| Entry |
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| Name |
2-pyrone-4,6-dicarboxylate lactonase;
2-pyrone-4,6-dicarboxylate hydrolase;
2-pyrone-4,6-dicarboxylate lactonohydrolase
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| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
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| Sysname |
2-oxo-2H-pyran-4,6-dicarboxylate lactonohydrolase
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| Reaction(IUBMB) |
2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [RN: R04277]
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| Reaction(KEGG) |
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| Substrate |
2-oxo-2H-pyran-4,6-dicarboxylate;
H2O [CPD: C00001]
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| Product |
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [CPD: C04434]
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| Comment |
The product is most likely the keto-form of 4-oxalomesaconate (as shown in the reaction) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC 5.3.2.8, 4-oxalomesaconate tautomerase [3].
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| History |
EC 3.1.1.57 created 1986, modified 2010
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| Pathway |
| Benzoate degradation | | Aminobenzoate degradation | | Microbial metabolism in diverse environments |
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| Orthology |
| 2-pyrone-4,6-dicarboxylate lactonase |
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| Genes |
SOD: | | SRH: | | SLM: | | VNA: | | VEJ: | | VFL: | | PPUH: | | PCG: | | PAT: | | AAW: | | MMW: | | MME: | | MPC: | | GSN: | | BPH: | | BPX: | | PTX: | | CDN: | | PHN: | | RFR: | | RSB: | | RHY: | | POL: | | PNA: | | ACK: | | ACRA: | | ACID: | | VEI: | | DAC: | | DEL: | | DTS: | | DHK: | | VAP: | | VPD: | | CTT: | | CTES: | | CKE: | | ADN: | | ADK: | | RTA: | | LIM: | | LIH: | | HYR: | | HYB: | | HYL: | | CBAA: | | CBAB: | | LCH: | | MIU: | | RGU: | | SHD: | | AZO: | | THU: | | TCL: | | MESO: | | ARA: | | RLE: | | BRA: | | BBT: | | AOL: | | RPA: | | RPB: | | RPD: | | RPE: | | RPT: | | RPX: | | RHZ: | | BSB: | | MALG: | | YAN: | | NAR: | | NPP: | | NPN: | | SMAZ: | | SPHI: | | SSAN: | | SPAN: | | SKR: | | SCH: | | SSY: | | SPHB: | | SPHR: | | SPHG: | | BLAS: | | AAY: | | ADO: | | CMAN: | | MAG: | | MAGX: | | MAGN: | | ABS: | | ABQ: | | MAGQ: | | PGV: | | ROA: | | SSX: | | SVL: | | SFA: | | SALB: | | STRP: | | SRC: | | STRF: | | STRD: | | KSK: | | ART: | | ACH: | | APN: | | SATK: | | AMQ: | | PSEQ: | | PECQ: | | PHH: | |
» show all
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| Reference |
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| Authors |
Kersten PJ, Dagley S, Whittaker JW, Arciero DM, Lipscomb JD. |
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| Title |
2-pyrone-4,6-dicarboxylic acid, a catabolite of gallic acids in Pseudomonas species. |
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| Journal |
J. Bacteriol. 152 (1982) 1154-62. |
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| Reference |
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| Authors |
Maruyama K. |
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| Title |
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase. |
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| Journal |
J. Biochem. (Tokyo). 93 (1983) 557-65. |
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| Reference |
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| Authors |
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E |
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| Title |
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida. |
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| Journal |
Mol. Microbiol. 79 (2011) 359-74. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 84177-55-9 |
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| LinkDB |
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