQ:	SPAB_02454
SEI:	SPC_2651(hpaB)
SEC:	SCH_1049(hpaB)
SEH:	SeHA_C1209(hpaB)
SHB:	SU5_01730
SENH:	CFSAN002069_03525
SEEH:	SEEH1578_14720
SEE:	SNSL254_A1194(hpaB)
SENN:	SN31241_21660
SEW:	SeSA_A1163(hpaB)
SEA:	SeAg_B1058(hpaB)
SENS:	Q786_04910
SED:	SeD_A1174(hpaB)
SEG:	SG0988(hpaB)
SEL:	SPUL_1958(hpaB)
SEGA:	SPUCDC_1944(hpaB)
SET:	SEN0963(hpaB)
SENA:	AU38_04970
SENO:	AU37_04960
SENV:	AU39_04960
SENQ:	AU40_05575
SENL:	IY59_05060
SENJ:	CFSAN001992_06150
SEEC:	CFSAN002050_11890
SEEB:	SEEB0189_014075
SEEP:	I137_08900
SENB:	BN855_10540
SENE:	IA1_05410
SENC:	SEET0819_12155
SES:	SARI_01904
SBG:	SBG_0945(hpaB)
SBZ:	A464_1038
SBV:	N643_04505
SFN:	SFy_6275 SFy_6277
SFS:	SFyv_6346 SFyv_6348
SFT:	NCTC1_04750(hpaB_1) NCTC1_04751(hpaB_2)
SSN:	SSON_4489(hpaB)
SBO:	SBO_4404(hpaB)
SBC:	SbBS512_E4882(hpaB)
SHQ:	A0259_03505
ENC:	ECL_00750(hpaB)
ENO:	ECENHK_03095
ECLO:	ENC_44640
EEC:	EcWSU1_00548(hpaB)
ENL:	A3UG_03000
ECLG:	EC036_05870
ECLE:	ECNIH2_03900
ECLN:	ECNIH4_19900
ECLI:	ECNIH5_03025
ECLX:	LI66_03020
ECLY:	LI62_03490
ECLZ:	LI64_02995
ECLA:	ECNIH3_03025
ECLC:	ECR091_03005
ESC:	Entcl_3805
KLE:	AO703_02890
EAS:	Entas_0528
EAU:	DI57_15620
EHM:	AB284_21985
EKB:	BFV64_02640
ELG:	BH714_17625
EXF:	BFV63_02975
ECLS:	LI67_003955
ENX:	NI40_002865
KPN:	KPN_04780(hpaB)
KPU:	KP1_0734(hpaB)
KPM:	KPHS_06260
KPP:	A79E_4372
KPK:	A593_13955
KPH:	KPNIH24_03225
KPZ:	KPNIH27_03100
KPV:	KPNIH29_03415
KPW:	KPNIH30_03375
KPY:	KPNIH31_04690
KPG:	KPNIH32_03380
KPC:	KPNIH10_03205
KPQ:	KPR0928_03215
KPT:	VK055_2659(hpaB)
KPO:	KPN2242_02035
KPR:	KPR_0857 KPR_0858
KPJ:	N559_4516
KPI:	D364_24355
KPA:	KPNJ1_04832
KPS:	KPNJ2_04780
KPX:	PMK1_02239(hpaB)
KPB:	FH42_20420
KPNE:	KU54_023370
KPNU:	LI86_23210
KVA:	Kvar_4472
KVD:	KR75_11405
KVQ:	SP68_18040
KOX:	KOX_10015
KOE:	A225_0705
KOY:	J415_27720
KOK:	KONIH1_03740
KOC:	AB185_20685 AB185_32450
KOM:	HR38_08740
KQU:	AVR78_07750
EAE:	EAE_10315
EAR:	CCG31932
CBRA:	A6J81_18505
EBT:	EBL_c34040(hpaB)
ROR:	RORB6_15565
RON:	TE10_05455
CED:	LH89_16320
PGE:	LG71_25560
LAX:	APT61_19365
EBF:	D782_3927
YPE:	YPO1769(hpaB)
YPK:	y2539(hpaB)
YPA:	YPA_1141
YPN:	YPN_2354
YPM:	YP_1624(hpaB)
YPP:	YPDSF_1354
YPG:	YpAngola_A1640(hpaB)
YPZ:	YPZ3_1949(hpaB)
YPT:	A1122_17020
YPD:	YPD4_1567(hpaB)
YPX:	YPD8_1987(hpaB)
YPH:	YPC_2512(hpaB)
