KEGG   ORTHOLOGY: K04105Help
Entry
K04105                      KO                                     

Name
hbaA
Definition
4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25]
Pathway
Benzoate degradation
Aminobenzoate degradation
Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K04105  hbaA; 4-hydroxybenzoate-CoA ligase
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04105  hbaA; 4-hydroxybenzoate-CoA ligase
   00627 Aminobenzoate degradation
    K04105  hbaA; 4-hydroxybenzoate-CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.25  benzoate---CoA ligase
     K04105  hbaA; 4-hydroxybenzoate-CoA ligase
    6.2.1.27  4-hydroxybenzoate---CoA ligase
     K04105  hbaA; 4-hydroxybenzoate-CoA ligase
BRITE hierarchy
Other DBs
Genes
BJA: 
BJU: 
BJP: 
BRA: 
BBT: 
BRS: 
AOL: 
BRC: 
RPA: 
RPA0669(hbaA)
RPB: 
RPC: 
RPC_1016
RPD: 
RPD_0878 RPD_1526
RPE: 
RPE_0592
RPT: 
Rpal_0736
RPX: 
Rpdx1_4117
SIL: 
SPO3697(badA-1)
JAN: 
Jann_0669
MAG: 
amb2869
MAGX: 
XM1_2792(bclA)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9006014
  Authors
Gibson J, Dispensa M, Harwood CS
  Title
4-hydroxybenzoyl coenzyme A reductase (dehydroxylating) is required for anaerobic degradation of 4-hydroxybenzoate by Rhodopseudomonas palustris and shares features with molybdenum-containing hydroxylases.
  Journal
J Bacteriol 179:634-42 (1997)
DOI:10.1128/JB.179.3.634-642.1997
Reference
PMID:8300518
  Authors
Gibson J, Dispensa M, Fogg GC, Evans DT, Harwood CS
  Title
4-Hydroxybenzoate-coenzyme A ligase from Rhodopseudomonas palustris: purification, gene sequence, and role in anaerobic degradation.
  Journal
J Bacteriol 176:634-41 (1994)
DOI:10.1128/JB.176.3.634-641.1994
  Sequence
[rpa:RPA0669]
LinkDB All DBs

KEGG   ORTHOLOGY: K20458Help
Entry
K20458                      KO                                     

Name
hcl
Definition
3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase [EC:6.2.1.37 6.2.1.27]
Pathway
Benzoate degradation
Aminobenzoate degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K20458  hcl; 3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase
   00627 Aminobenzoate degradation
    K20458  hcl; 3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.27  4-hydroxybenzoate---CoA ligase
     K20458  hcl; 3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase
    6.2.1.37  3-hydroxybenzoate---CoA ligase
     K20458  hcl; 3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase
BRITE hierarchy
Other DBs
RN: 
COG: 
GO: 
Genes
EBA: 
ebA727(hbcL)
AZI: 
RHZ: 
MAG: 
MAGX: 
AG: 
TaxonomyKoalaUniProt
Reference
  Authors
Laempe D, Jahn M, Breese K, Schagger H, Fuchs G
  Title
Anaerobic metabolism of 3-hydroxybenzoate by the denitrifying bacterium Thauera aromatica.
