KEGG   ORTHOLOGY: K01668
Entry
K01668                      KO                                     
Symbol
E4.1.99.2
Name
tyrosine phenol-lyase [EC:4.1.99.2]
Pathway
map00350  Tyrosine metabolism
Reaction
R00728  L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K01668  E4.1.99.2; tyrosine phenol-lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.99  Other carbon-carbon lyases
    4.1.99.2  tyrosine phenol-lyase
     K01668  E4.1.99.2; tyrosine phenol-lyase
Other DBs
GO: 0050371
Genes
KQV: B8P98_13910
KAR: LGL98_12615
CKO: CKO_03467
CFD: CFNIH1_09255
CBRA: A6J81_13920
CWE: CO701_18800
CYO: CD187_21020
CPOT: FOB25_08080
CFQ: C2U38_02820
CIF: AL515_04345
METY: MRY16398_33370(tpl)
PAM: PANA_3984(tpl)
PLF: PANA5342_p10091(tpl)
PAJ: PAJ_p0025(tpl)
PAQ: PAGR_p073
MMK: MU9_2951
LRI: NCTC12151_02412(tpl)
PMU: PM0811
PMV: PMCN06_0880(tpl)
PMP: Pmu_08910(tpl)
PMUL: DR93_1650
AAT: D11S_1940
AAN: D7S_01988
AACN: AANUM_2335
RPNE: NCTC8284_00313(tpl)
MVS: MVIS_2967(tnaA)
MYA: MORIYA_1533(tnaA)
DNO: DNO_0442
CHJ: NCTC10426_00445(tpl)
RGE: RGE_20590(tnaA)
RBN: RBXJA2T_17611(tnaA)
OFO: BRW83_0351(tpl)
EBA: ebA605(tnaA)
APET: ToN1_35920
TCL: Tchl_2494
RPB: RPB_1966
RPC: RPC_2787
RPD: RPD_3423
RPE: RPE_2915
RPT: Rpal_4083
RVA: Rvan_2623
BVR: BVIR_1448
BLAG: BLTE_20100(tpl)
MSC: BN69_2860
PSF: PSE_0962(tnaA)
RCP: RCAP_rcc00516(tpl) RCAP_rcc02309(tnaA)
RSU: NHU_02389(tnaA)
HNE: HNE_0810
RAP: RHOA_5189(tpl)
MAGX: XM1_0733(tpl)
MAGN: WV31_12030
CBLA: CBLAS_0788
ATP: ATR_1949(tnaA)
ATHR: ATH_1913(tnaA)
APOC: APORC_2028(tnaA)
SAT: SYN_01455
CTC: CTC_00818
CCOH: SAMEA4530647_0763(tpl_2)
HSC: HVS_04190(tpl)
STH: STH2842
DSY: DSY3653
DHD: Dhaf_1723
TAE: TepiRe1_2021(tpl)
NCD: ACONDI_01191(tpl_1) ACONDI_01327(tpl_2)
PUF: UFO1_1418
PFT: JBW_03623
LPIL: LIP_0995
CMD: B841_11865(tnaA)
CHM: B842_02140(tnaA)
CCYS: SAMEA4530656_1651(tnaA)
CGF: CGUA_12210(tpl)
SALU: DC74_716
SALL: SAZ_04135(tnaA)
NCA: Noca_1624
AOI: AORI_5366
AJA: AJAP_22805(tpl)
AMYY: YIM_16040(tpl)
AORI: SD37_23450
RCA: Rcas_0866
CAU: Caur_0573
CAG: Cagg_3438
PBF: CFX0092_A2268(tnaA)
DFC: DFI_10615
OTE: Oter_0376
AMU: Amuc_1995
SMAM: Mal15_56580(tnaA2)
SACI: Sinac_1688
TDE: TDE_1118(tpl)
TPED: TPE_1499(tpl)
SUS: Acid_6369
ABAC: LuPra_04134(tpl)
THYD: TTHT_1544(tnaA)
EMI: Emin_0932
FNU: FN1988
FPOL: ERS445057_00135(tpl_1) ERS445057_01797(tpl_3)
TAI: Taci_0642
PCRE: NCTC12858_00848(tpl_1)
PCAG: NCTC12856_00106(tpl_1)
PSOE: CE91St14_06700(tpl)
PMUC: ING2E5A_1495(tpl)
AIT: AI2BBH_02780(tpl)
DORI: FH5T_08715
ANF: AQPE_1860
SMIZ: 4412673_01210(tpl_2)
CHZ: CHSO_0681(tnaA)
CGLE: NCTC11432_03144(tpl_1)
CTAK: 4412677_01735(tpl_2)
CSAL: NBC122_01726(tpl_2)
RMR: Rmar_1948
SRU: SRU_1708
SRM: SRM_01915(tnaA)
IAL: IALB_2618(tnaA)
DTN: DTL3_0081(tpl)
CABY: Cabys_2412
NMV: NITMOv2_0067(tnaA)
NJA: NSJP_0536(tnaA)
NIF: W02_04720(tnaA)
BANA: BARAN1_0718(tpl)
PSYT: DSAG12_02524(tpl)
 » show all
Reference
PMID:7916622
  Authors
Antson AA, Demidkina TV, Gollnick P, Dauter Z, von Tersch RL, Long J, Berezhnoy SN, Phillips RS, Harutyunyan EH, Wilson KS
  Title
Three-dimensional structure of tyrosine phenol-lyase.