YPW:	CH59_3398(hpaB)
YPJ:	CH55_908(hpaB)
YPV:	BZ15_1780(hpaB)
YPL:	CH46_3354(hpaB)
YPS:	YPTB1645(hpaB)
YPO:	BZ17_857(hpaB)
YPI:	YpsIP31758_2357(hpaB)
YPY:	YPK_2453
YPB:	YPTS_1769
YPQ:	DJ40_578(hpaB)
YPU:	BZ21_995(hpaB)
YPR:	BZ20_330(hpaB)
YPC:	BZ23_1273(hpaB)
YPF:	BZ19_1072(hpaB)
SPE:	Spro_0634
SRR:	SerAS9_0570
SRL:	SOD_c05020(hpaB)
SRY:	M621_02650
SPLY:	Q5A_002640(hpaB)
SRS:	SerAS12_0570
SRA:	SerAS13_0570
SMAF:	D781_0578
SMW:	SMWW4_v1c05900
SMAR:	SM39_4967(hpaB)
SMAC:	SMDB11_4710(hpaB)
SLQ:	M495_02515
SERF:	L085_01150
SERS:	SERRSCBI_02790
SRZ:	AXX16_4529
SFO:	Z042_16840
PCV:	BCS7_01655
DZE:	Dd1591_0652
PLU:	plu0246 plu0975(hpaB) plu4027 plu4258
PAY:	PAU_00189(hpaB) PAU_00478 PAU_00910(hpaB)
PTT:	VY86_09160 VY86_13810
XBO:	XBJ1_3600
XBV:	XBW1_1452(hpaB) XBW1_4467
XNE:	XNC1_0446 XNC1_0449 XNC1_0811
XNM:	XNC2_0437 XNC2_0439 XNC2_0797
XDO:	XDD1_0415 XDD1_1013(hpaB)
XHO:	A9255_13900 A9255_13930 A9255_20565
PSI:	S70_06520
PSX:	DR96_1964(hpaB)
PSTA:	BGK56_09560
PRG:	RB151_008030(hpaB)
HAV:	AT03_16960
PMU:	PM1523
PMV:	PMCN06_1790(hpaB)
PUL:	NT08PM_1850
PMP:	Pmu_17900(hpaB)
PMUL:	DR93_372(hpaB)
PAE:	PA4091(hpaA)
PAEV:	N297_4221(hpaB)
PAEI:	N296_4221(hpaB)
PAU:	PA14_11000(hpaA)
PAP:	PSPA7_1007(hpaB)
PAG:	PLES_08851(hpaA)
PAF:	PAM18_0849(hpaA)
PNC:	NCGM2_5292(hpaA)
PAEB:	NCGM1900_0869(hpaA)
PDK:	PADK2_03870
PSG:	G655_04225
PRP:	M062_21575
PAEP:	PA1S_04375
PAER:	PA1R_gp1980
PAEM:	U769_04385
PAEL:	T223_04325
PAES:	SCV20265_0881
PAEU:	BN889_04541(hpaB)
PAEG:	AI22_29240
PAEC:	M802_4219(hpaB)
PAEO:	M801_4087(hpaB)
PFL:	PFL_3356(hpaB)
PPRC:	PFLCHA0_c33860(hpaB)
PPRO:	PPC_3380(hpaB)
PCH:	EY04_16655 EY04_26305
PCZ:	PCL1606_27180
PCP:	JM49_05440 JM49_14085
PSEM:	TO66_17310
PSOS:	POS17_3333(hpaB)
SWD:	Swoo_2019
CPS:	CPS_2047
CZA:	CYCME_2117(hpaB)
HAA:	A5892_03490
GBI:	PG2T_01205 PG2T_12225
RPJ:	N234_22415 N234_22475 N234_29420
REU:	Reut_A1585 Reut_C6314
REH:	H16_B0496(h16_B0496)
CNC:	CNE_2c04450(hpaH) CNE_BB1p03440(tcpA)
BUR:	Bcep18194_B2410
BCN:	Bcen_4663
BCH:	Bcen2424_3700
BCM:	Bcenmc03_3821
BCJ:	BCAM0734
BCEN:	DM39_4430
BCEO:	I35_4633
BCT:	GEM_5625
BCED:	DM42_4353
BCEP:	APZ15_20730
BCON:	NL30_22200
BLAT:	WK25_13940
BSEM:	WJ12_23670
BPSL:	WS57_10300
BMEC:	WJ16_22580
BYI:	BYI23_C002090 BYI23_C002900
BUE:	BRPE67_CCDS09320 BRPE67_CCDS10130
