KEGG   ORTHOLOGY: K01904Help
Entry
K01904                      KO                                     

Name
4CL
Definition
4-coumarate--CoA ligase [EC:6.2.1.12]
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Phenylalanine metabolism
Phenylpropanoid biosynthesis
Module
M00039  
Monolignol biosynthesis, phenylalanine/tyrosine  => monolignol
M00137  
Flavanone biosynthesis, phenylalanine => naringenin
M00350  
Capsaicin biosynthesis, L-Phenylalanine => Capsaicin
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00360 Phenylalanine metabolism
    K01904  4CL; 4-coumarate--CoA ligase
  Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K01904  4CL; 4-coumarate--CoA ligase
  Biosynthesis of other secondary metabolites
   00940 Phenylpropanoid biosynthesis
    K01904  4CL; 4-coumarate--CoA ligase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Aromatic amino acid metabolism
    M00350  Capsaicin biosynthesis, L-Phenylalanine => Capsaicin
     K01904  4CL; 4-coumarate--CoA ligase
  Secondary metabolism
   Biosynthesis of secondary metabolites
    M00039  Monolignol biosynthesis, phenylalanine / tyrosine  => monolignol
     K01904  4CL; 4-coumarate--CoA ligase
    M00137  Flavanone biosynthesis, phenylalanine => naringenin
     K01904  4CL; 4-coumarate--CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.12  4-coumarate---CoA ligase
     K01904  4CL; 4-coumarate--CoA ligase
BRITE hierarchy
Other DBs
Genes
RSS: 
SOC: 
CEL: 
TSP: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
104798452 104806267 104807135 104812629 104815164 104817929 104821776
CIT: 
102609336 102609606 102610430 102611686 102613925 102623419 102624997 102629456
CIC: 
CICLE_v10000735mg CICLE_v10007733mg CICLE_v10019532mg CICLE_v10025280mg CICLE_v10028138mg CICLE_v100281391m CICLE_v100281392m CICLE_v10029864mg CICLE_v10031133mg
TCC: 
18589246 18590950 18596332 18598026 18598027 18599509 18606860 18608984
GRA: 
105769383 105769702 105776276 105783644 105787925 105788981 105789399 105791879 105794492 105799750
GHI: 
107886731 107888070 107891158 107891657 107897473 107906026 107907481 107907702 107907703 107908281 107913823 107924716 107927147 107927154 107936009 107938562 107942427 107950562 107958337 107963914
EGR: 
104424278 104426337 104426338 104431583 104432065 104433684 104434060 104434065 104437368 104442380
GMX: 
100779668 100780741 100790396 100797843(4CL) 100804808 100808944 100810418 100811418 100814237 100819192 106795252 547492(4cl3) 547930(4CL4) 547944(4cl2) 548034(4CL1)
PVU: 
PHAVU_002G040100g PHAVU_002G132900g PHAVU_003G146900g PHAVU_003G147000g PHAVU_005G131400g PHAVU_005G184500g PHAVU_006G057300g PHAVU_011G020200g PHAVU_011G084300g
VRA: 
106759615 106761921 106767325 106767575 106768751 106776996 106777374 106777872 106778160 106779613
VAR: 
108320913 108322006 108322133 108322156 108322188 108333016 108333968 108335989 108340004 108341430
CCAJ: 
109798572 109799009 109807329 109808553 109810936 109811616 109812676 109813137
MTR: 
MTR_1g063110 MTR_1g063120 MTR_2g095510 MTR_2g105570 MTR_3g460770 MTR_4g005750 MTR_4g057730 MTR_4g077900 MTR_4g128337 MTR_5g007640 MTR_5g027480 MTR_5g027500
CAM: 
101490844 101491610 101497059 101500143 101501443 101502718 101509548 101514356
ADU: 
107459975 107459985 107461745 107472893 107476481 107477352 107477353 107477420 107487138 107488461
AIP: 
