KEGG ORTHOLOGY: K00512

ORTHOLOGY: K00512

Entry

K00512                      KO

Symbol

CYP17A

Name

steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04913

Ovarian steroidogenesis

map04917

Prolactin signaling pathway

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Reaction

R02211

progesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)

R03783

pregnenolone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)

R04852

11beta-hydroxyprogesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)

R04853

20alpha-hydroxycholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)

R08517

17alpha-hydroxypregnenolone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)

R08518

17alpha-hydroxyprogesterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)

R13212

5alpha-pregnane-3,20-dione,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)

R13213

allopregnanolone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)

R13218

5alpha-pregnane-3alpha,17alpha-diol-20-one,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)

Disease

H00216

Congenital adrenal hyperplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04917 Prolactin signaling pathway
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04927 Cortisol synthesis and secretion
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP17 family
   K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase

Other DBs

GO:	0004508 0047442

Genes

HSA:	1586(CYP17A1)

PTR:	450141(CYP17A1)

PPS:	100989182(CYP17A1)

GGO:

PON:

NLE:

HMH:

MCC:	678693(CYP17A1)

MCF:	102133235(CYP17A1)

MTHB:

126962752

MNI:

105478336

CSAB:

103216445(CYP17A1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100400572(CYP17A1)

SBQ:

101048584

CIMI:

108306253(CYP17A1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13074(Cyp17a1)

MCAL:

110285327

MPAH:

110334801

RNO:	25146(Cyp17a1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

101831170(Cyp17a1)

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	477807(CYP17A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	493967(CYP17A1)

PYU:

PCOO:

PBG:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	112444495 281739(CYP17A1)

BOM:	102270241 102270532

BIU:	109553214 109579081

BBUB:

102412624 112581551

BBIS:

105002787

CHX:	102182376 102182663(CYP17A1A)

OAS:	105601846(CYP17) 493968(CYP17A1)

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	403330(CYP17A1)

CFR:

CBAI:

CDK:

VPC:

BACU:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100034232(CYP17A1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:	119234280 119234908 119253889

SARA:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:	425056(CYP17A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PLET:

EHS:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102567971(CYP17A1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:	100553634 100553834

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

HCG:

GJA:

STOW:

EMC:

XLA:	100036774(cyp17a1.L)

XTR:	100145650(cyp17a1)

NPR:	108784547 108784564

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	399692(cyp17a1) 796487(cyp17a2)

SRX:	107707716 107750198

SANH:

107673162 107695149

SGH:	107574436 107588661

CCAR:

109076732 109111078

CAUA:

113041336 113056832 113074379 113085111

CGIB:

127970183 128012018

PTET:

122334561 122356746

LROH:

127161931 127174815

OMC:	131532047 131552199

PPRM:

120479844 120484073 120484098

RKG:	130071743 130072784

MAMB:

125260617 125276970 125276972

CIDE:

127504550 127525002

MASI:

127413875 127418618

TROS:

130545059 130559140

TDW:	130408901 130432033

MANU:

129416856 129431020

IPU:	100313515(cyp17) 108275468

IFU:	128605687 128619575

PHYP:

113530739 113542020

SMEO:

124396975 124398983

TFD:	113636291 113641757

TVC:	132847358 132862061

AMEX:

103036160 111194069

CMAO:

118810050 118822544

EEE:	113570353 113585465

CHAR:

105891434 105911586

TRU:	100125766(cyp17a2) 100125798(cyp17a1) 115249663

TFS:	130522769 130533807

LCO:	104935158 104936651

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117248465 117272651

EFO:	125883749 125904031

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:	100192329(cyp17a2) 100192330(cyp17a1)

PPUG:

119214573 119222944

AFB:	129091901 129093054

CLUM:

PSWI:

MSAM:

SCHU:

CUD:	121504405 121510915

ALAT:

119026703 119033497

MZE:	101475441 101477086

ONL:	100702216(cyp17a2) 100703469(cyp17)

OAU:	116332169 116335890

OLA:	100125816(cyp17) 101170547(cyp17a2)

OML:	112156384 112161529

CSAI:

133452414 133463668

XMA:	102221767 102238057

XCO:	114138338 114157614

XHE:	116712776 116732588 116732589

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122820816 122842871

PPRL:

129355868 129360155 129376685

CVG:	107083007 107099069

CTUL:

119773762 119787729

GMU:	124858740 124881307

NFU:	107375507 107396730

KMR:	108239115 108251556

ALIM:

106511002 106515325

NWH:	119417878 119430866

AOCE:

