KEGG   ORTHOLOGY: K10047Help
Entry
K10047                      KO                                     

Name
VTC4
Definition
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.25 3.1.3.93]
Pathway
Ascorbate and aldarate metabolism
Inositol phosphate metabolism
Phosphatidylinositol signaling system
Module
M00114  
Ascorbate biosynthesis, plants, glucose-6P => ascorbate
M00131  
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
   00562 Inositol phosphate metabolism
    K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
 Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00131  Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
     K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
  Nucleotide and amino acid metabolism
   Cofactor and vitamin biosynthesis
    M00114  Ascorbate biosynthesis, plants, glucose-6P => ascorbate
     K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.25  inositol-phosphate phosphatase
     K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
    3.1.3.93  L-galactose 1-phosphate phosphatase
     K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
BRITE hierarchy
Other DBs
Genes
ATH: 
AT3G02870(VTC4)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
105769546 105776961
GHI: 
107905686 107925171 107930396
EGR: 
104445626
GMX: 
100790820 100799849 100817591
PVU: 
PHAVU_003G084500g PHAVU_006G1424001
VRA: 
106766982 106774484
VAR: 
108332122 108341122
CCAJ: 
109804004 109808510
MTR: 
MTR_2g026060
CAM: 
101496687
ADU: 
107466189 107482925
AIP: 
107636682 107638701
LJA: 
Lj4g3v0119960.1(Lj4g3v0119960.1) Lj6g3v1753250.1(Lj6g3v1753250.1)
LANG: 
109334908 109362898
FVE: 
101293560
PPER: 
18779066
PMUM: 
103326976
MDM: 
103422491 103434428 103446901
PXB: 
103936818 103943393 103963758
ZJU: 
107434858 107435207
CSV: 
101206261 101217972
CMO: 
103484661 103501724
RCU: 
8285763
JCU: 
105638823
POP: 
POPTR_0006s01600g(POPTRDRAFT_716898) POPTR_0016s01220g(POPTRDRAFT_808295) POPTR_0016s01230g
VVI: 
100241840
SLY: 
544013(IMP3) 544014(IMP2) 544280(IMP1)
SPEN: 
107002996 107014064 107016217
SOT: 
102594242 102601018 102601710
INI: 
109165281
SIND: 
105168029 105175262
BVG: 
104900878
NNU: 
104594191 104602512 104606566
OSA: 
4333347
DOSA: 
Os03t0587000-01(Os03g0587000)
OBR: 
102705514
BDI: 
100844148
ATS: 
F775_30468
ZMA: 
100283131
SITA: 
101785092
PDA: 
103697686
EGU: 
105036034
MUS: 
103986548
ATR: 
18446646
SMO: 
SELMODRAFT_232297 SELMODRAFT_234860
PPP: 
PHYPADRAFT_205419 PHYPADRAFT_223991 PHYPADRAFT_224574
CRE: 
CHLREDRAFT_120462
VCN: 
VOLCADRAFT_78931
OLU: 
OSTLU_38679
OTA: 
Ot05g04910
BPG: 
Bathy03g05420
MIS: 
MICPUN_79551
MPP: 
MICPUCDRAFT_15690
CSL: 
COCSUDRAFT_47143
CVR: 
CHLNCDRAFT_34254
APRO: 
F751_0230
CCP: 
CHC_T00001291001
SRE: 
PTSG_02105
DDI: 
DDB_G0281239(impa1)
DFA: 
DFA_07272(impa1)
ACAN: 
ACA1_065900 ACA1_149190
TPS: 
THAPS_17443
AAF: 
AURANDRAFT_5328
NGD: 
NGA_0525100(IMPA)
EHX: 
EMIHUDRAFT_66633 EMIHUDRAFT_73492
GTT: 
GUITHDRAFT_118366
AG: 
AAV49506
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
  Sequence
[ath:AT3G02870]
Reference
  Authors
Torabinejad J, Donahue JL, Gunesekera BN, Allen-Daniels MJ, Gillaspy GE
  Title
VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants.
  Journal
Plant Physiol 150:951-61 (2009)
DOI:10.1104/pp.108.135129
  Sequence
[ath:AT3G02870]
LinkDB All DBs