  Journal
J Bacteriol 183:968-79 (2001)
DOI:10.1128/JB.183.3.968-979.2001
  Sequence
LinkDB All DBs

KEGG   ORTHOLOGY: K01075Help
Entry
K01075                      KO                                     

Name
E3.1.2.23
Definition
4-hydroxybenzoyl-CoA thioesterase [EC:3.1.2.23]
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Benzoate degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K01075  E3.1.2.23; 4-hydroxybenzoyl-CoA thioesterase
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K01075  E3.1.2.23; 4-hydroxybenzoyl-CoA thioesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.23  4-hydroxybenzoyl-CoA thioesterase
     K01075  E3.1.2.23; 4-hydroxybenzoyl-CoA thioesterase
BRITE hierarchy
Other DBs
RN: 
COG: 
GO: 
Genes
EBT: 
XDO: 
XHO: 
PRG: 
PAE: 
PAEV: 
N297_1002(ybgC)
PAEI: 
N296_1002(ybgC)
PAU: 
PAP: 
PAG: 
PAF: 
PAM18_4069
PNC: 
NCGM2_1775(ybgC)
PAEB: 
NCGM1900_1747(ybgC)
PDK: 
PADK2_20850
PSG: 
G655_20505
PRP: 
M062_04760
PAEP: 
PA1S_21570
PAER: 
PA1R_gp4495
PAEM: 
U769_20940
PAEL: 
T223_22205
PAES: 
SCV20265_4552
PAEU: 
BN889_01022
PAEG: 
AI22_12370
PAEC: 
M802_998(ybgC)
PAEO: 
M801_1002(ybgC)
PMY: 
Pmen_1273
PMK: 
MDS_1307
PRE: 
PCA10_44240
PPSE: 
BN5_3084
PALC: 
A0T30_16225
PCQ: 
PcP3B5_17220(ybgC_1)
PPU: 
PP_1218
PPF: 
Pput_1247
PPG: 
PputGB1_4200
PPW: 
PputW619_3997
PPT: 
PPS_3999
PPB: 
PPUBIRD1_1255
PPI: 
YSA_07517
PPX: 
T1E_5727
PPUH: 
B479_20300
PPUT: 
L483_25335
PPUN: 
PP4_11570(ybgC)
PPUD: 
DW66_4438
PFV: 
Psefu_1530
PMON: 
X969_19555
PMOT: 
X970_19190
PMOS: 
O165_001105
PPJ: 
RK21_00480
POR: 
APT59_14510
PST: 
PSPTO_3976
PSB: 
Psyr_1411
PSYR: 
N018_18605
PSP: 
PSPPH_3771
PCI: 
PCH70_13190
PFL: 
PFL_4762(ybgC)
PPRC: 
PFLCHA0_c47420(ybgC)
PPRO: 
PPC_4770(ybgC)
PFO: 
Pfl01_4406
PFS: 
PFLU_4912
PFE: 
PSF113_4614
PFC: 
PflA506_4221(ybgC)
PFN: 
HZ99_07205 HZ99_10605
PFW: 
PF1751_v1c44060(ybgC)
PFB: 
VO64_1765
PFF: 
PFLUOLIPICF714110
PFX: 
A7318_22695
PPZ: 
H045_15440
PMAN: 
OU5_4878
PTV: 
AA957_20290
PCG: 
AXG94_09170
PVR: 
PverR02_24895
PAZO: 
AYR47_00485
PEN: 
PSEEN4091
PSA: 
PST_2807
PSZ: 
PSTAB_2829
PSR: 
PSTAA_2930
PSC: 
A458_14700
PSJ: 
PSJM300_07325
PSH: 
Psest_1498
PSTU: 
UIB01_06925
PSTT: 
CH92_07145
PBM: 
CL52_13830
PBA: 
PSEBR_a4439
PBC: 
CD58_23505
PPUU: 
PputUW4_04295
PDR: 
H681_17800
PSV: 
PVLB_19145
PSK: 
U771_25465
PKC: 
PKB_1388
PCH: 
EY04_24260
PCZ: 
PCL1606_15020
PCP: 
JM49_07435
PFZ: 
AV641_16620
PALK: 
PSAKL28_40370
PRH: 
LT40_05005
PSW: 
LK03_11285
PPV: 
NJ69_12425
PSES: 
PSCI_3265
PSEM: 
TO66_24360
PSEC: 
CCOS191_4073
PPSY: 
AOC04_13910
PSOS: 
POS17_4737(ybgC)
PKR: 
AYO71_23985
