KEGG   ORTHOLOGY: K05711Help
Entry
K05711                      KO                                     

Name
hcaB
Definition
2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87]
Pathway
Phenylalanine metabolism
Degradation of aromatic compounds
Module
M00545  
Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K05711  hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
  Amino acid metabolism
   00360 Phenylalanine metabolism
    K05711  hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Aromatic amino acid metabolism
    M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
     K05711  hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.87  3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
     K05711  hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
BRITE hierarchy
Other DBs
Genes
ECO: 
b2541(hcaB)
ECJ: 
JW2525(hcaB)
ECD: 
EBW: 
BWG_2305(hcaB)
ECOK: 
ECE: 
Z3813(hcaB)
ECS: 
ECF: 
ETW: 
ECSP_3485(hcaB)
ELX: 
EOJ: 
ECO26_3588(hcaB)
EOI: 
ECO111_3265(hcaB)
EOH: 
ECO103_3061(hcaB)
EOK: 
G2583_3071(hcaB)
ELR: 
ECO55CA74_15200
ECX: 
EcHS_A2693(hcaB)
ECW: 
EcE24377A_2826(hcaB)
ECM: 
EcSMS35_2694(hcaB)
ECY: 
ECSE_2828
ECR: 
ECIAI1_2593(hcaB)
ECK: 
EC55989_2827(hcaB)
ECT: 
ECIAI39_2742(hcaB)
EOC: 
CE10_2973(hcaB)
EUM: 
ECUMN_2861(hcaB)
ELO: 
EC042_2745(hcaB)
ELH: 
ETEC_2698
ESO: 
O3O_18940
ESM: 
O3M_06755
ESL: 
O3K_06710
ECL: 
EcolC_1136
EBR: 
ECB_02433(hcaB)
EBD: 
ECBD_1143
EKO: 
EKO11_1192
EKF: 
KO11_10115(hcaB)
EDH: 
EcDH1_1127
EDJ: 
ECDH1ME8569_2468(hcaB)
EUN: 
UMNK88_3194
ELW: 
ECW_m2767(hcaB)
ELL: 
WFL_13550(hcaB)
ELP: 
P12B_c2641(hcaB)
EBL: 
ECD_02433(hcaB)
EBE: 
B21_02397(hcaB)
ECOA: 
APECO78_16435
ECOL: 
LY180_13035
SFL: 
SF2588(hcaB)
SFX: 
S2760(hcaB)
SFV: 
SFV_2589(hcaB)
SFE: 
SFxv_2844(hcaB)
SFN: 
SFy_3675
SFS: 
SFyv_3752
SFT: 
NCTC1_02844(hcaB)
SSN: 
SSON_2623(hcaB)
SBO: 
SBO_2565(hcaB)
SHQ: 
A0259_16430
KPV: 
KPNIH29_19735
CFD: 
CFNIH1_24140
CIF: 
AL515_17225
EBF: 
D782_1128
SFW: 
WN53_15155
PLU: 
plu2207(hcaB)
PAY: 
PAU_02354(hcaB)
PTT: 
VY86_20025
VNA: 
PN96_06455
VEJ: 
VEJY3_06595
VFU: 
vfu_A01968
AEI: 
AOY20_01935
AFA: 
UZ73_04225
DEL: 
DelCs14_1742
BTS: 
Btus_2899
MPA: 
MAP_2736(fabG5)
MAV: 
MAV_3512
MVA: 
Mvan_4412
MAB: 
MAB_4365c
MKM: 
Mkms_5615
ROP: 
ROP_pROB02-02080(narB)
SCB: 
SCAB_2141(hcaB)
NCA: 
Noca_0689
FRI: 
FraEuI1c_4101
TRO: 
trd_A0926
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
  Sequence
[eco:b2541]
LinkDB All DBs