107616407 107629260 107632209 107632457 107632460 107638370 107642241 107642252 107642381 107643184
LJA: 
Lj0g3v0146149.1(Lj0g3v0146149.1) Lj0g3v0165009.1(Lj0g3v0165009.1) Lj0g3v0306889.1(Lj0g3v0306889.1) Lj1g3v0129860.1(Lj1g3v0129860.1) Lj2g3v1536270.1(Lj2g3v1536270.1) Lj2g3v2125730.1(Lj2g3v2125730.1) Lj3g3v1113010.1(Lj3g3v1113010.1) Lj3g3v2040010.1(Lj3g3v2040010.1) Lj3g3v3054590.1(Lj3g3v3054590.1) Lj3g3v3055600.1(Lj3g3v3055600.1) Lj3g3v3055600.2(Lj3g3v3055600.2) Lj3g3v3056700.1(Lj3g3v3056700.1) Lj3g3v3639640.1(Lj3g3v3639640.1) Lj4g3v2093610.2(Lj4g3v2093610.2) Lj6g3v0750030.1(Lj6g3v0750030.1) Lj6g3v0933470.1(Lj6g3v0933470.1)
LANG: 
109331675 109335030 109342759 109346995 109346999 109348566 109350308 109351400 109351401 109355308 109355450 109362706
FVE: 
101291845 101296522 101297466 101299638 101304645 101312548 101313178
PPER: 
18767376 18769172 18770881 18772555 18781615 18786755 18792004 18792923
PMUM: 
103322128 103323519 103325926 103328252 103333496 103334989 103339665 103339831
MDM: 
103411718 103416690 103423332 103426517 103427406 103440010 103444094 103444452 103447296 103452424 108171757
PXB: 
103927375 103928538 103928616 103937530 103939486 103943288 103945464 103947702 103951504 103960242(4CL) 103961503 108867262
ZJU: 
107406438 107411478 107413992 107428172 107428304 107433976 107434556
CSV: 
101204417 101210868 101215427 101218077 101218121 101218361 101218595 101219578 101220141 101220731 101221344
CMO: 
103486502 103488874 103493360 103494274 103499264 103499867 103499868 103499870 103501067 103501216 103501298
RCU: 
8270667 8275217 8278533 8280301 8280463 8284003 8286786
JCU: 
105628033 105629481 105630258 105635600 105635601 105644823 105649004
POP: 
POPTR_0001s07400g(POPTRDRAFT_639764) POPTR_0001s13900g(POPTRDRAFT_548019) POPTR_0003s09880g(POPTRDRAFT_349958A) POPTR_0003s17130g POPTR_0003s18720g(POPTRDRAFT_758231) POPTR_0004s10170g(POPTRDRAFT_831184) POPTR_0006s18490g POPTR_0006s18510g POPTR_0017s13880g POPTR_0018s10210g(POPTRDRAFT_262277) POPTR_0019s07600g(POPTRDRAFT_665396)
VVI: 
100245991(4CL) 100254698 100261471 100264367 100265063 100267198 100267423
SLY: 
101245039 101248210 101249624(4CL) 101249706 101251197 101251363 101255909 101264276 109120040
SPEN: 
107004955 107005580 107009683 107014702 107015322 107023844 107026301 107027934
SOT: 
102581073 102584603 102589212 102589793 102590237 102594991 102596056(4CL-1) 102597265
INI: 
109149529 109163099 109183073 109183355 109185149 109189203 109192779 109193332
SIND: 
105155681 105158263 105165431 105166823 105168716 105168813 105170261 105172728 105177316
BVG: 
104888010 104893057 104897553 104902419 104902885
NNU: 
104599133 104599134 104600350 104600409 104603180 104604518 104611494 104612676
OSA: 
4328485(4CL-3) 4330407(4CL.2) 4331650(4CLL1) 4341718(4CL4) 4345054(4CL) 4345717(4CL5) 9267647 9269113(4CLL3) 9272068
DOSA: 
Os02t0177600-01(Os02g0177600) Os02t0697400-01(Os02g0697400) Os03t0152400-01(Os03g0152400) Os06t0656500-01(Os06g0656500) Os08t0143300-00(Os08g0143300) Os08t0245200-01(Os08g0245200) Os08t0448000-01(Os08g0448000) Os10t0578950-00(Os10g0578950)
OBR: 
102700731 102702350 102704165 102709430 102709878 102712977 102713516 102713931 102721287 107304069 107304070
BDI: 
100821663 100826883 100836460 100842361 100842528 100842862 100845913 100845934
ATS: 
F775_07279 F775_07782 F775_16423 F775_22333 F775_32218 F775_32463 F775_32705
SBI: 
