KEGG ORTHOLOGY: K04112

COG:

COG1775

GO:

Genes

EBA:	ebA5282(bcrC) ebA748(bcrC)
TMZ:	Tmz1t_2951
GLO:	Glov_2401
RPA:	RPA0657(badD)
RPC:	RPC_1029
RPD:	RPD_1538
RPE:	RPE_0608
RPT:	Rpal_0724
RPX:	Rpdx1_4129
RVA:	Rvan_0037
MAG:	amb2141
SLP:	Slip_0467
FPL:	Ferp_1184
AG:	CAA12247(bcrC)

Reference

PMID:8575453

Authors

Boll M, Fuchs G

Title

Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172.

Journal

Eur J Biochem 234:921-33 (1995)
DOI:10.1111/j.1432-1033.1995.921_a.x

Reference

PMID:9746358

Authors

Breese K, Boll M, Alt-Morbe J, Schagger H, Fuchs G

Title

Genes coding for the benzoyl-CoA pathway of anaerobic aromatic metabolism in the bacterium Thauera aromatica.

Journal

Eur J Biochem 256:148-54 (1998)
DOI:10.1046/j.1432-1327.1998.2560148.x

Sequence

[ag:CAA12247]

LinkDB

ORTHOLOGY: K04113

Entry

K04113 KO

Name

bcrB, badE

Definition

benzoyl-CoA reductase subunit B [EC:1.3.7.8]

Pathway

ko00362	Benzoate degradation
ko01220	Degradation of aromatic compounds

Module

M00541

Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K04113  bcrB, badE; benzoyl-CoA reductase subunit B
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04113  bcrB, badE; benzoyl-CoA reductase subunit B
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
     K04113  bcrB, badE; benzoyl-CoA reductase subunit B
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.8  benzoyl-CoA reductase
     K04113  bcrB, badE; benzoyl-CoA reductase subunit B

Other DBs

RN:

GO:

Genes

EBA:	ebA5284(bcrB)
TMZ:	Tmz1t_2950
GLO:	Glov_2400
RPA:	RPA0658(badE)
RPC:	RPC_1028
RPD:	RPD_1537
RPE:	RPE_0607
RPT:	Rpal_0725
RPX:	Rpdx1_4128
RVA:	Rvan_0038
MAG:	amb2140
SLP:	Slip_0468
FPL:	Ferp_1185
AG:	CAA12248(bcrB)

Reference

PMID:8575453

Authors

Boll M, Fuchs G

Title

Journal

Eur J Biochem 234:921-33 (1995)
DOI:10.1111/j.1432-1033.1995.921_a.x

Reference

PMID:9746358

Authors

Breese K, Boll M, Alt-Morbe J, Schagger H, Fuchs G

Title

Genes coding for the benzoyl-CoA pathway of anaerobic aromatic metabolism in the bacterium Thauera aromatica.

Journal

Eur J Biochem 256:148-54 (1998)
DOI:10.1046/j.1432-1327.1998.2560148.x

Sequence

[ag:CAA12248]

LinkDB

ORTHOLOGY: K04114

Entry

K04114 KO

Name

bcrA, badF

Definition

benzoyl-CoA reductase subunit A [EC:1.3.7.8]

Pathway

ko00362	Benzoate degradation
ko01220	Degradation of aromatic compounds

Module

M00541

Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K04114  bcrA, badF; benzoyl-CoA reductase subunit A
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04114  bcrA, badF; benzoyl-CoA reductase subunit A
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
     K04114  bcrA, badF; benzoyl-CoA reductase subunit A
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.8  benzoyl-CoA reductase
     K04114  bcrA, badF; benzoyl-CoA reductase subunit A

Other DBs

RN:

GO:

Genes

EBA:	ebA5287(bcrA) ebA742(bcrA)
TMZ:	Tmz1t_2949
RPA:	RPA0659(badF)
RPC:	RPC_1027
RPD:	RPD_1536
RPE:	RPE_0606
RPT:	Rpal_0726
RPX:	Rpdx1_4127
RVA:	Rvan_0039
MAG:	amb2139
FPL:	Ferp_1187
AG:	CAA12249(bcrA)

Reference

PMID:8575453

Authors

Boll M, Fuchs G

Title

Journal

Eur J Biochem 234:921-33 (1995)
DOI:10.1111/j.1432-1033.1995.921_a.x

Reference

PMID:9746358

Authors

Breese K, Boll M, Alt-Morbe J, Schagger H, Fuchs G

Title

Genes coding for the benzoyl-CoA pathway of anaerobic aromatic metabolism in the bacterium Thauera aromatica.

