KEGG   ORTHOLOGY: K09754Help
Entry
K09754                      KO                                     

Name
CYP98A, C3'H
Definition
coumaroylquinate(coumaroylshikimate) 3'-monooxygenase [EC:1.14.13.36]
Pathway
Phenylpropanoid biosynthesis
Flavonoid biosynthesis
Stilbenoid, diarylheptanoid and gingerol biosynthesis
Module
M00039  
Monolignol biosynthesis, phenylalanine/tyrosine  => monolignol
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Biosynthesis of other secondary metabolites
   00940 Phenylpropanoid biosynthesis
    K09754  CYP98A, C3'H; coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
   00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
    K09754  CYP98A, C3'H; coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
   00941 Flavonoid biosynthesis
    K09754  CYP98A, C3'H; coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Secondary metabolism
   Biosynthesis of secondary metabolites
    M00039  Monolignol biosynthesis, phenylalanine / tyrosine  => monolignol
     K09754  CYP98A, C3'H; coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.36  5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase
     K09754  CYP98A, C3'H; coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP98 family
   K09754  CYP98A, C3'H; coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
BRITE hierarchy
Other DBs
Genes
RSS: 
ATH: 
AT2G40890(CYP98A3)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18598608
GRA: 
105782306 105786247
GHI: 
107920919 107935532 107950342
EGR: 
104443731 104443755 104454510
GMX: 
100811080 606506(CYP98A2)
PVU: 
PHAVU_001G117900g
VRA: 
106753926
VAR: 
108346061
CCAJ: 
109802555
CAM: 
101502624
ADU: 
107494128
AIP: 
107604697
LJA: 
Lj1g3v4081860.1(Lj1g3v4081860.1)
LANG: 
109326958
FVE: 
101310387
PPER: 
18789678 18789708 18789709 18792412
PMUM: 
103319005 103319006 103319007 103344449
MDM: 
103402429 103411054 103425389 103428961 103431803 103441965
PXB: 
103944996 103944997 103944999 103946365 103946366
ZJU: 
107431535
CSV: 
101217257
CMO: 
103486874
RCU: 
8277408 8277879 8277880
JCU: 
105636120
POP: 
POPTR_0006s03180g(POPTRDRAFT_685839) POPTR_0016s03080g POPTR_0016s03090g(POPTRDRAFT_576112)
VVI: 
100263633
SLY: 
101246092 101247849 101261765 101262063 101262367
SPEN: 
107001769 107001863 107002593 107008188 107028331
SOT: 
102578406 102578747 102585799 102586130 102590105 102590484 102590830 102590870 102593896 102603170 102606401 107059425
INI: 
109159148
SIND: 
105162700 105172202
BVG: 
104887604 104889547 104889649 104889748
NNU: 
104588272
OSA: 
4339188
DOSA: 
Os05t0494000-01(Os05g0494000) Os10t0196100-00(Os10g0196100)
OBR: 
102712257
BDI: 
100835531
ATS: 
F775_19165 F775_21689 F775_21690 F775_27986
SBI: 
8077042 8082405
ZMA: 
100191539 100274274 103649031
SITA: 
101771055
PDA: 
103705056 103706282
EGU: 
105033349 105033350 105052441
MUS: 
103995155
ATR: 
18427105 18441256
SMO: 
SELMODRAFT_104330 SELMODRAFT_450942(C3'H1-1) SELMODRAFT_450943(C3'H1-2)
PPP: 
PHYPADRAFT_98753
AG: 
AAL99200(CYP98A13v1) AAL99201(CYP98A13v2) CAE47490(CYP98A11)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9484480 (CYP98A1)
  Authors
Bak S, Kahn RA, Nielsen HL, Moller BL, Halkier BA
  Title
Cloning of three A-type cytochromes P450, CYP71E1, CYP98, and CYP99 from Sorghum  bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome P450 in the biosynthesis of the cyanogenic glucoside dhurrin.
  Journal
Plant Mol Biol 36:393-405 (1998)
DOI:10.1023/A:1005915507497
  Sequence
Reference
PMID:17160453 (CYP98A11)
  Authors
Morant M, Schoch GA, Ullmann P, Ertunc T, Little D, Olsen CE, Petersen M, Negrel J, Werck-Reichhart D
  Title
Catalytic activity, duplication and evolution of the CYP98 cytochrome P450 family in wheat.
  Journal
Plant Mol Biol 63:1-19 (2007)
DOI:10.1007/s11103-006-9028-8
  Sequence
Reference
PMID:12428018 (CYP98A13)
  Authors
Gang DR, Beuerle T, Ullmann P, Werck-Reichhart D, Pichersky E
  Title
Differential production of meta hydroxylated phenylpropanoids in sweet basil peltate glandular trichomes and leaves is controlled by the activities of specific acyltransferases and hydroxylases.
  Journal
Plant Physiol 130:1536-44 (2002)
DOI:10.1104/pp.007146
  Sequence
Reference
  Authors
Costa MA, Collins RE, Anterola AM, Cochrane FC, Davin LB, Lewis NG.
  Title
An in silico assessment of gene function and organization of the phenylpropanoid pathway metabolic networks in Arabidopsis thaliana and limitations thereof.
  Journal
Phytochemistry 64:1097-112 (2003)
DOI:10.1016/S0031-9422(03)00517-X
LinkDB All DBs