KEGG   ORTHOLOGY: K18649Help
Entry
K18649                      KO                                     

Name
IMPL2
Definition
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]
Pathway
Ascorbate and aldarate metabolism
Histidine metabolism
Inositol phosphate metabolism
Biosynthesis of amino acids
Phosphatidylinositol signaling system
Module
M00026  
Histidine biosynthesis, PRPP => histidine
M00114  
Ascorbate biosynthesis, plants, glucose-6P => ascorbate
M00131  
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01230 Biosynthesis of amino acids
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
  Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
   00562 Inositol phosphate metabolism
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
  Amino acid metabolism
   00340 Histidine metabolism
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
 Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00131  Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
  Nucleotide and amino acid metabolism
   Histidine metabolism
    M00026  Histidine biosynthesis, PRPP => histidine
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
   Cofactor and vitamin biosynthesis
    M00114  Ascorbate biosynthesis, plants, glucose-6P => ascorbate
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.15  histidinol-phosphatase
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
    3.1.3.25  inositol-phosphate phosphatase
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
    3.1.3.93  L-galactose 1-phosphate phosphatase
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
BRITE hierarchy
Other DBs
Genes
AQU: 
ATH: 
AT4G39120(IMPL2)
ALY: 
CRB: 
EUS: 
BRP: 
103835143(VTC4)
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18607733
GRA: 
105795327
GHI: 
107908803 107927829
EGR: 
104453354
GMX: 
100527811
PVU: 
PHAVU_009G005100g
VRA: 
106762079
VAR: 
108330818
CCAJ: 
109788874
MTR: 
MTR_3g117220
CAM: 
101502853
ADU: 
107459071 107459873
AIP: 
107609158 107613726
LJA: 
Lj1g3v3381210.1(Lj1g3v3381210.1) Lj1g3v3381210.2(Lj1g3v3381210.2)
LANG: 
109327793
FVE: 
101290997
PPER: 
18768639
PMUM: 
103335696
MDM: 
103410485 103412081 103445134
PXB: 
103939855 103962046
ZJU: 
107426610
CSV: 
101205614
CMO: 
103499699
RCU: 
8284328
JCU: 
105630124
POP: 
POPTR_0009s12340g(POPTRDRAFT_557208) POPTR_0014s05340g
VVI: 
100260677
SLY: 
101254644
SPEN: 
107004365 107025374
SOT: 
102589172 107060700
INI: 
109162162
SIND: 
105169672
BVG: 
104904312 104907756
NNU: 
104595613
OSA: 
4342620
DOSA: 
Os07t0191000-01(Os07g0191000) Os09t0322900-00(Os09g0322900)
OBR: 
102719163
BDI: 
100838580
ATS: 
F775_29934
SBI: 
8085818
ZMA: 
100280816
SITA: 
101782298
PDA: 
103711558
EGU: 
105058778
MUS: 
103994951
ATR: 
18426768
SMO: 
SELMODRAFT_270021 SELMODRAFT_81253
PPP: 
PHYPADRAFT_135827 PHYPADRAFT_138795 PHYPADRAFT_207923
CRE: 
CHLREDRAFT_205880(CPLD4)
VCN: 
VOLCADRAFT_109540
OLU: 
OSTLU_31726
OTA: 
Ot05g02720
BPG: 
Bathy03g03320
MIS: 
MICPUN_108257
MPP: 
MICPUCDRAFT_14899
CSL: 
COCSUDRAFT_17466
CVR: 
CHLNCDRAFT_58575
APRO: 
F751_5675
CME: 
CYME_CMH095C
GSL: 
Gasu_46960
CCP: 
CHC_T00007726001
TPS: 
THAPSDRAFT_31846
AAF: 
AURANDRAFT_4399
BLEP: 
AL038_01805
MGY: 
MGMSRv2__3872
MAGN: 
WV31_04510
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Torabinejad J, Donahue JL, Gunesekera BN, Allen-Daniels MJ, Gillaspy GE
  Title
VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants.
  Journal
Plant Physiol 150:951-61 (2009)
DOI:10.1104/pp.108.135129
  Sequence
[ath:AT4G39120]
Reference
  Authors
Petersen LN, Marineo S, Mandala S, Davids F, Sewell BT, Ingle RA
  Title
The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.
  Journal
Plant Physiol 152:1186-96 (2010)
DOI:10.1104/pp.109.150805
  Sequence
[ath:AT4G39120]
LinkDB All DBs