PPK:	U875_16245
PPNO:	DA70_08135
PPNM:	LV28_22445
PRB:	X636_18135
PPUL:	RO07_16865
PAPI:	SG18_15675
DAC:	Daci_3024
DEL:	DelCs14_3704
DTS:	BI380_08205
DHK:	BO996_13935
RBU:	PG1C_06920
MSD:	MYSTI_04802
SCU:	SCE1572_13565
DBR:	Deba_1051
MCI:	Mesci_0674
MOP:	Mesop_0688
MAMO:	A6B35_09760
MESW:	A9K65_003390
MES:	Meso_2465
AAK:	AA2016_5887
PLA:	Plav_1785
RHI:	NGR_b20090(hpaB)
SFH:	SFHH103_05222(hpaB)
SIX:	BSY16_2360 BSY16_3678 BSY16_4601
EAD:	OV14_a0070(hpaB)
EAH:	FA04_27315
RLT:	Rleg2_4429
RTR:	RTCIAT899_PC03915
SHZ:	shn_16275
XAU:	Xaut_0377 Xaut_2574
AZC:	AZC_4189
SNO:	Snov_2630
CHEL:	AL346_04825
HMC:	HYPMC_0261
DEQ:	XM25_03690(pvcC)
RHZ:	RHPLAN_16150 RHPLAN_17100 RHPLAN_22700 RHPLAN_32460 RHPLAN_51690 RHPLAN_54270 RHPLAN_62260
PSIN:	CAK95_10695 CAK95_16885 CAK95_27280
RHP:	LPB142_07400
PAMI:	JCM7686_pAMI6p015
PYE:	A6J80_01470
PTP:	RCA23_c29330(hpaH)
CON:	TQ29_11625 TQ29_16040
LAP:	ACP90_16480
LAGG:	B0E33_28320
DAA:	AKL17_0233 AKL17_3242 AKL17_3250
SSY:	SLG_11330
GXL:	H845_1141
KEU:	S101446_00275(hpaB)
ASZ:	ASN_1362(hpaB)
AACE:	A0U92_02580
APB:	SAR116_0256
BSU:	BSU18620(yoaI)
BSR:	I33_2090(hpaB)
BSL:	A7A1_2448
BSH:	BSU6051_18620(yoaI)
BSY:	I653_09690
BSUT:	BSUB_02002(yoaI)
BSUL:	BSUA_02002(yoaI)
BSUS:	Q433_11010
BSS:	BSUW23_09940(yoaI)
BST:	GYO_2242(hpaB)
BSN:	BSn5_00675
BSQ:	B657_18620(yoaI)
BSX:	C663_1926
BSP:	U712_09805
BAY:	RBAM_002630(yoaI)
BAQ:	BACAU_0205(yoaI)
BYA:	BANAU_0209(yoaI)
BAMP:	B938_01060
BAML:	BAM5036_0217(yoaI)
BAMA:	RBAU_0233(yoaI)
BAMN:	BASU_0220(yoaI)
BAMB:	BAPNAU_0209(yoaI)
BAMT:	AJ82_01435
BAMY:	V529_02230
BMP:	NG74_00247
BAO:	BAMF_0207(yoaI)
BAZ:	BAMTA208_01065(yoaI)
BQL:	LL3_00211(yoaI)
BXH:	BAXH7_00218
BQY:	MUS_0220(yoaI)
BAMI:	KSO_018345
BAMC:	U471_02150
BAMF:	U722_01355
BHA:	BH3836
BCA:	BCE_2148 BCE_2601
BCB:	BCB4264_A2558
BCX:	BCA_2146
BCF:	bcf_10170
BCER:	BCK_24265
BCEF:	BcrFT9_01682 BcrFT9_02035
BCY:	Bcer98_0966
BTL:	BALH_1835
BTB:	BMB171_C2288
BTT:	HD73_3423 HD73_3424
BTHR:	YBT1520_16870
BTHI:	BTK_16895
BTC:	CT43_CH2513
BTF:	YBT020_12875 YBT020_29196
BTG:	BTB_c26350
BTHT:	H175_ch2554
BTHU:	YBT1518_14235 YBT1518_14245
BTHY:	AQ980_14115
BMYC:	DJ92_4629
BCL:	ABC0890
BMQ:	BMQ_2417(hpaB) BMQ_3596(hpaB)
BMD:	BMD_2382(hpaB) BMD_3581(hpaB)
BMH:	BMWSH_2819(pvcC)
BMEG:	BG04_4791(hpaB)
