KEGG   ORTHOLOGY: K03362Help
Entry
K03362                      KO                                     
Name
FBXW1_11, BTRC, beta-TRCP
Definition
F-box and WD-40 domain protein 1/11
Pathway
Oocyte meiosis
Ubiquitin mediated proteolysis
Wnt signaling pathway
Hedgehog signaling pathway
Hippo signaling pathway
Circadian rhythm
Shigellosis
Module
M00380  
SCF-BTRC complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04340 Hedgehog signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04390 Hippo signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 Organismal Systems
  Environmental adaptation
   04710 Circadian rhythm
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 Human Diseases
  Infectious diseases
   05131 Shigellosis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
KEGG pathway modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00380  SCF-BTRC complex [BR:ko04121]
     K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   SCF complex
    target recognizing subunit (F-box)
     K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
BRITE hierarchy
Genes
HSA: 
23291(FBXW11) 8945(BTRC)
PTR: 
450685(BTRC) 462263(FBXW11)
PPS: 
100976100(FBXW11) 100977066(BTRC)
GGO: 
101142383(FBXW11) 101152319(BTRC)
PON: 
100171847(BTRC) 100432610(FBXW11)
MCC: 
708990(FBXW11)
MMU: 
103583(Fbxw11) 12234(Btrc)
RNO: 
303024(Fbxw11) 361765(Btrc)
CFA: 
479291(FBXW11) 486851(BTRC)
AML: 
100470916(BTRC) 100479018(FBXW11)
FCA: 
101094156(FBXW11) 101097596(BTRC)
BTA: 
534072(BTRC) 540642(FBXW11)
SSC: 
100157842(BTRC)
ECB: 
100069972(FBXW11) 100070200(BTRC)
MDO: 
100029508(BTRC) 100031160(FBXW11)
SHR: 
100923383(FBXW11) 100925642(BTRC)
OAA: 
100076818 100080584(BTRC)
GGA: 
416181(FBXW11) 423854(BTRC)
MGP: 
100545331(BTRC) 100551173
TGU: 
100217770(FBXW11) 100220854(BTRC)
ACS: 
100555677(btrc) 100566594
XLA: 
394362(btrc)
XTR: 
549140(btrc)
DRE: 
334373(fbxw11a) 406825(fbxw11b)
TRU: 
101067263
OLA: 
101174029
BFO: 
BRAFLDRAFT_59445(BTRCa)
CIN: 
445628(betaTrCP)
SPU: 
578954(btrc)
DME: 
Dmel_CG3412(slmb)
DPO: 
Dpse_GA27349
DAN: 
Dana_GF18514
DER: 
Dere_GG14860
DPE: 
Dper_GL22031
DSE: 
Dsec_GM15099
DSI: 
Dsim_GD20006
DWI: 
Dwil_GK13501
DYA: 
Dyak_GE25013
DGR: 
Dgri_GH15796
DMO: 
Dmoj_GI23727
DVI: 
Dvir_GJ23285
AGA: 
AgaP_AGAP001944
AAG: 
AaeL_AAEL003371
CQU: 
CpipJ_CPIJ017102
AME: 
551517(slmb)
NVI: 
100122997(NV10775)
TCA: 
664308(slmb)
API: 
100166937
PHU: 
Phum_PHUM317850
CEL: 
CELE_K10B2.1(lin-23)
CBR: 
CBG02640(Cbr-lin-23)
BMY: 
Bm1_14105
TSP: 
Tsp_05213
SMM: 
Smp_099930
NVE: 
NEMVE_v1g228088
HMG: 
100199403(fbxw11)
TAD: 
TRIADDRAFT_50617
AQU: 
100634006(Btrc)
YLI: 
YALI0F21901g
NCR: 
NCU04540 NCU07521
SMP: 
SMAC_06089 SMAC_09515
PAN: 
PODANSg1857 PODANSg4690
TTT: 
THITE_2117904 THITE_2118362
MTM: 
MYCTH_2305406 MYCTH_2308005
MGR: 
MGG_00261 MGG_09696
FGR: 
FG06615.1
NHE: 
NECHADRAFT_100263 NECHADRAFT_31774
VAL: 
VDBG_02549 VDBG_02862
SSL: 
SS1G_05720
BFU: 
BC1G_03664 BC1G_09392
ANI: 
AN2861.2 AN5593.2
NFI: 
NFIA_065450 NFIA_104760
AFM: 
AFUA_3G11870 AFUA_4G11440
AOR: 
AOR_1_1326154(AO090003000750) AOR_1_1920154(AO090003001079)
ANG: 
ANI_1_1890184(An04g05180)
AFV: 
AFLA_027420 AFLA_030670
ACT: 
ACLA_039760 ACLA_050510
PCS: 
Pc18g00540 Pc22g05900
CIM: 
CIMG_01565 CIMG_03748
CPW: 
CPC735_005560 CPC735_048970
PBL: 
PAAG_02706 PAAG_07190
URE: 
UREG_05266 UREG_07532
ABE: 
ARB_02341 ARB_05691
TVE: 
TRV_03694 TRV_04682
AJE: 
HCAG_01562 HCAG_06606
PNO: 
SNOG_06163 SNOG_11667
PTE: 
PTT_01335 PTT_09911
ZTR: 
MYCGRDRAFT_104452 MYCGRDRAFT_38013
TML: 
GSTUM_00005683001 GSTUM_00007331001
SPO: 
SPAC29E6.01(pof11)
PPL: 
POSPLDRAFT_88036
MPR: 
MPER_07558
CCI: 
CC1G_06922 CC1G_10581
SCM: 
SCHCODRAFT_103803 SCHCODRAFT_68501
MGL: 
MGL_2979
PGR: 
PGTG_14767
MBR: 
MONBRDRAFT_15157
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Rogers GC, Rusan NM, Roberts DM, Peifer M, Rogers SL
  Title
The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.
  Journal
J Cell Biol 184:225-39 (2009)
Reference
  Authors
Petroski MD, Deshaies RJ.
  Title
Function and regulation of cullin-RING ubiquitin ligases.
  Journal
Nat Rev Mol Cell Biol 6:9-20 (2005)
Reference
  Authors
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW.
  Title
Systematic analysis and nomenclature of mammalian F-box proteins.
  Journal
Genes Dev 18:2573-80 (2004)
Reference
  Authors
Frescas D, Pagano M
  Title
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.
  Journal
Nat Rev Cancer 8:438-49 (2008)
Reference
  Authors
Shirogane T, Jin J, Ang XL, Harper JW
  Title
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
  Journal
J Biol Chem 280:26863-72 (2005)
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