| Entry |
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| Name |
4-hydroxy-4-methyl-2-oxoglutarate aldolase;
pyruvate aldolase;
gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase;
4-hydroxy-4-methyl-2-ketoglutarate aldolase;
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase;
HMG aldolase;
CHA aldolase;
4-carboxy-4-hydroxy-2-oxoadipate aldolase
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| Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
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| Sysname |
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)
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| Reaction(IUBMB) |
(1) 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate [RN: R00008];
(2) 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate [RN: R00350]
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| Reaction(KEGG) |
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| Substrate |
4-hydroxy-4-methyl-2-oxoglutarate [CPD: C06033];
2-hydroxy-4-oxobutane-1,2,4-tricarboxylate [CPD: C04115]
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| Product |
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| Comment |
Requires a divalent metal ion [3]. This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), phthalate, syringate and 3,4,5-trihydroxybenzoate [1-3]. The enzyme from Pseudomonas ochraceae can also cleave 4-hydroxy-2-oxoglutarate to glyoxylate and pyruvate, and also catalyses the reaction of EC 4.1.1.3 (oxaloacetate decarboxylase) [3].
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| History |
EC 4.1.3.17 created 1972, modified 2012
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| Pathway |
| Benzoate degradation | | C5-Branched dibasic acid metabolism | | Microbial metabolism in diverse environments |
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| Orthology |
| 4-hydroxy-4-methyl-2-oxoglutarate aldolase |
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| Genes |
KPN: | | KPU: | | KPM: | | KPP: | | KPK: | | KPH: | | KPZ: | | KPV: | | KPW: | | KPY: | | KPG: | | KPC: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPR: | | KPJ: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KPNE: | | KPNU: | | KVA: | | KVD: | | KVQ: | | KMI: | | KQU: | | CRO: | | ROR: | | PGE: | | YPE: | | YPK: | | YPA: | | YPN: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPW: | | YPJ: | | YPV: | | YPL: | | YPS: | | YPO: | | YPI: | | YPY: | | YPB: | | YPQ: | | YPU: | | YPR: | | YPC: | | YPF: | | SPE: | | SMAF: | | SRZ: | | SFO: | | RAH: | | RAA: | | PCV: | | SOD: | | DSO: | | EAM: | | EAY: | | EBI: | | PAO: | | KLN: | | TCI: | | XCC: | | XCB: | | XCA: | | XCP: | | XCV: | | XAC: | | XCI: | | XCT: | | XCU: | | XCN: | | XCW: | | XCR: | | XCM: | | XCF: | | XCJ: | | XFU: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOY: | | XOR: | | XOZ: | | XGA: | | XVE: | | XPE: | | SRH: | | SLM: | | LRZ: | | VNA: | | VEJ: | | VFL: | | PCQ: | | PPU: | | PPF: | | PPW: | | PPB: | | PPI: | | PPX: | | PPUT: | | PPUN: | | PFE: | | PAZO: | | PSTT: | | PPUU: | | PSES: | | AVN: | | AVL: | | AVD: | | PAT: | | MBS: | | AAW: | | CSA: | | HALO: | | MMW: | | MME: | | MPC: | | GSN: | | PSE: | | RSO: | | RSL: | | RSN: | | RSM: | | RSE: | | RPJ: | | RIN: | | REU: | | CNC: | | RME: | | CBW: | | CGD: | | CCUP: | | BUR: | | BCEN: | | BCEO: | | BMU: | | BMJ: | | BMK: | | BMUL: | | BCED: | | BUB: | | BDF: | | BTEI: | | BPSL: | | BMEC: | | BGP: | | BGE: | | BGF: | | BGD: | | BGO: | | BYI: | | BUO: | | BUE: | | BUQ: | | BPLA: | | BPH: | | BPX: | | BFN: | | BCAI: | | PSPW: | | PPK: | | PPNO: | | PPNM: | | PRB: | | PPUL: | | PSPU: | | PAPI: | | PVE: | | POX: | | PTX: | | PFG: | | PNR: | | BBM: | | BPT: | | BHO: | | BHM: | | BHZ: | | BTRM: | | BBRO: | | AIS: | | CDN: | | PHN: | | RFR: | | RSB: | | RHY: | | POL: | | PNA: | | ACK: | | ACRA: | | ACID: | | DAC: | | DEL: | | DTS: | | DHK: | | VAP: | | VPE: | | VPD: | | CTT: | | CTES: | | CKE: | | ADN: | | ADK: | | RTA: | | LIM: | | LIH: | | HYR: | | HYB: | | HYL: | | CBAA: | | CBAB: | | HSE: | | HSZ: | | MASW: | | LCH: | | MIU: | | RGU: | | SHD: | | AZO: | | THU: | | TCL: | | APP: | | BEB: | | BEBA: | | DTI: | | MAMO: | | MESO: | | AAK: | | SME: | | SMK: | | SMQ: | | SMX: | | SMEG: | | SMEL: | | SMER: | | RHI: | | SFH: | | SAME: | | ATU: | | ARA: | | ATF: | | AVI: | | AGR: | | ARO: | | RET: | | REL: | | REI: | | REP: | | RLE: | | RLT: | | RLG: | | RLB: | | RLU: | | RIR: | | RHL: | | RGA: | | RHN: | | RPHA: | | RHT: | | RHX: | | NGL: | | NGG: | | SHZ: | | BJA: | | BJU: | | BJP: | | BRA: | | BBT: | | BRS: | | AOL: | | BRC: | | BRAD: | | BIC: | | RPA: | | RPB: | | RPD: | | RPE: | | RPT: | | RPX: | | BOP: | | AZC: | | MOR: | | MAQU: | | PHL: | | DEQ: | | MAAD: | | MMED: | | PSIN: | | BSB: | | AEX: | | RSP: | | RSH: | | RSK: | | PAMI: | | KVU: | | KVL: | | PGA: | | PTP: | | MALG: | | LAP: | | LAGG: | | DAA: | | YAN: | | NAR: | | NPP: | | NPN: | | NRE: | | SMAZ: | | SWI: | | SPHI: | | SSAN: | | SPAN: | | SKR: | | SJP: | | SCH: | | SSY: | | SPHB: | | SPHR: | | SINB: | | SPHG: | | BLAS: | | AAY: | | ADO: | | CMAN: | | RGI: | | MAG: | | MAGX: | | MAGN: | | AZL: | | ALI: | | ABS: | | ABQ: | | ABF: | | ATI: | | AHU: | | MAGQ: | | PGV: | | APB: | | BEO: | | GCT: | | GOT: | | PNP: | | AAC: | | AAD: | | ECAS: | | CCK: | | TPZ: | | LPIL: | | MSM: | | MSG: | | MSB: | | MSN: | | MSH: | | MRH: | | MGO: | | RHA: | | RER: | | REB: | | ROP: | | ROA: | | GPO: | | GOR: | | SMA: | | SSX: | | SVL: | | SFA: | | SBH: | | SALB: | | STRP: | | SRC: | | SCW: | | SXI: | | SCX: | | STRF: | | SLE: | | SLS: | | STRD: | | KSK: | | ART: | | ARR: | | ARE: | | ARH: | | ARZ: | | AAU: | | ACH: | | APN: | | SATK: | | MPH: | | SRO: | | NOA: | | BSD: | | MMAR: | | SVI: | | AMQ: | | PDX: | | PSEA: | | PSEE: | | PSEQ: | | PECQ: | | PHH: | | KPHY: | | MAU: | | ACTN: | | RXY: | | CWO: | | ABAI: | | TRO: | | STI: | | TSC: | | THC: | | TOS: | | TBC: | | MRB: | | MRE: | | SUS: | | SLI: | | RSI: | | EOL: | | SACS: | | MSE: | |
» show all
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| Reference |
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| Authors |
Tack BF, Chapman PJ, Dagley S. |
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| Title |
Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase. |
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| Journal |
J. Biol. Chem. 247 (1972) 6444-9. |
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| Reference |
2 |
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| Authors |
Wood, W.A. |
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| Title |
2-Keto-3-deoxy-6-phosphogluconic and related aldolases. |
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| Journal |
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302. |
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| Reference |
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| Authors |
Maruyama K. |
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| Title |
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase. |
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| Journal |
J. Biochem. (Tokyo). 93 (1983) 557-65. |
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| Reference |
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| Authors |
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E |
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| Title |
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida. |
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| Journal |
Mol. Microbiol. 79 (2011) 359-74. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37290-65-6 |
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| LinkDB |
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