BCO:	Bcell_2010
BJS:	MY9_2034
BACI:	B1NLA3E_10730 B1NLA3E_17945 B1NLA3E_17950
BIF:	N288_24560
BLE:	BleG1_3140
GST:	HW35_13010
BACP:	SB24_08490
BACB:	OY17_04010
BBY:	CY96_11695
BACO:	OXB_2499 OXB_2686 OXB_3446 OXB_3454
BACY:	QF06_08435
BACL:	BS34A_20630(yoaI)
BALM:	BsLM_1985
BEO:	BEH_04630 BEH_12545
BSM:	BSM4216_0733 BSM4216_2177
BSJ:	UP17_15195 UP17_22410
BGY:	BGLY_3123
BGI:	BGM20_03880
BWH:	A9C19_03240
BHK:	B4U37_04110
OIH:	OB2872
GKA:	GK2138 GK3034
GTE:	GTCCBUS3UF5_24190 GTCCBUS3UF5_33960
GTK:	GT3570_10150 GT3570_14800
GTN:	GTNG_2992(hpaB) GTNG_3160
GYC:	GYMC61_3113
GYA:	GYMC52_3140
GCT:	GC56T3_0470
GMC:	GY4MC1_0462 GY4MC1_1588
GGH:	GHH_c22230(yoaI) GHH_c31080(hpaB)
GJF:	M493_12230 M493_15810 M493_17955
GSE:	GT50_06875
GSR:	GS3922_06215
GTH:	Geoth_0530 Geoth_1671
PTL:	AOT13_00545 AOT13_14480
ANM:	GFC28_1574(hpaB) GFC28_3725(hpaB)
AAMY:	GFC30_1755(hpaB)
ANL:	GFC29_1708(hpaB) GFC29_54(hpaB)
LSP:	Bsph_3875(pvcC)
LGY:	T479_15720 T479_19670
LFU:	HR49_07505
HHD:	HBHAL_2383(hpaB) HBHAL_3970(yoaI)
HMN:	HM131_07195 HM131_18375
TAP:	GZ22_02140
VIR:	X953_15535
VHL:	BME96_15020
VIG:	BKP57_18425
FPN:	ABE65_007020 ABE65_019825
FAR:	ABE41_002760 ABE41_008075
BBE:	BBR47_29710
GYM:	GYMC10_2686
PMS:	KNP414_04955
PMQ:	PM3016_4358
PMW:	B2K_22570
PLV:	ERIC2_c16720(hpaB)
PBD:	PBOR_19255
PAEF:	R50345_13370
PAEJ:	H70737_12745
PBJ:	VN24_08080 VN24_09465 VN24_09470 VN24_23030 VN24_23040
PIH:	UB51_09320
PRI:	PRIO_3489
PNP:	IJ22_02430 IJ22_35230 IJ22_35330 IJ22_36190 IJ22_40300 IJ22_40320 IJ22_47340 IJ22_47350
POW:	IJ21_24840 IJ21_24850
PXL:	BS614_17050 BS614_22065
ANX:	ACH33_14090
AAC:	Aaci_0339
AAD:	TC41_0460(hpaB)
BTS:	Btus_1571 Btus_2072
SIV:	SSIL_0564(yoaI)
SSIL:	SOLI23_15940
SPSY:	AZE41_13970 AZE41_14175
SPOR:	SporoP33_07570
SPOP:	SporoP37_08005
SURE:	SporoP32a_08025
RST:	ATY39_04190
LGR:	LCGT_0012
LGV:	LCGL_0012
LPK:	LACPI_0013
LPL:	lp_0070
LPJ:	JDM1_0079
LPT:	zj316_0284
LPS:	LPST_C0059
LPR:	LBP_cg0058
LPB:	SH83_00305
LPX:	ASU28_03125
LBT:	AYR52_01005
DSY:	DSY4732
TMR:	Tmar_1818
SAY:	TPY_2462(hpaB)
SAP:	Sulac_3216
MVA:	Mvan_3156
MIZ:	BAB75_18985
MMC:	Mmcs_2617
MKM:	Mkms_2661
MJL:	Mjls_2646
MFT:	XA26_16640
MVQ:	MYVA_2937
CII:	CIMIT_11890
CHM:	B842_09825
CTED:	CTEST_09800(nphA1)
NFA:	NFA_20870 NFA_30560 NFA_43650
