KEGG   ORTHOLOGY: K10046Help
Entry
K10046                      KO                                     

Name
GME
Definition
GDP-D-mannose 3', 5'-epimerase [EC:5.1.3.18 5.1.3.-]
Pathway
Ascorbate and aldarate metabolism
Amino sugar and nucleotide sugar metabolism
Module
M00114  
Ascorbate biosynthesis, plants, glucose-6P => ascorbate
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K10046  GME; GDP-D-mannose 3', 5'-epimerase
   00520 Amino sugar and nucleotide sugar metabolism
    K10046  GME; GDP-D-mannose 3', 5'-epimerase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Cofactor and vitamin biosynthesis
    M00114  Ascorbate biosynthesis, plants, glucose-6P => ascorbate
     K10046  GME; GDP-D-mannose 3', 5'-epimerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.18  GDP-mannose 3,5-epimerase
     K10046  GME; GDP-D-mannose 3', 5'-epimerase
    5.1.3.-  
     K10046  GME; GDP-D-mannose 3', 5'-epimerase
BRITE hierarchy
Other DBs
Genes
RSS: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18600196
GRA: 
105783228 105792573
GHI: 
107894853 107899156 107936906
EGR: 
104415433 104423523 104432512
GMX: 
100527798(GME1) 100780764 100794772 100797618 100806498
PVU: 
PHAVU_006G101600g PHAVU_007G187300g
VRA: 
106772513 106776083
VAR: 
108343687 108345806
CCAJ: 
109791853 109797468
MTR: 
MTR_1g080950 MTR_7g115080
CAM: 
101497510 101501356
ADU: 
107492040
AIP: 
107645815
LJA: 
Lj0g3v0283729.1(Lj0g3v0283729.1) Lj0g3v0283729.2(Lj0g3v0283729.2) Lj0g3v0283729.3(Lj0g3v0283729.3) Lj0g3v0283729.4(Lj0g3v0283729.4) Lj0g3v0283729.5(Lj0g3v0283729.5) Lj0g3v0283729.6(Lj0g3v0283729.6) Lj1g3v4979970.1(Lj1g3v4979970.1)
LANG: 
109336358 109354284
FVE: 
101304010
PPER: 
18772650 18792175
PMUM: 
103318635 103324176
MDM: 
103408656 103430505 103434162
PXB: 
103954400
ZJU: 
107412204 107413123
CSV: 
101222554
CMO: 
103495988
RCU: 
8269339
JCU: 
105647687
POP: 
POPTR_0005s05450g POPTR_0013s03790g(POPTRDRAFT_823669)
VVI: 
100233034 100245900
SLY: 
100316874(GME2) 100316902(GME1)
SPEN: 
107006921 107031214(GME2)
SOT: 
102577923 102582256
INI: 
109153793 109158190
SIND: 
105158417 105171617
BVG: 
104890910
NNU: 
104609581 104613267
OSA: 
4348636(GME-1) 4350816(GME-2)
DOSA: 
Os10t0417600-01(Os10g0417600) Os11t0591100-01(Os11g0591100)
OBR: 
102714961 102718679
BDI: 
100824332 100826361
ATS: 
F775_27949 F775_29141
SBI: 
8059467
ZMA: 
100192102(IDP512) 100280325(gpm480)
SITA: 
101752979 101772247 101778042
PDA: 
103695731 103716162 103718012
EGU: 
105046574 105053413 105055709
MUS: 
103975282 103978838 103990359 103993866
ATR: 
18429544
SMO: 
SELMODRAFT_110416 SELMODRAFT_128181 SELMODRAFT_157784 SELMODRAFT_178232 SELMODRAFT_272082 SELMODRAFT_406366 SELMODRAFT_76013 SELMODRAFT_76257 SELMODRAFT_79000 SELMODRAFT_83391
PPP: 
PHYPADRAFT_168267 PHYPADRAFT_170239 PHYPADRAFT_186902
CRE: 
CHLREDRAFT_196952(SNE1)
VCN: 
VOLCADRAFT_77112
OLU: 
OSTLU_18701
OTA: 
Ot18g01190
BPG: 
Bathy09g00960
MIS: 
MICPUN_80077 MICPUN_92683
MPP: 
MICPUCDRAFT_46037
CSL: 
COCSUDRAFT_52441
CVR: 
CHLNCDRAFT_140350
APRO: 
F751_1084
CME: 
CYME_CMS308C
GSL: 
Gasu_54810
CCP: 
CHC_T00009453001
ACAN: 
ACA1_183570
AAF: 
AURANDRAFT_69812
EHX: 
EMIHUDRAFT_433869
GTT: 
GUITHDRAFT_157063
TVA: 
TVAG_381690
 » show all
TaxonomyKoalaUniProt
Reference
PMID:12954627 (A.thaliana)
  Authors
Wolucka BA, Van Montagu M
  Title
GDP-mannose 3',5'-epimerase forms GDP-L-gulose, a putative intermediate for the de novo biosynthesis of vitamin C in plants.
  Journal
J Biol Chem 278:47483-90 (2003)
DOI:10.1074/jbc.M309135200
LinkDB All DBs