8058452 8073882 8077554 8077870 8079391 8082428
ZMA: 
100191850 100191997 100280065(gpm212c) 100280100 100283944 100382272 103637741 103652288 103653401 103653944 109939191 542166(pco063262)
SITA: 
101757683 101762300 101764384 101766826 101769243 101769729 101770138 101775054 101776259 101781346 101781746
PDA: 
103701563 103707092 103708041 103717120 103718393 103718408 103720770 103720909
EGU: 
105039259 105039619 105042958 105049351 105050370 105053813
MUS: 
103970530 103971474 103972208 103973145 103975240 103980720 103981280 103985739 103990241 103990586 103994510 103995769 103998718
ATR: 
18432876 18435511 18440800 18443822 18443861
SMO: 
SELMODRAFT_110329 SELMODRAFT_115483 SELMODRAFT_116209 SELMODRAFT_116986 SELMODRAFT_123905 SELMODRAFT_128539 SELMODRAFT_133629 SELMODRAFT_157069 SELMODRAFT_173133 SELMODRAFT_181279 SELMODRAFT_231716 SELMODRAFT_232017 SELMODRAFT_234540 SELMODRAFT_235993 SELMODRAFT_429785 SELMODRAFT_446445 SELMODRAFT_450526(4CL1-1) SELMODRAFT_450546(4CL1-2) SELMODRAFT_450547(4CL2-1) SELMODRAFT_450548(4CL2-2) SELMODRAFT_85691
PPP: 
PHYPADRAFT_104959 PHYPADRAFT_113172 PHYPADRAFT_140413 PHYPADRAFT_150981 PHYPADRAFT_152177 PHYPADRAFT_209184 PHYPADRAFT_233094 PHYPADRAFT_81614 PHYPADRAFT_89614
AFM: 
AFUA_1G13110
DPP: 
DICPUDRAFT_26531 DICPUDRAFT_88289
HHA: 
Hhal_1819
SIL: 
SPO0801(fadD)
RDE: 
RD1_1868
RHA: 
RHA1_ro08971
 » show all
TaxonomyKoalaUniProt
LinkDB All DBs

KEGG   ENZYME: 6.2.1.12Help
Entry
EC 6.2.1.12                 Enzyme                                 

Name
4-coumarate---CoA ligase;
4-coumaroyl-CoA synthetase;
p-coumaroyl CoA ligase;
p-coumaryl coenzyme A synthetase;
p-coumaryl-CoA synthetase;
p-coumaryl-CoA ligase;
feruloyl CoA ligase;
hydroxycinnamoyl CoA synthetase;
4-coumarate:coenzyme A ligase;
caffeolyl coenzyme A synthetase;
p-hydroxycinnamoyl coenzyme A synthetase;
feruloyl coenzyme A synthetase;
sinapoyl coenzyme A synthetase;
4-coumaryl-CoA synthetase;
hydroxycinnamate:CoA ligase;
p-coumaryl-CoA ligase;
p-hydroxycinnamic acid:CoA ligase;
4CL
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-coumarate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-coumarate [CPD:C00811];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-coumaroyl-CoA [CPD:C00223]
History
EC 6.2.1.12 created 1976
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Phenylalanine metabolism
Phenylpropanoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01904  
4-coumarate--CoA ligase
Genes
RSS: 
SOC: 
CEL: 
TSP: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
104798452 104806267 104807135 104812629 104815164 104817929 104821776
CIT: 
102609336 102609606 102610430 102611686 102613925 102623419 102624997 102629456
CIC: 
CICLE_v10000735mg CICLE_v10007733mg CICLE_v10019532mg CICLE_v10025280mg CICLE_v10028138mg CICLE_v100281391m CICLE_v100281392m CICLE_v10029864mg CICLE_v10031133mg
TCC: 
18589246 18590950 18596332 18598026 18598027 18599509 18606860 18608984
GRA: 
105769383 105769702 105776276 105783644 105787925 105788981 105789399 105791879 105794492 105799750
GHI: 
107886731 107888070 107891158 107891657 107897473 107906026 107907481 107907702 107907703 107908281 107913823 107924716 107927147 107927154 107936009 107938562 107942427 107950562 107958337 107963914
EGR: 
104424278 104426337 104426338 104431583 104432065 104433684 104434060 104434065 104437368 104442380
GMX: 