  Journal
Biochemistry 32:4195-206 (1993)
DOI:10.1021/bi00067a006
  Sequence
LinkDB

KEGG   ENZYME: 4.1.99.2
Entry
EC 4.1.99.2                 Enzyme                                 
Name
tyrosine phenol-lyase;
beta-tyrosinase;
L-tyrosine phenol-lyase (deaminating)
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
Sysname
L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Reaction(IUBMB)
L-tyrosine + H2O = phenol + pyruvate + NH3 (overall reaction) [RN:R00728];
(1a) L-tyrosine = phenol + 2-aminoprop-2-enoate [RN:R12759];
(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous) [RN:R11100];
(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) [RN:R11099]
Reaction(KEGG)
Substrate
L-tyrosine [CPD:C00082];
H2O [CPD:C00001];
2-aminoprop-2-enoate [CPD:C02218];
2-iminopropanoate [CPD:C20904]
Product
phenol [CPD:C00146];
pyruvate [CPD:C00022];
NH3 [CPD:C00014];
2-aminoprop-2-enoate [CPD:C02218];
2-iminopropanoate [CPD:C20904]
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme also slowly catalyses similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.
History
EC 4.1.99.2 created 1972
Pathway
ec00350  Tyrosine metabolism
Orthology
K01668  tyrosine phenol-lyase
Genes
KQVB8P98_13910
KARLGL98_12615
CKOCKO_03467
CFDCFNIH1_09255
CBRAA6J81_13920
CWECO701_18800
CYOCD187_21020
CPOTFOB25_08080
CFQC2U38_02820
CIFAL515_04345
CIEAN232_00695
CPARCUC49_22445
CITZE4Z61_13950
CARSE1B03_04065
CIXM4I31_20605
CIBHF677_020385
CENSP2W74_20015
ASUBNLZ15_03930
KINAB182_14870
PDZHHA33_17405
METYMRY16398_33370(tpl)
EBCC2U52_25405
YMADA391_12585
PAMPANA_3984(tpl)
PLFPANA5342_p10091(tpl)
PAJPAJ_p0025(tpl)
PAQPAGR_p073
PMAGJI723_05445
MMKMU9_2951
PRAGEKN56_08045 EKN56_12310
LRINCTC12151_02412(tpl)
HPRPARA_06000
PMUPM0811
PMVPMCN06_0880(tpl)
PULNT08PM_0453
PMPPmu_08910(tpl)
PMULDR93_1650
PSKYA6B44_09725
AAPNT05HA_0124
AAZADJ80_05155
AATD11S_1940
AAOANH9381_0123
AAND7S_01988
AAHCF65_02970
AACNAANUM_2335
AACTACT75_02960
RPNENCTC8284_00313(tpl)
RHEYFEE42_07995
VMIAL543_07035
EAZJHT90_07445
MVSMVIS_2967(tnaA)
MYAMORIYA_1533(tnaA)
MCELLPW13_08815
KIMG3T16_05495
THIMKFB96_22295
ENWMJO57_30775
DNODNO_0442
CHJNCTC10426_00445(tpl)
AFFH3L97_00400
BGEBC1002_6700
PTXABW99_12265
CDNBN940_06946
COFFOZ74_12245
SIMPC6571_06710
RGERGE_20590(tnaA)
RBNRBXJA2T_17611(tnaA)
OFOBRW83_0351(tpl)
OVBNB640_06150
OALNB647_01400
EBAebA605(tnaA)
APETToN1_35920
AZIAzCIB_0931
AZDCDA09_05540
TMZTmz1t_1789
TCLTchl_2494
TAKTharo_1668
RPBRPB_1966
RPCRPC_2787