PFK: 
PFAS1_04955
PANR: 
A7J50_4682
AVN: 
Avin_14220 Avin_36680(ybgC)
AVL: 
AvCA_14220 AvCA_36680(ybgC)
AVD: 
AvCA6_14220 AvCA6_36680(ybgC)
ACX: 
Achr_12920(ybgC)
PBB: 
AKN87_06390
MLQ: 
ASQ50_20260
CEB: 
B0D95_01235
TTU: 
TERTU_3433(ybgC)
SPOI: 
IMCC21906_02758
ZAL: 
AZF00_05625
OSG: 
BST96_13745
MTHD: 
A3224_03380
MICC: 
AUP74_00187(ybgC)
CSA: 
Csal_1849
HEL: 
HELO_3952
HAK: 
KO116_00936
HAM: 
HALO3248
CMAI: 
BFX80_09195
ABO: 
ABO_0754
ADI: 
B5T_03230
APAC: 
S7S_06315
ALN: 
AS19_07790
AXE: 
P40_15100
MMW: 
Mmwyl1_3016
MPC: 
Mar181_1045
MARS: 
A8C75_04825
GSN: 
YC6258_02578
GPB: 
HDN1F_32790
RSO: 
RSc1827 RSp0038
RSL: 
RPSI07_mp0054
RSN: 
RSPO_m00054(ybgC)
RSM: 
CMR15_11834 CMR15_mp10040
RSE: 
F504_1562 F504_3544
RPI: 
Rpic_3837
RPF: 
Rpic12D_3950
RPJ: 
N234_03105 N234_14065
RMN: 
TK49_19430
RIN: 
ACS15_5525
REU: 
Reut_A2179
REH: 
H16_A2456(h16_A2456)
CNC: 
CNE_1c23650 CNE_2c20780
RME: 
Rmet_2197
CTI: 
RALTA_A1987
CBW: 
RR42_m2746 RR42_s0687
CGD: 
CR3_1769
CCUP: 
BKK81_14230
BGL: 
bglu_2g11430
BGP: 
BGL_2c14270
BGU: 
KS03_4780
BUG: 
BC1001_4667
BGE: 
BC1002_4976
BGF: 
BC1003_4831
BYI: 
BYI23_D000280 BYI23_D002080
BUO: 
BRPE64_DCDS01920
BUE: 
BRPE67_DCDS02310 BRPE67_DCDS03830
BUQ: 
AC233_26690
BPLA: 
bpln_2g15030
BXE: 
Bxe_B0277
BXB: 
DR64_5618
BPH: 
Bphy_4073
BPX: 
BUPH_01242
BPY: 
Bphyt_7163
BFN: 
OI25_5788
BCAI: 
K788_0001054
PSPW: 
BJG93_22135
PPK: 
U875_07415
PPNO: 
DA70_00060
PPNM: 
LV28_06215
PRB: 
X636_02165
PPUL: 
RO07_00205
PSPU: 
NA29_11430
PAPI: 
SG18_00500 SG18_14780
PVE: 
UC34_16565
POX: 
MB84_21350
PTX: 
ABW99_11395
PFG: 
AB870_03390
PNR: 
AT302_15615
BPE: 
BP0312
BPC: 
BPTD_0307
BPER: 
BN118_0335
BPET: 
B1917_0314
BPEU: 
Q425_35250
BPA: 
BPP3939
BPAR: 
BN117_4013
BBR: 
BB4412
BBM: 
BN115_4088
BBH: 
BN112_4010
BBX: 
BBS798_4189
BPT: 
Bpet0554
BAV: 
BAV3019
BHO: 
D560_1956
BHM: 
D558_1941
BHZ: 
ACR54_04138(fadM)
BTRM: 
SAMEA390648700749
AXY: 
AXYL_00589
AXO: 
NH44784_015901
AXN: 
AX27061_0600
AXS: 
LH59_02960
AXX: 
ERS451415_00592(fadM_1)
ADT: 
APT56_03085
AIS: 
BUW96_22900
CDN: 
BN940_15386
AFA: 
UZ73_10395
PHN: 
PAEH1_09410
RFR: 
Rfer_0270
RSB: 
RS694_10305
RHY: 
RD110_17125
POL: 
Bpro_0588 Bpro_3115
PNA: 
Pnap_0799 Pnap_3622
AAA: 
Acav_3343
DTS: 
BI380_01290
DHK: 
BO996_20210
VAP: 
Vapar_0657 Vapar_1512 Vapar_3916
VPE: 
Varpa_1667 Varpa_4528
VPD: 
VAPA_1c16040 VAPA_1c40390
CTT: 
CtCNB1_0395
CTES: 
O987_02035
RTA: 
Rta_32470
LIM: 
L103DPR2_01473
LIH: 
L63ED372_00985
HYR: 
BSY239_2242
HYB: 
Q5W_08945
HYL: 
LPB072_16190
CBAA: 
SRAA_0575
HSE: 
Hsero_4010
HSZ: 
ACP92_20020
HRB: 
Hrubri_3964 Hrubri_4428
LCH: 
