KEGG   ORTHOLOGY: K05933Help
Entry
K05933                      KO                                     

Name
E1.14.17.4
Definition
aminocyclopropanecarboxylate oxidase [EC:1.14.17.4]
Pathway
Cysteine and methionine metabolism
Module
M00368  
Ethylene biosynthesis, methionine => ethylene
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K05933  E1.14.17.4; aminocyclopropanecarboxylate oxidase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Cysteine and methionine metabolism
    M00368  Ethylene biosynthesis, methionine => ethylene
     K05933  E1.14.17.4; aminocyclopropanecarboxylate oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.17  With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.17.4  aminocyclopropanecarboxylate oxidase
     K05933  E1.14.17.4; aminocyclopropanecarboxylate oxidase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
RSS: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18588418 18592410 18597239 18612358
GRA: 
105769639 105773340 105783020 105789924 105789942 105789967 105790536 105791688 105796114 105797149 105802573 105803453
GHI: 
107903979 107905674 107905676 107905899 107908352 107910369 107912629 107915412 107923209 107932273 107945007 107950208 107951489 107952114 107952577 107954048 107956389 107957214 107962059
EGR: 
104424713 104424714 104424715 104424716 104424717 104424718 104424719 104424720 104424721 104436497 104438309 104440284 104441437 104445669 104450538 104450539
GMX: 
100780155 100784455 100784459 100785514 100789627 100790622 100792063 100793294 100794816 100796909 100807427 100808025 100814810 100815336 100819184 100820256
PVU: 
PHAVU_002G304200g PHAVU_002G326600g PHAVU_003G082300g PHAVU_006G144900g PHAVU_007G135600g PHAVU_008G213800g PHAVU_008G214200g PHAVU_009G129500g
VRA: 
106762735 106763329 106765078 106765079 106765175 106766639 106766745 106769830
VAR: 
108322886 108323412(AB-ACO1) 108330808 108336202 108338025 108338027 108341045 108342451 108345036
CCAJ: 
109793755 109797540 109799389 109803578 109804404 109808078 109817071 109817981 109818885
MTR: 
MTR_2g025120 MTR_3g083370 MTR_3g088565 MTR_5g085330 MTR_6g092620
CAM: 
101490526 101495891 101500864(aco) 101505638 101514819
ADU: 
107460718 107466373 107482960 107490141 107496871 107496872 107496874
AIP: 
107606021 107608930 107608931 107609126 107609932 107636528 107638664 107644485
LJA: 
Lj0g3v0109219.1(Lj0g3v0109219.1) Lj0g3v0109219.2(Lj0g3v0109219.2) Lj1g3v0884400.1(Lj1g3v0884400.1) Lj2g3v0911850.1(Lj2g3v0911850.1) Lj2g3v0911860.1(Lj2g3v0911860.1) Lj2g3v2879460.1(Lj2g3v2879460.1) Lj4g3v0120430.1(Lj4g3v0120430.1) Lj6g3v1789900.1(Lj6g3v1789900.1)
LANG: 
109326282 109328346 109330191 109333359 109334607 109356783 109361097
FVE: 
101290700 101291370 101295098 101298627 101306888
PPER: 
18770210 18781368 18784056 18791775
PMUM: 
103319772 103324450 103329345 103340748
MDM: 
103400792 103404960 103411278 103411280 103434461(ACO) 103446762(ACO1) 103453365
PXB: 
103933106 103937366 103937371 103943975 103946813 103948231 103954990
ZJU: 
107414763 107417150 107421119 107423970
CSV: 
101203726 101204103(Cs-ACO2) 101209525(CS-ACO1) 101221460 101221653(CS-ACO2)
CMO: 
103484645(ACO3) 103487610 103491357(ACO1) 103496355 103498449
RCU: 
8260997 8265073 8267624 8270983
JCU: 
105637864 105638993 105640861 105640863 105649282
POP: 
POPTR_0002s07880g(POPTRDRAFT_643574) POPTR_0002s21750g(POPTRDRAFT_552732) POPTR_0004s00460g POPTR_0005s20530g(POPTRDRAFT_559288) POPTR_0006s15610g(POPTRDRAFT_762678) POPTR_0011s00970g(POPTRDRAFT_568162) POPTR_0014s15710g(POPTRDRAFT_573016)
VVI: 
100232928(ACO1) 100252394 100256784(ACO2) 100257676(ACO3)
SLY: 