NFR:	ERS450000_01009(hpaB_1) ERS450000_02023(hpaB_2) ERS450000_05550(hpaB_3)
NBR:	O3I_018985
RHA:	RHA1_ro01782 RHA1_ro02380 RHA1_ro02514(pheA1) RHA1_ro03853 RHA1_ro03872 RHA1_ro08077
RER:	RER_54270
REY:	O5Y_25790 O5Y_28105
REB:	XU06_26125
ROP:	ROP_14550 ROP_20940 ROP_pROB02-01900(hpaB)
ROA:	Pd630_LPD00219 Pd630_LPD05941 Pd630_LPD06576 Pd630_LPD06741
RPY:	Y013_12530 Y013_13560
RAV:	AAT18_08140 AAT18_20190 AAT18_24410
GBR:	Gbro_0220 Gbro_1818
GPO:	GPOL_c17090
SBH:	SBI_01405
SVE:	SVEN_5100
SRC:	M271_03085
SVT:	SVTN_26250
SXI:	SXIM_24760
SPAV:	Spa2297_23925
STSI:	A4E84_01180
SNW:	BBN63_09610
CPHY:	B5808_01110
ART:	Arth_1935 Arth_2569
ARR:	ARUE_c05860(hpaB)
ARI:	UM93_06905
ARH:	AHiyo8_57300 AHiyo8_57310
AAU:	AAur_0618
RSA:	RSal33209_1499
KFV:	AS188_10310
SATK:	SA2016_3710
BCV:	Bcav_0870
LMOI:	VV02_01280 VV02_15335
PSIM:	KR76_24440
FRA:	Francci3_2770
BSD:	BLASA_1435
AOI:	AORI_4289(hpaB)
AJA:	AJAP_17445(hpaH)
AMQ:	AMETH_1856 AMETH_5243
ALU:	BB31_31855
PDX:	Psed_0216 Psed_2227 Psed_2279 Psed_3087 Psed_6066
PSEA:	WY02_09470
PSEE:	FRP1_25220
PSEH:	XF36_28690
PSEQ:	AD006_04400
PECQ:	AD017_12220
PHH:	AFB00_29310
SESP:	BN6_55630 BN6_58660(sam5)
KPHY:	AOZ06_39990
LED:	BBK82_43835
ACTI:	UA75_20985
ACAD:	UA74_20490
RXY:	Rxyl_1857
CWO:	Cwoe_4365
CYJ:	Cyan7822_6021
RRS:	RoseRS_2569
RCA:	Rcas_2414
CAU:	Caur_1347
CAG:	Cagg_2030
CHL:	Chy400_1469
TRO:	trd_1395 trd_A0929 trd_A0931
STI:	Sthe_2805
CAP:	CLDAP_41000
DRA:	DR_A0223
DGE:	Dgeo_2418
DDR:	Deide_2p00060
DMR:	Deima_0220 Deima_1883
DPT:	Deipr_2619
DGO:	DGo_CA0562
DPD:	Deipe_0884
TRA:	Trad_1888
TTH:	TT_C0594
TTJ:	TTHA0960 TTHB249
TTS:	Ththe16_0956
TTL:	TtJL18_1092
TSC:	TSC_c10450(hpaB)
THC:	TCCBUS3UF1_12430
TOS:	Theos_0972
TAQ:	TO73_1002
TPAR:	AV541_05910
TBC:	A0O31_00119
MRB:	Mrub_1332
MRE:	K649_06315
MSV:	Mesil_2312
MHD:	Marky_1264
AFU:	AF_0885 AF_1027
AFG:	AFULGI_00009740
FPL:	Ferp_0911
GAC:	GACE_0594
HDL:	HALDL1_15845
SSO:	SSO2053(hpaA)
STO:	STK_07260(pheA1)
SAI:	Saci_2294(hpaA)
SACN:	SacN8_11190
SACR:	SacRon12I_11430
SACS:	SUSAZ_10780
SIS:	LS215_0936
SIA:	M1425_0686
SIM:	M1627_0691
SID:	M164_0713
SIY:	YG5714_1009
SIN:	YN1551_1864
SII:	LD85_0739
SIH:	SiH_0629
SIR:	SiRe_0706
SIC:	SiL_0742
SULA:	BFU36_08220
MSE:	Msed_0996 Msed_1776
MCN:	Mcup_0455 Mcup_1186
AMAN:	B6F84_05385
POG:	Pogu_1357