Lcho_0444
PKT: 
AT984_10450
MIU: 
ABE85_02430
BBAG: 
E1O_00540
PBH: 
AAW51_1944
SHD: 
SUTH_01213(fcbC1) SUTH_01666
AZO: 
azo1929 azo2495(fcbC1) azo3044(ybgC) azo3771(fcbC2)
AZA: 
AZKH_1859(abmF) AZKH_4507
AZI: 
AzCIB_1777 AzCIB_4625
TMZ: 
Tmz1t_2489
TCL: 
Tchl_0786 Tchl_2975
DTO: 
TOL2_C37360
ACP: 
A2cp1_0777
VIN: 
AKJ08_2653
SCL: 
sce1756(fcbC)
SCU: 
SCE1572_10950
CCRO: 
CMC5_031430
LLU: 
AKJ09_08412
MRM: 
A7982_12749
MESO: 
BSQ44_21450
HOE: 
IMCC20628_01410
AAK: 
AA2016_5727
SIX: 
BSY16_4356
EAH: 
FA04_32455
RTR: 
RTCIAT899_CH14285
NGL: 
RG1141_CH38300
NGG: 
RG540_CH38950
BJA: 
blr3414 blr7847
BJU: 
BJ6T_62370 BJ6T_84700
BJP: 
RN69_30230 RN69_40930
BRA: 
BRADO0965
BBT: 
BBta_3245 BBta_7090
BRS: 
S23_09410
AOL: 
S58_66640
BRC: 
BCCGELA001_33020
BRAD: 
BF49_4142
BIC: 
LMTR13_35495
RPA: 
RPA1788
RPE: 
RPE_3801
RPT: 
Rpal_1990
RPX: 
Rpdx1_3744
AZC: 
AZC_3186
MAQU: 
Maq22A_c00755(fcbC)
PHL: 
KKY_2322
DEQ: 
XM25_21580
BVR: 
BVIR_1678
RHZ: 
RHPLAN_69970
MMED: 
Mame_00666 Mame_00668
PSIN: 
CAK95_06190 CAK95_08370
BNE: 
DA69_02060
CBOT: 
ATE48_08955
SIL: 
SPO0786 SPO1457
SIT: 
TM1040_2232
RMB: 
K529_002700
JAN: 
Jann_1329
PDE: 
Pden_5092
PSF: 
PSE_3158
CID: 
P73_0182
MALG: 
MALG_04444
LAP: 
ACP90_18540
LAGG: 
B0E33_02310 B0E33_30180
SUAM: 
BOO69_03865 BOO69_19305
TOM: 
BWR18_13925
PABY: 
Ga0080574_TMP204
NPP: 
PP1Y_AT11643
NRE: 
BES08_24460
SPHP: 
LH20_14110
SGI: 
SGRAN_0822
SWI: 
Swit_0821
SPHI: 
TS85_01650 TS85_07575 TS85_07890
SSAN: 
NX02_11380
SSY: 
SLG_12450
BLAS: 
BSY18_661
AMX: 
AM2010_2425
MAGX: 
XM1_0600 XM1_2264
MAGN: 
WV31_11530
ALI: 
AZOLI_p40108
ATI: 
AL072_23335
TXI: 
TH3_13995
RHA: 
RHA1_ro02376
SALU: 
DC74_825
SALL: 
SAZ_04655
RBA: 
RB8462
LIL: 
LA_3529
LAJ: 
A0128_05635
GAU: 
GAU_3270
GPH: 
GEMMAAP_16730
FIN: 
KQS_01635
HLR: 
HALLA_19905
AG: 
ABQ44580
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1610806
  Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D
  Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
  Journal
Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025
  Sequence
LinkDB All DBs

KEGG   ENZYME: 3.1.2.23Help
Entry
EC 3.1.2.23                 Enzyme                                 

Name
4-hydroxybenzoyl-CoA thioesterase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
4-hydroxybenzoyl-CoA hydrolase
Reaction(IUBMB)
4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA [RN:R01301]
Reaction(KEGG)
Substrate
4-hydroxybenzoyl-CoA [CPD:C02949];
H2O [CPD:C00001]
Product
4-hydroxybenzoate [CPD:C00156];
CoA [CPD:C00010]
Comment
This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.