100125909 101251255(ACO2) 101266529 543506(ACO4-like) 543800(aco5) 544052(ACO1) 544285(ACO4)
SPEN: 
107005451 107010265 107011760 107023167 107024027 107024035 107024353 107024662
SOT: 
102577542 102577821(ACO2) 102577917(ACO1) 102578788 102582504 102584001 102584835 102592023
INI: 
109158714 109159218(ACO1) 109164607 109167198(ACO3) 109169737 109171074 109186912
SIND: 
105155254 105159448 105161839 105162912 105162915 105162916 105162918 105162919 105162920 105162921 105162966 105168010 105173607 105175306 105180280
BVG: 
104884391 104893204 104900929 104902721
NNU: 
104586595 104594112 104600753 104605834 104606504 104606667
OSA: 
107278688 4324194(B1097D05.1) 4330873(OJ1353_F08.16-1) 4337818 4347224(OJ1163_C07.10) 4347225(ACO1) 4349970
DOSA: 
Os01t0580500-01(Os01g0580500) Os02t0771600-01(Os02g0771600) Os05t0149300-00(Os05g0149300) Os05t0149400-01(Os05g0149400) Os09t0451000-01(Os09g0451000) Os09t0451400-01(Os09g0451400) Os11t0186900-01(Os11g0186900)
OBR: 
102702762 102702913 102704086 102706500 102712857 102716840 102717708 102717987 102721801
BDI: 
100825510 100826347 100826865 100827208 100831517 100838946 100839084
ATS: 
F775_09413 F775_15958 F775_27311 F775_29309 F775_32857 F775_52717
SBI: 
8069498 8072801 8075978 8078636 8078948 8079305 8079762 8081032
ZMA: 
100191321 100273458 100280566 100283053 100382364(cl955_1) 103631299 103641390 103641391 103642621 103646970 109939280 542136(ACO31) 542137(acco20)
SITA: 
101756803 101766113 101766368 101766733 101780742 101780769 101781172 101781542
PDA: 
103701356 103702049 103709582 103713801 103713802 103713805 103713806 103717060 103718519 103718638 103718711 103719939
EGU: 
105032553 105035107 105038434 105038435 105039092 105040421 105047690 105047965 105051796 105061033
MUS: 
103968395 103972710 103974167 103974593 103974594 103974595 103974596 103974656 103984705 103986610 103987677 103992167 103994603
ATR: 
18428159 18434128 18436883
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8262380
  Authors
Gomez-Lim MA, Valdes-Lopez V, Cruz-Hernandez A, Saucedo-Arias LJ
  Title
Isolation and characterization of a gene involved in ethylene biosynthesis from Arabidopsis thaliana.
  Journal
Gene 134:217-21 (1993)
DOI:10.1016/0378-1119(93)90096-L
Reference
  Authors
Iwai T, Miyasaka A, Seo S, Ohashi Y
  Title
Contribution of ethylene biosynthesis for resistance to blast fungus infection in young rice plants.
  Journal
Plant Physiol 142:1202-15 (2006)
DOI:10.1104/pp.106.085258
Reference
  Authors
Zhang Z, Ren JS, Clifton IJ, Schofield CJ
  Title
Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme.
  Journal
Chem Biol 11:1383-94 (2004)
DOI:10.1016/j.chembiol.2004.08.012
Reference
PMID:8292780
  Authors
Tang X, Wang H, Brandt AS, Woodson WR
  Title
Organization and structure of the 1-aminocyclopropane-1-carboxylate oxidase gene  family from Petunia hybrida.
  Journal
Plant Mol Biol 23:1151-64 (1993)
DOI:10.1007/BF00042349
LinkDB All DBs

KEGG   ENZYME: 1.14.17.4Help
Entry
EC 1.14.17.4                Enzyme                                 

Name
aminocyclopropanecarboxylate oxidase;
ACC oxidase;
ethylene-forming enzyme
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)
Reaction(IUBMB)
1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethylene + cyanide + dehydroascorbate + CO2 + 2 H2O [RN:R07214]
Reaction(KEGG)
Substrate
1-aminocyclopropane-1-carboxylate [CPD:C01234];
ascorbate [CPD:C00072];
O2 [CPD:C00007]
Product
ethylene [CPD:C06547];
cyanide [CPD:C00177];
dehydroascorbate [CPD:C05422];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethylene has signalling functions such as stimulation of fruit-ripening.
