KEGG   ORTHOLOGY: K04110Help
Entry
K04110                      KO                                     

Name
badA
Definition
benzoate-CoA ligase [EC:6.2.1.25]
Pathway
Benzoate degradation
Aminobenzoate degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04110  badA; benzoate-CoA ligase
   00627 Aminobenzoate degradation
    K04110  badA; benzoate-CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.25  benzoate---CoA ligase
     K04110  badA; benzoate-CoA ligase
BRITE hierarchy
Other DBs
RN: 
COG: 
GO: 
Genes
RPJ: 
REU: 
REH: 
H16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNC: 
RME: 
Rmet_1224(bzdA)
CTI: 
CBW: 
BGL: 
BUG: 
BGE: 
BGF: 
BC1003_1063
BXE: 
Bxe_A1419 Bxe_C0896
BPH: 
Bphy_1543
BRH: 
RBRH_00494
BPY: 
Bphyt_2700
BPT: 
Bpet3574
AXY: 
AXYL_05035
RFR: 
Rfer_0216
POL: 
Bpro_1624 Bpro_2983
PNA: 
Pnap_2948
VEI: 
Veis_0730
DAC: 
Daci_0076
DEL: 
DelCs14_0077
VAP: 
Vapar_0089
VPE: 
Varpa_0102
CTT: 
CtCNB1_0097
RTA: 
Rta_22340
LCH: 
Lcho_3655
SHD: 
SUTH_01659
EBA: 
ebA2757(bclA) ebA5301(bclA)
AZO: 
azo3052(bzdA)
AZA: 
AZKH_4514(bclA)
AZI: 
AzCIB_4632
TMZ: 
Tmz1t_3136
GME: 
Gmet_2143(bamY)
GLO: 
Glov_2397
GEO: 
Geob_0200(bamY)
GEM: 
GM21_2825
DMA: 
DMR_19390
DPR: 
Despr_3172
SAT: 
SYN_02896 SYN_02898
BBT: 
BBta_6637(badA)
RPA: 
RPA0661(badA)
RPC: 
RPC_1025
RPD: 
RPD_1534
RPE: 
RPE_0604
RPT: 
Rpal_0728
RVA: 
Rvan_0044
RHZ: 
RHPLAN_60910
SWI: 
Swit_0829
GYC: 
GYMC61_2828
SCB: 
SCAB_8391
AMD: 
AMED_8609(badA)
PDX: 
Psed_1491
 » show all
TaxonomyKoalaUniProt
LinkDB All DBs

KEGG   ORTHOLOGY: K04105Help
Entry
K04105                      KO                                     

Name
hbaA
Definition
4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25]
Pathway
Benzoate degradation
Aminobenzoate degradation
Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K04105  hbaA; 4-hydroxybenzoate-CoA ligase
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04105  hbaA; 4-hydroxybenzoate-CoA ligase
   00627 Aminobenzoate degradation
    K04105  hbaA; 4-hydroxybenzoate-CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.25  benzoate---CoA ligase
     K04105  hbaA; 4-hydroxybenzoate-CoA ligase
    6.2.1.27  4-hydroxybenzoate---CoA ligase
     K04105  hbaA; 4-hydroxybenzoate-CoA ligase
BRITE hierarchy
Other DBs
Genes
BJA: 
BJU: 
BJP: 
BRA: 
BBT: 
BRS: 
AOL: 
BRC: 
RPA: 
RPA0669(hbaA)
RPB: 
RPC: 
RPC_1016
RPD: 
RPD_0878 RPD_1526
RPE: 
RPE_0592
RPT: 
Rpal_0736
RPX: 
Rpdx1_4117
SIL: 
SPO3697(badA-1)
JAN: 
Jann_0669
MAG: 
amb2869
MAGX: 
XM1_2792(bclA)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9006014
  Authors
Gibson J, Dispensa M, Harwood CS
  Title
4-hydroxybenzoyl coenzyme A reductase (dehydroxylating) is required for anaerobic degradation of 4-hydroxybenzoate by Rhodopseudomonas palustris and shares features with molybdenum-containing hydroxylases.
  Journal
J Bacteriol 179:634-42 (1997)
DOI:10.1128/JB.179.3.634-642.1997
Reference
PMID:8300518
  Authors
Gibson J, Dispensa M, Fogg GC, Evans DT, Harwood CS
  Title
4-Hydroxybenzoate-coenzyme A ligase from Rhodopseudomonas palustris: purification, gene sequence, and role in anaerobic degradation.
  Journal
J Bacteriol 176:634-41 (1994)
DOI:10.1128/JB.176.3.634-641.1994
  Sequence
[rpa:RPA0669]
LinkDB All DBs

