KEGG   ORTHOLOGY: K01615Help
Entry
K01615                      KO                                     

Name
gcdA
Definition
glutaconyl-CoA decarboxylase [EC:4.1.1.70]
Pathway
Benzoate degradation
Butanoate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00650 Butanoate metabolism
    K01615  gcdA; glutaconyl-CoA decarboxylase
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K01615  gcdA; glutaconyl-CoA decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.70  glutaconyl-CoA decarboxylase
     K01615  gcdA; glutaconyl-CoA decarboxylase
Transporters [BR:ko02000]
 Other Transporters
  Primary active transporters
   K01615  gcdA; glutaconyl-CoA decarboxylase
BRITE hierarchy
Other DBs
RN: 
GO: 
TC: 
Genes
GBM: 
Gbem_1453(gcdA)
GEO: 
Geob_0238(gcdA)
GEM: 
DAT: 
HRM2_38510(gcdA1) HRM2_38640(gcdA2)
DTO: 
SAT: 
DTI: 
DBR: 
CSO: 
FAA: 
DOR: 
Desor_1195 Desor_1197
OVA: 
OBV_10900
BPRS: 
CK3_23950
PED: 
ING2D1G_1422(gcdA)
VPR: 
Vpar_1240 Vpar_1243
SSG: 
Selsp_1604
SRI: 
SELR_08970
SELE: 
ADJ74_05415
MHG: 
MHY_07190
PFT: 
JBW_01700
AFN: 
Acfer_1817 Acfer_1834 Acfer_1835 Acfer_1836
AIN: 
Acin_0296 Acin_0297(mmdC) Acin_0298(oadB) Acin_0318
TRM: 
JO41_09895
FNU: 
FN0204
FNC: 
HMPREF0946_01480
FNT: 
HMPREF0405_01480
FUS: 
HMPREF0409_01246
FNE: 
FSDG_02107
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Braune A, Bendrat K, Rospert S, Buckel W
  Title
The sodium ion translocating glutaconyl-CoA decarboxylase from Acidaminococcus fermentans: cloning and function of the genes forming a second operon.
  Journal
Mol Microbiol 31:473-87 (1999)
DOI:10.1046/j.1365-2958.1999.01189.x
  Sequence
LinkDB All DBs

KEGG   ENZYME: 4.1.1.70Help
Entry
EC 4.1.1.70                 Enzyme                                 

Name
glutaconyl-CoA decarboxylase;
glutaconyl coenzyme A decarboxylase;
pent-2-enoyl-CoA carboxy-lyase;
4-carboxybut-2-enoyl-CoA carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)
Reaction(IUBMB)
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2 [RN:R03028]
Reaction(KEGG)
Substrate
4-carboxybut-2-enoyl-CoA [CPD:C02411]
Product
but-2-enoyl-CoA [CPD:C00877];
CO2 [CPD:C00011]
Comment
The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
History
EC 4.1.1.70 created 1986, modified 2003
Pathway
Benzoate degradation
Butanoate metabolism
Microbial metabolism in diverse environments
Orthology
K01615  
glutaconyl-CoA decarboxylase
Genes
GBM: 
Gbem_1453(gcdA)
GEO: 
Geob_0238(gcdA)
GEM: 
DAT: 
HRM2_38510(gcdA1) HRM2_38640(gcdA2)
DTO: 
SAT: 
DTI: 
DBR: 
CSO: 
FAA: 
DOR: 
Desor_1195 Desor_1197
OVA: 
OBV_10900
BPRS: 
CK3_23950
PED: 
ING2D1G_1422(gcdA)
VPR: 
Vpar_1240 Vpar_1243
SSG: 
Selsp_1604
SRI: 
SELR_08970
SELE: 
ADJ74_05415
MHG: 
MHY_07190
PFT: 
JBW_01700
AFN: 
Acfer_1817 Acfer_1834 Acfer_1835 Acfer_1836
AIN: 
Acin_0296 Acin_0297(mmdC) Acin_0298(oadB) Acin_0318
TRM: 
JO41_09895
FNU: 
FN0204
FNC: 
HMPREF0946_01480
FNT: 
HMPREF0405_01480
FUS: 
HMPREF0409_01246
FNE: 
FSDG_02107
 » show all
Taxonomy
Reference
1  [PMID:6628393]
  Authors
Buckel W, Semmler R.
  Title
Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria.
  Journal
Eur. J. Biochem. 136 (1983) 427-34.
Reference
2  [PMID:11248185]
  Authors
Buckel W.
  Title
Sodium ion-translocating decarboxylases.
  Journal
Biochim. Biophys. Acta. 1505 (2001) 15-27.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
84399-93-9
LinkDB All DBs

KEGG   REACTION: R03028Help
Entry
R03028                      Reaction                               

Name
glutaconyl-1-CoA carboxy-lyase;
4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)
Definition
Glutaconyl-1-CoA <=> Crotonoyl-CoA + CO2
Equation
Comment
following after R10074 (ec 1.3.8.6)
requires Na+ and acts as a sodium pump (ec 4.1.1.70)
Reaction class
C00877_C02411
Enzyme
1.3.8.6         4.1.1.70
Pathway
Benzoate degradation
Butanoate metabolism
Microbial metabolism in diverse environments
Orthology
K01615  
glutaconyl-CoA decarboxylase [EC:4.1.1.70]
Other DBs
RHEA: 
LinkDB All DBs

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