History
EC 1.14.17.4 created 2003
Pathway
Cysteine and methionine metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K05933  
aminocyclopropanecarboxylate oxidase
Genes
RSS: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18588418 18592410 18597239 18612358
GRA: 
105769639 105773340 105783020 105789924 105789942 105789967 105790536 105791688 105796114 105797149 105802573 105803453
GHI: 
107903979 107905674 107905676 107905899 107908352 107910369 107912629 107915412 107923209 107932273 107945007 107950208 107951489 107952114 107952577 107954048 107956389 107957214 107962059
EGR: 
104424713 104424714 104424715 104424716 104424717 104424718 104424719 104424720 104424721 104436497 104438309 104440284 104441437 104445669 104450538 104450539
GMX: 
100780155 100784455 100784459 100785514 100789627 100790622 100792063 100793294 100794816 100796909 100807427 100808025 100814810 100815336 100819184 100820256
PVU: 
PHAVU_002G304200g PHAVU_002G326600g PHAVU_003G082300g PHAVU_006G144900g PHAVU_007G135600g PHAVU_008G213800g PHAVU_008G214200g PHAVU_009G129500g
VRA: 
106762735 106763329 106765078 106765079 106765175 106766639 106766745 106769830
VAR: 
108322886 108323412(AB-ACO1) 108330808 108336202 108338025 108338027 108341045 108342451 108345036
CCAJ: 
109793755 109797540 109799389 109803578 109804404 109808078 109817071 109817981 109818885
MTR: 
MTR_2g025120 MTR_3g083370 MTR_3g088565 MTR_5g085330 MTR_6g092620
CAM: 
101490526 101495891 101500864(aco) 101505638 101514819
ADU: 
107460718 107466373 107482960 107490141 107496871 107496872 107496874
AIP: 
107606021 107608930 107608931 107609126 107609932 107636528 107638664 107644485
LJA: 
Lj0g3v0109219.1(Lj0g3v0109219.1) Lj0g3v0109219.2(Lj0g3v0109219.2) Lj1g3v0884400.1(Lj1g3v0884400.1) Lj2g3v0911850.1(Lj2g3v0911850.1) Lj2g3v0911860.1(Lj2g3v0911860.1) Lj2g3v2879460.1(Lj2g3v2879460.1) Lj4g3v0120430.1(Lj4g3v0120430.1) Lj6g3v1789900.1(Lj6g3v1789900.1)
LANG: 
109326282 109328346 109330191 109333359 109334607 109356783 109361097
FVE: 
101290700 101291370 101295098 101298627 101306888
PPER: 
18770210 18781368 18784056 18791775
PMUM: 
103319772 103324450 103329345 103340748
MDM: 
103400792 103404960 103411278 103411280 103434461(ACO) 103446762(ACO1) 103453365
PXB: 
103933106 103937366 103937371 103943975 103946813 103948231 103954990
ZJU: 
107414763 107417150 107421119 107423970
CSV: 
101203726 101204103(Cs-ACO2) 101209525(CS-ACO1) 101221460 101221653(CS-ACO2)
CMO: 
103484645(ACO3) 103487610 103491357(ACO1) 103496355 103498449
RCU: 
8260997 8265073 8267624 8270983
JCU: 
105637864 105638993 105640861 105640863 105649282
POP: 
POPTR_0002s07880g(POPTRDRAFT_643574) POPTR_0002s21750g(POPTRDRAFT_552732) POPTR_0004s00460g POPTR_0005s20530g(POPTRDRAFT_559288) POPTR_0006s15610g(POPTRDRAFT_762678) POPTR_0011s00970g(POPTRDRAFT_568162) POPTR_0014s15710g(POPTRDRAFT_573016)
VVI: 
100232928(ACO1) 100252394 100256784(ACO2) 100257676(ACO3)
SLY: 
100125909 101251255(ACO2) 101266529 543506(ACO4-like) 543800(aco5) 544052(ACO1) 544285(ACO4)
SPEN: 
107005451 107010265 107011760 107023167 107024027 107024035 107024353 107024662
SOT: 
102577542 102577821(ACO2) 102577917(ACO1) 102578788 102582504 102584001 102584835 102592023
INI: 
109158714 109159218(ACO1) 109164607 109167198(ACO3) 109169737 109171074 109186912