100779668 100780741 100790396 100797843(4CL) 100804808 100808944 100810418 100811418 100814237 100819192 106795252 547492(4cl3) 547930(4CL4) 547944(4cl2) 548034(4CL1)
PVU: 
PHAVU_002G040100g PHAVU_002G132900g PHAVU_003G146900g PHAVU_003G147000g PHAVU_005G131400g PHAVU_005G184500g PHAVU_006G057300g PHAVU_011G020200g PHAVU_011G084300g
VRA: 
106759615 106761921 106767325 106767575 106768751 106776996 106777374 106777872 106778160 106779613
VAR: 
108320913 108322006 108322133 108322156 108322188 108333016 108333968 108335989 108340004 108341430
CCAJ: 
109798572 109799009 109807329 109808553 109810936 109811616 109812676 109813137
MTR: 
MTR_1g063110 MTR_1g063120 MTR_2g095510 MTR_2g105570 MTR_3g460770 MTR_4g005750 MTR_4g057730 MTR_4g077900 MTR_4g128337 MTR_5g007640 MTR_5g027480 MTR_5g027500
CAM: 
101490844 101491610 101497059 101500143 101501443 101502718 101509548 101514356
ADU: 
107459975 107459985 107461745 107472893 107476481 107477352 107477353 107477420 107487138 107488461
AIP: 
107616407 107629260 107632209 107632457 107632460 107638370 107642241 107642252 107642381 107643184
LJA: 
Lj0g3v0146149.1(Lj0g3v0146149.1) Lj0g3v0165009.1(Lj0g3v0165009.1) Lj0g3v0306889.1(Lj0g3v0306889.1) Lj1g3v0129860.1(Lj1g3v0129860.1) Lj2g3v1536270.1(Lj2g3v1536270.1) Lj2g3v2125730.1(Lj2g3v2125730.1) Lj3g3v1113010.1(Lj3g3v1113010.1) Lj3g3v2040010.1(Lj3g3v2040010.1) Lj3g3v3054590.1(Lj3g3v3054590.1) Lj3g3v3055600.1(Lj3g3v3055600.1) Lj3g3v3055600.2(Lj3g3v3055600.2) Lj3g3v3056700.1(Lj3g3v3056700.1) Lj3g3v3639640.1(Lj3g3v3639640.1) Lj4g3v2093610.2(Lj4g3v2093610.2) Lj6g3v0750030.1(Lj6g3v0750030.1) Lj6g3v0933470.1(Lj6g3v0933470.1)
LANG: 
109331675 109335030 109342759 109346995 109346999 109348566 109350308 109351400 109351401 109355308 109355450 109362706
FVE: 
101291845 101296522 101297466 101299638 101304645 101312548 101313178
PPER: 
18767376 18769172 18770881 18772555 18781615 18786755 18792004 18792923
PMUM: 
103322128 103323519 103325926 103328252 103333496 103334989 103339665 103339831
MDM: 
103411718 103416690 103423332 103426517 103427406 103440010 103444094 103444452 103447296 103452424 108171757
PXB: 
103927375 103928538 103928616 103937530 103939486 103943288 103945464 103947702 103951504 103960242(4CL) 103961503 108867262
ZJU: 
107406438 107411478 107413992 107428172 107428304 107433976 107434556
CSV: 
101204417 101210868 101215427 101218077 101218121 101218361 101218595 101219578 101220141 101220731 101221344
CMO: 
103486502 103488874 103493360 103494274 103499264 103499867 103499868 103499870 103501067 103501216 103501298
RCU: 
8270667 8275217 8278533 8280301 8280463 8284003 8286786
JCU: 
105628033 105629481 105630258 105635600 105635601 105644823 105649004
POP: 
POPTR_0001s07400g(POPTRDRAFT_639764) POPTR_0001s13900g(POPTRDRAFT_548019) POPTR_0003s09880g(POPTRDRAFT_349958A) POPTR_0003s17130g POPTR_0003s18720g(POPTRDRAFT_758231) POPTR_0004s10170g(POPTRDRAFT_831184) POPTR_0006s18490g POPTR_0006s18510g POPTR_0017s13880g POPTR_0018s10210g(POPTRDRAFT_262277) POPTR_0019s07600g(POPTRDRAFT_665396)
VVI: 
100245991(4CL) 100254698 100261471 100264367 100265063 100267198 100267423
SLY: 
101245039 101248210 101249624(4CL) 101249706 101251197 101251363 101255909 101264276 109120040
SPEN: 
107004955 107005580 107009683 107014702 107015322 107023844 107026301 107027934
SOT: 
102581073 102584603 102589212 102589793 102590237 102594991 102596056(4CL-1) 102597265