KEGG   ENZYME: 1.3.1.87Help
Entry
EC 1.3.1.87                 Enzyme                                 

Name
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
hcaB (gene name);
cis-dihydrodiol dehydrogenase;
2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
Reaction(IUBMB)
(1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+ [RN:R06784];
(2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ [RN:R06785]
Reaction(KEGG)
Substrate
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate [CPD:C11588];
NAD+ [CPD:C00003];
(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate [CPD:C12622]
Product
3-(2,3-dihydroxyphenyl)propanoate [CPD:C04044];
NADH [CPD:C00004];
H+ [CPD:C00080];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]
Comment
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
History
EC 1.3.1.87 created 2011
Pathway
Phenylalanine metabolism
Microbial metabolism in diverse environments
Orthology
K05711  
2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
Genes
ECO: 
b2541(hcaB)
ECJ: 
JW2525(hcaB)
ECD: 
EBW: 
BWG_2305(hcaB)
ECOK: 
ECE: 
Z3813(hcaB)
ECS: 
ECF: 
ETW: 
ECSP_3485(hcaB)
ELX: 
EOJ: 
ECO26_3588(hcaB)
EOI: 
ECO111_3265(hcaB)
EOH: 
ECO103_3061(hcaB)
EOK: 
G2583_3071(hcaB)
ELR: 
ECO55CA74_15200
ECX: 
EcHS_A2693(hcaB)
ECW: 
EcE24377A_2826(hcaB)
ECM: 
EcSMS35_2694(hcaB)
ECY: 
ECSE_2828
ECR: 
ECIAI1_2593(hcaB)
ECK: 
EC55989_2827(hcaB)
ECT: 
ECIAI39_2742(hcaB)
EOC: 
CE10_2973(hcaB)
EUM: 
ECUMN_2861(hcaB)
ELO: 
EC042_2745(hcaB)
ELH: 
ETEC_2698
ESO: 
O3O_18940
ESM: 
O3M_06755
ESL: 
O3K_06710
ECL: 
EcolC_1136
EBR: 
ECB_02433(hcaB)
EBD: 
ECBD_1143
EKO: 
EKO11_1192
EKF: 
KO11_10115(hcaB)
EDH: 
EcDH1_1127
EDJ: 
ECDH1ME8569_2468(hcaB)
EUN: 
UMNK88_3194
ELW: 
ECW_m2767(hcaB)
ELL: 
WFL_13550(hcaB)
ELP: 
P12B_c2641(hcaB)
EBL: 
ECD_02433(hcaB)
EBE: 
B21_02397(hcaB)
ECOA: 
APECO78_16435
ECOL: 
LY180_13035
SFL: 
SF2588(hcaB)
SFX: 
S2760(hcaB)
SFV: 
SFV_2589(hcaB)
SFE: 
SFxv_2844(hcaB)
SFN: 
SFy_3675
SFS: 
SFyv_3752
SFT: 
NCTC1_02844(hcaB)
SSN: 
SSON_2623(hcaB)
SBO: 
SBO_2565(hcaB)
SHQ: 
A0259_16430
KPV: 
KPNIH29_19735
CFD: 
CFNIH1_24140
CIF: 
AL515_17225
EBF: 
D782_1128
SFW: 
WN53_15155
PLU: 
plu2207(hcaB)
PAY: 
PAU_02354(hcaB)
PTT: 
VY86_20025
VNA: 
PN96_06455
VEJ: 
VEJY3_06595
VFU: 
vfu_A01968
AEI: 
AOY20_01935
AFA: 
UZ73_04225
DEL: 
DelCs14_1742
BTS: 
Btus_2899
MPA: 
MAP_2736(fabG5)
MAV: 
MAV_3512
MVA: 
Mvan_4412
MAB: 
MAB_4365c
MKM: 
Mkms_5615
ROP: 
ROP_pROB02-02080(narB)
SCB: 
SCAB_2141(hcaB)
NCA: 
Noca_0689
FRI: 
FraEuI1c_4101
TRO: 
trd_A0926
 » show all
Taxonomy
Reference
1  [PMID:9603882]
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J. Bacteriol. 180 (1998) 2915-23.
  Sequence
[eco:b2541]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R06784Help
Entry
R06784                      Reaction                               

Name
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
Definition
cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol + NAD+ <=> 3-(2,3-Dihydroxyphenyl)propanoate + NADH + H+
Equation
Reaction class
C00003_C00004
C04044_C11588
Enzyme
Pathway
Phenylalanine metabolism
Microbial metabolism in diverse environments
Degradation of aromatic compounds
Orthology
K05711  
2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87]
Other DBs
RHEA: 
LinkDB All DBs

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