KEGG   ENZYME: 5.1.3.18Help
Entry
EC 5.1.3.18                 Enzyme                                 

Name
GDP-mannose 3,5-epimerase;
GDP-D-mannose:GDP-L-galactose epimerase;
guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
GDP-alpha-D-mannose 3,5-epimerase
Reaction(IUBMB)
GDP-alpha-D-mannose = GDP-beta-L-galactose [RN:R00889]
Reaction(KEGG)
R00889;
(other) R07672
Show
Substrate
GDP-alpha-D-mannose [CPD:C00096]
Product
GDP-beta-L-galactose
History
EC 5.1.3.18 created 1986
Pathway
Ascorbate and aldarate metabolism
Amino sugar and nucleotide sugar metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K10046  
GDP-D-mannose 3', 5'-epimerase
Genes
RSS: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18600196
GRA: 
105783228 105792573
GHI: 
107894853 107899156 107936906
EGR: 
104415433 104423523 104432512
GMX: 
100527798(GME1) 100780764 100794772 100797618 100806498
PVU: 
PHAVU_006G101600g PHAVU_007G187300g
VRA: 
106772513 106776083
VAR: 
108343687 108345806
CCAJ: 
109791853 109797468
MTR: 
MTR_1g080950 MTR_7g115080
CAM: 
101497510 101501356
ADU: 
107492040
AIP: 
107645815
LJA: 
Lj0g3v0283729.1(Lj0g3v0283729.1) Lj0g3v0283729.2(Lj0g3v0283729.2) Lj0g3v0283729.3(Lj0g3v0283729.3) Lj0g3v0283729.4(Lj0g3v0283729.4) Lj0g3v0283729.5(Lj0g3v0283729.5) Lj0g3v0283729.6(Lj0g3v0283729.6) Lj1g3v4979970.1(Lj1g3v4979970.1)
LANG: 
109336358 109354284
FVE: 
101304010
PPER: 
18772650 18792175
PMUM: 
103318635 103324176
MDM: 
103408656 103430505 103434162
PXB: 
103954400
ZJU: 
107412204 107413123
CSV: 
101222554
CMO: 
103495988
RCU: 
8269339
JCU: 
105647687
POP: 
POPTR_0005s05450g POPTR_0013s03790g(POPTRDRAFT_823669)
VVI: 
100233034 100245900
SLY: 
100316874(GME2) 100316902(GME1)
SPEN: 
107006921 107031214(GME2)
SOT: 
102577923 102582256
INI: 
109153793 109158190
SIND: 
105158417 105171617
BVG: 
104890910
NNU: 
104609581 104613267
OSA: 
4348636(GME-1) 4350816(GME-2)
DOSA: 
Os10t0417600-01(Os10g0417600) Os11t0591100-01(Os11g0591100)
OBR: 
102714961 102718679
BDI: 
100824332 100826361
ATS: 
F775_27949 F775_29141
SBI: 
8059467
ZMA: 
100192102(IDP512) 100280325(gpm480)
SITA: 
101752979 101772247 101778042
PDA: 
103695731 103716162 103718012
EGU: 
105046574 105053413 105055709
MUS: 
103975282 103978838 103990359 103993866
ATR: 
18429544
SMO: 
SELMODRAFT_110416 SELMODRAFT_128181 SELMODRAFT_157784 SELMODRAFT_178232 SELMODRAFT_272082 SELMODRAFT_406366 SELMODRAFT_76013 SELMODRAFT_76257 SELMODRAFT_79000 SELMODRAFT_83391
PPP: 
PHYPADRAFT_168267 PHYPADRAFT_170239 PHYPADRAFT_186902
CRE: 
CHLREDRAFT_196952(SNE1)
VCN: 
VOLCADRAFT_77112
OLU: 
OSTLU_18701
OTA: 
Ot18g01190
BPG: 
Bathy09g00960
MIS: 
MICPUN_80077 MICPUN_92683
MPP: 
MICPUCDRAFT_46037
CSL: 
COCSUDRAFT_52441
CVR: 
CHLNCDRAFT_140350
APRO: 
F751_1084
CME: 
CYME_CMS308C
GSL: 
Gasu_54810
CCP: 
CHC_T00009453001
ACAN: 
ACA1_183570
AAF: 
AURANDRAFT_69812
EHX: 
EMIHUDRAFT_433869
GTT: 
GUITHDRAFT_157063
TVA: 
TVAG_381690
 » show all
Taxonomy
Reference
1  [PMID:7098948]
  Authors
Barber GA, Hebda PA.
  Title
GDP-D-mannose: GDP-L-galactose epimerase from Chlorella pyrenoidosa.
  Journal
Methods. Enzymol. 83 (1982) 522-5.
Reference
2  [PMID:443816]
  Authors
Hebda PA, Behrman EJ, Barber GA.
  Title
The guanosine 5'-diphosphate D-mannose: guanosine 5'-diphosphate L-galactose epimerase of Chlorella pyrenoidosa. Chemical synthesis of guanosine 5'-diphosphate L-galactose and further studies of the enzyme and the reaction it catalyzes.
  Journal
Arch. Biochem. Biophys. 194 (1979) 496-502.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
72162-82-4
LinkDB All DBs

KEGG   REACTION: R00889Help
Entry
R00889                      Reaction                               

Name
GDP-mannose 3,5-epimerase
Definition
GDP-mannose <=> GDP-L-galactose
Equation
Reaction class
C00096_C02280
Enzyme
Pathway
Ascorbate and aldarate metabolism
Amino sugar and nucleotide sugar metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Module
M00114  
Ascorbate biosynthesis, plants, glucose-6P => ascorbate
Orthology
K10046  
GDP-D-mannose 3', 5'-epimerase [EC:5.1.3.18 5.1.3.-]
LinkDB All DBs

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