Journal

Eur J Biochem 256:148-54 (1998)
DOI:10.1046/j.1432-1327.1998.2560148.x

Sequence

[ag:CAA12249]

LinkDB

ORTHOLOGY: K04115

Entry

K04115 KO

Name

bcrD, badG

Definition

benzoyl-CoA reductase subunit D [EC:1.3.7.8]

Pathway

ko00362	Benzoate degradation
ko01220	Degradation of aromatic compounds

Module

M00541

Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K04115  bcrD, badG; benzoyl-CoA reductase subunit D
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04115  bcrD, badG; benzoyl-CoA reductase subunit D
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
     K04115  bcrD, badG; benzoyl-CoA reductase subunit D
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.8  benzoyl-CoA reductase
     K04115  bcrD, badG; benzoyl-CoA reductase subunit D

Other DBs

RN:

GO:

Genes

EBA:	ebA5286(bcrD) ebA744(bcrD)
TMZ:	Tmz1t_2948
RPA:	RPA0660(badG)
RPC:	RPC_1026
RPD:	RPD_1535
RPE:	RPE_0605
RPT:	Rpal_0727
RPX:	Rpdx1_4126
RVA:	Rvan_0040
MAG:	amb2138
FPL:	Ferp_1186
AG:	CAA12250(bcrD)

Reference

PMID:8575453

Authors

Boll M, Fuchs G

Title

Journal

Eur J Biochem 234:921-33 (1995)
DOI:10.1111/j.1432-1033.1995.921_a.x

Reference

PMID:9746358

Authors

Breese K, Boll M, Alt-Morbe J, Schagger H, Fuchs G

Title

Genes coding for the benzoyl-CoA pathway of anaerobic aromatic metabolism in the bacterium Thauera aromatica.

Journal

Eur J Biochem 256:148-54 (1998)
DOI:10.1046/j.1432-1327.1998.2560148.x

Sequence

[ag:CAA12250]

LinkDB

ORTHOLOGY: K19515

Entry

K19515 KO

Name

bamB

Definition

benzoyl-CoA reductase subunit BamB [EC:1.3.-.-]

Pathway

ko00362

Benzoate degradation

Module

M00541

Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K19515  bamB; benzoyl-CoA reductase subunit BamB
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
     K19515  bamB; benzoyl-CoA reductase subunit BamB
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.-  Acting on the CH-CH group of donors
    1.3.-.-
     K19515  bamB; benzoyl-CoA reductase subunit BamB

Other DBs

RN:

R10961

COG:

COG2414

Genes

GME:	Gmet_2087(bamB-1)
GBM:	Gbem_1444(bamB-1)
GEO:	Geob_0212(bamB-1)
GEM:	GM21_2810
DTO:	TOL2_C03790(bamB1)
DTI:	Desti_1912
DGI:	Desgi_1970

Reference

PMID:19815533

Authors

Kung JW, Loffler C, Dorner K, Heintz D, Gallien S, Van Dorsselaer A, Friedrich T, Boll M

Title

Identification and characterization of the tungsten-containing class of benzoyl-coenzyme A reductases.

Journal

Proc Natl Acad Sci U S A 106:17687-92 (2009)
DOI:10.1073/pnas.0905073106

Sequence

[gme:Gmet_2087]

LinkDB

ORTHOLOGY: K19516

Entry

K19516 KO

Name

bamC

Definition

benzoyl-CoA reductase subunit BamC [EC:1.3.-.-]

Pathway

ko00362

Benzoate degradation

Module

M00541

Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K19516  bamC; benzoyl-CoA reductase subunit BamC
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
     K19516  bamC; benzoyl-CoA reductase subunit BamC
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.-  Acting on the CH-CH group of donors
    1.3.-.-
     K19516  bamC; benzoyl-CoA reductase subunit BamC

Other DBs

RN:

R10961

COG:

COG0437

Genes

GME:	Gmet_2086(bamC-1)
GBM:	Gbem_1445(bamC-1)
GEO:	Geob_0213(bamC-1)
GEM:	GM21_2809
DTO:	TOL2_C03780(bamC1)
DTI:	Desti_1913
DGI:	Desgi_0478

Reference

PMID:19815533

Authors

Kung JW, Loffler C, Dorner K, Heintz D, Gallien S, Van Dorsselaer A, Friedrich T, Boll M

Title

Identification and characterization of the tungsten-containing class of benzoyl-coenzyme A reductases.