KEGG   ENZYME: 3.1.3.93Help
Entry
EC 3.1.3.93                 Enzyme                                 

Name
L-galactose 1-phosphate phosphatase;
VTC4 (gene name) (ambiguous);
IMPL2 (gene name) (ambiguous)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
beta-L-galactose-1-phosphate phosphohydrolase
Reaction(IUBMB)
beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate [RN:R07674]
Reaction(KEGG)
Substrate
beta-L-galactose 1-phosphate [CPD:C15926];
H2O [CPD:C00001]
Product
L-galactose [CPD:C01825];
phosphate [CPD:C00009]
Comment
The enzyme from plants also has the activity of EC 3.1.3.25, inositol-phosphate phosphatase. The enzymes have very low activity with D-galactose 1-phosphate (cf. EC 3.1.3.94, D-galactose 1-phosphate phosphatase).
History
EC 3.1.3.93 created 2014
Pathway
Ascorbate and aldarate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K10047  
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
K18649  
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
Genes
AQU: 
ATH: 
AT3G02870(VTC4) AT4G39120(IMPL2)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18597288 18607733
GRA: 
105769546 105776961 105795327
GHI: 
107905686 107908803 107925171 107927829 107930396
EGR: 
104445626 104453354
GMX: 
100527811 100790820 100799849 100817591
PVU: 
PHAVU_003G084500g PHAVU_006G1424001 PHAVU_009G005100g
VRA: 
106762079 106766982 106774484
VAR: 
108330818 108332122 108341122
CCAJ: 
109788874 109804004 109808510
MTR: 
MTR_2g026060 MTR_3g117220
CAM: 
101496687 101502853
ADU: 
107459071 107459873 107466189 107482925
AIP: 
107609158 107613726 107636682 107638701
LJA: 
Lj1g3v3381210.1(Lj1g3v3381210.1) Lj1g3v3381210.2(Lj1g3v3381210.2) Lj4g3v0119960.1(Lj4g3v0119960.1) Lj6g3v1753250.1(Lj6g3v1753250.1)
LANG: 
109327793 109334908 109362898
FVE: 
101290997 101293560
PPER: 
18768639 18779066
PMUM: 
103326976 103335696
MDM: 
103410485 103412081 103422491 103434428 103445134 103446901
PXB: 
103936818 103939855 103943393 103962046 103963758
ZJU: 
107426610 107434858 107435207
CSV: 
101205614 101206261 101217972
CMO: 
103484661 103499699 103501724
RCU: 
8284328 8285763
JCU: 
105630124 105638823
POP: 
POPTR_0006s01600g(POPTRDRAFT_716898) POPTR_0009s12340g(POPTRDRAFT_557208) POPTR_0014s05340g POPTR_0016s01220g(POPTRDRAFT_808295) POPTR_0016s01230g
VVI: 
100241840 100260677
SLY: 
101254644 544013(IMP3) 544014(IMP2) 544280(IMP1)
SPEN: 
107002996 107004365 107014064 107016217 107025374
SOT: 
102589172 102594242 102601018 102601710 107060700
INI: 
109162162 109165281
SIND: 
105168029 105169672 105175262
BVG: 
104900878 104904312 104907756
NNU: 
104594191 104595613 104602512 104606566
OSA: 
4333347 4342620
