Entry
Symbol
lipA, LIAS, LIP1, LIP5
Name
Pathway
Module
M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H
M00882 Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H
M00883 Lipoic acid biosynthesis, animals and bacteria, octanoyl-ACP => dihydrolipoyl-H => dihydrolipoyl-E2
M00884 Lipoic acid biosynthesis, octanoyl-CoA => dihydrolipoyl-E2
Reaction
R07767 [protein]-N6-(octanoyl)-L-lysine:an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase
R12423 [lipoyl-carrier protein E2]-N6-(octanoyl)-L-lysine:[Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase
R12424 [glycine cleavage system H]-N6-octanoyl-L-lysine:[Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase
Disease
H02438 Hyperglycinemia, lactic acidosis, and seizures
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
K03644 lipA, LIAS, LIP1, LIP5; lipoyl synthase
Enzymes [BR:ko01000 ]
2. Transferases
2.8 Transferring sulfur-containing groups
2.8.1 Sulfurtransferases
2.8.1.8 lipoyl synthase
K03644 lipA, LIAS, LIP1, LIP5; lipoyl synthase
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Genes
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Taxonomy UniProt
Reference
Authors
Vanden Boom TJ, Reed KE, Cronan JE Jr
Title
Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system.
Journal
Sequence
Reference
Authors
Mayr JA, Zimmermann FA, Fauth C, Bergheim C, Meierhofer D, Radmayr D, Zschocke J, Koch J, Sperl W
Title
Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.
Journal
Sequence
Reference
Authors
Yasuno R, Wada H.
Title
Biosynthesis of lipoic acid in Arabidopsis: cloning and characterization of the cDNA for lipoic acid synthase.
Journal
Sequence
Reference
Authors
Yasuno R, Wada H
Title
The biosynthetic pathway for lipoic acid is present in plastids and mitochondria in Arabidopsis thaliana.
Journal
Sequence
Reference
Authors
Sulo P, Martin NC
Title
Isolation and characterization of LIP5. A lipoate biosynthetic locus of Saccharomyces cerevisiae.
Journal
J Biol Chem 268:17634-9 (1993)
Sequence
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