RPDRPD_3423
RPERPE_2915
RPTRpal_4083
RPXRpdx1_1790
RVARvan_2623
RLACQMO75_10805
BVRBVIR_1448
BLAGBLTE_20100(tpl)
MSCBN69_2860
MBRYB1812_17480
MROSEHO51_02135
MTWCQW49_09160
PSFPSE_0962(tnaA)
RSQRsph17025_3640
CAZTLV780_17545
RCPRCAP_rcc00516(tpl) RCAP_rcc02309(tnaA)
RSUNHU_02389(tnaA)
RHMB5V46_07690
HNEHNE_0810
RAPRHOA_5189(tpl)
RPMRSPPHO_03014
MAGXXM1_0733(tpl)
MAGNWV31_12030
CBLACBLAS_0788
ATPATR_1949(tnaA)
ATHRATH_1913(tnaA)
APOCAPORC_2028(tnaA)
SATSYN_01455
NANNO0S08_25630
BWDCT694_33960
BSHILGQ02_13810
SPAEE2C16_02905
SPOOJ3U78_00095
SURLBI350_06705
UTHDKZ56_00685
CTCCTC_00818
CTETBN906_00858
CCOHSAMEA4530647_0763(tpl_2)
CCAAKQH81_12795
PROQP6M73_13460
CCLClocl_1892
HSCHVS_04190(tpl)
RHEREHE19_004455
RPAYP0092_05030
STHSTH2842
DSYDSY3653
DHDDhaf_1723
DDLDesdi_0330
DORDesor_4416
DFGB0537_00095 B0537_11110
ACAEHYG86_05650
PROMQO263_16355
CSHClosa_0252
LBWC3V36_04545
TEPTepRe1_1876
TAETepiRe1_2021(tpl)
NTHNther_1802
NCDACONDI_01191(tpl_1) ACONDI_01327(tpl_2)
HPKHprae_1906
MHAPJFY71_03580 JFY71_06480
TISP3962_14550
TIZRBU61_00645
PUFUFO1_1418
PFTJBW_03623
LPILLIP_0995
TBKHF295_07920
ERZER308_16190
CMDB841_11865(tnaA)
CHMB842_02140(tnaA)
CSPHCSPHI_06785
CCYSSAMEA4530656_1651(tnaA)
CFYI6L56_04290
CGFCGUA_12210(tpl)
CBREQP027_11135
CBQAL705_05405
SALUDC74_716
SALLSAZ_04135(tnaA)
SKACP970_07480
ICAIntca_0142
ARSADJ73_00465
AUSIPK37_00915 IPK37_04765
BRTJ4N02_01260 J4N02_04045
NCANoca_1624
AOIAORI_5366
AJAAJAP_22805(tpl)
AMYCCU254_28905
AMYYYIM_16040(tpl)
AORISD37_23450
AROONQK81_11530
RUBGBA63_15970
CMPCha6605_2878
KOVK9N68_37855
LSKJ5X98_22205
NPUNpun_R5724
NOPNos7524_2080
NONNOS3756_28400
NOECLI64_22335
TOQHCG51_14585
RRSRoseRS_0320
RCARcas_0866
CAUCaur_0573
CHLChy400_0619
CAGCagg_3438
PSUBPelsub_P0466
PBFCFX0092_A2268(tnaA)
THUGKNN16_10440
DFCDFI_10615
OPROcepr_1553 Ocepr_1720
MHDMarky_1642
NPYNPRO_01750 NPRO_16190
OTEOter_0376
ELUTCKA38_03105
OBTOPIT5_12280
AMUAmuc_1995
ABIWAbiwalacus_23920
AMAKJ5W79_10920
SMAMMal15_56580(tnaA2)
SACISinac_1688
TDETDE_1118(tpl)
TPEDTPE_1499(tpl)
TPKJO40_08670
TPHGFUT81_00030
ABAAcid345_3931
ORPMOP44_23725
SUSAcid_6369
PFERIRI77_11825
ABACLuPra_04134(tpl)
THYDTTHT_1544(tnaA)
SCORJ3U87_27205
GEPQ9293_13855
EMIEmin_0932
FNUFN1988
FNCHMPREF0946_02086
FNTHMPREF0405_01819
FUSHMPREF0409_01828
FNEFSDG_02356
FHWRN87_01430 RN87_05525
FPDCTM68_07230
FVAFV113G1_10500 FV113G1_23210
FULC4N20_00420 C4N20_11335
FNFBSQ88_03445
FPEIC4N17_00230
FCII6I83_00260
FPOLERS445057_00135(tpl_1) ERS445057_01797(tpl_3)