» show all

Reference

1 [PMID:14263147]

Authors

ADACHI K, TAKEDA Y, SENOH S, KITA H.

Title

METABOLISM OF P-HYDROXYPHENYLACETIC ACID IN PSEUDOMONAS OVALIS.

Journal

Biochim. Biophys. Acta. 93 (1964) 483-93.

Reference

2 [PMID:8458860]

Authors

Prieto MA, Perez-Aranda A, Garcia JL

Title

Characterization of an Escherichia coli aromatic hydroxylase with a broad substrate range.

Journal

J. Bacteriol. 175 (1993) 2162-7.

Reference

3 [PMID:8077235]

Authors

Prieto MA, Garcia JL

Title

Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.

Journal

J. Biol. Chem. 269 (1994) 22823-9.

Sequence

[elw:ECW_m4705]

Reference

4 [PMID:10653707]

Authors

Xun L, Sandvik ER

Title

Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase.

Journal

Appl. Environ. Microbiol. 66 (2000) 481-6.

Sequence

[elw:ECW_m4705]

Reference

5 [PMID:10633095]

Authors

Galan B, Diaz E, Prieto MA, Garcia JL

Title

Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily.

Journal

J. Bacteriol. 182 (2000) 627-36.

Reference

6 [PMID:12809507]

Authors

Louie TM, Xie XS, Xun L

Title

Coordinated production and utilization of FADH2 by NAD(P)H-flavin oxidoreductase and 4-hydroxyphenylacetate 3-monooxygenase.

Journal

Biochemistry. 42 (2003) 7509-17.

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.9

IUBMB Enzyme Nomenclature:

1.14.14.9

ExPASy - ENZYME nomenclature database:

1.14.14.9

UM-BBD (Biocatalysis/Biodegradation Database):

1.14.14.9

BRENDA, the Enzyme Database:

1.14.14.9

CAS:

37256-71-6

LinkDB

REACTION: R02698

Entry

R02698 Reaction

Name

4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)

Definition

4-Hydroxyphenylacetate + Oxygen + NADH + H+ <=> 3,4-Dihydroxyphenylacetate + NAD+ + H2O

Equation

C00642 + C00007 + C00004 + C00080 <=> C01161 + C00003 + C00001

Reaction class

RC00001	C00003_C00004
RC00046	C00642_C01161

Enzyme

1.14.14.9

Pathway

rn00350	Tyrosine metabolism
rn01120	Microbial metabolism in diverse environments
rn01220	Degradation of aromatic compounds

Orthology

K00483	4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K00484	flavin reductase (NADH) [EC:1.5.1.36]
K16901	anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]

Other DBs

RHEA:

16684

LinkDB

DBGET integrated database retrieval system