| Entry |
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| Name |
2,4-dichlorophenol 6-monooxygenase;
2,4-dichlorophenol hydroxylase;
2,4-dichlorophenol monooxygenase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)
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| Reaction(IUBMB) |
2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O [RN: R03997]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but more slowly.
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| History |
EC 1.14.13.20 created 1983
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| Pathway |
| Chlorocyclohexane and chlorobenzene degradation | | Metabolic pathways | | Microbial metabolism in diverse environments |
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| Orthology |
| 2,4-dichlorophenol 6-monooxygenase |
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| Genes |
PCQ: | | PPUH: | | PDR: | | PSV: | | ACB: | | ACD: | | AEI: | | REU: | | CNC: | | BCEN: | | BMU: | | BMJ: | | BCT: | | BPSL: | | BYI: | | BPT: | | AXY: | | ADN: | | ADK: | | DAR: | | MLN: | | MCI: | | MAMO: | | MESO: | | MESW: | | SIX: | | AVI: | | AGC: | | RLE: | | RLG: | | RHL: | | SHZ: | | BRA: | | MSL: | | PHL: | | MAAD: | | MMED: | | OAT: | | NRE: | | SWI: | | SJP: | | SINB: | | MVA: | | CEF: | | CHN: | | CMD: | | CHM: | | CDX: | | NSL: | | RHA: | | REB: | | ROP: | | ROA: | | RPY: | | RAV: | | SCB: | | SVL: | | SHY: | | SHO: | | SDV: | | SCW: | | SXI: | | STRC: | | SCX: | | SLE: | | SGS: | | STSI: | | SLS: | | SNW: | | MVD: | | FRP: | | ART: | | ACH: | | KPL: | | NAE: | | PSIM: | | NML: | | AMD: | | AMN: | | AMM: | | AMZ: | | AMQ: | | PSEA: | | PSEH: | | PHH: | | KPHY: | | AHM: | | AFS: | |
» show all
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| Reference |
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| Authors |
Beadle CA, Smith AR. |
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| Title |
The purification and properties of 2,4-dichlorophenol hydroxylase from a strain of Acinetobacter species. |
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| Journal |
Eur. J. Biochem. 123 (1982) 323-32. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 82047-82-3 |
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| LinkDB |
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