KEGG   ORTHOLOGY: K08248Help
Entry
K08248                      KO                                     

Name
MDL3
Definition
(R)-mandelonitrile lyase [EC:4.1.2.10]
Pathway
Cyanoamino acid metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K08248  MDL3; (R)-mandelonitrile lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.10  (R)-mandelonitrile lyase
     K08248  MDL3; (R)-mandelonitrile lyase
BRITE hierarchy
Other DBs
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
105767552
GHI: 
107906346 107958501
EGR: 
104423258
GMX: 
100820069
PVU: 
PHAVU_010G162900g
VRA: 
106773780
VAR: 
108320669
CCAJ: 
109808261
MTR: 
MTR_4g005860
CAM: 
101508164
ADU: 
107482361
AIP: 
107635832
LJA: 
Lj3g3v2040180.1(Lj3g3v2040180.1)
LANG: 
109356592
FVE: 
101298340 101314080
PPER: 
109946273 109946518 109946533 109946707 109946708 109946737 109948219 109948555 18788267 18788307 18789360 18790170 18790921 18792725 18792970
PMUM: 
103323319 103323417 103323418 103323458 103323460 103323461 103323462 103323463 103323464 103323465 103323466 103328816 103344346 103344354
MDM: 
103403009 103416927 103417232 103417299 103420796 103429895 103429959 103443315 103447445 103447446
PXB: 
103926833 103926855 103931741 103944089 103944905 103944906 103944908 103954303 108867073
ZJU: 
107405884 107405886 107405923 107405924 107405925 107405927 107405928 107407673 107410829 107410921 107411003 107414194 107414212 107414223 107414258 107414267 107414277 107414288 107414317 107414339 107414349 107414388 107415173 107428185 107432121 107432123 107432124 107432125 107432126
CSV: 
101211615 101212821 101213062 101213549 101213785 101214030 101214272 101214723 101218493
CMO: 
103493044 103493053 103493064 103493073 103493083 103493093 103493130 103493164 103493179 103493189 103500635
RCU: 
107260750
JCU: 
105643749
POP: 
POPTR_0008s01010g(POPTRDRAFT_421315) POPTR_0010s25590g
VVI: 
100254058
SLY: 
101250204
SPEN: 
107014093
SOT: 
102580581
INI: 
109187446 109187563 109192240
SIND: 
105157899
BVG: 
104901404
NNU: 
104599090
OSA: 
9266710
DOSA: 
Os06t0656000-00(Os06g0656000)
OBR: 
102719124
BDI: 
100822804
ATS: 
F775_10060
ZMA: 
100382914
SITA: 
101763110
PDA: 
103715972
EGU: 
105039402
MUS: 
103977401
ATR: 
18438828 18440898
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9414550
  Authors
Hu Z, Poulton JE
  Title
Sequencing, genomic organization, and preliminary promoter analysis of a black cherry (R)-(+)-mandelonitrile lyase gene.
  Journal
Plant Physiol 115:1359-69 (1997)
DOI:10.1104/pp.115.4.1359
LinkDB All DBs

KEGG   ORTHOLOGY: K20802Help
Entry
K20802                      KO                                     

Name
HNL
Definition
(R)-mandelonitrile lyase [EC:4.1.2.10]
Pathway
Cyanoamino acid metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K20802  HNL; (R)-mandelonitrile lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.10  (R)-mandelonitrile lyase
     K20802  HNL; (R)-mandelonitrile lyase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
ATH: 
AT5G10300(MES5)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
TaxonomyKoalaUniProt
Reference
  Authors
Andexer J, von Langermann J, Mell A, Bocola M, Kragl U, Eggert T, Pohl M
  Title
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold.
  Journal
Angew Chem Int Ed Engl 46:8679-81 (2007)
DOI:10.1002/anie.200701455
  Sequence
[ath:AT5G10300]
LinkDB All DBs