INI: 
109149529 109163099 109183073 109183355 109185149 109189203 109192779 109193332
SIND: 
105155681 105158263 105165431 105166823 105168716 105168813 105170261 105172728 105177316
BVG: 
104888010 104893057 104897553 104902419 104902885
NNU: 
104599133 104599134 104600350 104600409 104603180 104604518 104611494 104612676
OSA: 
4328485(4CL-3) 4330407(4CL.2) 4331650(4CLL1) 4341718(4CL4) 4345054(4CL) 4345717(4CL5) 9267647 9269113(4CLL3) 9272068
DOSA: 
Os02t0177600-01(Os02g0177600) Os02t0697400-01(Os02g0697400) Os03t0152400-01(Os03g0152400) Os06t0656500-01(Os06g0656500) Os08t0143300-00(Os08g0143300) Os08t0245200-01(Os08g0245200) Os08t0448000-01(Os08g0448000) Os10t0578950-00(Os10g0578950)
OBR: 
102700731 102702350 102704165 102709430 102709878 102712977 102713516 102713931 102721287 107304069 107304070
BDI: 
100821663 100826883 100836460 100842361 100842528 100842862 100845913 100845934
ATS: 
F775_07279 F775_07782 F775_16423 F775_22333 F775_32218 F775_32463 F775_32705
SBI: 
8058452 8073882 8077554 8077870 8079391 8082428
ZMA: 
100191850 100191997 100280065(gpm212c) 100280100 100283944 100382272 103637741 103652288 103653401 103653944 109939191 542166(pco063262)
SITA: 
101757683 101762300 101764384 101766826 101769243 101769729 101770138 101775054 101776259 101781346 101781746
PDA: 
103701563 103707092 103708041 103717120 103718393 103718408 103720770 103720909
EGU: 
105039259 105039619 105042958 105049351 105050370 105053813
MUS: 
103970530 103971474 103972208 103973145 103975240 103980720 103981280 103985739 103990241 103990586 103994510 103995769 103998718
ATR: 
18432876 18435511 18440800 18443822 18443861
SMO: 
SELMODRAFT_110329 SELMODRAFT_115483 SELMODRAFT_116209 SELMODRAFT_116986 SELMODRAFT_123905 SELMODRAFT_128539 SELMODRAFT_133629 SELMODRAFT_157069 SELMODRAFT_173133 SELMODRAFT_181279 SELMODRAFT_231716 SELMODRAFT_232017 SELMODRAFT_234540 SELMODRAFT_235993 SELMODRAFT_429785 SELMODRAFT_446445 SELMODRAFT_450526(4CL1-1) SELMODRAFT_450546(4CL1-2) SELMODRAFT_450547(4CL2-1) SELMODRAFT_450548(4CL2-2) SELMODRAFT_85691
PPP: 
PHYPADRAFT_104959 PHYPADRAFT_113172 PHYPADRAFT_140413 PHYPADRAFT_150981 PHYPADRAFT_152177 PHYPADRAFT_209184 PHYPADRAFT_233094 PHYPADRAFT_81614 PHYPADRAFT_89614
AFM: 
AFUA_1G13110
DPP: 
DICPUDRAFT_26531 DICPUDRAFT_88289
HHA: 
Hhal_1819
SIL: 
SPO0801(fadD)
RDE: 
RD1_1868
RHA: 
RHA1_ro08971
 » show all
Taxonomy
Reference
1  [PMID:4364250]
  Authors
Gross GG, Zenk MH.
  Title
Isolation and properties of hydroxycinnamate: CoA ligase from lignifying tissue of Forsythia.
  Journal
Eur. J. Biochem. 42 (1974) 453-9.
Reference
2  [PMID:4699252]
  Authors
Lindl T, Kreuzaler F, Hahlbrock K.
  Title
Synthesis of p-coumaroyl coenzyme a with a partially purified p-coumarate:CoA ligase from cell suspension cultures of soybean (Glycine max).
  Journal
Biochim. Biophys. Acta. 302 (1973) 457-64.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37332-51-7
LinkDB All DBs

KEGG   REACTION: R02194Help
Entry
R02194                      Reaction                               

Name
Ferulate:CoA ligase (AMP-forming)
Definition
ATP + Ferulate + CoA <=> AMP + Diphosphate + Feruloyl-CoA
Equation
Reaction class
C00010_C00406
C00406_C01494
Enzyme
Pathway
Phenylpropanoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01904  
4-coumarate--CoA ligase [EC:6.2.1.12]
LinkDB All DBs

DBGET integrated database retrieval system