111563640 111579695

MCEP:

125009171 125018366

CSEM:

103387725 103389439

POV:	109634757 109639880

SSEN:

122766283 122781515

HHIP:

117751868 117775903

HSP:	118102904 118119196

SMAU:

118283790 118320091

LCF:	108892361 108895342

SDU:	111233121 111239202

SLAL:

111661066 111669513

XGL:	120796819 120797261

HCQ:	109516617 109523214

SSCV:

125978579 125992396

SBIA:

133494674 133509358

PEE:	133397560 133409947

PTAO:

BPEC:

MALB:

BSPL:

SJO:	128372655 128384087

SASA:

106576693 106592366

STRU:

115193858 115198019

OTW:	112238453 112252939

OMY:	100137017(cyp17a1) 110509408

OGO:	124013898 124040788

ONE:

115136350

OKI:	109882966 109889877

OKE:	118369634 127906903

SALP:

111951662 112078788

SNH:

120017914

CCLU:

121553719 121559195

ELS:	105006241 105008018

SFM:	108926160 108933747

PKI:	111836781 111859263

AANG:

118218511 118231945

LOC:	102683310 102696373

PSPA:

121321480 121326245

ARUT:

117409034 117415544

PSEX:

120514450

LCM:	102350866 102365866

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133345432 133345701 133346921

BFO:	118425323 118425478

BBEL:

LPIC:

DSV:

RSAN:

RMP:

BGT:

HRJ:	124264060 124275507

CRG:

105337314

CVN:	111101403 111101451 111135334

CANU:

128160771 128161280 128167344 128185043

OED:	125646576 125646578 125646588 125663947 125675636

PMAX:

MMER:

RPHI:

OSN:

ATEN:

116286226 116287483 116289234 116292213 116292286 116300224 116300467 116304432 116305619 116307262 116308086 116309069

XEN:	124452194 124452197 124452291 124455834

HSY:	130614135 130614136 130630581 130634454 130645371 130648549

AG:	AAF65823(CYP17A1) AAG02227(CYP17A1)

» show all

Reference

PMID:3025870 (CYP17A1)

Authors

Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL

Title

Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

Journal

Proc Natl Acad Sci U S A 84:407-11 (1987)
DOI:10.1073/pnas.84.2.407

Sequence

[hsa:1586]

Reference

PMID:17569754 (CYP17A2)

Authors

Zhou LY, Wang DS, Kobayashi T, Yano A, Paul-Prasanth B, Suzuki A, Sakai F, Nagahama Y

Title

A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney.

Journal

Endocrinology 148:4282-91 (2007)
DOI:10.1210/en.2007-0487

Sequence

[ola:101170547]

LinkDB

ENZYME: 1.14.99.9

Entry

EC 1.14.99.9      Obsolete  Enzyme

Name

Transferred to 1.14.14.19

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous

Comment

Transferred entry: steroid 17alpha-monooxygenase, now classified as EC 1.14.14.19, steroid 17alpha-monooxygenase

History

EC 1.14.99.9 created 1961 as EC 1.99.1.9, transferred 1965 to EC 1.14.1.7, transferred 1972 to EC 1.14.99.9, modified 2013, deleted 2015

LinkDB

REACTION: R02211

Entry

R02211                      Reaction

Name

progesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)

Definition

Progesterone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 17alpha-Hydroxyprogesterone + [Oxidized NADPH---hemoprotein reductase] + H2O

Equation

C00410 + C03024 + C00007 <=> C01176 + C03161 + C00001

Reaction class

RC00660

C00410_C01176

Enzyme

1.14.14.19

Pathway

rn00140

Steroid hormone biosynthesis

rn01100

Metabolic pathways

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19
     R02211  Progesterone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 17alpha-Hydroxyprogesterone + [Oxidized NADPH---hemoprotein reductase] + H2O
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
  1.14.14.19
   R02131  Steroid <=> 17alpha-Hydroxysteroid
    R02211  Progesterone <=> 17alpha-Hydroxyprogesterone

Orthology

K00512

steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]

Reference

1 [PMID:6971291]

Authors

Nakajin S, Hall PF.

Title

Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase).

Journal

J Biol Chem 256:3871-6 (1981)

Reference

2 [PMID:12693981]

Authors

Gilep AA, Estabrook RW, Usanov SA

Title

Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species.

Journal

Biochemistry (Mosc) 68:86-98 (2003)
DOI:10.1023/a:1022101703670

Other DBs

RHEA:

46311

LinkDB

DBGET integrated database retrieval system