Journal

Proc Natl Acad Sci U S A 106:17687-92 (2009)
DOI:10.1073/pnas.0905073106

Sequence

[gme:Gmet_2086]

LinkDB

ENZYME: 1.3.7.8

Entry

EC 1.3.7.8 Enzyme

Name

benzoyl-CoA reductase;
benzoyl-CoA reductase (dearomatizing)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor

Sysname

cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)

Reaction(IUBMB)

cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O [RN:R02451]

Reaction(KEGG)

R02451;
(other) R00283

Substrate

cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
oxidized ferredoxin [CPD:C00139];
ADP [CPD:C00008];
phosphate [CPD:C00009]

Product

benzoyl-CoA [CPD:C00512];
reduced ferredoxin [CPD:C00138];
ATP [CPD:C00002];
H2O [CPD:C00001]

Comment

An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.

History

EC 1.3.7.8 created 1999 as EC 1.3.99.15, transferred 2011 to EC 1.3.7.8, modified 2011

Pathway

ec00362	Benzoate degradation
ec01100	Metabolic pathways
ec01120	Microbial metabolism in diverse environments

Orthology

K04112	benzoyl-CoA reductase subunit C
K04113	benzoyl-CoA reductase subunit B
K04114	benzoyl-CoA reductase subunit A
K04115	benzoyl-CoA reductase subunit D

Genes

EBA:	ebA5282(bcrC) ebA5284(bcrB) ebA5286(bcrD) ebA5287(bcrA) ebA742(bcrA) ebA744(bcrD) ebA748(bcrC)
TMZ:	Tmz1t_2948 Tmz1t_2949 Tmz1t_2950 Tmz1t_2951
GLO:	Glov_2400 Glov_2401
RPA:	RPA0657(badD) RPA0658(badE) RPA0659(badF) RPA0660(badG)
RPC:	RPC_1026 RPC_1027 RPC_1028 RPC_1029
RPD:	RPD_1535 RPD_1536 RPD_1537 RPD_1538
RPE:	RPE_0605 RPE_0606 RPE_0607 RPE_0608
RPT:	Rpal_0724 Rpal_0725 Rpal_0726 Rpal_0727
RPX:	Rpdx1_4126 Rpdx1_4127 Rpdx1_4128 Rpdx1_4129
RVA:	Rvan_0037 Rvan_0038 Rvan_0039 Rvan_0040
MAG:	amb2138 amb2139 amb2140 amb2141
SLP:	Slip_0467 Slip_0468
FPL:	Ferp_1184 Ferp_1185 Ferp_1186 Ferp_1187

Reference

1 [PMID:8575453]

Authors

Boll M, Fuchs G.

Title

Journal

Eur. J. Biochem. 234 (1995) 921-33.

Sequence

[ag:CAA12249 CAA12248 CAA12247 CAA12250]

Reference

2 [PMID:20578740]

Authors

Kung JW, Baumann S, von Bergen M, Muller M, Hagedoorn PL, Hagen WR, Boll M

Title

Reversible biological Birch reduction at an extremely low redox potential.

Journal

J. Am. Chem. Soc. 132 (2010) 9850-6.

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

UM-BBD (Biocatalysis/Biodegradation Database):

BRENDA, the Enzyme Database:

CAS:

176591-18-7

LinkDB

REACTION: R02451

Entry

R02451 Reaction

Name

cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)

Definition

Benzoyl-CoA + Reduced ferredoxin + 2 ATP + 2 H2O <=> Cyclohexa-1,5-diene-1-carbonyl-CoA + Oxidized ferredoxin + 2 Orthophosphate + 2 ADP

Equation

C00512 + C00138 + 2 C00002 + 2 C00001 <=> C06322 + C00139 + 2 C00009 + 2 C00008

Comment

BadD,BadE,BadF,BadG
multi-step reaction

Reaction class

RC00002	C00002_C00008
RC01839	C00512_C06322

Enzyme