History
EC 3.1.2.23 created 1999
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Benzoate degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K01075  
4-hydroxybenzoyl-CoA thioesterase
Genes
EBT: 
XDO: 
XHO: 
PRG: 
PAE: 
PAEV: 
N297_1002(ybgC)
PAEI: 
N296_1002(ybgC)
PAU: 
PAP: 
PAG: 
PAF: 
PAM18_4069
PNC: 
NCGM2_1775(ybgC)
PAEB: 
NCGM1900_1747(ybgC)
PDK: 
PADK2_20850
PSG: 
G655_20505
PRP: 
M062_04760
PAEP: 
PA1S_21570
PAER: 
PA1R_gp4495
PAEM: 
U769_20940
PAEL: 
T223_22205
PAES: 
SCV20265_4552
PAEU: 
BN889_01022
PAEG: 
AI22_12370
PAEC: 
M802_998(ybgC)
PAEO: 
M801_1002(ybgC)
PMY: 
Pmen_1273
PMK: 
MDS_1307
PRE: 
PCA10_44240
PPSE: 
BN5_3084
PALC: 
A0T30_16225
PCQ: 
PcP3B5_17220(ybgC_1)
PPU: 
PP_1218
PPF: 
Pput_1247
PPG: 
PputGB1_4200
PPW: 
PputW619_3997
PPT: 
PPS_3999
PPB: 
PPUBIRD1_1255
PPI: 
YSA_07517
PPX: 
T1E_5727
PPUH: 
B479_20300
PPUT: 
L483_25335
PPUN: 
PP4_11570(ybgC)
PPUD: 
DW66_4438
PFV: 
Psefu_1530
PMON: 
X969_19555
PMOT: 
X970_19190
PMOS: 
O165_001105
PPJ: 
RK21_00480
POR: 
APT59_14510
PST: 
PSPTO_3976
PSB: 
Psyr_1411
PSYR: 
N018_18605
PSP: 
PSPPH_3771
PCI: 
PCH70_13190
PFL: 
PFL_4762(ybgC)
PPRC: 
PFLCHA0_c47420(ybgC)
PPRO: 
PPC_4770(ybgC)
PFO: 
Pfl01_4406
PFS: 
PFLU_4912
PFE: 
PSF113_4614
PFC: 
PflA506_4221(ybgC)
PFN: 
HZ99_07205 HZ99_10605
PFW: 
PF1751_v1c44060(ybgC)
PFB: 
VO64_1765
PFF: 
PFLUOLIPICF714110
PFX: 
A7318_22695
PPZ: 
H045_15440
PMAN: 
OU5_4878
PTV: 
AA957_20290
PCG: 
AXG94_09170
PVR: 
PverR02_24895
PAZO: 
AYR47_00485
PEN: 
PSEEN4091
PSA: 
PST_2807
PSZ: 
PSTAB_2829
PSR: 
PSTAA_2930
PSC: 
A458_14700
PSJ: 
PSJM300_07325
PSH: 
Psest_1498
PSTU: 
UIB01_06925
PSTT: 
CH92_07145
PBM: 
CL52_13830
PBA: 
PSEBR_a4439
PBC: 
CD58_23505
PPUU: 
PputUW4_04295
PDR: 
H681_17800
PSV: 
PVLB_19145
PSK: 
U771_25465
PKC: 
PKB_1388
PCH: 
EY04_24260
PCZ: 
PCL1606_15020
PCP: 
JM49_07435
PFZ: 
AV641_16620
PALK: 
PSAKL28_40370
PRH: 
LT40_05005
PSW: 
LK03_11285
PPV: 
NJ69_12425
PSES: 
PSCI_3265
PSEM: 
TO66_24360
PSEC: 
CCOS191_4073
PPSY: 
AOC04_13910
PSOS: 
POS17_4737(ybgC)
PKR: 
AYO71_23985
PFK: 
PFAS1_04955
PANR: 
A7J50_4682
AVN: 
Avin_14220 Avin_36680(ybgC)
AVL: 
AvCA_14220 AvCA_36680(ybgC)
AVD: 
AvCA6_14220 AvCA6_36680(ybgC)
