KEGG   ORTHOLOGY: K06279Help
Entry
K06279                      KO                                     

Name
SHC1
Definition
SHC- transforming protein 1
Pathway
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
Focal adhesion
Natural killer cell mediated cytotoxicity
Neurotrophin signaling pathway
Insulin signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Alcoholism
Bacterial invasion of epithelial cells
MicroRNAs in cancer
Glioma
Chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K06279  SHC1; SHC- transforming protein 1
   04012 ErbB signaling pathway
    K06279  SHC1; SHC- transforming protein 1
 Cellular Processes
  Cellular commiunity
   04510 Focal adhesion
    K06279  SHC1; SHC- transforming protein 1
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06279  SHC1; SHC- transforming protein 1
   04062 Chemokine signaling pathway
    K06279  SHC1; SHC- transforming protein 1
  Endocrine system
   04910 Insulin signaling pathway
    K06279  SHC1; SHC- transforming protein 1
   04915 Estrogen signaling pathway
    K06279  SHC1; SHC- transforming protein 1
   04917 Prolactin signaling pathway
    K06279  SHC1; SHC- transforming protein 1
  Nervous system
   04722 Neurotrophin signaling pathway
    K06279  SHC1; SHC- transforming protein 1
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K06279  SHC1; SHC- transforming protein 1
   05214 Glioma
    K06279  SHC1; SHC- transforming protein 1
   05220 Chronic myeloid leukemia
    K06279  SHC1; SHC- transforming protein 1
  Substance dependence
   05034 Alcoholism
    K06279  SHC1; SHC- transforming protein 1
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K06279  SHC1; SHC- transforming protein 1
BRITE hierarchy
Genes
HSA: 
6464(SHC1)
PTR: 
457351(SHC1)
PPS: 
100993361(SHC1)
GGO: 
101136424(SHC1)
PON: 
100173225(SHC1)
MCC: 
718982(SHC1)
MCF: 
102142777(SHC1)
MMU: 
20416(Shc1)
RNO: 
85385(Shc1)
CGE: 
100758936(Shc1)
HGL: 
101717434(Shc1)
TUP: 
102481002(SHC1)
CFA: 
490439(SHC1)
AML: 
100480856(SHC1)
FCA: 
101092911(SHC1)
PTG: 
102949026(SHC1)
BTA: 
507196(SHC1)
BOM: 
102265814(SHC1)
PHD: 
102344979(SHC1)
CHX: 
102170926(SHC1)
OAS: 
101113548(SHC1)
SSC: 
100156321(SHC1)
CFR: 
102524489(SHC1)
BACU: 
103015382(SHC1)
LVE: 
103074885(SHC1)
ECB: 
100063053(SHC1)
MYB: 
102245916(SHC1)
MYD: 
102755241(SHC1)
PALE: 
102894443(SHC1)
MDO: 
100016090(SHC1)
SHR: 
100926921(SHC1)
GGA: 
395934(SHC1)
MGP: 
100540048(SHC1)
TGU: 
100229782(SHC1)
FAB: 
101807411(SHC1)
PHI: 
102106714(SHC1)
APLA: 
101791792(SHC1)
FPG: 
101919976(SHC1)
FCH: 
102048929(SHC1)
CLV: 
102093713(SHC1)
ASN: 
102376721(SHC1)
AMJ: 
102574737(SHC1)
PSS: 
102457971(SHC1)
CMY: 
102941809(SHC1)
ACS: 
100566335(shc1)
PBI: 
103049298(SHC1)
XLA: 
399198(shc1)
XTR: 
DRE: 
323818(shc1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102356771(SHC1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412172(GB18039)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG05128(Cbr-shc-1)
BMY: 
LOA: 
SMM: 
NVE: 
AQU: 
MBR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, Bussolino F
  Title
Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration  and sprouting but not survival of endothelial cells.
  Journal
J Biol Chem 279:13224-33 (2004)
Reference
  Authors
Wills MK, Jones N
  Title
Teaching an old dogma new tricks: twenty years of Shc adaptor signalling.
  Journal
Biochem J 447:1-16 (2012)
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