CSOMMKD34_06135
TAITaci_0642
ARAMKAR29_11770
PCRENCTC12858_00848(tpl_1)
PCAGNCTC12856_00106(tpl_1)
PENDLA319_03700
PSOECE91St14_06700(tpl)
PBTING2E5B_1329
PMUCING2E5A_1495(tpl)
PETPEIBARAKI_5473 PEIBARAKI_6464
PSACPSM36_1292 PSM36_2654(tpl)
PROJKDN43_00735 KDN43_09795
PPNPalpr_1828
ALQC7Y71_008285
ALDGFH31_00760
AITAI2BBH_02780(tpl)
RBCBN938_2021
DORIFH5T_08715
MCOSGM418_17880
ANFAQPE_1860
ASXCDL62_16620
ALKQM9189_07190
COYHF329_00540 HF329_11305
NYNU0035_07050
HHYHalhy_0884
SMIZ4412673_01210(tpl_2)
SPHZE3D81_15330
LUTLupro_11550
AQDD1816_15070
WVIWeevi_1094
ELTFGE20_04745
CHZCHSO_0681(tnaA)
CGNOK18_07025
CHHA0O34_09960
CIOCEQ15_17460
CPIPCJF12_15000
CARHEGY05_20955
CSHAEG350_19400
CNKEG343_13340
CGLENCTC11432_03144(tpl_1)
CTAK4412677_01735(tpl_2)
CSALNBC122_01726(tpl_2)
CSUPMTP09_03975
CCASEIB73_09735
KDAEIB71_04020
KFAQ73A0000_00315
EVAEIB75_11400
CNREB819_10635
EBVF0358_05840
RMRRmar_1948
RMGRhom172_0915
RBARAWN76_012460
SRUSRU_1708
SRMSRM_01915(tnaA)
IALIALB_2618(tnaA)
MROMROS_0698 MROS_1546
DTNDTL3_0081(tpl)
CABYCabys_2412
NMVNITMOv2_0067(tnaA)
NJANSJP_0536(tnaA)
NIFW02_04720(tnaA)
NALLPP769_10995
NNEOPQG83_01705
BANABARAN1_0718(tpl)
BIHBIP78_0966
THGTCELL_0288
PSYTDSAG12_02524(tpl)
 » show all
Reference
1  [PMID:4908868]
  Authors
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
  Title
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
  Journal
J Biol Chem 245:1767-72 (1970)
Reference
2  [PMID:4908869]
  Authors
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
  Title
Tyrosine phenol lyase. II. Cofactor requrements.
  Journal
J Biol Chem 245:1773-7 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.99.2
IUBMB Enzyme Nomenclature: 4.1.99.2
ExPASy - ENZYME nomenclature database: 4.1.99.2
BRENDA, the Enzyme Database: 4.1.99.2
CAS: 9059-31-8
LinkDB

KEGG   REACTION: R00728
Entry
R00728                      Reaction                               
Name
L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Definition
L-Tyrosine + H2O <=> Phenol + Pyruvate + Ammonia
Equation
Reaction class
RC00355  C00022_C00082
RC00364  C00082_C00146
Enzyme
Pathway
rn00350  Tyrosine metabolism
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.99  Other carbon-carbon lyases
    4.1.99.2
     R00728  L-Tyrosine + H2O <=> Phenol + Pyruvate + Ammonia
Orthology
K01668  tyrosine phenol-lyase [EC:4.1.99.2]
Other DBs
RHEA: 21707
LinkDB

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