SIND: 
105155254 105159448 105161839 105162912 105162915 105162916 105162918 105162919 105162920 105162921 105162966 105168010 105173607 105175306 105180280
BVG: 
104884391 104893204 104900929 104902721
NNU: 
104586595 104594112 104600753 104605834 104606504 104606667
OSA: 
107278688 4324194(B1097D05.1) 4330873(OJ1353_F08.16-1) 4337818 4347224(OJ1163_C07.10) 4347225(ACO1) 4349970
DOSA: 
Os01t0580500-01(Os01g0580500) Os02t0771600-01(Os02g0771600) Os05t0149300-00(Os05g0149300) Os05t0149400-01(Os05g0149400) Os09t0451000-01(Os09g0451000) Os09t0451400-01(Os09g0451400) Os11t0186900-01(Os11g0186900)
OBR: 
102702762 102702913 102704086 102706500 102712857 102716840 102717708 102717987 102721801
BDI: 
100825510 100826347 100826865 100827208 100831517 100838946 100839084
ATS: 
F775_09413 F775_15958 F775_27311 F775_29309 F775_32857 F775_52717
SBI: 
8069498 8072801 8075978 8078636 8078948 8079305 8079762 8081032
ZMA: 
100191321 100273458 100280566 100283053 100382364(cl955_1) 103631299 103641390 103641391 103642621 103646970 109939280 542136(ACO31) 542137(acco20)
SITA: 
101756803 101766113 101766368 101766733 101780742 101780769 101781172 101781542
PDA: 
103701356 103702049 103709582 103713801 103713802 103713805 103713806 103717060 103718519 103718638 103718711 103719939
EGU: 
105032553 105035107 105038434 105038435 105039092 105040421 105047690 105047965 105051796 105061033
MUS: 
103968395 103972710 103974167 103974593 103974594 103974595 103974596 103974656 103984705 103986610 103987677 103992167 103994603
ATR: 
18428159 18434128 18436883
 » show all
Taxonomy
Reference
1  [PMID:7717997]
  Authors
Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P.
  Title
Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli.
  Journal
Biochem. J. 307 ( Pt 1) (1995) 77-85.
Reference
2  [PMID:9398335]
  Authors
Zhang Z, Barlow JN, Baldwin JE, Schofield CJ.
  Title
Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase.
  Journal
Biochemistry. 36 (1997) 15999-6007.
Reference
3
  Authors
Pirrung, M.C.
  Title
Ethylene biosynthesis from 1-aminocyclopropanecarboxylic acid.
  Journal
Acc. Chem. Res. 32 (1999) 711-718.
Reference
4  [PMID:11361015]
  Authors
Charng YY, Chou SJ, Jiaang WT, Chen ST, Yang SF.
  Title
The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase.
  Journal
Arch. Biochem. Biophys. 385 (2001) 179-85.
Reference
5  [PMID:11583172]
  Authors
Thrower JS, Blalock R 3rd, Klinman JP.
  Title
Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.
  Journal
Biochemistry. 40 (2001) 9717-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
98668-53-2
LinkDB All DBs

KEGG   REACTION: R07214Help
Entry
R07214                      Reaction                               

Name
1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)
Definition
1-Aminocyclopropane-1-carboxylate + Ascorbate + Oxygen <=> Ethylene + Cyanide ion + Dehydroascorbate + CO2 + 2 H2O
Equation
Reaction class
C00072_C05422
C01234_C06547
Enzyme
Pathway
Cysteine and methionine metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Module
M00368  
Ethylene biosynthesis, methionine => ethylene
Orthology
K05933  
aminocyclopropanecarboxylate oxidase [EC:1.14.17.4]
LinkDB All DBs

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