KEGG   ENZYME: 6.2.1.25Help
Entry
EC 6.2.1.25                 Enzyme                                 

Name
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
benzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
Comment
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
History
EC 6.2.1.25 created 1989
Pathway
Benzoate degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K04105  
4-hydroxybenzoate-CoA ligase
K04110  
benzoate-CoA ligase
Genes
RPJ: 
REU: 
REH: 
H16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNC: 
RME: 
Rmet_1224(bzdA)
CTI: 
CBW: 
BGL: 
BUG: 
BGE: 
BGF: 
BC1003_1063
BXE: 
Bxe_A1419 Bxe_C0896
BPH: 
Bphy_1543
BRH: 
RBRH_00494
BPY: 
Bphyt_2700
BPT: 
Bpet3574
AXY: 
AXYL_05035
RFR: 
Rfer_0216
POL: 
Bpro_1624 Bpro_2983
PNA: 
Pnap_2948
VEI: 
Veis_0730
DAC: 
Daci_0076
DEL: 
DelCs14_0077
VAP: 
Vapar_0089
VPE: 
Varpa_0102
CTT: 
CtCNB1_0097
RTA: 
Rta_22340
LCH: 
Lcho_3655
SHD: 
SUTH_01659
EBA: 
ebA2757(bclA) ebA5301(bclA)
AZO: 
azo3052(bzdA)
AZA: 
AZKH_4514(bclA)
AZI: 
AzCIB_4632
TMZ: 
Tmz1t_3136
GME: 
Gmet_2143(bamY)
GLO: 
Glov_2397
GEO: 
Geob_0200(bamY)
GEM: 
GM21_2825
DMA: 
DMR_19390
DPR: 
Despr_3172
SAT: 
SYN_02896 SYN_02898
BJA: 
blr1077
BJU: 
BJ6T_11070
BJP: 
RN69_05405
BRA: 
BRADO6791
BBT: 
BBta_0747 BBta_6637(badA)
BRS: 
S23_67390
AOL: 
S58_06690
BRC: 
BCCGELA001_34230
RPA: 
RPA0661(badA) RPA0669(hbaA)
RPB: 
RPB_4656
RPC: 
RPC_1016 RPC_1025
RPD: 
RPD_0878 RPD_1526 RPD_1534
RPE: 
RPE_0592 RPE_0604
RPT: 
Rpal_0728 Rpal_0736
RPX: 
Rpdx1_4117
RVA: 
Rvan_0044
RHZ: 
RHPLAN_60910
SIL: 
SPO3697(badA-1)
JAN: 
Jann_0669
SWI: 
Swit_0829
MAG: 
amb2869
MAGX: 
XM1_2792(bclA)
GYC: 
GYMC61_2828
SCB: 
SCAB_8391
AMD: 
AMED_8609(badA)
PDX: 
Psed_1491
 » show all
Taxonomy
Reference
1
  Authors
Hutber, G.N. and Ribbons, D.W.
  Title
Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
  Journal
J. Gen. Microbiol. 129 (1983) 2413-2420.
Reference
2  [PMID:2857161]
  Authors
Schennen U, Braun K, Knackmuss HJ.
  Title
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
  Journal
J. Bacteriol. 161 (1985) 321-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
95329-17-2
LinkDB All DBs

KEGG   REACTION: R01422Help
Entry
R01422                      Reaction                               

Name
benzoate:CoA ligase (AMP-forming)
Definition
ATP + Benzoate + CoA <=> AMP + Diphosphate + Benzoyl-CoA
Equation
Reaction class
C00010_C00512
C00180_C00512
Enzyme
Pathway
Benzoate degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K04105  
4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25]
K04110  
benzoate-CoA ligase [EC:6.2.1.25]
Other DBs
RHEA: 
LinkDB All DBs

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