ACX: 
Achr_12920(ybgC)
PBB: 
AKN87_06390
MLQ: 
ASQ50_20260
CEB: 
B0D95_01235
TTU: 
TERTU_3433(ybgC)
SPOI: 
IMCC21906_02758
ZAL: 
AZF00_05625
OSG: 
BST96_13745
MTHD: 
A3224_03380
MICC: 
AUP74_00187(ybgC)
CSA: 
Csal_1849
HEL: 
HELO_3952
HAK: 
KO116_00936
HAM: 
HALO3248
CMAI: 
BFX80_09195
ABO: 
ABO_0754
ADI: 
B5T_03230
APAC: 
S7S_06315
ALN: 
AS19_07790
AXE: 
P40_15100
MMW: 
Mmwyl1_3016
MPC: 
Mar181_1045
MARS: 
A8C75_04825
GSN: 
YC6258_02578
GPB: 
HDN1F_32790
RSO: 
RSc1827 RSp0038
RSL: 
RPSI07_mp0054
RSN: 
RSPO_m00054(ybgC)
RSM: 
CMR15_11834 CMR15_mp10040
RSE: 
F504_1562 F504_3544
RPI: 
Rpic_3837
RPF: 
Rpic12D_3950
RPJ: 
N234_03105 N234_14065
RMN: 
TK49_19430
RIN: 
ACS15_5525
REU: 
Reut_A2179
REH: 
H16_A2456(h16_A2456)
CNC: 
CNE_1c23650 CNE_2c20780
RME: 
Rmet_2197
CTI: 
RALTA_A1987
CBW: 
RR42_m2746 RR42_s0687
CGD: 
CR3_1769
CCUP: 
BKK81_14230
BGL: 
bglu_2g11430
BGP: 
BGL_2c14270
BGU: 
KS03_4780
BUG: 
BC1001_4667
BGE: 
BC1002_4976
BGF: 
BC1003_4831
BYI: 
BYI23_D000280 BYI23_D002080
BUO: 
BRPE64_DCDS01920
BUE: 
BRPE67_DCDS02310 BRPE67_DCDS03830
BUQ: 
AC233_26690
BPLA: 
bpln_2g15030
BXE: 
Bxe_B0277
BXB: 
DR64_5618
BPH: 
Bphy_4073
BPX: 
BUPH_01242
BPY: 
Bphyt_7163
BFN: 
OI25_5788
BCAI: 
K788_0001054
PSPW: 
BJG93_22135
PPK: 
U875_07415
PPNO: 
DA70_00060
PPNM: 
LV28_06215
PRB: 
X636_02165
PPUL: 
RO07_00205
PSPU: 
NA29_11430
PAPI: 
SG18_00500 SG18_14780
PVE: 
UC34_16565
POX: 
MB84_21350
PTX: 
ABW99_11395
PFG: 
AB870_03390
PNR: 
AT302_15615
BPE: 
BP0312
BPC: 
BPTD_0307
BPER: 
BN118_0335
BPET: 
B1917_0314
BPEU: 
Q425_35250
BPA: 
BPP3939
BPAR: 
BN117_4013
BBR: 
BB4412
BBM: 
BN115_4088
BBH: 
BN112_4010
BBX: 
BBS798_4189
BPT: 
Bpet0554
BAV: 
BAV3019
BHO: 
D560_1956
BHM: 
D558_1941
BHZ: 
ACR54_04138(fadM)
BTRM: 
SAMEA390648700749
AXY: 
AXYL_00589
AXO: 
NH44784_015901
AXN: 
AX27061_0600
AXS: 
LH59_02960
AXX: 
ERS451415_00592(fadM_1)
ADT: 
APT56_03085
AIS: 
BUW96_22900
CDN: 
BN940_15386
AFA: 
UZ73_10395
PHN: 
PAEH1_09410
RFR: 
Rfer_0270
RSB: 
RS694_10305
RHY: 
RD110_17125
POL: 
Bpro_0588 Bpro_3115
PNA: 
Pnap_0799 Pnap_3622
AAA: 
Acav_3343
DTS: 
BI380_01290
DHK: 
BO996_20210
VAP: 
Vapar_0657 Vapar_1512 Vapar_3916
VPE: 
Varpa_1667 Varpa_4528