KEGG   ENZYME: 4.1.2.10Help
Entry
EC 4.1.2.10                 Enzyme                                 

Name
(R)-mandelonitrile lyase;
(R)-oxynitrilase;
oxynitrilase;
D-oxynitrilase;
D-alpha-hydroxynitrile lyase;
mandelonitrile benzaldehyde-lyase;
PaHNL;
AtHNL;
PhaMDL;
(R)-HNL;
(R)-PeHNL;
(R)-hydroxynitrile lyase;
R-selective hydroxynitrile lyase;
R-selective HNL;
(R)-(+)-mandelonitrile lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
(R)-mandelonitrile benzaldehyde-lyase (cyanide-forming)
Reaction(IUBMB)
(R)-mandelonitrile = cyanide + benzaldehyde [RN:R01767]
Reaction(KEGG)
R01767;
(other) R01409 R02811
Show
Substrate
(R)-mandelonitrile [CPD:C00561]
Product
cyanide [CPD:C00177];
benzaldehyde [CPD:C00261]
Comment
A variety of enzymes from different sources and with different properties. Some are flavoproteins, others are not. Active towards a number of aromatic and aliphatic hydroxynitriles (cyanohydrins).
History
EC 4.1.2.10 created 1961, modified 1999, modified 2011
Pathway
Cyanoamino acid metabolism
Biosynthesis of secondary metabolites
Orthology
K08248  
(R)-mandelonitrile lyase
K20802  
(R)-mandelonitrile lyase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
105767552
GHI: 
107906346 107958501
EGR: 
104423258
GMX: 
100820069
PVU: 
PHAVU_010G162900g
VRA: 
106773780
VAR: 
108320669
CCAJ: 
109808261
MTR: 
MTR_4g005860
CAM: 
101508164
ADU: 
107482361
AIP: 
107635832
LJA: 
Lj3g3v2040180.1(Lj3g3v2040180.1)
LANG: 
109356592
FVE: 
101298340 101314080
PPER: 
109946273 109946518 109946533 109946707 109946708 109946737 109948219 109948555 18788267 18788307 18789360 18790170 18790921 18792725 18792970
PMUM: 
103323319 103323417 103323418 103323458 103323460 103323461 103323462 103323463 103323464 103323465 103323466 103328816 103344346 103344354
MDM: 
103403009 103416927 103417232 103417299 103420796 103429895 103429959 103443315 103447445 103447446
PXB: 
103926833 103926855 103931741 103944089 103944905 103944906 103944908 103954303 108867073
ZJU: 
107405884 107405886 107405923 107405924 107405925 107405927 107405928 107407673 107410829 107410921 107411003 107414194 107414212 107414223 107414258 107414267 107414277 107414288 107414317 107414339 107414349 107414388 107415173 107428185 107432121 107432123 107432124 107432125 107432126
CSV: 
101211615 101212821 101213062 101213549 101213785 101214030 101214272 101214723 101218493
CMO: 
103493044 103493053 103493064 103493073 103493083 103493093 103493130 103493164 103493179 103493189 103500635
RCU: 
107260750
JCU: 
105643749
POP: 
POPTR_0008s01010g(POPTRDRAFT_421315) POPTR_0010s25590g
VVI: 
100254058
SLY: 
101250204
SPEN: 
107014093
SOT: 
102580581
INI: 
109187446 109187563 109192240
SIND: 
105157899
BVG: 
104901404
NNU: 
104599090
OSA: 
9266710
DOSA: 
Os06t0656000-00(Os06g0656000)
OBR: 
102719124
BDI: 
100822804
ATS: 
F775_10060
ZMA: 
100382914
SITA: 
101763110
PDA: 
103715972
EGU: 
105039402
MUS: 
103977401
ATR: 
18438828 18440898
 » show all
Taxonomy
Reference
1  [PMID:18540101]
  Authors
Ueatrongchit T, Kayo A, Komeda H, Asano Y, H-Kittikun A
  Title
Purification and characterization of a novel (R)-hydroxynitrile lyase from Eriobotrya japonica (Loquat).
  Journal
Biosci. Biotechnol. Biochem. 72 (2008) 1513-22.
Reference
2
  Authors
Lin, G., Han, S. and Li, Z.
  Title
Enzymic synthesis of (R)-cyanohydrins by three (R)-oxynitrilase sources in micro-aqueous organic medium.
  Journal
Tetrahedron 55 (1999) 3531-3540.
Reference
3
  Authors
de Gonzalo, G., Brieva, R. and Gotor, V.
  Title
(R)-Oxynitrilase-catalyzed transformation of omega-hydroxyalkanals.
  Journal
J. Mol. Catal. B 19-20 (2002) 223-230.
Reference
4
  Authors
Ueatrongchit, T., Tamura, K., Ohmiya, T., H-Kittikun, A. and Asano, Y.
  Title
Hydroxynitrile lyase from Passiflora edulis. Purification, characteristics and application in asymmetric synthesis of (R)-mandelonitrile.
  Journal
Enzyme Microb. Technol. 46 (2010) 456-465.
Reference
5  [PMID:17907254]
  Authors
Andexer J, von Langermann J, Mell A, Bocola M, Kragl U, Eggert T, Pohl M
  Title
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold.
  Journal
Angew. Chem. Int. Ed. Engl. 46 (2007) 8679-81.
  Sequence
[ath:AT5G10300]
Reference
6  [PMID:19433222]
  Authors
Guterl JK, Andexer JN, Sehl T, von Langermann J, Frindi-Wosch I, Rosenkranz T, Fitter J, Gruber K, Kragl U, Eggert T, Pohl M
  Title
Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha/beta-hydrolase fold.
  Journal
J. Biotechnol. 141 (2009) 166-73.
  Sequence
[ath:AT5G10300]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9024-43-5
LinkDB All DBs

KEGG   REACTION: R01767Help
Entry
R01767                      Reaction                               

Name
mandelonitrile benzaldehyde-lyase (cyanide-forming)
Definition
Mandelonitrile <=> Hydrogen cyanide + Benzaldehyde
Equation
Reaction class
C00261_C00561
C00561_C01326
Enzyme
Pathway
Cyanoamino acid metabolism
Biosynthesis of secondary metabolites
Orthology
K08248  
(R)-mandelonitrile lyase [EC:4.1.2.10]
K20802  
(R)-mandelonitrile lyase [EC:4.1.2.10]
LinkDB All DBs

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