DOSA: 
Os03t0587000-01(Os03g0587000) Os07t0191000-01(Os07g0191000) Os09t0322900-00(Os09g0322900)
OBR: 
102705514 102719163
BDI: 
100838580 100844148
ATS: 
F775_29934 F775_30468
SBI: 
8085818
ZMA: 
100280816 100283131
SITA: 
101782298 101785092
PDA: 
103697686 103711558
EGU: 
105036034 105058778
MUS: 
103986548 103994951
ATR: 
18426768 18446646
SMO: 
SELMODRAFT_232297 SELMODRAFT_234860 SELMODRAFT_270021 SELMODRAFT_81253
PPP: 
PHYPADRAFT_135827 PHYPADRAFT_138795 PHYPADRAFT_205419 PHYPADRAFT_207923 PHYPADRAFT_223991 PHYPADRAFT_224574
CRE: 
CHLREDRAFT_120462 CHLREDRAFT_205880(CPLD4)
VCN: 
VOLCADRAFT_109540 VOLCADRAFT_78931
OLU: 
OSTLU_31726 OSTLU_38679
OTA: 
Ot05g02720 Ot05g04910
BPG: 
Bathy03g03320 Bathy03g05420
MIS: 
MICPUN_108257 MICPUN_79551
MPP: 
MICPUCDRAFT_14899 MICPUCDRAFT_15690
CSL: 
COCSUDRAFT_17466 COCSUDRAFT_47143
CVR: 
CHLNCDRAFT_34254 CHLNCDRAFT_58575
APRO: 
F751_0230 F751_5675
CME: 
CYME_CMH095C
GSL: 
Gasu_46960
CCP: 
CHC_T00001291001 CHC_T00007726001
SRE: 
PTSG_02105
DDI: 
DDB_G0281239(impa1)
DFA: 
DFA_07272(impa1)
ACAN: 
ACA1_065900 ACA1_149190
TPS: 
THAPSDRAFT_31846 THAPS_17443
AAF: 
AURANDRAFT_4399 AURANDRAFT_5328
NGD: 
NGA_0525100(IMPA)
EHX: 
EMIHUDRAFT_66633 EMIHUDRAFT_73492
GTT: 
GUITHDRAFT_118366
BLEP: 
AL038_01805
MGY: 
MGMSRv2__3872
MAGN: 
WV31_04510
 » show all
Taxonomy
Reference
1  [PMID:15550539]
  Authors
Laing WA, Bulley S, Wright M, Cooney J, Jensen D, Barraclough D, MacRae E
  Title
A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 16976-81.
  Sequence
Reference
2  [PMID:19339506]
  Authors
Torabinejad J, Donahue JL, Gunesekera BN, Allen-Daniels MJ, Gillaspy GE
  Title
VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants.
  Journal
Plant. Physiol. 150 (2009) 951-61.
  Sequence
Reference
3  [PMID:20023146]
  Authors
Petersen LN, Marineo S, Mandala S, Davids F, Sewell BT, Ingle RA
  Title
The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.
  Journal
Plant. Physiol. 152 (2010) 1186-96.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R07674Help
Entry
R07674                      Reaction                               

Name
beta-L-galactose-1-phosphate phosphohydrolase
Definition
beta-L-Galactose 1-phosphate + H2O <=> L-Galactose + Orthophosphate
Equation
Reaction class
C01825_C15926
Enzyme
Pathway
Ascorbate and aldarate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Module
M00114  
Ascorbate biosynthesis, plants, glucose-6P => ascorbate
Orthology
K10047  
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.25 3.1.3.93]
K18649  
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]
LinkDB All DBs

DBGET integrated database retrieval system