VPD: 
VAPA_1c16040 VAPA_1c40390
CTT: 
CtCNB1_0395
CTES: 
O987_02035
RTA: 
Rta_32470
LIM: 
L103DPR2_01473
LIH: 
L63ED372_00985
HYR: 
BSY239_2242
HYB: 
Q5W_08945
HYL: 
LPB072_16190
CBAA: 
SRAA_0575
HSE: 
Hsero_4010
HSZ: 
ACP92_20020
HRB: 
Hrubri_3964 Hrubri_4428
LCH: 
Lcho_0444
PKT: 
AT984_10450
MIU: 
ABE85_02430
BBAG: 
E1O_00540
PBH: 
AAW51_1944
SHD: 
SUTH_01213(fcbC1) SUTH_01666
AZO: 
azo1929 azo2495(fcbC1) azo3044(ybgC) azo3771(fcbC2)
AZA: 
AZKH_1859(abmF) AZKH_4507
AZI: 
AzCIB_1777 AzCIB_4625
TMZ: 
Tmz1t_2489
TCL: 
Tchl_0786 Tchl_2975
DTO: 
TOL2_C37360
ACP: 
A2cp1_0777
VIN: 
AKJ08_2653
SCL: 
sce1756(fcbC)
SCU: 
SCE1572_10950
CCRO: 
CMC5_031430
LLU: 
AKJ09_08412
MRM: 
A7982_12749
MESO: 
BSQ44_21450
HOE: 
IMCC20628_01410
AAK: 
AA2016_5727
SIX: 
BSY16_4356
EAH: 
FA04_32455
RTR: 
RTCIAT899_CH14285
NGL: 
RG1141_CH38300
NGG: 
RG540_CH38950
BJA: 
blr3414 blr7847
BJU: 
BJ6T_62370 BJ6T_84700
BJP: 
RN69_30230 RN69_40930
BRA: 
BRADO0965
BBT: 
BBta_3245 BBta_7090
BRS: 
S23_09410
AOL: 
S58_66640
BRC: 
BCCGELA001_33020
BRAD: 
BF49_4142
BIC: 
LMTR13_35495
RPA: 
RPA1788
RPE: 
RPE_3801
RPT: 
Rpal_1990
RPX: 
Rpdx1_3744
AZC: 
AZC_3186
MAQU: 
Maq22A_c00755(fcbC)
PHL: 
KKY_2322
DEQ: 
XM25_21580
BVR: 
BVIR_1678
RHZ: 
RHPLAN_69970
MMED: 
Mame_00666 Mame_00668
PSIN: 
CAK95_06190 CAK95_08370
BNE: 
DA69_02060
CBOT: 
ATE48_08955
SIL: 
SPO0786 SPO1457
SIT: 
TM1040_2232
RMB: 
K529_002700
JAN: 
Jann_1329
PDE: 
Pden_5092
PSF: 
PSE_3158
CID: 
P73_0182
MALG: 
MALG_04444
LAP: 
ACP90_18540
LAGG: 
B0E33_02310 B0E33_30180
SUAM: 
BOO69_03865 BOO69_19305
TOM: 
BWR18_13925
PABY: 
Ga0080574_TMP204
NPP: 
PP1Y_AT11643
NRE: 
BES08_24460
SPHP: 
LH20_14110
SGI: 
SGRAN_0822
SWI: 
Swit_0821
SPHI: 
TS85_01650 TS85_07575 TS85_07890
SSAN: 
NX02_11380
SSY: 
SLG_12450
BLAS: 
BSY18_661
AMX: 
AM2010_2425
MAGX: 
XM1_0600 XM1_2264
MAGN: 
WV31_11530
ALI: 
AZOLI_p40108
ATI: 
AL072_23335
TXI: 
TH3_13995
RHA: 
RHA1_ro02376
SALU: 
DC74_825
SALL: 
SAZ_04655
RBA: 
RB8462
LIL: 
LA_3529
LAJ: 
A0128_05635
GAU: 
GAU_3270
GPH: 
GEMMAAP_16730
FIN: 
KQS_01635
HLR: 
HALLA_19905
 » show all
Taxonomy
Reference
1  [PMID:1610806]
  Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D.
  Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
  Journal
Biochemistry. 31 (1992) 5605-10.
  Sequence
Reference
2  [PMID:7765837]
  Authors
Dunaway-Mariano D, Babbitt PC.
  Title
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.
  Journal
Biodegradation. 5 (1994) 259-76.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
141583-19-9
LinkDB All DBs

KEGG   ENZYME: 6.2.1.27Help
Entry
EC 6.2.1.27                 Enzyme                                 

Name
4-hydroxybenzoate---CoA ligase;
4-hydroxybenzoate-CoA synthetase;
4-hydroxybenzoate---coenzyme A ligase (AMP-forming);
4-hydroxybenzoyl coenzyme A synthetase;
4-hydroxybenzoyl-CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-hydroxybenzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA [RN:R01300]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-hydroxybenzoate [CPD:C00156];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybenzoyl-CoA [CPD:C02949]
History
EC 6.2.1.27 created 1992
Pathway
Benzoate degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K04105  
4-hydroxybenzoate-CoA ligase
K20458  
3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase
Genes
EBA: 
ebA727(hbcL)
AZI: 
BJA: 
BJU: 
BJP: 
BRA: 
BBT: 
BRS: 
AOL: 
BRC: 
RPA: 
RPA0669(hbaA)
RPB: 
RPB_4656
RPC: 
RPC_1016
RPD: 
RPD_0878 RPD_1526
RPE: 
RPE_0592
RPT: 
Rpal_0736
RPX: 
Rpdx1_4117
RHZ: 
RHPLAN_70010
SIL: 
SPO3697(badA-1)
JAN: 
Jann_0669
MAG: 
amb1551 amb2869
MAGX: 
XM1_2792(bclA) XM1_3957(hcl)
 » show all
Taxonomy
Reference
1  [PMID:2914844]
  Authors
Merkel SM, Eberhard AE, Gibson J, Harwood CS.
  Title
Involvement of coenzyme A thioesters in anaerobic metabolism of 4-hydroxybenzoate by Rhodopseudomonas palustris.
  Journal
J. Bacteriol. 171 (1989) 1-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
119699-80-8
LinkDB All DBs

KEGG   REACTION: R01300Help
Entry
R01300                      Reaction                               

Name
4-hydroxybenzoate:CoA ligase (AMP-forming)
Definition
ATP + 4-Hydroxybenzoate + CoA <=> AMP + Diphosphate + 4-Hydroxybenzoyl-CoA
Equation
Reaction class
C00010_C02949
C00156_C02949
Enzyme
Pathway
Benzoate degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Degradation of aromatic compounds
Orthology
K04105  
4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25]
K20458  
3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase [EC:6.2.1.37 6.2.1.27]
Other DBs
RHEA: 
LinkDB All DBs

KEGG   REACTION: R01301Help
Entry
R01301                      Reaction                               

Name
4-Hydroxybenzoyl-CoA hydrolase
Definition
4-Hydroxybenzoyl-CoA + H2O <=> 4-Hydroxybenzoate + CoA
Equation
Reaction class
C00010_C02949
C00156_C02949
Enzyme
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Benzoate degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K01075  
4-hydroxybenzoyl-CoA thioesterase [EC:3.1.2.23]
Other DBs
RHEA: 
LinkDB All DBs

DBGET integrated database retrieval system