KEGG   ENZYME: 1.14.13.36Help
Entry
EC 1.14.13.36               Enzyme                                 

Name
5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase;
5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase;
coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)
Reaction(IUBMB)
trans-5-O-(4-coumaroyl)-D-quinate + NADPH + H+ + O2 = trans-5-O-caffeoyl-D-quinate + NADP+ + H2O [RN:R04342]
Reaction(KEGG)
R04342;
(other) R06582
Show
Substrate
trans-5-O-(4-coumaroyl)-D-quinate [CPD:C12208];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
trans-5-O-caffeoyl-D-quinate [CPD:C00852];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Also acts on trans-5-O-(4-coumaroyl)shikimate.
History
EC 1.14.13.36 created 1990
Pathway
Phenylpropanoid biosynthesis
Flavonoid biosynthesis
Stilbenoid, diarylheptanoid and gingerol biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K09754  
coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
Genes
RSS: 
ATH: 
AT2G40890(CYP98A3)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18598608
GRA: 
105782306 105786247
GHI: 
107920919 107935532 107950342
EGR: 
104443731 104443755 104454510
GMX: 
100811080 606506(CYP98A2)
PVU: 
PHAVU_001G117900g
VRA: 
106753926
VAR: 
108346061
CCAJ: 
109802555
CAM: 
101502624
ADU: 
107494128
AIP: 
107604697
LJA: 
Lj1g3v4081860.1(Lj1g3v4081860.1)
LANG: 
109326958
FVE: 
101310387
PPER: 
18789678 18789708 18789709 18792412
PMUM: 
103319005 103319006 103319007 103344449
MDM: 
103402429 103411054 103425389 103428961 103431803 103441965
PXB: 
103944996 103944997 103944999 103946365 103946366
ZJU: 
107431535
CSV: 
101217257
CMO: 
103486874
RCU: 
8277408 8277879 8277880
JCU: 
105636120
POP: 
POPTR_0006s03180g(POPTRDRAFT_685839) POPTR_0016s03080g POPTR_0016s03090g(POPTRDRAFT_576112)
VVI: 
100263633
SLY: 
101246092 101247849 101261765 101262063 101262367
SPEN: 
107001769 107001863 107002593 107008188 107028331
SOT: 
102578406 102578747 102585799 102586130 102590105 102590484 102590830 102590870 102593896 102603170 102606401 107059425
INI: 
109159148
SIND: 
105162700 105172202
BVG: 
104887604 104889547 104889649 104889748
NNU: 
104588272
OSA: 
4339188
DOSA: 
Os05t0494000-01(Os05g0494000) Os10t0196100-00(Os10g0196100)
OBR: 
102712257
BDI: 
100835531
ATS: 
F775_19165 F775_21689 F775_21690 F775_27986
SBI: 
8077042 8082405
ZMA: 
100191539 100274274 103649031
SITA: 
101771055
PDA: 
103705056 103706282
EGU: 
105033349 105033350 105052441
MUS: 
103995155
ATR: 
18427105 18441256
SMO: 
SELMODRAFT_104330 SELMODRAFT_450942(C3'H1-1) SELMODRAFT_450943(C3'H1-2)
PPP: 
PHYPADRAFT_98753
 » show all
Taxonomy
Reference
1  [PMID:2821918]
  Authors
Kuhnl T, Koch U, Heller W, Wellmann E.
  Title
Chlorogenic acid biosynthesis: characterization of a light-induced microsomal 5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase from carrot (Daucus carota L.) cell suspension cultures.
  Journal
Arch. Biochem. Biophys. 258 (1987) 226-32.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
112131-08-5
LinkDB All DBs

KEGG   REACTION: R06582Help
Entry
R06582                      Reaction                               

Name
trans-5-O-(4-coumaroyl)-D-shikimate,NADPH:oxygen oxidoreductase (3'-hydorxylating)
Definition
4-Coumaroylshikimate + Oxygen + NADPH + H+ <=> 5-O-Caffeoylshikimic acid + NADP+ + H2O
Equation
Reaction class
C00005_C00006
C02947_C10434
Enzyme
Pathway
Phenylpropanoid biosynthesis
Flavonoid biosynthesis
Stilbenoid, diarylheptanoid and gingerol biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Module
M00039  
Monolignol biosynthesis, phenylalanine/tyrosine  => monolignol
Orthology
K09754  
coumaroylquinate(coumaroylshikimate) 3'-monooxygenase [EC:1.14.13.36]
LinkDB All DBs

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